Design and Synthesis of Peptidomimetic Severe Acute Respiratory Syndrome Chymotrypsin-like Protease Inhibitors
Identifieur interne : 000346 ( Istex/Curation ); précédent : 000345; suivant : 000347Design and Synthesis of Peptidomimetic Severe Acute Respiratory Syndrome Chymotrypsin-like Protease Inhibitors
Auteurs : Arun K. Ghosh [Géorgie (pays), États-Unis] ; Kai Xi [Géorgie (pays), États-Unis] ; Kiira Ratia [Géorgie (pays)] ; Bernard D. Santarsiero [Géorgie (pays)] ; Wentao Fu [Géorgie (pays)] ; Brian H. Harcourt [Géorgie (pays)] ; Paul A. Rota [Géorgie (pays)] ; Susan C. Baker [Géorgie (pays)] ; Michael E. Johnson [Géorgie (pays)] ; Andrew D. Mesecar [Géorgie (pays)]Source :
- Journal of Medicinal Chemistry [ 0022-2623 ] ; 2005.
Abstract
Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.
Url:
DOI: 10.1021/jm050548m
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000366
Links to Exploration step
ISTEX:AD6693F86E9D863C197B903A7B71C09B78082110Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Design and Synthesis of Peptidomimetic Severe Acute Respiratory Syndrome Chymotrypsin-like Protease Inhibitors</title>
<author><name sortKey="Ghosh, Arun K" sort="Ghosh, Arun K" uniqKey="Ghosh A" first="Arun K." last="Ghosh">Arun K. Ghosh</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Purdue University.</mods:affiliation>
<wicri:noCountry code="no comma"> Purdue University.</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><mods:affiliation> Department of Chemistry, University of Illinois at Chicago.</mods:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
</placeName>
<orgName type="university">Université de l'Illinois à Chicago</orgName>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation> To whom correspondence should be addressed. Phone: 765-494-5323. Fax: 765-496-1612. E-mail: akghosh@purdue.edu.</mods:affiliation>
<country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Xi, Kai" sort="Xi, Kai" uniqKey="Xi K" first="Kai" last="Xi">Kai Xi</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Purdue University.</mods:affiliation>
<wicri:noCountry code="no comma"> Purdue University.</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><mods:affiliation> Department of Chemistry, University of Illinois at Chicago.</mods:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
</placeName>
<orgName type="university">Université de l'Illinois à Chicago</orgName>
</affiliation>
</author>
<author><name sortKey="Ratia, Kiira" sort="Ratia, Kiira" uniqKey="Ratia K" first="Kiira" last="Ratia">Kiira Ratia</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
<wicri:noCountry code="subField">atChicago.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Santarsiero, Bernard D" sort="Santarsiero, Bernard D" uniqKey="Santarsiero B" first="Bernard D." last="Santarsiero">Bernard D. Santarsiero</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
<wicri:noCountry code="subField">atChicago.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Fu, Wentao" sort="Fu, Wentao" uniqKey="Fu W" first="Wentao" last="Fu">Wentao Fu</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
<wicri:noCountry code="subField">atChicago.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Harcourt, Brian H" sort="Harcourt, Brian H" uniqKey="Harcourt B" first="Brian H." last="Harcourt">Brian H. Harcourt</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Disease Control and Prevention.</mods:affiliation>
<wicri:noCountry code="no comma"> Center for Disease Control and Prevention.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rota, Paul A" sort="Rota, Paul A" uniqKey="Rota P" first="Paul A." last="Rota">Paul A. Rota</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Disease Control and Prevention.</mods:affiliation>
<wicri:noCountry code="no comma"> Center for Disease Control and Prevention.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Baker, Susan C" sort="Baker, Susan C" uniqKey="Baker S" first="Susan C." last="Baker">Susan C. Baker</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Loyola University of Chicago.</mods:affiliation>
<wicri:noCountry code="no comma"> Loyola University of Chicago.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Johnson, Michael E" sort="Johnson, Michael E" uniqKey="Johnson M" first="Michael E." last="Johnson">Michael E. Johnson</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
<wicri:noCountry code="subField">atChicago.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
<wicri:noCountry code="subField">atChicago.</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:AD6693F86E9D863C197B903A7B71C09B78082110</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1021/jm050548m</idno>
<idno type="url">https://api.istex.fr/ark:/67375/TPS-WHX6D4F8-M/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000366</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000366</idno>
<idno type="wicri:Area/Istex/Curation">000346</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Design and Synthesis of Peptidomimetic
Severe Acute Respiratory Syndrome
Chymotrypsin-like Protease Inhibitors</title>
<author><name sortKey="Ghosh, Arun K" sort="Ghosh, Arun K" uniqKey="Ghosh A" first="Arun K." last="Ghosh">Arun K. Ghosh</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Purdue University.</mods:affiliation>
</affiliation>
<affiliation wicri:level="4"><mods:affiliation> Department of Chemistry, University of Illinois at Chicago.</mods:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
</placeName>
<orgName type="university">Université de l'Illinois à Chicago</orgName>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation> To whom correspondence should be addressed. Phone: 765-494-5323. Fax: 765-496-1612. E-mail: akghosh@purdue.edu.</mods:affiliation>
<country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Xi, Kai" sort="Xi, Kai" uniqKey="Xi K" first="Kai" last="Xi">Kai Xi</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Purdue University.</mods:affiliation>
</affiliation>
<affiliation wicri:level="4"><mods:affiliation> Department of Chemistry, University of Illinois at Chicago.</mods:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Chicago</settlement>
<region type="state">Illinois</region>
</placeName>
<orgName type="university">Université de l'Illinois à Chicago</orgName>
</affiliation>
</author>
<author><name sortKey="Ratia, Kiira" sort="Ratia, Kiira" uniqKey="Ratia K" first="Kiira" last="Ratia">Kiira Ratia</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Santarsiero, Bernard D" sort="Santarsiero, Bernard D" uniqKey="Santarsiero B" first="Bernard D." last="Santarsiero">Bernard D. Santarsiero</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Fu, Wentao" sort="Fu, Wentao" uniqKey="Fu W" first="Wentao" last="Fu">Wentao Fu</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Harcourt, Brian H" sort="Harcourt, Brian H" uniqKey="Harcourt B" first="Brian H." last="Harcourt">Brian H. Harcourt</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Disease Control and Prevention.</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Rota, Paul A" sort="Rota, Paul A" uniqKey="Rota P" first="Paul A." last="Rota">Paul A. Rota</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Disease Control and Prevention.</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Baker, Susan C" sort="Baker, Susan C" uniqKey="Baker S" first="Susan C." last="Baker">Susan C. Baker</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Loyola University of Chicago.</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Johnson, Michael E" sort="Johnson, Michael E" uniqKey="Johnson M" first="Michael E." last="Johnson">Michael E. Johnson</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta, Georgia</mods:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Departments of Chemistry and Medicinal Chemistry,Purdue University, West Lafayette, Indiana 47907,Department of Chemistry, University of Illinois at Chicago,Chicago, Illinois 60607, Center for PharmaceuticalBiotechnology and Department of Medicinal Chemistry andPharmacognosy, University of Illinois at Chicago, 900 S.Ashland, Illinois 60607, Department of Microbiology andImmunology, Loyola University of Chicago, Stritch School ofMedicine, Maywood, Illinois, and Center for Disease Controland Prevention, Atlanta</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation> Center for Pharmaceutical Biotechnology and Department ofMedicinal Chemistry and Pharmacognosy, University of Illinois atChicago.</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Journal of Medicinal Chemistry</title>
<title level="j" type="abbrev">J. Med. Chem.</title>
<idno type="ISSN">0022-2623</idno>
<idno type="eISSN">1520-4804</idno>
<imprint><publisher>American Chemical Society</publisher>
<date type="e-published" when="2005-10-04">2005</date>
<date when="2005-11-03">2005</date>
<biblScope unit="vol">48</biblScope>
<biblScope unit="issue">22</biblScope>
<biblScope unit="page" from="6767">6767</biblScope>
<biblScope unit="page" to="6771">6771</biblScope>
</imprint>
<idno type="ISSN">0022-2623</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-2623</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000346 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000346 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:AD6693F86E9D863C197B903A7B71C09B78082110 |texte= Design and Synthesis of Peptidomimetic Severe Acute Respiratory Syndrome Chymotrypsin-like Protease Inhibitors }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |