Demyelination in mice resulting from infection with a mutant of Semliki Forest virus
Identifieur interne : 001709 ( Main/Curation ); précédent : 001708; suivant : 001710Demyelination in mice resulting from infection with a mutant of Semliki Forest virus
Auteurs : B. J. Sheahan [Irlande (pays)] ; P. N. Barrett [Irlande (pays)] ; G. J. Atkins [Irlande (pays)]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1981-06-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Avirulent, Avirulent semliki forest virus, Axon, Berl, Degeneration, Demyelination, Dystrophic fibres, Encephalomyelitis, Grey matter, Inflammatory cells, Lesion, Lipid vacuoles, Mature virus particles, Medulla oblongata, Mouse, Mutant, Mutant virus, Myelin, Myelin debris, Myelin sheaths, Myelinated axons, Necrotic cells, Neuropathol, Oligodendrocyte, Perivascular, Perivascular spaces, Polymorphonuclear leucocytes, Putative, Pycnotic, Pycnotic nuclei, Semliki, Semliki forest virus, Spinal, Spinal cord, Spinal cords, Spongiform, Spongiform degeneration, Spongiform lesions, Suckling, Toluidine, Vacuole, Viral nucleocapsids, Virulent, Virus particles, Webb, White matter.
Abstract
Summary: Twelve of 34 weanling mice (35%) developed lesions in the brain and spinal cord following i.p. infection with 102 p.f.u. of a mutant of Semliki Forest virus (SFV). Six of 12 mice examined 13 days post infection (p.i.) showed meningo-encephalomyelitis with focal spongiform lesions in the grey and white matter. The spongiform lesions were characterised by necrosis of putative oligodendrocytes, myelinic vacuolation and mononuclear cell infiltration. Only one of six mice examined 21 days p.i. and one of six mice examined 28 days p.i. showed lesions which comprised reactive and dystrophic changes in the white matter. Spongiform lesions and pycnotic nuclei were not seen at these times. Viral nucleocapsids were seen in the early stages of the disease in putative necrotic oligodendrocytes. Mature virus particles were not seen. This was in contrast to mice infected with virulent wild-type SFV when lesions were more severe and were accompanied by large numbers of immature and mature virus particles. It is suggested that the demyelination in mice infected with mutant SFV results primarily from selective destruction of oligodendrocytes by the mutant virus.
Url:
DOI: 10.1007/BF00689993
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000253
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000233
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000820
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001738
Links to Exploration step
ISTEX:9FAC351FCF58B3E9C1936715EEF91DA0F43750DDLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Demyelination in mice resulting from infection with a mutant of Semliki Forest virus</title>
<author><name sortKey="Sheahan, B J" sort="Sheahan, B J" uniqKey="Sheahan B" first="B. J." last="Sheahan">B. J. Sheahan</name>
</author>
<author><name sortKey="Barrett, P N" sort="Barrett, P N" uniqKey="Barrett P" first="P. N." last="Barrett">P. N. Barrett</name>
</author>
<author><name sortKey="Atkins, G J" sort="Atkins, G J" uniqKey="Atkins G" first="G. J." last="Atkins">G. J. Atkins</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:9FAC351FCF58B3E9C1936715EEF91DA0F43750DD</idno>
<date when="1981" year="1981">1981</date>
<idno type="doi">10.1007/BF00689993</idno>
<idno type="url">https://api.istex.fr/ark:/67375/1BB-S99LX2K5-V/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000253</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000253</idno>
<idno type="wicri:Area/Istex/Curation">000233</idno>
<idno type="wicri:Area/Istex/Checkpoint">000820</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000820</idno>
<idno type="wicri:doubleKey">0001-6322:1981:Sheahan B:demyelination:in:mice</idno>
<idno type="wicri:Area/Main/Merge">001738</idno>
<idno type="wicri:Area/Main/Curation">001709</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Demyelination in mice resulting from infection with a mutant of Semliki Forest virus</title>
<author><name sortKey="Sheahan, B J" sort="Sheahan, B J" uniqKey="Sheahan B" first="B. J." last="Sheahan">B. J. Sheahan</name>
<affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Veterinary Pathology and Microbiology, Veterinary College of Ireland, Ballsbridge, Dublin 4</wicri:regionArea>
<wicri:noRegion>Dublin 4</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barrett, P N" sort="Barrett, P N" uniqKey="Barrett P" first="P. N." last="Barrett">P. N. Barrett</name>
<affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Microbiology, Moyne Institute, Trinity College, Dublin 2</wicri:regionArea>
<wicri:noRegion>Dublin 2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Atkins, G J" sort="Atkins, G J" uniqKey="Atkins G" first="G. J." last="Atkins">G. J. Atkins</name>
<affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Microbiology, Moyne Institute, Trinity College, Dublin 2</wicri:regionArea>
<wicri:noRegion>Dublin 2</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Acta Neuropathologica</title>
<title level="j" type="abbrev">Acta Neuropathol</title>
<idno type="ISSN">0001-6322</idno>
<idno type="eISSN">1432-0533</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1981-06-01">1981-06-01</date>
<biblScope unit="volume">53</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="129">129</biblScope>
<biblScope unit="page" to="136">136</biblScope>
</imprint>
<idno type="ISSN">0001-6322</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0001-6322</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Demyelinating diseases</term>
<term>Oligodendrocytes</term>
<term>Semliki Forest virus</term>
<term>Spongy degeneration</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acta</term>
<term>Acta neuropathol</term>
<term>Avirulent</term>
<term>Avirulent semliki forest virus</term>
<term>Axon</term>
<term>Berl</term>
<term>Degeneration</term>
<term>Demyelination</term>
<term>Dystrophic fibres</term>
<term>Encephalomyelitis</term>
<term>Grey matter</term>
<term>Inflammatory cells</term>
<term>Lesion</term>
<term>Lipid vacuoles</term>
<term>Mature virus particles</term>
<term>Medulla oblongata</term>
<term>Mouse</term>
<term>Mutant</term>
<term>Mutant virus</term>
<term>Myelin</term>
<term>Myelin debris</term>
<term>Myelin sheaths</term>
<term>Myelinated axons</term>
<term>Necrotic cells</term>
<term>Neuropathol</term>
<term>Oligodendrocyte</term>
<term>Perivascular</term>
<term>Perivascular spaces</term>
<term>Polymorphonuclear leucocytes</term>
<term>Putative</term>
<term>Pycnotic</term>
<term>Pycnotic nuclei</term>
<term>Semliki</term>
<term>Semliki forest virus</term>
<term>Spinal</term>
<term>Spinal cord</term>
<term>Spinal cords</term>
<term>Spongiform</term>
<term>Spongiform degeneration</term>
<term>Spongiform lesions</term>
<term>Suckling</term>
<term>Toluidine</term>
<term>Vacuole</term>
<term>Viral nucleocapsids</term>
<term>Virulent</term>
<term>Virus particles</term>
<term>Webb</term>
<term>White matter</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Summary: Twelve of 34 weanling mice (35%) developed lesions in the brain and spinal cord following i.p. infection with 102 p.f.u. of a mutant of Semliki Forest virus (SFV). Six of 12 mice examined 13 days post infection (p.i.) showed meningo-encephalomyelitis with focal spongiform lesions in the grey and white matter. The spongiform lesions were characterised by necrosis of putative oligodendrocytes, myelinic vacuolation and mononuclear cell infiltration. Only one of six mice examined 21 days p.i. and one of six mice examined 28 days p.i. showed lesions which comprised reactive and dystrophic changes in the white matter. Spongiform lesions and pycnotic nuclei were not seen at these times. Viral nucleocapsids were seen in the early stages of the disease in putative necrotic oligodendrocytes. Mature virus particles were not seen. This was in contrast to mice infected with virulent wild-type SFV when lesions were more severe and were accompanied by large numbers of immature and mature virus particles. It is suggested that the demyelination in mice infected with mutant SFV results primarily from selective destruction of oligodendrocytes by the mutant virus.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001709 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001709 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:9FAC351FCF58B3E9C1936715EEF91DA0F43750DD |texte= Demyelination in mice resulting from infection with a mutant of Semliki Forest virus }}
This area was generated with Dilib version V0.6.33. |