Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor
Identifieur interne : 000330 ( Istex/Curation ); précédent : 000329; suivant : 000331Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor
Auteurs : Akio Suzumura [Japon] ; Makoto Sawada [Japon] ; Tohru Marunouchi [Japon]Source :
- Brain Research [ 0006-8993 ] ; 1996.
English descriptors
- KwdEn :
- Teeft :
Abstract
Abstract: Astrocytes produce granulocyte/macrophage colony-stimulating factor (GM-CSF) and support the survival and proliferation of microglia. To study the functions of GM-CSF in the central nervous system (CNS), we examined the effects of GM-CSF on cytokine production by glial cells. GM-CSF induced interleukin-6 (IL-6) production by microglia, but not by astrocytes, in a dose-dependent manner as assessed by bioassay and the detection of IL-6 mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. GM-CSF did not induce tumor necrosis factor (TNF)a or IL-1 in microglia and astrocytes, whereas lipopolysaccharide induced all these cytokines. The induction of IL-6 by GM-CSF in microglia was completely inhibited by antibodies to GM-CSF. Neither IL-3 nor macrophage-CSF (M-CSF) induced IL-6 production in microglia. Given that IL-1 and TNFα, monokines derived from microglia, induce IL-6 production in astrocytes, but not in microglia, results indicate that astrocytes and microglia may mutually regulate IL-6 production by different cytokines.
Url:
DOI: 10.1016/0006-8993(95)01535-3
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000350
Links to Exploration step
ISTEX:2606DC96DF43678F52B4BB4E0148DB73ABA70859Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor</title>
<author><name sortKey="Suzumura, Akio" sort="Suzumura, Akio" uniqKey="Suzumura A" first="Akio" last="Suzumura">Akio Suzumura</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, School of Medicine Fujita Health University, Toyoake, Aichi 470-11, Japan</mods:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, School of Medicine Fujita Health University, Toyoake, Aichi 470-11</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sawada, Makoto" sort="Sawada, Makoto" uniqKey="Sawada M" first="Makoto" last="Sawada">Makoto Sawada</name>
<affiliation wicri:level="1"><mods:affiliation>Dicision of Cell Biology, Institute for Comprehensive Medical Sciences, Fujita Health Uniuersity, Toyoake, Aichi 470-11, Japan</mods:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Dicision of Cell Biology, Institute for Comprehensive Medical Sciences, Fujita Health Uniuersity, Toyoake, Aichi 470-11</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marunouchi, Tohru" sort="Marunouchi, Tohru" uniqKey="Marunouchi T" first="Tohru" last="Marunouchi">Tohru Marunouchi</name>
<affiliation wicri:level="1"><mods:affiliation>Dicision of Cell Biology, Institute for Comprehensive Medical Sciences, Fujita Health Uniuersity, Toyoake, Aichi 470-11, Japan</mods:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Dicision of Cell Biology, Institute for Comprehensive Medical Sciences, Fujita Health Uniuersity, Toyoake, Aichi 470-11</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:2606DC96DF43678F52B4BB4E0148DB73ABA70859</idno>
<date when="1996" year="1996">1996</date>
<idno type="doi">10.1016/0006-8993(95)01535-3</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-P9TMRJ92-3/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000350</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000350</idno>
<idno type="wicri:Area/Istex/Curation">000330</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor</title>
<author><name sortKey="Suzumura, Akio" sort="Suzumura, Akio" uniqKey="Suzumura A" first="Akio" last="Suzumura">Akio Suzumura</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, School of Medicine Fujita Health University, Toyoake, Aichi 470-11, Japan</mods:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, School of Medicine Fujita Health University, Toyoake, Aichi 470-11</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sawada, Makoto" sort="Sawada, Makoto" uniqKey="Sawada M" first="Makoto" last="Sawada">Makoto Sawada</name>
<affiliation wicri:level="1"><mods:affiliation>Dicision of Cell Biology, Institute for Comprehensive Medical Sciences, Fujita Health Uniuersity, Toyoake, Aichi 470-11, Japan</mods:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Dicision of Cell Biology, Institute for Comprehensive Medical Sciences, Fujita Health Uniuersity, Toyoake, Aichi 470-11</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marunouchi, Tohru" sort="Marunouchi, Tohru" uniqKey="Marunouchi T" first="Tohru" last="Marunouchi">Tohru Marunouchi</name>
<affiliation wicri:level="1"><mods:affiliation>Dicision of Cell Biology, Institute for Comprehensive Medical Sciences, Fujita Health Uniuersity, Toyoake, Aichi 470-11, Japan</mods:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Dicision of Cell Biology, Institute for Comprehensive Medical Sciences, Fujita Health Uniuersity, Toyoake, Aichi 470-11</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain Research</title>
<title level="j" type="abbrev">BRES</title>
<idno type="ISSN">0006-8993</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1996">1996</date>
<biblScope unit="volume">713</biblScope>
<biblScope unit="issue">1–2</biblScope>
<biblScope unit="page" from="192">192</biblScope>
<biblScope unit="page" to="198">198</biblScope>
</imprint>
<idno type="ISSN">0006-8993</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8993</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Astrocyte</term>
<term>Cytokine</term>
<term>Granulocyte/macrophage colony-stimulating factor</term>
<term>Microglia</term>
<term>interleukin-6</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Antigen expression</term>
<term>Astrocyte</term>
<term>Brain research</term>
<term>Cerebrospinal fluid</term>
<term>Csfs</term>
<term>Cytokine</term>
<term>Cytokine production</term>
<term>Glial</term>
<term>Glial cells</term>
<term>Human monocytes</term>
<term>Lmmunol</term>
<term>Marunouchi</term>
<term>Microglia</term>
<term>Mrna</term>
<term>Neurotrophic factor</term>
<term>Receptor</term>
<term>Receptor mrna</term>
<term>Sawada</term>
<term>Suzumura</term>
<term>Tumor necrosis</term>
<term>Various cytokines</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Astrocytes produce granulocyte/macrophage colony-stimulating factor (GM-CSF) and support the survival and proliferation of microglia. To study the functions of GM-CSF in the central nervous system (CNS), we examined the effects of GM-CSF on cytokine production by glial cells. GM-CSF induced interleukin-6 (IL-6) production by microglia, but not by astrocytes, in a dose-dependent manner as assessed by bioassay and the detection of IL-6 mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. GM-CSF did not induce tumor necrosis factor (TNF)a or IL-1 in microglia and astrocytes, whereas lipopolysaccharide induced all these cytokines. The induction of IL-6 by GM-CSF in microglia was completely inhibited by antibodies to GM-CSF. Neither IL-3 nor macrophage-CSF (M-CSF) induced IL-6 production in microglia. Given that IL-1 and TNFα, monokines derived from microglia, induce IL-6 production in astrocytes, but not in microglia, results indicate that astrocytes and microglia may mutually regulate IL-6 production by different cytokines.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000330 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000330 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:2606DC96DF43678F52B4BB4E0148DB73ABA70859 |texte= Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |