A case series on common cold to severe bronchiolitis and pneumonia in children following human metapneumovirus infection in Sri Lanka
Identifieur interne : 000738 ( Main/Exploration ); précédent : 000737; suivant : 000739A case series on common cold to severe bronchiolitis and pneumonia in children following human metapneumovirus infection in Sri Lanka
Auteurs : J. A. A. S. Jayaweera [Sri Lanka] ; F. Noordeen [Sri Lanka] ; S. Kothalaweala [Sri Lanka] ; F. N. N. Pitchai [Sri Lanka] ; M. L. M. Rayes [Sri Lanka]Source :
- BMC Research Notes [ 1756-0500 ] ; 2018.
Abstract
The prevalence of hMPV infections in Sri Lanka has not been reported and here we report a case series of hMPV infection in children less than 5 years. Patients with ARTI were included from Teaching Hospital, Anuradhapura from March 2013 to August 2014. Indirect fluorescence assay was performed on nasopharyngeal aspirates for the identification of respiratory viruses [respiratory syncytial virus (RSV), parainfluenza virus 1, 2 and 3, influenza A and B and hMPV]. Moreover, reverse transcriptase-polymerase chain reaction was done to further confirm the hMPV infection.
In this case series, hMPV infection showed a range of respiratory symptoms from common cold to life threatening lower respiratory tract infections with varying severity. In some cases, the clinical presentation of hMPV infection was similar to the ARTI caused by RSV. hMPV co-infections with of RSV have also been seen in some cases of ARTI. A child delivered through cesarean section and birth order > 3 has an Odds ratio of 3.5 and 4.3 (95% CI) for developing co-infection with RSV compared to hMPV mono-infections. Lack of diagnostic facilities to identify the viral aetiology has contributed to the use of antibiotics indicating the need for establishing viral diagnostic facilities in the country.
The online version of this article (10.1186/s13104-018-3239-3) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13104-018-3239-3
PubMed: 29444701
PubMed Central: 5813322
Affiliations:
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A. A. S." last="Jayaweera">J. A. A. S. Jayaweera</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.430357.6</institution-id><institution>Department of Microbiology, Faculty of Medical and Allied Sciences,</institution><institution>Rajarata University of Sri Lanka,</institution></institution-wrap>Anuradhapura, Sri Lanka</nlm:aff><country xml:lang="fr">Sri Lanka</country><wicri:regionArea>Anuradhapura</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9816 8637</institution-id><institution-id institution-id-type="GRID">grid.11139.3b</institution-id><institution>Department of Microbiology, Faculty of Medicine,</institution><institution>University of Peradeniya,</institution></institution-wrap>Peradeniya, Sri Lanka</nlm:aff><country xml:lang="fr">Sri Lanka</country><wicri:regionArea>Peradeniya</wicri:regionArea></affiliation></author><author><name sortKey="Noordeen, F" sort="Noordeen, F" uniqKey="Noordeen F" first="F." last="Noordeen">F. 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Rayes</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.430357.6</institution-id><institution>Department of Pediatrics, Faculty of Medical and Allied Sciences,</institution><institution>Rajarata University of Sri Lanka,</institution></institution-wrap>Anuradhapura, Sri Lanka</nlm:aff><country xml:lang="fr">Sri Lanka</country><wicri:regionArea>Anuradhapura</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Research Notes</title><idno type="eISSN">1756-0500</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p id="Par1">The prevalence of hMPV infections in Sri Lanka has not been reported and here we report a case series of hMPV infection in children less than 5 years. Patients with ARTI were included from Teaching Hospital, Anuradhapura from March 2013 to August 2014. Indirect fluorescence assay was performed on nasopharyngeal aspirates for the identification of respiratory viruses [respiratory syncytial virus (RSV), parainfluenza virus 1, 2 and 3, influenza A and B and hMPV]. Moreover, reverse transcriptase-polymerase chain reaction was done to further confirm the hMPV infection.</p></sec><sec><title>Results</title><p id="Par2">In this case series, hMPV infection showed a range of respiratory symptoms from common cold to life threatening lower respiratory tract infections with varying severity. In some cases, the clinical presentation of hMPV infection was similar to the ARTI caused by RSV. hMPV co-infections with of RSV have also been seen in some cases of ARTI. A child delivered through cesarean section and birth order > 3 has an Odds ratio of 3.5 and 4.3 (95% CI) for developing co-infection with RSV compared to hMPV mono-infections. Lack of diagnostic facilities to identify the viral aetiology has contributed to the use of antibiotics indicating the need for establishing viral diagnostic facilities in the country.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (10.1186/s13104-018-3239-3) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pebody, Mb" uniqKey="Pebody M">MB Pebody</name></author><author><name sortKey="Edmunds, Wj" uniqKey="Edmunds W">WJ Edmunds</name></author><author><name sortKey="Zambon, Mc" uniqKey="Zambon M">MC Zambon</name></author><author><name sortKey="Gay, Nj" uniqKey="Gay N">NJ Gay</name></author><author><name sortKey="Crowcroft, Ns" uniqKey="Crowcroft N">NS Crowcroft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Hoogen, Bg" uniqKey="Van Den Hoogen B">BG van den 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Pitchai</name></author><author><name sortKey="Kothalawala, S" uniqKey="Kothalawala S">S Kothalawala</name></author><author><name sortKey="Abeykoon, A" uniqKey="Abeykoon A">A Abeykoon</name></author><author><name sortKey="Peiris, J" uniqKey="Peiris J">J Peiris</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Sri Lanka</li></country></list><tree><country name="Sri Lanka"><noRegion><name sortKey="Jayaweera, J A A S" sort="Jayaweera, J A A S" uniqKey="Jayaweera J" first="J. 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