Marine Sponges as Pharmacy
Identifieur interne : 000851 ( Istex/Corpus ); précédent : 000850; suivant : 000852Marine Sponges as Pharmacy
Auteurs : Detmer Sipkema ; Maurice C. R. Franssen ; Ronald Osinga ; Johannes Tramper ; René H. WijffelsSource :
- Marine Biotechnology [ 1436-2228 ] ; 2005-06-01.
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- KwdEn :
Abstract
Abstract: Marine sponges have been considered as a gold mine during the past 50 years, with respect to the diversity of their secondary metabolites. The biological effects of new metabolites from sponges have been reported in hundreds of scientific papers, and they are reviewed here. Sponges have the potential to provide future drugs against important diseases, such as cancer, a range of viral diseases, malaria, and inflammations. Although the molecular mode of action of most metabolites is still unclear, for a substantial number of compounds the mechanisms by which they interfere with the pathogenesis of a wide range of diseases have been reported. This knowledge is one of the key factors necessary to transform bioactive compounds into medicines. Sponges produce a plethora of chemical compounds with widely varying carbon skeletons, which have been found to interfere with pathogenesis at many different points. The fact that a particular disease can be fought at different points increases the chance of developing selective drugs for specific targets.
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DOI: 10.1007/s10126-004-0405-5
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ISTEX:1540923A5B8D059015E6BAB730A5F8576710FF9CLe document en format XML
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The biological effects of new metabolites from sponges have been reported in hundreds of scientific papers, and they are reviewed here. Sponges have the potential to provide future drugs against important diseases, such as cancer, a range of viral diseases, malaria, and inflammations. Although the molecular mode of action of most metabolites is still unclear, for a substantial number of compounds the mechanisms by which they interfere with the pathogenesis of a wide range of diseases have been reported. This knowledge is one of the key factors necessary to transform bioactive compounds into medicines. Sponges produce a plethora of chemical compounds with widely varying carbon skeletons, which have been found to interfere with pathogenesis at many different points. 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Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><PageHeaders><RunningTitle>Marine Sponges in Pharmacy</RunningTitle><RunningAuthor>Detmer Sipkema et al.</RunningAuthor></PageHeaders><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Detmer</GivenName><FamilyName>Sipkema</FamilyName></AuthorName><Contact><Phone>+31(0)317-482237</Phone><Fax>+31(0)317-485097</Fax><Email>detmer.sipkema@wur.nl</Email></Contact></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Maurice</GivenName><GivenName>C.</GivenName><GivenName>R.</GivenName><FamilyName>Franssen</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Ronald</GivenName><FamilyName>Osinga</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Johannes</GivenName><FamilyName>Tramper</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>René</GivenName><GivenName>H.</GivenName><FamilyName>Wijffels</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgName>Wageningen University, Food and Bioprocess Engineering Group</OrgName><OrgAddress><Postbox>8129</Postbox><City>6700 EV Wageningen</City><Country>The Netherlands</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Wageningen University, Laboratory of Organic Chemistry</OrgName><OrgAddress><Street>Dreijenplein 8</Street><City>6703 HB Wageningen</City><Country>The Netherlands</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para TextBreak="No">Marine sponges have been considered as a gold mine during the past 50 years, with respect to the diversity of their secondary metabolites. The biological effects of new metabolites from sponges have been reported in hundreds of scientific papers, and they are reviewed here. Sponges have the potential to provide future drugs against important diseases, such as cancer, a range of viral diseases, malaria, and inflammations. Although the molecular mode of action of most metabolites is still unclear, for a substantial number of compounds the mechanisms by which they interfere with the pathogenesis of a wide range of diseases have been reported. This knowledge is one of the key factors necessary to transform bioactive compounds into medicines. Sponges produce a plethora of chemical compounds with widely varying carbon skeletons, which have been found to interfere with pathogenesis at many different points. The fact that a particular disease can be fought at different points increases the chance of developing selective drugs for specific targets.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>sponge medicine</Keyword><Keyword>natural product</Keyword><Keyword>cancer</Keyword><Keyword>inflammation</Keyword><Keyword>virus</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Marine Sponges as Pharmacy</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Marine Sponges as Pharmacy</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Detmer</namePart><namePart type="family">Sipkema</namePart><affiliation>Wageningen University, Food and Bioprocess Engineering Group, 8129, 6700 EV Wageningen, The Netherlands</affiliation><affiliation>E-mail: detmer.sipkema@wur.nl</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maurice</namePart><namePart type="given">C.</namePart><namePart type="given">R.</namePart><namePart type="family">Franssen</namePart><affiliation>Wageningen University, Laboratory of Organic Chemistry, Dreijenplein 8, 6703 HB Wageningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ronald</namePart><namePart type="family">Osinga</namePart><affiliation>Wageningen University, Food and Bioprocess Engineering Group, 8129, 6700 EV Wageningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Johannes</namePart><namePart type="family">Tramper</namePart><affiliation>Wageningen University, Food and Bioprocess Engineering Group, 8129, 6700 EV Wageningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">René</namePart><namePart type="given">H.</namePart><namePart type="family">Wijffels</namePart><affiliation>Wageningen University, Food and Bioprocess Engineering Group, 8129, 6700 EV Wageningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag; www.springer-ny.com</publisher><place><placeTerm type="text">New York</placeTerm></place><dateCreated encoding="w3cdtf">2004-01-19</dateCreated><dateIssued encoding="w3cdtf">2005-06-01</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Marine sponges have been considered as a gold mine during the past 50 years, with respect to the diversity of their secondary metabolites. The biological effects of new metabolites from sponges have been reported in hundreds of scientific papers, and they are reviewed here. Sponges have the potential to provide future drugs against important diseases, such as cancer, a range of viral diseases, malaria, and inflammations. Although the molecular mode of action of most metabolites is still unclear, for a substantial number of compounds the mechanisms by which they interfere with the pathogenesis of a wide range of diseases have been reported. This knowledge is one of the key factors necessary to transform bioactive compounds into medicines. Sponges produce a plethora of chemical compounds with widely varying carbon skeletons, which have been found to interfere with pathogenesis at many different points. The fact that a particular disease can be fought at different points increases the chance of developing selective drugs for specific targets.</abstract><note>Review</note><subject lang="en"><genre>Keywords</genre><topic>sponge medicine</topic><topic>natural product</topic><topic>cancer</topic><topic>inflammation</topic><topic>virus</topic></subject><relatedItem type="host"><titleInfo><title>Marine Biotechnology</title></titleInfo><titleInfo type="abbreviated"><title>Mar Biotechnol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2005-06-01</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><subject><genre>Geosciences</genre><topic>Oceanography</topic></subject><identifier type="ISSN">1436-2228</identifier><identifier type="eISSN">1436-2236</identifier><identifier type="JournalID">10126</identifier><identifier type="JournalSPIN">s10126</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>2005</date><detail type="volume"><number>7</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="pages"><start>142</start><end>162</end></extent></part><recordInfo><recordOrigin>Springer Science+Business Media, Inc., 2005</recordOrigin></recordInfo></relatedItem><identifier type="istex">1540923A5B8D059015E6BAB730A5F8576710FF9C</identifier><identifier type="ark">ark:/67375/VQC-4V4S0VQC-X</identifier><identifier type="DOI">10.1007/s10126-004-0405-5</identifier><identifier type="ArticleID">405</identifier><identifier type="ArticleID">Art1</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer Science+Business Media, Inc., 2005</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer Science+Business Media, Inc., 2005</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-4V4S0VQC-X/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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