Host restriction factors for hepatitis C virus
Identifieur interne : 000858 ( Main/Exploration ); précédent : 000857; suivant : 000859Host restriction factors for hepatitis C virus
Auteurs : Li-Ya Zhou ; Lei-Liang ZhangSource :
- World Journal of Gastroenterology [ 1007-9327 ] ; 2016.
Abstract
Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.
Url:
DOI: 10.3748/wjg.v22.i4.1477
PubMed: 26819515
PubMed Central: 4721981
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.</p>
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