Distinguishing effects of cocaine IV and SC on mesoaccumbens dopamine and serotonin release with chloral hydrate anesthesia
Identifieur interne : 000800 ( Istex/Corpus ); précédent : 000799; suivant : 000801Distinguishing effects of cocaine IV and SC on mesoaccumbens dopamine and serotonin release with chloral hydrate anesthesia
Auteurs : Patricia A. BroderickSource :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1992.
English descriptors
- Teeft :
- Accumbens, Anesthesia, Anesthetic, Anova, Anova statistics, Ascorbic acid, Basal, Basal synaptic concentrations, Behav, Biochem, Brain power, Brain tissue, Broderick, Chloral, Chloral hydrate, Chloral hydrate anesthesia, Chloral paradigm, Cocaine, Cocaine administration, Cocaine effects, Daergic, Daergic response, Dopamine, Dopaminergic neurons, Electroactive, Electroactive species, Electrochemical, Electrochemical signal, Extracellular, General anesthetic effects, General anesthetics, Hydrate, Impulse flow, Mesoaccumbens, Microelectrode, Microelectrodes, Nacc, Neuroanatomic substrate, Neuron, Neuronal, Nucleus accumbens, Other hand, Pearson product, Pharmacol, Plsd, Posthoc, Posthoc analysis, Present data, Release mechanisms, Serotonin, Significant differences, Statistical significance, Synaptic, Synaptic concentrations, Temporal effects, Time period, Ventral, Ventral tegmental area, Ventrolateral nacc, Vivo, Vivo electrochemical signal, Vivo electrochemistry, Vivo voltammetric studies.
Abstract
Abstract: The effect of IV cocaine (0.5 and 1.0 mg/kg) was studied on synaptic concentrations of dopamine (DA) and serotonin [5-hydroxytryptamine (5-HT)] in the mesoaccumbens nerve terminal, the nucleus accumbens (NAcc), in chloral hydrate-anesthetized, male Sprague-Dawley rats (Rattus norvegicus) with in vivo electrochemistry (voltammetry). In further in vivo voltammetric studies, the effects of SC cocaine on synaptic concentrations of DA and 5-HT were studied in the chloral hydrate-anesthetized paradigm in two neuroanatomic substrates, NAcc and mesoaccumbens somatodendrites, the ventral tegmental area (VTA-A10), in a dose-response fashion (10, 20 and 40 mg/kg) in six separate studies. Moreover, in two additional in vivo voltammetric studies, again using the chloral hydrate-anesthetized paradigm, the impulse flow blocker, γ-butyrolactone (γ-BL) (750 mg/kg, IP), was studied alone and in combination with SC cocaine (20 mg/kg) to determine whether or not cocaine can act by presynaptic releasing mechanisms for DA and 5-HT. The results show that IV cocaine concurrently and significantly increased DA and 5-HT release in the NAcc (p < 0.001, p < 0.0005, respectively) at both doses tested. Moreover, IV cocaine effects on DA and 5-HT release were significantly and positively correlated (p < 0.01). On the other hand, SC cocaine concurrently and significantly decreased DA and 5-HT release in NAcc (p < 0.0001) and VTA (p < 0.0001) at each separate dose tested. SC cocaine effects on DA and 5-HT release were significantly and positively correlated across dose and neuroanatomic substrate (p < 0.01). Furthermore, the γ-BL studies indicate that cocaine's action includes a presynaptic release mechanism for the biogenic amines. Summarily, the data show that a consideration of the route of cocaine administration is crucial in determining the underlying neurochemical basis for cocaine.
Url:
DOI: 10.1016/0091-3057(92)90427-H
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ISTEX:E346F25BCF164D123A4E82F1AB6FBD4E6C3E5905Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Distinguishing effects of cocaine IV and SC on mesoaccumbens dopamine and serotonin release with chloral hydrate anesthesia</title><author><name sortKey="Broderick, Patricia A" sort="Broderick, Patricia A" uniqKey="Broderick P" first="Patricia A." last="Broderick">Patricia A. 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Broderick</name><affiliation><mods:affiliation>Department of Pharmacology, The City University of New York Medical School, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="ISSN">0091-3057</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">43</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="929">929</biblScope><biblScope unit="page" to="937">937</biblScope></imprint><idno type="ISSN">0091-3057</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-3057</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Accumbens</term><term>Anesthesia</term><term>Anesthetic</term><term>Anova</term><term>Anova statistics</term><term>Ascorbic acid</term><term>Basal</term><term>Basal synaptic concentrations</term><term>Behav</term><term>Biochem</term><term>Brain power</term><term>Brain tissue</term><term>Broderick</term><term>Chloral</term><term>Chloral hydrate</term><term>Chloral hydrate anesthesia</term><term>Chloral paradigm</term><term>Cocaine</term><term>Cocaine administration</term><term>Cocaine effects</term><term>Daergic</term><term>Daergic response</term><term>Dopamine</term><term>Dopaminergic neurons</term><term>Electroactive</term><term>Electroactive species</term><term>Electrochemical</term><term>Electrochemical signal</term><term>Extracellular</term><term>General anesthetic effects</term><term>General anesthetics</term><term>Hydrate</term><term>Impulse flow</term><term>Mesoaccumbens</term><term>Microelectrode</term><term>Microelectrodes</term><term>Nacc</term><term>Neuroanatomic substrate</term><term>Neuron</term><term>Neuronal</term><term>Nucleus accumbens</term><term>Other hand</term><term>Pearson product</term><term>Pharmacol</term><term>Plsd</term><term>Posthoc</term><term>Posthoc analysis</term><term>Present data</term><term>Release mechanisms</term><term>Serotonin</term><term>Significant differences</term><term>Statistical significance</term><term>Synaptic</term><term>Synaptic concentrations</term><term>Temporal effects</term><term>Time period</term><term>Ventral</term><term>Ventral tegmental area</term><term>Ventrolateral nacc</term><term>Vivo</term><term>Vivo electrochemical signal</term><term>Vivo electrochemistry</term><term>Vivo voltammetric studies</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The effect of IV cocaine (0.5 and 1.0 mg/kg) was studied on synaptic concentrations of dopamine (DA) and serotonin [5-hydroxytryptamine (5-HT)] in the mesoaccumbens nerve terminal, the nucleus accumbens (NAcc), in chloral hydrate-anesthetized, male Sprague-Dawley rats (Rattus norvegicus) with in vivo electrochemistry (voltammetry). In further in vivo voltammetric studies, the effects of SC cocaine on synaptic concentrations of DA and 5-HT were studied in the chloral hydrate-anesthetized paradigm in two neuroanatomic substrates, NAcc and mesoaccumbens somatodendrites, the ventral tegmental area (VTA-A10), in a dose-response fashion (10, 20 and 40 mg/kg) in six separate studies. Moreover, in two additional in vivo voltammetric studies, again using the chloral hydrate-anesthetized paradigm, the impulse flow blocker, γ-butyrolactone (γ-BL) (750 mg/kg, IP), was studied alone and in combination with SC cocaine (20 mg/kg) to determine whether or not cocaine can act by presynaptic releasing mechanisms for DA and 5-HT. The results show that IV cocaine concurrently and significantly increased DA and 5-HT release in the NAcc (p < 0.001, p < 0.0005, respectively) at both doses tested. Moreover, IV cocaine effects on DA and 5-HT release were significantly and positively correlated (p < 0.01). On the other hand, SC cocaine concurrently and significantly decreased DA and 5-HT release in NAcc (p < 0.0001) and VTA (p < 0.0001) at each separate dose tested. SC cocaine effects on DA and 5-HT release were significantly and positively correlated across dose and neuroanatomic substrate (p < 0.01). Furthermore, the γ-BL studies indicate that cocaine's action includes a presynaptic release mechanism for the biogenic amines. Summarily, the data show that a consideration of the route of cocaine administration is crucial in determining the underlying neurochemical basis for cocaine.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>nacc</json:string><json:string>cocaine</json:string><json:string>synaptic</json:string><json:string>synaptic concentrations</json:string><json:string>chloral</json:string><json:string>anova</json:string><json:string>dopamine</json:string><json:string>pharmacol</json:string><json:string>electrochemical</json:string><json:string>plsd</json:string><json:string>broderick</json:string><json:string>accumbens</json:string><json:string>hydrate</json:string><json:string>chloral paradigm</json:string><json:string>serotonin</json:string><json:string>nucleus accumbens</json:string><json:string>anesthesia</json:string><json:string>daergic</json:string><json:string>mesoaccumbens</json:string><json:string>microelectrode</json:string><json:string>biochem</json:string><json:string>chloral hydrate</json:string><json:string>microelectrodes</json:string><json:string>pearson product</json:string><json:string>behav</json:string><json:string>posthoc</json:string><json:string>cocaine administration</json:string><json:string>basal</json:string><json:string>electroactive</json:string><json:string>ventral</json:string><json:string>extracellular</json:string><json:string>anesthetic</json:string><json:string>neuron</json:string><json:string>impulse flow</json:string><json:string>cocaine effects</json:string><json:string>posthoc analysis</json:string><json:string>electroactive species</json:string><json:string>release mechanisms</json:string><json:string>significant differences</json:string><json:string>ventral tegmental area</json:string><json:string>temporal effects</json:string><json:string>electrochemical signal</json:string><json:string>anova statistics</json:string><json:string>time period</json:string><json:string>neuronal</json:string><json:string>ventrolateral nacc</json:string><json:string>other hand</json:string><json:string>general anesthetics</json:string><json:string>vivo electrochemical signal</json:string><json:string>dopaminergic neurons</json:string><json:string>brain power</json:string><json:string>vivo voltammetric studies</json:string><json:string>vivo electrochemistry</json:string><json:string>neuroanatomic substrate</json:string><json:string>basal synaptic concentrations</json:string><json:string>present data</json:string><json:string>ascorbic acid</json:string><json:string>daergic response</json:string><json:string>statistical significance</json:string><json:string>general anesthetic effects</json:string><json:string>chloral hydrate anesthesia</json:string><json:string>brain tissue</json:string><json:string>vivo</json:string></teeft></keywords><author><json:item><name>Patricia A. Broderick</name><affiliations><json:string>Department of Pharmacology, The City University of New York Medical School, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Cocaine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Dopamine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Serotonin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Ventrolateral nucleus accumbens</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>In vivo electrochemistry (voltammetry)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Chloral hydrate anesthesia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Ventral tegmental area</value></json:item></subject><arkIstex>ark:/67375/6H6-RVH1K8KQ-T</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Short communication</json:string></originalGenre><abstract>Abstract: The effect of IV cocaine (0.5 and 1.0 mg/kg) was studied on synaptic concentrations of dopamine (DA) and serotonin [5-hydroxytryptamine (5-HT)] in the mesoaccumbens nerve terminal, the nucleus accumbens (NAcc), in chloral hydrate-anesthetized, male Sprague-Dawley rats (Rattus norvegicus) with in vivo electrochemistry (voltammetry). In further in vivo voltammetric studies, the effects of SC cocaine on synaptic concentrations of DA and 5-HT were studied in the chloral hydrate-anesthetized paradigm in two neuroanatomic substrates, NAcc and mesoaccumbens somatodendrites, the ventral tegmental area (VTA-A10), in a dose-response fashion (10, 20 and 40 mg/kg) in six separate studies. Moreover, in two additional in vivo voltammetric studies, again using the chloral hydrate-anesthetized paradigm, the impulse flow blocker, γ-butyrolactone (γ-BL) (750 mg/kg, IP), was studied alone and in combination with SC cocaine (20 mg/kg) to determine whether or not cocaine can act by presynaptic releasing mechanisms for DA and 5-HT. The results show that IV cocaine concurrently and significantly increased DA and 5-HT release in the NAcc (p > 0.001, p > 0.0005, respectively) at both doses tested. Moreover, IV cocaine effects on DA and 5-HT release were significantly and positively correlated (p > 0.01). On the other hand, SC cocaine concurrently and significantly decreased DA and 5-HT release in NAcc (p > 0.0001) and VTA (p > 0.0001) at each separate dose tested. SC cocaine effects on DA and 5-HT release were significantly and positively correlated across dose and neuroanatomic substrate (p > 0.01). Furthermore, the γ-BL studies indicate that cocaine's action includes a presynaptic release mechanism for the biogenic amines. Summarily, the data show that a consideration of the route of cocaine administration is crucial in determining the underlying neurochemical basis for cocaine.</abstract><qualityIndicators><score>10</score><pdfWordCount>7365</pdfWordCount><pdfCharCount>40993</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>280</abstractWordCount><abstractCharCount>1898</abstractCharCount><keywordCount>7</keywordCount></qualityIndicators><title>Distinguishing effects of cocaine IV and SC on mesoaccumbens dopamine and serotonin release with chloral hydrate anesthesia</title><pmid><json:string>1448488</json:string></pmid><pii><json:string>0091-3057(92)90427-H</json:string></pii><genre><json:string>brief-communication</json:string></genre><host><title>Pharmacology, Biochemistry and Behavior</title><language><json:string>unknown</json:string></language><publicationDate>1992</publicationDate><issn><json:string>0091-3057</json:string></issn><pii><json:string>S0091-3057(00)X0287-0</json:string></pii><volume>43</volume><issue>3</issue><pages><first>929</first><last>937</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1992</json:string></date><geogName></geogName><orgName><json:string>Fisher Scientific Co.</json:string><json:string>The City University</json:string><json:string>Brain Power Inc.</json:string><json:string>Fisher Scientific</json:string><json:string>Professional Staff Congress</json:string><json:string>Sigma Chemical Co.</json:string><json:string>Charles River Laboratories</json:string><json:string>Smith Co.</json:string><json:string>Department of Pharmacology, Room J</json:string><json:string>American Hospital Supply, Edison</json:string><json:string>National Institute on Drug Abuse Award R01</json:string></orgName><orgName_funder><json:string>National Institute on Drug Abuse Award R01</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>An Ag</json:string><json:string>Frank T. 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Broderick, Department of Pharmacology, Room J-910, The City University of New York Medical School, and Departments of Biology and Psychology, CUNY Graduate School, Convent Avenue and West 138th Street, New York, NY 10031, USA.</note><affiliation>Requests for reprints should be addressed to Dr. Patricia A. Broderick, Department of Pharmacology, Room J-910, The City University of New York Medical School, and Departments of Biology and Psychology, CUNY Graduate School, Convent Avenue and West 138th Street, New York, NY 10031, USA.</affiliation><affiliation>Department of Pharmacology, The City University of New York Medical School, USA</affiliation></author><idno type="istex">E346F25BCF164D123A4E82F1AB6FBD4E6C3E5905</idno><idno type="ark">ark:/67375/6H6-RVH1K8KQ-T</idno><idno type="DOI">10.1016/0091-3057(92)90427-H</idno><idno type="PII">0091-3057(92)90427-H</idno></analytic><monogr><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="pISSN">0091-3057</idno><idno type="PII">S0091-3057(00)X0287-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992"></date><biblScope unit="volume">43</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="929">929</biblScope><biblScope unit="page" to="937">937</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1992</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The effect of IV cocaine (0.5 and 1.0 mg/kg) was studied on synaptic concentrations of dopamine (DA) and serotonin [5-hydroxytryptamine (5-HT)] in the mesoaccumbens nerve terminal, the nucleus accumbens (NAcc), in chloral hydrate-anesthetized, male Sprague-Dawley rats (Rattus norvegicus) with in vivo electrochemistry (voltammetry). In further in vivo voltammetric studies, the effects of SC cocaine on synaptic concentrations of DA and 5-HT were studied in the chloral hydrate-anesthetized paradigm in two neuroanatomic substrates, NAcc and mesoaccumbens somatodendrites, the ventral tegmental area (VTA-A10), in a dose-response fashion (10, 20 and 40 mg/kg) in six separate studies. Moreover, in two additional in vivo voltammetric studies, again using the chloral hydrate-anesthetized paradigm, the impulse flow blocker, γ-butyrolactone (γ-BL) (750 mg/kg, IP), was studied alone and in combination with SC cocaine (20 mg/kg) to determine whether or not cocaine can act by presynaptic releasing mechanisms for DA and 5-HT. The results show that IV cocaine concurrently and significantly increased DA and 5-HT release in the NAcc (p < 0.001, p < 0.0005, respectively) at both doses tested. Moreover, IV cocaine effects on DA and 5-HT release were significantly and positively correlated (p < 0.01). On the other hand, SC cocaine concurrently and significantly decreased DA and 5-HT release in NAcc (p < 0.0001) and VTA (p < 0.0001) at each separate dose tested. SC cocaine effects on DA and 5-HT release were significantly and positively correlated across dose and neuroanatomic substrate (p < 0.01). Furthermore, the γ-BL studies indicate that cocaine's action includes a presynaptic release mechanism for the biogenic amines. Summarily, the data show that a consideration of the route of cocaine administration is crucial in determining the underlying neurochemical basis for cocaine.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Cocaine</term></item><item><term>Dopamine</term></item><item><term>Serotonin</term></item><item><term>Ventrolateral nucleus accumbens</term></item><item><term>In vivo electrochemistry (voltammetry)</term></item><item><term>Chloral hydrate anesthesia</term></item><item><term>Ventral tegmental area</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1992">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-RVH1K8KQ-T/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="sco"><item-info><jid>PBB</jid><aid>9290427H</aid><ce:pii>0091-3057(92)90427-H</ce:pii><ce:doi>10.1016/0091-3057(92)90427-H</ce:doi><ce:copyright type="unknown" year="1992"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Rapid communication</ce:textfn></ce:dochead><ce:title>Distinguishing effects of cocaine IV and SC on mesoaccumbens dopamine and serotonin release with chloral hydrate anesthesia</ce:title><ce:author-group><ce:author><ce:given-name>Patricia A.</ce:given-name><ce:surname>Broderick</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Pharmacology, The City University of New York Medical School, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Departments of Biology and Psychology, CUNY Graduate School, New York, NY 10031, USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>Requests for reprints should be addressed to Dr. Patricia A. Broderick, Department of Pharmacology, Room J-910, The City University of New York Medical School, and Departments of Biology and Psychology, CUNY Graduate School, Convent Avenue and West 138th Street, New York, NY 10031, USA.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="24" month="6" year="1992"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The effect of IV cocaine (0.5 and 1.0 mg/kg) was studied on synaptic concentrations of dopamine (DA) and serotonin [5-hydroxytryptamine (5-HT)] in the mesoaccumbens nerve terminal, the nucleus accumbens (NAcc), in chloral hydrate-anesthetized, male Sprague-Dawley rats (<ce:italic>Rattus norvegicus</ce:italic>) with in vivo electrochemistry (voltammetry). In further in vivo voltammetric studies, the effects of SC cocaine on synaptic concentrations of DA and 5-HT were studied in the chloral hydrate-anesthetized paradigm in two neuroanatomic substrates, NAcc and mesoaccumbens somatodendrites, the ventral tegmental area (VTA-A<ce:inf>10</ce:inf>), in a dose-response fashion (10, 20 and 40 mg/kg) in six separate studies. Moreover, in two additional in vivo voltammetric studies, again using the chloral hydrate-anesthetized paradigm, the impulse flow blocker, γ-butyrolactone (γ-BL) (750 mg/kg, IP), was studied alone and in combination with SC cocaine (20 mg/kg) to determine whether or not cocaine can act by presynaptic releasing mechanisms for DA and 5-HT. The results show that IV cocaine concurrently and significantly increased DA and 5-HT release in the NAcc (<ce:italic>p</ce:italic> < 0.001, <ce:italic>p</ce:italic> < 0.0005, respectively) at both doses tested. Moreover, IV cocaine effects on DA and 5-HT release were significantly and positively correlated (<ce:italic>p</ce:italic> < 0.01). On the other hand, SC cocaine concurrently and significantly decreased DA and 5-HT release in NAcc (<ce:italic>p</ce:italic> < 0.0001) and VTA (<ce:italic>p</ce:italic> < 0.0001) at each separate dose tested. SC cocaine effects on DA and 5-HT release were significantly and positively correlated across dose and neuroanatomic substrate (<ce:italic>p</ce:italic> < 0.01). Furthermore, the γ-BL studies indicate that cocaine's action includes a presynaptic release mechanism for the biogenic amines. Summarily, the data show that a consideration of the route of cocaine administration is crucial in determining the underlying neurochemical basis for cocaine.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Cocaine</ce:text></ce:keyword><ce:keyword><ce:text>Dopamine</ce:text></ce:keyword><ce:keyword><ce:text>Serotonin</ce:text></ce:keyword><ce:keyword><ce:text>Ventrolateral nucleus accumbens</ce:text></ce:keyword><ce:keyword><ce:text>In vivo electrochemistry (voltammetry)</ce:text></ce:keyword><ce:keyword><ce:text>Chloral hydrate anesthesia</ce:text></ce:keyword><ce:keyword><ce:text>Ventral tegmental area</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Distinguishing effects of cocaine IV and SC on mesoaccumbens dopamine and serotonin release with chloral hydrate anesthesia</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Distinguishing effects of cocaine IV and SC on mesoaccumbens dopamine and serotonin release with chloral hydrate anesthesia</title></titleInfo><name type="personal"><namePart type="given">Patricia A.</namePart><namePart type="family">Broderick</namePart><affiliation>Department of Pharmacology, The City University of New York Medical School, USA</affiliation><description>Requests for reprints should be addressed to Dr. Patricia A. Broderick, Department of Pharmacology, Room J-910, The City University of New York Medical School, and Departments of Biology and Psychology, CUNY Graduate School, Convent Avenue and West 138th Street, New York, NY 10031, USA.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="Short communication" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The effect of IV cocaine (0.5 and 1.0 mg/kg) was studied on synaptic concentrations of dopamine (DA) and serotonin [5-hydroxytryptamine (5-HT)] in the mesoaccumbens nerve terminal, the nucleus accumbens (NAcc), in chloral hydrate-anesthetized, male Sprague-Dawley rats (Rattus norvegicus) with in vivo electrochemistry (voltammetry). In further in vivo voltammetric studies, the effects of SC cocaine on synaptic concentrations of DA and 5-HT were studied in the chloral hydrate-anesthetized paradigm in two neuroanatomic substrates, NAcc and mesoaccumbens somatodendrites, the ventral tegmental area (VTA-A10), in a dose-response fashion (10, 20 and 40 mg/kg) in six separate studies. Moreover, in two additional in vivo voltammetric studies, again using the chloral hydrate-anesthetized paradigm, the impulse flow blocker, γ-butyrolactone (γ-BL) (750 mg/kg, IP), was studied alone and in combination with SC cocaine (20 mg/kg) to determine whether or not cocaine can act by presynaptic releasing mechanisms for DA and 5-HT. The results show that IV cocaine concurrently and significantly increased DA and 5-HT release in the NAcc (p < 0.001, p < 0.0005, respectively) at both doses tested. Moreover, IV cocaine effects on DA and 5-HT release were significantly and positively correlated (p < 0.01). On the other hand, SC cocaine concurrently and significantly decreased DA and 5-HT release in NAcc (p < 0.0001) and VTA (p < 0.0001) at each separate dose tested. SC cocaine effects on DA and 5-HT release were significantly and positively correlated across dose and neuroanatomic substrate (p < 0.01). Furthermore, the γ-BL studies indicate that cocaine's action includes a presynaptic release mechanism for the biogenic amines. Summarily, the data show that a consideration of the route of cocaine administration is crucial in determining the underlying neurochemical basis for cocaine.</abstract><note type="content">Section title: Rapid communication</note><subject><genre>Keywords</genre><topic>Cocaine</topic><topic>Dopamine</topic><topic>Serotonin</topic><topic>Ventrolateral nucleus accumbens</topic><topic>In vivo electrochemistry (voltammetry)</topic><topic>Chloral hydrate anesthesia</topic><topic>Ventral tegmental area</topic></subject><relatedItem type="host"><titleInfo><title>Pharmacology, Biochemistry and Behavior</title></titleInfo><titleInfo type="abbreviated"><title>PBB</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued></originInfo><identifier type="ISSN">0091-3057</identifier><identifier type="PII">S0091-3057(00)X0287-0</identifier><part><date>1992</date><detail type="volume"><number>43</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>661</start><end>977</end></extent><extent unit="pages"><start>929</start><end>937</end></extent></part></relatedItem><identifier type="istex">E346F25BCF164D123A4E82F1AB6FBD4E6C3E5905</identifier><identifier type="ark">ark:/67375/6H6-RVH1K8KQ-T</identifier><identifier type="DOI">10.1016/0091-3057(92)90427-H</identifier><identifier type="PII">0091-3057(92)90427-H</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-RVH1K8KQ-T/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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