The potential use of thalidomide in the therapy of graft-versus-host disease—A review of clinical and laboratory information
Identifieur interne : 000656 ( Istex/Curation ); précédent : 000655; suivant : 000657The potential use of thalidomide in the therapy of graft-versus-host disease—A review of clinical and laboratory information
Auteurs : Philip M. D. Wood [Royaume-Uni] ; Stephen J. Proctor [Royaume-Uni]Source :
- Leukemia Research [ 0145-2126 ] ; 1990.
English descriptors
- Teeft :
- Active compound, Acute disease, Acute gvhd, Allogeneic bone marrow transplantation, Allogeneic marrow transplantation, Bone marrow transplantation, Cell depletion, Chronic disease, Chronic gvhd, Cyclosporin, Donor marrow, Early stage, Graft, Gvhd, Immunosuppressive, Immunosuppressive actions, Lancet, Local lymph nodes, Lymphocyte, Marrow, Marrow transplantation, Methotrexate, Methyl prednisolone, Prophylactic agent, Prophylaxis, Queen victoria road, Royal victoria infirmary, Same system, Skin grafts, Skin homografts, Successful treatment, Surface receptor, Thalidomide, Thalidomide derivatives, Thalidomide metabolites, Thalidomide molecule, Thalidomide therapy, Transplant, Transplantation, University department, Vogelsang.
Abstract
Abstract: This article reviews the historical development of thalidomide as an immunosuppressive agent and the current state of knowledge of thalidomide as an anti-graft-versus-host disease (GVHD) agent. The evidence suggests that metabolites of thalidomide act at an early stage in the antigen recognition-activation pathway of graft T lymphocytes and down regulate normal lymphocyte responses. This effect seems to have beneficial effects in both acute and chronic GVHD, but the optimal mode of use in the clinical setting remains to be determined.
Url:
DOI: 10.1016/0145-2126(90)90024-4
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D." last="Wood">Philip M. D. Wood</name><affiliation wicri:level="1"><mods:affiliation>Leukaemia Research Fund Remission Unit, University Department of Haematology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leukaemia Research Fund Remission Unit, University Department of Haematology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP</wicri:regionArea></affiliation></author><author><name sortKey="Proctor, Stephen J" sort="Proctor, Stephen J" uniqKey="Proctor S" first="Stephen J." last="Proctor">Stephen J. 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The evidence suggests that metabolites of thalidomide act at an early stage in the antigen recognition-activation pathway of graft T lymphocytes and down regulate normal lymphocyte responses. This effect seems to have beneficial effects in both acute and chronic GVHD, but the optimal mode of use in the clinical setting remains to be determined.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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