Differential surface expression and possible function of 9- O - and 7- O -acetylated GD3 (CD60 b and c) during activation and apoptosis of human tonsillar B and T lymphocytes
Identifieur interne : 000710 ( Istex/Curation ); précédent : 000709; suivant : 000711Differential surface expression and possible function of 9- O - and 7- O -acetylated GD3 (CD60 b and c) during activation and apoptosis of human tonsillar B and T lymphocytes
Auteurs : Michael Erdmann [Allemagne] ; Dirk Wipfler [Allemagne] ; Anette Merling [Allemagne] ; Yi Cao [Allemagne] ; Christine Claus [Allemagne] ; Bernhard Kniep [Allemagne] ; Haneen Sadick [Allemagne] ; Wolfgang Bergler [Allemagne] ; Reinhard Vlasak [Autriche] ; Reinhard Schwartz-Albiez [Allemagne]Source :
- Glycoconjugate Journal [ 0282-0080 ] ; 2006-12-01.
English descriptors
Abstract
Abstract: The disialoganglioside GD3 (CD60 a) and its O-acetylated variants have previously been described as surface molecules of human T lymphocytes of the peripheral blood system. Here we report the expression of the 9-O-, and 7-O-acetylated disialoglycans of GD3 (CD60 b and CD60 c respectively) on human tonsillar lymphocytes. CD60 b and c are surface-expressed on activated germinal centre B cells and colocalize in raft-like structures on the cell surface together with the cytoplasmic tyrosine kinase Lyn and Syk. Addition of CD60 b and c mAb together with anti-IgM/IL-4 to in vitro cultivated tonsillar B cells resulted in a costimulatory effect. During spontaneous and staurosporine-induced apoptosis a distinct population of activated annexin V+/CD60 b+/CD60 c- B cells was observed. CD60 b and c are also found on cells of the extrafollicular T cell area. On tonsillar T cells, CD60 b mAb had a costimulatory effect together with PHA while CD60 c mAb alone was sufficient to induce proliferation. In further contrast to B cells, during apoptosis a distinct CD60 b+ T cell subpopulation was not observed. Together, surface-expressed CD60 b and c are differently expressed on tonsillar B and T cells and may be involved in the regulation of activation and apoptosis of lymphocytes in secondary lymphatic tissue.
Url:
DOI: 10.1007/s10719-006-9000-5
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<series><title level="j">Glycoconjugate Journal</title>
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<front><div type="abstract" xml:lang="en">Abstract: The disialoganglioside GD3 (CD60 a) and its O-acetylated variants have previously been described as surface molecules of human T lymphocytes of the peripheral blood system. Here we report the expression of the 9-O-, and 7-O-acetylated disialoglycans of GD3 (CD60 b and CD60 c respectively) on human tonsillar lymphocytes. CD60 b and c are surface-expressed on activated germinal centre B cells and colocalize in raft-like structures on the cell surface together with the cytoplasmic tyrosine kinase Lyn and Syk. Addition of CD60 b and c mAb together with anti-IgM/IL-4 to in vitro cultivated tonsillar B cells resulted in a costimulatory effect. During spontaneous and staurosporine-induced apoptosis a distinct population of activated annexin V+/CD60 b+/CD60 c- B cells was observed. CD60 b and c are also found on cells of the extrafollicular T cell area. On tonsillar T cells, CD60 b mAb had a costimulatory effect together with PHA while CD60 c mAb alone was sufficient to induce proliferation. In further contrast to B cells, during apoptosis a distinct CD60 b+ T cell subpopulation was not observed. Together, surface-expressed CD60 b and c are differently expressed on tonsillar B and T cells and may be involved in the regulation of activation and apoptosis of lymphocytes in secondary lymphatic tissue.</div>
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