A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications
Identifieur interne : 000888 ( Main/Exploration ); précédent : 000887; suivant : 000889A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications
Auteurs : Bochuan Yuan ; Rui Yang ; Yongsheng Ma ; Shan Zhou ; Xiaodong Zhang ; Ying LiuSource :
- Pharmaceutical Biology [ 1388-0209 ] ; 2016.
Abstract
Url:
DOI: 10.1080/13880209.2016.1262433
PubMed: 27951737
PubMed Central: 6130612
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications</title><author><name sortKey="Yuan, Bochuan" sort="Yuan, Bochuan" uniqKey="Yuan B" first="Bochuan" last="Yuan">Bochuan Yuan</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Yang, Rui" sort="Yang, Rui" uniqKey="Yang R" first="Rui" last="Yang">Rui Yang</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Ma, Yongsheng" sort="Ma, Yongsheng" uniqKey="Ma Y" first="Yongsheng" last="Ma">Yongsheng Ma</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Zhou, Shan" sort="Zhou, Shan" uniqKey="Zhou S" first="Shan" last="Zhou">Shan Zhou</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Xiaodong" sort="Zhang, Xiaodong" uniqKey="Zhang X" first="Xiaodong" last="Zhang">Xiaodong Zhang</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27951737</idno><idno type="pmc">6130612</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130612</idno><idno type="RBID">PMC:6130612</idno><idno type="doi">10.1080/13880209.2016.1262433</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000793</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000793</idno><idno type="wicri:Area/Pmc/Curation">000793</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000793</idno><idno type="wicri:Area/Pmc/Checkpoint">000298</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000298</idno><idno type="wicri:Area/Ncbi/Merge">000593</idno><idno type="wicri:Area/Ncbi/Curation">000593</idno><idno type="wicri:Area/Ncbi/Checkpoint">000593</idno><idno type="wicri:doubleKey">1388-0209:2016:Yuan B:a:systematic:review</idno><idno type="wicri:Area/Main/Merge">000890</idno><idno type="wicri:Area/Main/Curation">000888</idno><idno type="wicri:Area/Main/Exploration">000888</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications</title><author><name sortKey="Yuan, Bochuan" sort="Yuan, Bochuan" uniqKey="Yuan B" first="Bochuan" last="Yuan">Bochuan Yuan</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Yang, Rui" sort="Yang, Rui" uniqKey="Yang R" first="Rui" last="Yang">Rui Yang</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Ma, Yongsheng" sort="Ma, Yongsheng" uniqKey="Ma Y" first="Yongsheng" last="Ma">Yongsheng Ma</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Zhou, Shan" sort="Zhou, Shan" uniqKey="Zhou S" first="Shan" last="Zhou">Shan Zhou</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Xiaodong" sort="Zhang, Xiaodong" uniqKey="Zhang X" first="Xiaodong" last="Zhang">Xiaodong Zhang</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Pharmaceutical Biology</title><idno type="ISSN">1388-0209</idno><idno type="eISSN">1744-5116</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p><bold>Context:</bold> Radix Bupleuri has been used in traditional Chinese medicine for over 2000 years with functions of relieving exterior syndrome, clearing heat, regulating liver-<italic>qi</italic>, and lifting yang-<italic>qi</italic>. More natural active compounds, especially saikosaponins, have been isolated from Radix Bupleuri, which possess various valuable pharmacological activities.</p><p><bold>Objective:</bold> To summarize the current knowledge on pharmacological activities, mechanisms and applications of extracts and saikosaponins isolated from Radix Bupleuri, and obtain new insights for further research and development of Radix Bupleuri.</p><p><bold>Methods:</bold> PubMed, Web of Science, Science Direct, Research Gate, Academic Journals and Google Scholar were used as information sources through the inclusion of the search terms ‘Radix Bupleuri’, ‘<italic>Bupleurum</italic>’, ‘saikosaponins’, ‘Radix Bupleuri preparation’, and their combinations, mainly from the year 2008 to 2016 without language restriction. Clinical preparations containing Radix Bupleuri were collected from official website of China Food and Drug Administration (CFDA).</p><p><bold>Results and conclusion:</bold> 296 papers were searched and 128 papers were reviewed. A broad spectrum of <italic>in vitro</italic> and <italic>in vivo</italic> research has proved that Radix Bupleuri extracts, saikosaponin a, saikosaponin d, saikosaponin c, and saikosaponin b<sub>2</sub>, exhibit evident anti-inflammatory, antitumor, antiviral, anti-allergic, immunoregulation, and neuroregulation activities mainly through NF-<italic>κ</italic>B, MAPK or other pathways. 15 clinical preparations approved by CFDA remarkably broaden the application of Radix Bupleuri. The main side effect of Radix Bupleuri is liver damage when the dosage is excess, which indicates that the maximum tolerated dose is critical for clinical use of Radix Bupleuri extract and purified compounds.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ashour, Ml" uniqKey="Ashour M">ML Ashour</name></author><author><name sortKey="El Readi, M" uniqKey="El Readi M">M El-Readi</name></author><author><name sortKey="Youns, M" uniqKey="Youns M">M Youns</name></author><author><name sortKey="Mulyaningsih, S" uniqKey="Mulyaningsih S">S Mulyaningsih</name></author><author><name sortKey="Sporer, F" uniqKey="Sporer F">F Sporer</name></author><author><name sortKey="Efferth, T" uniqKey="Efferth T">T Efferth</name></author><author><name sortKey="Wink, M" uniqKey="Wink M">M. 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Song</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name><name sortKey="Ma, Yongsheng" sort="Ma, Yongsheng" uniqKey="Ma Y" first="Yongsheng" last="Ma">Yongsheng Ma</name><name sortKey="Yang, Rui" sort="Yang, Rui" uniqKey="Yang R" first="Rui" last="Yang">Rui Yang</name><name sortKey="Yuan, Bochuan" sort="Yuan, Bochuan" uniqKey="Yuan B" first="Bochuan" last="Yuan">Bochuan Yuan</name><name sortKey="Zhang, Xiaodong" sort="Zhang, Xiaodong" uniqKey="Zhang X" first="Xiaodong" last="Zhang">Xiaodong Zhang</name><name sortKey="Zhou, Shan" sort="Zhou, Shan" uniqKey="Zhou S" first="Shan" last="Zhou">Shan Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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