Outbreak of influenza‐like illness investigated during August 2013 near Indo‐China border of Arunachal Pradesh, Northeast India
Identifieur interne : 000899 ( Main/Exploration ); précédent : 000898; suivant : 000900Outbreak of influenza‐like illness investigated during August 2013 near Indo‐China border of Arunachal Pradesh, Northeast India
Auteurs : Dipankar Biswas [Inde] ; Manika Buragohain [Inde] ; Kaushal Yadav [Inde] ; Mousumi Dutta [Inde] ; Kimmi Sarmah [Inde] ; Pranjal Jyoti Baruah [Inde] ; Biswajyoti Borkakoty [Inde]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2016-11.
Abstract
During August 2013, an outbreak of influenza‐like illnesses (ILI) was investigated in Monigong area, near Indo‐China border of Arunachal Pradesh, Northeast India. Influenza type A/H3N2 was detected by RT‐PCR in 33.3% (8/24) of ILI cases. Sequence analysis of HA and NA genes revealed eight and five amino acid substitutions, respectively in Monigong H3N2 (Mo/H3N2) strains as compared to vaccine strain A/Victoria/361/2011. Four non‐synonymous substitutions, three localizing at antigenic sites T144A, A; R158G, B; L173S, D, and one H9Y in close proximity to a potential glycosylation site aa8 in HA1 domain along with the substitution T329N in NA are likely to influence the antigenicity/virulence of Mo/H3N2 viruses. J. Med. Virol. 88:1999–2003, 2016. © 2016 Wiley Periodicals, Inc.
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DOI: 10.1002/jmv.24539
Affiliations:
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Influenza type A/H3N2 was detected by RT‐PCR in 33.3% (8/24) of ILI cases. Sequence analysis of HA and NA genes revealed eight and five amino acid substitutions, respectively in Monigong H3N2 (Mo/H3N2) strains as compared to vaccine strain A/Victoria/361/2011. Four non‐synonymous substitutions, three localizing at antigenic sites T144A, A; R158G, B; L173S, D, and one H9Y in close proximity to a potential glycosylation site aa8 in HA1 domain along with the substitution T329N in NA are likely to influence the antigenicity/virulence of Mo/H3N2 viruses. J. Med. 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