Hippocampal Sclerosis in Feline Epilepsy
Identifieur interne : 000724 ( Istex/Curation ); précédent : 000723; suivant : 000725Hippocampal Sclerosis in Feline Epilepsy
Auteurs : Eva Wagner [Allemagne] ; Marco Rosati [Allemagne] ; Jessica Molin [Allemagne] ; Ulrike Foitzik [Allemagne] ; Andrea M. Wahle [Allemagne] ; Andrea Fischer [Allemagne] ; Lara A. Matiasek [Allemagne] ; Sven Reese [Allemagne] ; Thomas Flegel [Allemagne] ; Kaspar Matiasek [Allemagne]Source :
- Brain Pathology [ 1015-6305 ] ; 2014-11.
Abstract
Hippocampal sclerosis (HS) refers to loss of hippocampal neurons and astrogliosis. In temporal lobe epilepsy (TLE), HS is a key factor for pharmacoresistance, even though the mechanisms are not quite understood. While experimental TLE models are available, there is lack of models reflecting the natural HS development. Among domestic animals, cats may present with TLE‐like seizures in natural and experimental settings. With this study on the prevalence, segmental pattern and clinicopathological correlates of feline HS, we evaluated the translational value for human research. Evaluation schemes for human brains were applied to epileptic cats. The loss of neurons was morphometrically assessed and the degree of gliosis was recorded. Hippocampal changes resembling human HS were seen in about one third of epileptic cats. Most of these were associated with infiltrative diseases such as limbic encephalitis. Irrespective of the etiology and semiology of seizures, total hippocampal sclerosis was the most prevalent form seen in epileptic animals. Other HS types also occur at varying frequencies. Segmental differences to human HS can be explained by species‐specific synaptic connectivities and a different spectrum of etiologies. All these variables require consideration when translating results from feline studies regarding seizure‐associated changes of the temporal lobe and especially HS.
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DOI: 10.1111/bpa.12147
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Wahle</name><affiliation wicri:level="1"><mods:affiliation>Section of Neurology, Small Animal Medical Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University of Munich, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Neurology, Small Animal Medical Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Fischer, Andrea" sort="Fischer, Andrea" uniqKey="Fischer A" first="Andrea" last="Fischer">Andrea Fischer</name><affiliation wicri:level="1"><mods:affiliation>Section of Neurology, Small Animal Medical Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University of Munich, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Neurology, Small Animal Medical Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Matiasek, Lara A" sort="Matiasek, Lara A" uniqKey="Matiasek L" first="Lara A." last="Matiasek">Lara A. Matiasek</name><affiliation wicri:level="1"><mods:affiliation>Section of Neurology, Small Animal Medical Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University of Munich, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Neurology, Small Animal Medical Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Reese, Sven" sort="Reese, Sven" uniqKey="Reese S" first="Sven" last="Reese">Sven Reese</name><affiliation wicri:level="1"><mods:affiliation>Institute of Veterinary Anatomy, Department of Veterinary Sciences, Ludwig Maximilians University of Munich, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Veterinary Anatomy, Department of Veterinary Sciences, Ludwig Maximilians University of Munich, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Flegel, Thomas" sort="Flegel, Thomas" uniqKey="Flegel T" first="Thomas" last="Flegel">Thomas Flegel</name><affiliation wicri:level="1"><mods:affiliation>Neurology Service, Department of Small Animal Medicine, University of Leipzig, Leipzig, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurology Service, Department of Small Animal Medicine, University of Leipzig, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Matiasek, Kaspar" sort="Matiasek, Kaspar" uniqKey="Matiasek K" first="Kaspar" last="Matiasek">Kaspar Matiasek</name><affiliation wicri:level="1"><mods:affiliation>Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University of Munich, Munich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University of Munich, Munich</wicri:regionArea></affiliation><affiliation wicri:level="4"><mods:affiliation>Kaspar Matiasek, MRCVS, Section of Clinical & Comparative Neuropathology, Institute of Veterinary Pathology, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University of Munich, Veterinarstr. 13, Munich D‐80539, Germany (E‐mail: )</mods:affiliation><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: kaspar.matiasek@neuropathologie.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Brain Pathology</title><title level="j" type="alt">BRAIN PATHOLOGY</title><idno type="ISSN">1015-6305</idno><idno type="eISSN">1750-3639</idno><imprint><biblScope unit="vol">24</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="607">607</biblScope><biblScope unit="page" to="619">619</biblScope><biblScope unit="page-count">13</biblScope><date type="published" when="2014-11">2014-11</date></imprint><idno type="ISSN">1015-6305</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1015-6305</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Hippocampal sclerosis (HS) refers to loss of hippocampal neurons and astrogliosis. In temporal lobe epilepsy (TLE), HS is a key factor for pharmacoresistance, even though the mechanisms are not quite understood. While experimental TLE models are available, there is lack of models reflecting the natural HS development. Among domestic animals, cats may present with TLE‐like seizures in natural and experimental settings. With this study on the prevalence, segmental pattern and clinicopathological correlates of feline HS, we evaluated the translational value for human research. Evaluation schemes for human brains were applied to epileptic cats. The loss of neurons was morphometrically assessed and the degree of gliosis was recorded. Hippocampal changes resembling human HS were seen in about one third of epileptic cats. Most of these were associated with infiltrative diseases such as limbic encephalitis. Irrespective of the etiology and semiology of seizures, total hippocampal sclerosis was the most prevalent form seen in epileptic animals. Other HS types also occur at varying frequencies. Segmental differences to human HS can be explained by species‐specific synaptic connectivities and a different spectrum of etiologies. All these variables require consideration when translating results from feline studies regarding seizure‐associated changes of the temporal lobe and especially HS.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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