Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature
Identifieur interne : 000842 ( Main/Exploration ); précédent : 000841; suivant : 000843Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature
Auteurs : Hussein Algahtani [Arabie saoudite] ; Ahmad Subahi [Arabie saoudite] ; Bader Shirah [Arabie saoudite]Source :
- Case Reports in Neurological Medicine [ 2090-6668 ] ; 2016.
Abstract
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism.
Url:
DOI: 10.1155/2016/3502683
PubMed: 27239356
PubMed Central: 4864560
Affiliations:
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Box 12723, Jeddah 21483, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdulaziz Medical City/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483</wicri:regionArea><wicri:noRegion>Jeddah 21483</wicri:noRegion></affiliation></author><author><name sortKey="Subahi, Ahmad" sort="Subahi, Ahmad" uniqKey="Subahi A" first="Ahmad" last="Subahi">Ahmad Subahi</name><affiliation wicri:level="1"><nlm:aff id="I2">King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483</wicri:regionArea><wicri:noRegion>Jeddah 21483</wicri:noRegion></affiliation></author><author><name sortKey="Shirah, Bader" sort="Shirah, Bader" uniqKey="Shirah B" first="Bader" last="Shirah">Bader Shirah</name><affiliation wicri:level="1"><nlm:aff id="I3">King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483</wicri:regionArea><wicri:noRegion>Jeddah 21483</wicri:noRegion></affiliation></author></analytic><series><title level="j">Case Reports in Neurological Medicine</title><idno type="ISSN">2090-6668</idno><idno type="eISSN">2090-6676</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A. M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. Van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T. M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A. D. M. E. 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Perlman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li></country></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Algahtani, Hussein" sort="Algahtani, Hussein" uniqKey="Algahtani H" first="Hussein" last="Algahtani">Hussein Algahtani</name></noRegion><name sortKey="Shirah, Bader" sort="Shirah, Bader" uniqKey="Shirah B" first="Bader" last="Shirah">Bader Shirah</name><name sortKey="Subahi, Ahmad" sort="Subahi, Ahmad" uniqKey="Subahi A" first="Ahmad" last="Subahi">Ahmad Subahi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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