Thrombotic Thrombocytopenic Purpura‐Hemolytic Uremic Syndrome in a Hemodialysis Patient Following Hematoma
Identifieur interne : 000971 ( Istex/Corpus ); précédent : 000970; suivant : 000972Thrombotic Thrombocytopenic Purpura‐Hemolytic Uremic Syndrome in a Hemodialysis Patient Following Hematoma
Auteurs : N. R. Wood ; S. S. HaqqieSource :
- Hemodialysis International [ 1492-7535 ] ; 2004-01.
English descriptors
- Teeft :
- 1department, Annual dialysis conference, Arthroplasty, Baseline, Bioartificial, Blood flow, Blood flow rate, Blood pressure, Body weight, Carotid, Catheter, Catheter patients, Comorbidity, Creatinine, Cytokine, Daily hemodialysis, Daugirdas, Diabetic, Dialysate, Dialysis, Dialysis adequacy, Dialysis patients, Dialysis therapy, Dialyzer, Doppler, Doppler ultrasonography, Dos, Einc, Elderly patients, Endothelial, Erythropoietin, Esrd, Extracorporeal, Ferritin, Fibrinogen, Filtration, Fistula, Fresenius, Gluconate, Graft, Hemodialysis, Hemodialysis hemodialysis, Hemodialysis patients, Heparin, Hypertension, Hypotension, Inflammation, Internal medicine, International society, Lifesite, Lithium, Mmhg, Morbidity, Nephrology, Nhhd, Online, Pediatric, Pentosidine, Pepa, Phosphorus, Platelet count, Predialysis, Rawt, Renal, Renal disease, Renal failure, Sars, Sepsis, Serum creatinine, Serum levels, Sickle, Solute, Systolic, Tesio, Thrombosis, Thrombotic, Ultrafiltration, Ultrasonography, Uncoated, Urea, Uremic, Vascular access, Venous, Viral, Viral load.
Abstract
Thrombotic thrombocytopenic purpura‐hemolytic uremic syndrome (TTP‐HUS) is a rare clinical syndrome defined by the presence of thrombocytopenia and microangiopathic hemolytic anemia. The etiology of TTP‐HUS is diverse, and many cases remain idiopathic. Recognized causes include Shiga toxin‐producing Escherichia coli, quinine toxicity, certain cancers and cancer chemotherapy, antiphospholipid antibodies, pregnancy and OCP's, cyclosporine, tacrolimus, OKT3, antiplatelet agents, AIDS and HIV infection, and pneumococcal infection. After an extensive literature review, we found no cases of TTP‐HUS following traumatic injury. We present the case of a 57‐year‐old white male hemodialysis patient with end‐stage renal disease secondary to type 2 diabetes, severe CAD with multiple MI's, HTN, history of coronary artery bypass grafting ×4, and transmyocardial reperfusion. The patient fell in the bathroom with questionable LOC and was found to have a subarachnoid hemorrhage diagnosed by head CT. 4 days after the fall, he developed TTP‐HUS with severe thrombocytopenia (platelet‐count falling from 181,000 to 6000), hemolytic anemia, mental status changes, and renal function abnormalities. He was treated by plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Of interest, we present another case of TTP‐HUS following trauma. A 42‐year‐old white male with no applicable medical history fell 6 feet from a ladder, developing a renal hematoma. 4 days after the fall, he developed TTP‐HUS. This patient was also treated with plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Based on these two case studies, we suggest that hematoma be considered as a potential trigger in the development of TTP‐HUS.
Url:
DOI: 10.1111/j.1492-7535.2004.0085z.x
Links to Exploration step
ISTEX:B2B6B24C16DED721E7B50F1F4F8DF97781BD9187Le document en format XML
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The etiology of TTP‐HUS is diverse, and many cases remain idiopathic. Recognized causes include Shiga toxin‐producing Escherichia coli, quinine toxicity, certain cancers and cancer chemotherapy, antiphospholipid antibodies, pregnancy and OCP's, cyclosporine, tacrolimus, OKT3, antiplatelet agents, AIDS and HIV infection, and pneumococcal infection. After an extensive literature review, we found no cases of TTP‐HUS following traumatic injury. We present the case of a 57‐year‐old white male hemodialysis patient with end‐stage renal disease secondary to type 2 diabetes, severe CAD with multiple MI's, HTN, history of coronary artery bypass grafting ×4, and transmyocardial reperfusion. The patient fell in the bathroom with questionable LOC and was found to have a subarachnoid hemorrhage diagnosed by head CT. 4 days after the fall, he developed TTP‐HUS with severe thrombocytopenia (platelet‐count falling from 181,000 to 6000), hemolytic anemia, mental status changes, and renal function abnormalities. He was treated by plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Of interest, we present another case of TTP‐HUS following trauma. A 42‐year‐old white male with no applicable medical history fell 6 feet from a ladder, developing a renal hematoma. 4 days after the fall, he developed TTP‐HUS. This patient was also treated with plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Based on these two case studies, we suggest that hematoma be considered as a potential trigger in the development of TTP‐HUS.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>hemodialysis</json:string><json:string>international society</json:string><json:string>annual dialysis conference</json:string><json:string>nephrology</json:string><json:string>fistula</json:string><json:string>hemodialysis patients</json:string><json:string>dialyzer</json:string><json:string>heparin</json:string><json:string>dialysate</json:string><json:string>renal</json:string><json:string>urea</json:string><json:string>venous</json:string><json:string>creatinine</json:string><json:string>esrd</json:string><json:string>online</json:string><json:string>solute</json:string><json:string>nhhd</json:string><json:string>hemodialysis 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health</json:string><json:string>relative donor</json:string><json:string>tremendous improvement</json:string><json:string>component scale</json:string><json:string>individual scales</json:string><json:string>general hospital</json:string><json:string>venous sides</json:string><json:string>split catheter</json:string><json:string>hemodialysis access</json:string><json:string>ischemic heart disease</json:string><json:string>urea kinetics</json:string><json:string>body size</json:string><json:string>urea mass</json:string><json:string>dialysis modality</json:string><json:string>diabetic nephropathy</json:string><json:string>average time</json:string><json:string>hemodialysis treatments</json:string><json:string>other abstracts</json:string><json:string>peer pressure</json:string><json:string>syndrome</json:string><json:string>ontario</json:string><json:string>albumin</json:string><json:string>clearance</json:string><json:string>mortality</json:string><json:string>complication</json:string><json:string>hemoglobin</json:string><json:string>diabetes</json:string><json:string>infection</json:string></teeft></keywords><author><json:item><name>N.r. Wood</name><affiliations><json:string>Albany Medical College, Albany, NY, U.S.A.</json:string></affiliations></json:item><json:item><name>S.s. Haqqie</name><affiliations><json:string>Albany Medical College, Albany, NY, U.S.A.</json:string></affiliations></json:item></author><articleId><json:string>HDI085Z</json:string></articleId><arkIstex>ark:/67375/WNG-83V2GPMR-W</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><abstract>Thrombotic thrombocytopenic purpura‐hemolytic uremic syndrome (TTP‐HUS) is a rare clinical syndrome defined by the presence of thrombocytopenia and microangiopathic hemolytic anemia. The etiology of TTP‐HUS is diverse, and many cases remain idiopathic. Recognized causes include Shiga toxin‐producing Escherichia coli, quinine toxicity, certain cancers and cancer chemotherapy, antiphospholipid antibodies, pregnancy and OCP's, cyclosporine, tacrolimus, OKT3, antiplatelet agents, AIDS and HIV infection, and pneumococcal infection. After an extensive literature review, we found no cases of TTP‐HUS following traumatic injury. We present the case of a 57‐year‐old white male hemodialysis patient with end‐stage renal disease secondary to type 2 diabetes, severe CAD with multiple MI's, HTN, history of coronary artery bypass grafting ×4, and transmyocardial reperfusion. The patient fell in the bathroom with questionable LOC and was found to have a subarachnoid hemorrhage diagnosed by head CT. 4 days after the fall, he developed TTP‐HUS with severe thrombocytopenia (platelet‐count falling from 181,000 to 6000), hemolytic anemia, mental status changes, and renal function abnormalities. He was treated by plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Of interest, we present another case of TTP‐HUS following trauma. A 42‐year‐old white male with no applicable medical history fell 6 feet from a ladder, developing a renal hematoma. 4 days after the fall, he developed TTP‐HUS. This patient was also treated with plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Based on these two case studies, we suggest that hematoma be considered as a potential trigger in the development of TTP‐HUS.</abstract><qualityIndicators><score>9.976</score><pdfWordCount>24342</pdfWordCount><pdfCharCount>151874</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>33</pdfPageCount><pdfPageSize>595 x 782 pts</pdfPageSize><pdfWordsPerPage>738</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>false</refBibsNative><abstractWordCount>248</abstractWordCount><abstractCharCount>1769</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Thrombotic Thrombocytopenic Purpura‐Hemolytic Uremic Syndrome in a Hemodialysis Patient Following Hematoma</title><genre><json:string>abstract</json:string></genre><host><title>Hemodialysis International</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1542-4758</json:string></doi><issn><json:string>1492-7535</json:string></issn><eissn><json:string>1542-4758</json:string></eissn><publisherId><json:string>HDI</json:string></publisherId><volume>8</volume><issue>1</issue><pages><first>88</first><last>88</last><total>100</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>8/1/03</json:string><json:string>2/8/03</json:string><json:string>between May 2002 and September 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Shore</json:string><json:string>A. Bidani</json:string><json:string>Ht</json:string><json:string>E. Tutal</json:string><json:string>N. Kanbara</json:string><json:string>T. Suzuki</json:string><json:string>L. Renner</json:string><json:string>T. McComb</json:string><json:string>A. Zolota</json:string><json:string>S.W. McConnell</json:string><json:string>C. Rizos</json:string><json:string>Y. Kanno</json:string><json:string>G. Seydaoglu</json:string><json:string>M. Oadri</json:string><json:string>D. Motta</json:string><json:string>M. Salomone</json:string><json:string>D.C. Holland</json:string><json:string>Val Val</json:string><json:string>Elevation</json:string><json:string>K. Masuhara</json:string><json:string>M.P. Ruiz</json:string><json:string>A. Pierratos</json:string><json:string>S. Dobrev</json:string><json:string>M.F. Pipkin</json:string><json:string>El Pilar</json:string><json:string>H.Y. Choi</json:string><json:string>C.R. Blagg</json:string><json:string>D.T. 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We present the case of a 57‐year‐old white male hemodialysis patient with end‐stage renal disease secondary to type 2 diabetes, severe CAD with multiple MI's, HTN, history of coronary artery bypass grafting ×4, and transmyocardial reperfusion. The patient fell in the bathroom with questionable LOC and was found to have a subarachnoid hemorrhage diagnosed by head CT. 4 days after the fall, he developed TTP‐HUS with severe thrombocytopenia (platelet‐count falling from 181,000 to 6000), hemolytic anemia, mental status changes, and renal function abnormalities. He was treated by plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Of interest, we present another case of TTP‐HUS following trauma. A 42‐year‐old white male with no applicable medical history fell 6 feet from a ladder, developing a renal hematoma. 4 days after the fall, he developed TTP‐HUS. 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The etiology of TTP‐HUS is diverse, and many cases remain idiopathic. Recognized causes include Shiga toxin‐producing <i>Escherichia coli</i>, quinine toxicity, certain cancers and cancer chemotherapy, antiphospholipid antibodies, pregnancy and OCP's, cyclosporine, tacrolimus, OKT3, antiplatelet agents, AIDS and HIV infection, and pneumococcal infection. After an extensive literature review, we found no cases of TTP‐HUS following traumatic injury. We present the case of a 57‐year‐old white male hemodialysis patient with end‐stage renal disease secondary to type 2 diabetes, severe CAD with multiple MI's, HTN, history of coronary artery bypass grafting ×4, and transmyocardial reperfusion. The patient fell in the bathroom with questionable LOC and was found to have a subarachnoid hemorrhage diagnosed by head CT. 4 days after the fall, he developed TTP‐HUS with severe thrombocytopenia (platelet‐count falling from 181,000 to 6000), hemolytic anemia, mental status changes, and renal function abnormalities. He was treated by plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Of interest, we present another case of TTP‐HUS following trauma. A 42‐year‐old white male with no applicable medical history fell 6 feet from a ladder, developing a renal hematoma. 4 days after the fall, he developed TTP‐HUS. This patient was also treated with plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. 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The etiology of TTP‐HUS is diverse, and many cases remain idiopathic. Recognized causes include Shiga toxin‐producing Escherichia coli, quinine toxicity, certain cancers and cancer chemotherapy, antiphospholipid antibodies, pregnancy and OCP's, cyclosporine, tacrolimus, OKT3, antiplatelet agents, AIDS and HIV infection, and pneumococcal infection. After an extensive literature review, we found no cases of TTP‐HUS following traumatic injury. We present the case of a 57‐year‐old white male hemodialysis patient with end‐stage renal disease secondary to type 2 diabetes, severe CAD with multiple MI's, HTN, history of coronary artery bypass grafting ×4, and transmyocardial reperfusion. The patient fell in the bathroom with questionable LOC and was found to have a subarachnoid hemorrhage diagnosed by head CT. 4 days after the fall, he developed TTP‐HUS with severe thrombocytopenia (platelet‐count falling from 181,000 to 6000), hemolytic anemia, mental status changes, and renal function abnormalities. He was treated by plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Of interest, we present another case of TTP‐HUS following trauma. A 42‐year‐old white male with no applicable medical history fell 6 feet from a ladder, developing a renal hematoma. 4 days after the fall, he developed TTP‐HUS. This patient was also treated with plasma exchange with subsequent improvement of symptoms and laboratory abnormalities. Based on these two case studies, we suggest that hematoma be considered as a potential trigger in the development of TTP‐HUS.</abstract><relatedItem type="host"><titleInfo><title>Hemodialysis International</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1492-7535</identifier><identifier type="eISSN">1542-4758</identifier><identifier type="DOI">10.1111/(ISSN)1542-4758</identifier><identifier type="PublisherID">HDI</identifier><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>88</start><end>88</end><total>100</total></extent></part></relatedItem><identifier type="istex">B2B6B24C16DED721E7B50F1F4F8DF97781BD9187</identifier><identifier type="ark">ark:/67375/WNG-83V2GPMR-W</identifier><identifier type="DOI">10.1111/j.1492-7535.2004.0085z.x</identifier><identifier type="ArticleID">HDI085Z</identifier><accessCondition type="use and reproduction" contentType="copyright">© Wiley. 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