Mycotoxicosis produced in rats by cultural products of an isolate of aspergillus ochraceus
Identifieur interne : 000798 ( Istex/Corpus ); précédent : 000797; suivant : 000799Mycotoxicosis produced in rats by cultural products of an isolate of aspergillus ochraceus
Auteurs : J. L. Zimmermann ; W. W. Carlton ; J. TuiteSource :
- Food and Cosmetics Toxicology [ 0015-6264 ] ; 1978.
English descriptors
- Teeft :
- Acute toxicity, Adipose, Appl, Aspergillus, Aspergillus ochraceus, Bile ducts, Biliary, Blood vessels, Carlton, Carlton tuite, Convoluted tubules, Corneal, Corneal oedema, Cultural products, Duct, Enomoto, Epididymal, Epididymal ducts, Epithelium, Extrahepatic ducts, Fibrinoid necrosis, Fungal, Fusarium, Gastric, Gastric lesions, Gastric ulceration, Greenish discoloration, Hepatic, Hepatic lesions, Inflammatory, Inflammatory cells, Lesion, Leucocyte, Male rats, Mccracken, Mycotoxicosis, Mycotoxin, Necrosis, Necrotic, Necrotizing, Necrotizing cholangitis, Ochraceus, Ochratoxin, Ocular lesions, Oedema, Oiridicatum, Penicillic acid, Penicillium, Penicillium oiridicatum, Portal areas, Rat, Renal lesions, Rice culture, Saito, Sakai, Scrotal, Scrotal lesions, Tatsuno, Tissue debris, Toxic, Toxic microorganisms, Toxicity, Tsunoda, Tubule, Tuite, Ueno, Ulceration, Viridicatum, Weight gains.
Abstract
Abstract: The toxicity of an isolate of Aspergillus ochraceus was examined in weanling male Sprague-Dawley rats fed diets containing a rice culture or fungal mat of the organism for 5 wk. The ground rice culture was mixed with a commercial purified diet at concentrations of 5, 7·5 and 10% and the fungal mat at concentrations of 1, 2 and 3%. In groups fed the rice-culture diets, weight gains were reduced and all the rats in the group fed the 10% diet died. Rats fed fungal-mat diets showed a marked reduction in weight gain, and the death rate was high (about 83%) in groups fed the 2 or 3% diet. Gross lesions found in groups fed either type of diet included focal necrosis in the liver, greenish discoloration of the kidneys, gastric ulceration, ulceration of the scrotal epidermis and corneal opacity. Histological changes in the liver included necrosis of the epithelium of biliary ducts, periductal oedema, pericholangitis, periductal fibrosis and disseminated focal hepatocellular necrosis. Necrosis of epithelium occurred also in the extraheptic ducts and was accompanied by an interstitial pancreatitis in certain rats. Foci of leucocytes and macrophages were found in the dermis of the scrotum and in the epididymal adipose connective tissue. Ulceration of the epidermis occurred late in the sequence of scrotal changes. Ocular lesions comprised corneal oedema, interstitital keratitis, iridocyclitis and hypopyon. Renal lesions consisted of tubular necrosis and hyaline and biliary casts within convoluted tubules.
Url:
DOI: 10.1016/S0015-6264(78)80303-4
Links to Exploration step
ISTEX:369A9573CF12DB02DB7B6D9FB0128358F3D2E678Le document en format XML
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Tuite</name><affiliation><mods:affiliation>Department of Botany and Plant Pathology, School of Agriculture, Purdue University, West Lafayette, IN47907, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Food and Cosmetics Toxicology</title><title level="j" type="abbrev">FCTOX</title><idno type="ISSN">0015-6264</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1978">1978</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="449">449</biblScope><biblScope unit="page" to="461">461</biblScope></imprint><idno type="ISSN">0015-6264</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0015-6264</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute toxicity</term><term>Adipose</term><term>Appl</term><term>Aspergillus</term><term>Aspergillus ochraceus</term><term>Bile ducts</term><term>Biliary</term><term>Blood vessels</term><term>Carlton</term><term>Carlton tuite</term><term>Convoluted tubules</term><term>Corneal</term><term>Corneal oedema</term><term>Cultural products</term><term>Duct</term><term>Enomoto</term><term>Epididymal</term><term>Epididymal ducts</term><term>Epithelium</term><term>Extrahepatic ducts</term><term>Fibrinoid necrosis</term><term>Fungal</term><term>Fusarium</term><term>Gastric</term><term>Gastric lesions</term><term>Gastric ulceration</term><term>Greenish discoloration</term><term>Hepatic</term><term>Hepatic lesions</term><term>Inflammatory</term><term>Inflammatory cells</term><term>Lesion</term><term>Leucocyte</term><term>Male rats</term><term>Mccracken</term><term>Mycotoxicosis</term><term>Mycotoxin</term><term>Necrosis</term><term>Necrotic</term><term>Necrotizing</term><term>Necrotizing cholangitis</term><term>Ochraceus</term><term>Ochratoxin</term><term>Ocular lesions</term><term>Oedema</term><term>Oiridicatum</term><term>Penicillic acid</term><term>Penicillium</term><term>Penicillium oiridicatum</term><term>Portal areas</term><term>Rat</term><term>Renal lesions</term><term>Rice culture</term><term>Saito</term><term>Sakai</term><term>Scrotal</term><term>Scrotal lesions</term><term>Tatsuno</term><term>Tissue debris</term><term>Toxic</term><term>Toxic microorganisms</term><term>Toxicity</term><term>Tsunoda</term><term>Tubule</term><term>Tuite</term><term>Ueno</term><term>Ulceration</term><term>Viridicatum</term><term>Weight gains</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The toxicity of an isolate of Aspergillus ochraceus was examined in weanling male Sprague-Dawley rats fed diets containing a rice culture or fungal mat of the organism for 5 wk. The ground rice culture was mixed with a commercial purified diet at concentrations of 5, 7·5 and 10% and the fungal mat at concentrations of 1, 2 and 3%. In groups fed the rice-culture diets, weight gains were reduced and all the rats in the group fed the 10% diet died. Rats fed fungal-mat diets showed a marked reduction in weight gain, and the death rate was high (about 83%) in groups fed the 2 or 3% diet. Gross lesions found in groups fed either type of diet included focal necrosis in the liver, greenish discoloration of the kidneys, gastric ulceration, ulceration of the scrotal epidermis and corneal opacity. Histological changes in the liver included necrosis of the epithelium of biliary ducts, periductal oedema, pericholangitis, periductal fibrosis and disseminated focal hepatocellular necrosis. Necrosis of epithelium occurred also in the extraheptic ducts and was accompanied by an interstitial pancreatitis in certain rats. Foci of leucocytes and macrophages were found in the dermis of the scrotum and in the epididymal adipose connective tissue. Ulceration of the epidermis occurred late in the sequence of scrotal changes. Ocular lesions comprised corneal oedema, interstitital keratitis, iridocyclitis and hypopyon. Renal lesions consisted of tubular necrosis and hyaline and biliary casts within convoluted tubules.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>ochraceus</json:string><json:string>carlton</json:string><json:string>tuite</json:string><json:string>scrotal</json:string><json:string>rice culture</json:string><json:string>corneal</json:string><json:string>aspergillus</json:string><json:string>hepatic</json:string><json:string>enomoto</json:string><json:string>epithelium</json:string><json:string>epididymal</json:string><json:string>penicillium</json:string><json:string>sakai</json:string><json:string>lesion</json:string><json:string>mycotoxin</json:string><json:string>cultural products</json:string><json:string>duct</json:string><json:string>appl</json:string><json:string>saito</json:string><json:string>ulceration</json:string><json:string>tatsuno</json:string><json:string>adipose</json:string><json:string>biliary</json:string><json:string>gastric</json:string><json:string>ochratoxin</json:string><json:string>oiridicatum</json:string><json:string>fungal</json:string><json:string>tsunoda</json:string><json:string>oedema</json:string><json:string>viridicatum</json:string><json:string>leucocyte</json:string><json:string>mycotoxicosis</json:string><json:string>toxicity</json:string><json:string>ueno</json:string><json:string>carlton tuite</json:string><json:string>aspergillus ochraceus</json:string><json:string>tubule</json:string><json:string>necrotizing</json:string><json:string>fusarium</json:string><json:string>necrosis</json:string><json:string>hepatic lesions</json:string><json:string>rat</json:string><json:string>bile ducts</json:string><json:string>scrotal lesions</json:string><json:string>necrotic</json:string><json:string>inflammatory</json:string><json:string>acute toxicity</json:string><json:string>ocular lesions</json:string><json:string>renal lesions</json:string><json:string>toxic microorganisms</json:string><json:string>extrahepatic ducts</json:string><json:string>mccracken</json:string><json:string>penicillic acid</json:string><json:string>male rats</json:string><json:string>fibrinoid necrosis</json:string><json:string>epididymal ducts</json:string><json:string>inflammatory cells</json:string><json:string>corneal oedema</json:string><json:string>necrotizing cholangitis</json:string><json:string>tissue debris</json:string><json:string>portal areas</json:string><json:string>greenish discoloration</json:string><json:string>gastric lesions</json:string><json:string>blood vessels</json:string><json:string>weight gains</json:string><json:string>penicillium oiridicatum</json:string><json:string>convoluted tubules</json:string><json:string>gastric ulceration</json:string><json:string>toxic</json:string></teeft></keywords><author><json:item><name>J.L. Zimmermann</name><affiliations><json:string>Department of Veterinary Microbiology, Pathology and Public Health, School of Veterinary Medicine</json:string></affiliations></json:item><json:item><name>W.W. Carlton</name><affiliations><json:string>Department of Veterinary Microbiology, Pathology and Public Health, School of Veterinary Medicine</json:string></affiliations></json:item><json:item><name>J. Tuite</name><affiliations><json:string>Department of Botany and Plant Pathology, School of Agriculture, Purdue University, West Lafayette, IN47907, USA</json:string></affiliations></json:item></author><articleId><json:string>80303</json:string></articleId><arkIstex>ark:/67375/6H6-LXP71G4C-3</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The toxicity of an isolate of Aspergillus ochraceus was examined in weanling male Sprague-Dawley rats fed diets containing a rice culture or fungal mat of the organism for 5 wk. The ground rice culture was mixed with a commercial purified diet at concentrations of 5, 7·5 and 10% and the fungal mat at concentrations of 1, 2 and 3%. In groups fed the rice-culture diets, weight gains were reduced and all the rats in the group fed the 10% diet died. Rats fed fungal-mat diets showed a marked reduction in weight gain, and the death rate was high (about 83%) in groups fed the 2 or 3% diet. Gross lesions found in groups fed either type of diet included focal necrosis in the liver, greenish discoloration of the kidneys, gastric ulceration, ulceration of the scrotal epidermis and corneal opacity. Histological changes in the liver included necrosis of the epithelium of biliary ducts, periductal oedema, pericholangitis, periductal fibrosis and disseminated focal hepatocellular necrosis. Necrosis of epithelium occurred also in the extraheptic ducts and was accompanied by an interstitial pancreatitis in certain rats. Foci of leucocytes and macrophages were found in the dermis of the scrotum and in the epididymal adipose connective tissue. Ulceration of the epidermis occurred late in the sequence of scrotal changes. Ocular lesions comprised corneal oedema, interstitital keratitis, iridocyclitis and hypopyon. Renal lesions consisted of tubular necrosis and hyaline and biliary casts within convoluted tubules.</abstract><qualityIndicators><score>9.632</score><pdfWordCount>4776</pdfWordCount><pdfCharCount>29871</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>13</pdfPageCount><pdfPageSize>576 x 828 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>238</abstractWordCount><abstractCharCount>1527</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Mycotoxicosis produced in rats by cultural products of an isolate of aspergillus ochraceus</title><pmid><json:string>711069</json:string></pmid><pii><json:string>S0015-6264(78)80303-4</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Food and Cosmetics Toxicology</title><language><json:string>unknown</json:string></language><publicationDate>1978</publicationDate><issn><json:string>0015-6264</json:string></issn><pii><json:string>S0015-6264(78)X8256-3</json:string></pii><volume>16</volume><issue>5</issue><pages><first>449</first><last>461</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1978</json:string></date><geogName></geogName><orgName><json:string>TUITE Department of Botany and Plant Pathology</json:string><json:string>Purdue University</json:string><json:string>CARLTON Department of Veterinary Microbiology, Pathology and Public Health</json:string><json:string>Department of Botany and Plant Pathology</json:string><json:string>Grant ESCA-00463</json:string></orgName><orgName_funder><json:string>Grant ESCA-00463</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>J. TtJITt</json:string><json:string>I. Hypcrplasia</json:string><json:string>S. Occlusion</json:string><json:string>C. Water</json:string></persName><placeName><json:string>Mishima</json:string><json:string>IN</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Ucno, Ueno, Iitoi, Tsunoda, Enomoto & Ohtsubo, 1971</json:string><json:string>Leyendecker, 1954</json:string><json:string>Dikstein & Maurice, 1972</json:string><json:string>Ciegler, 1972</json:string><json:string>McCracken et al. (1974b)</json:string><json:string>McCracken, Carlton & Tuite, 1974b</json:string><json:string>Mishima & Hayakawa, 1972</json:string><json:string>Uraguchi, Tatsuno, Sakai, Tsukioka, Sakai, Yonemitsu, Ito, Miyake, Saito, Enomoto, Shikata & Ishiko, 1961</json:string><json:string>Ueno, Ishii, Sakai, Kanaeda, Tsunoda, Tanaka & Enomoto, 1972</json:string><json:string>Jacoby, Bhatt & Jonas, 1975</json:string><json:string>Kobayashi, Uraguchi, Sakai, Tatsuno, Tsukioka, Sakai, Sato, Miyake, Saito, Enomoto, Shikata & Ishiko, 1958</json:string><json:string>Doupnik & Bell, 1971</json:string><json:string>Purchase & van der Watt, 1969</json:string><json:string>Budiarso et al. 1971</json:string><json:string>Carlton, Stack & Eppley, 1976</json:string><json:string>Zimmermann, Carlton & Tuite, 1976</json:string><json:string>Rafiquzzaman, 1974</json:string><json:string>Natori, Sakaki, Kurata, Udagawa, Ichinoe, Saito & Umeda, 1970</json:string><json:string>Done, Mortimer, Taylor & Russell, 1961</json:string><json:string>Christensen, Fanse, Nelson, Bates & Mirocha, 1967</json:string><json:string>Tatsuno, Saito, Enomoto & Tsunoda, 1968</json:string><json:string>van der Merwe, Steyn, Fourie, Scott & Theron, 1965</json:string><json:string>Saito, Enomoto & Tatsuno, 1969</json:string><json:string>van der Watt & Purchase, 1970</json:string><json:string>Purchase & Theron, 1968</json:string><json:string>Ueno et al. 1971</json:string><json:string>Ishii, Sakai, Ueno, Tsunoda & Enomoto, 1971</json:string><json:string>Wogan, 1965</json:string><json:string>Carlton & Tuite, 1970</json:string><json:string>Munro, Scott, Moodie & Willes, 1973</json:string><json:string>Carlton et al. 1968</json:string><json:string>Remington, Slater, Spector, Strauli & Willoughby, 1962</json:string><json:string>Lopez & Christensen, 1967</json:string><json:string>Jonas, Craft, Black, Bhatt & Hilding, 1969</json:string><json:string>Wallace & Sinha, 1962</json:string><json:string>Hunt, 1963</json:string><json:string>Wogan, Edwards & Newberne, 1971</json:string><json:string>Zimmermann et al. 1976</json:string><json:string>Purchase, 1971</json:string><json:string>Udagawa, Ichinoe & Kurata, 1970</json:string><json:string>Bamburg & Strong, 1971</json:string><json:string>Tatsuno, 1968</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-LXP71G4C-3</json:string></ark><categories><wos></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Pharmacology, Toxicology and Pharmaceutics</json:string><json:string>3 - Toxicology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1978</publicationDate><copyrightDate>1978</copyrightDate><doi><json:string>10.1016/S0015-6264(78)80303-4</json:string></doi><id>369A9573CF12DB02DB7B6D9FB0128358F3D2E678</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-LXP71G4C-3/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-LXP71G4C-3/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-LXP71G4C-3/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Mycotoxicosis produced in rats by cultural products of an isolate of aspergillus ochraceus</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©1978 Pergamon Press Ltd</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>1978</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Mycotoxicosis produced in rats by cultural products of an isolate of aspergillus ochraceus</title><author xml:id="author-0000"><persName><forename type="first">J.L.</forename><surname>Zimmermann</surname></persName><affiliation>Department of Veterinary Microbiology, Pathology and Public Health, School of Veterinary Medicine</affiliation></author><author xml:id="author-0001"><persName><forename type="first">W.W.</forename><surname>Carlton</surname></persName><affiliation>Department of Veterinary Microbiology, Pathology and Public Health, School of Veterinary Medicine</affiliation></author><author xml:id="author-0002"><persName><forename type="first">J.</forename><surname>Tuite</surname></persName><affiliation>Department of Botany and Plant Pathology, School of Agriculture, Purdue University, West Lafayette, IN47907, USA</affiliation></author><idno type="istex">369A9573CF12DB02DB7B6D9FB0128358F3D2E678</idno><idno type="ark">ark:/67375/6H6-LXP71G4C-3</idno><idno type="DOI">10.1016/S0015-6264(78)80303-4</idno><idno type="PII">S0015-6264(78)80303-4</idno><idno type="article-id">80303</idno></analytic><monogr><title level="j">Food and Cosmetics Toxicology</title><title level="j" type="abbrev">FCTOX</title><idno type="pISSN">0015-6264</idno><idno type="PII">S0015-6264(78)X8256-3</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1978"></date><biblScope unit="volume">16</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="449">449</biblScope><biblScope unit="page" to="461">461</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1978</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The toxicity of an isolate of Aspergillus ochraceus was examined in weanling male Sprague-Dawley rats fed diets containing a rice culture or fungal mat of the organism for 5 wk. The ground rice culture was mixed with a commercial purified diet at concentrations of 5, 7·5 and 10% and the fungal mat at concentrations of 1, 2 and 3%. In groups fed the rice-culture diets, weight gains were reduced and all the rats in the group fed the 10% diet died. Rats fed fungal-mat diets showed a marked reduction in weight gain, and the death rate was high (about 83%) in groups fed the 2 or 3% diet. Gross lesions found in groups fed either type of diet included focal necrosis in the liver, greenish discoloration of the kidneys, gastric ulceration, ulceration of the scrotal epidermis and corneal opacity. Histological changes in the liver included necrosis of the epithelium of biliary ducts, periductal oedema, pericholangitis, periductal fibrosis and disseminated focal hepatocellular necrosis. Necrosis of epithelium occurred also in the extraheptic ducts and was accompanied by an interstitial pancreatitis in certain rats. Foci of leucocytes and macrophages were found in the dermis of the scrotum and in the epididymal adipose connective tissue. Ulceration of the epidermis occurred late in the sequence of scrotal changes. Ocular lesions comprised corneal oedema, interstitital keratitis, iridocyclitis and hypopyon. Renal lesions consisted of tubular necrosis and hyaline and biliary casts within convoluted tubules.</p></abstract></profileDesc><revisionDesc><change when="1978-05-09">Modified</change><change when="1978">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-LXP71G4C-3/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>FCTOX</jid><aid>80303</aid><ce:pii>S0015-6264(78)80303-4</ce:pii><ce:doi>10.1016/S0015-6264(78)80303-4</ce:doi><ce:copyright type="unknown" year="1978">Pergamon Press Ltd</ce:copyright></item-info><head><ce:title>Mycotoxicosis produced in rats by cultural products of an isolate of <ce:italic>aspergillus ochraceus</ce:italic></ce:title><ce:author-group><ce:author><ce:given-name>J.L.</ce:given-name><ce:surname>Zimmermann</ce:surname></ce:author><ce:author><ce:given-name>W.W.</ce:given-name><ce:surname>Carlton</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Veterinary Microbiology, Pathology and Public Health, School of Veterinary Medicine</ce:textfn></ce:affiliation></ce:author-group><ce:author-group><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Tuite</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Botany and Plant Pathology, School of Agriculture, Purdue University, West Lafayette, IN47907, USA</ce:textfn></ce:affiliation></ce:author-group><ce:date-revised day="9" month="5" year="1978"></ce:date-revised><ce:abstract id="ab1"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The toxicity of an isolate of <ce:italic>Aspergillus ochraceus</ce:italic> was examined in weanling male Sprague-Dawley rats fed diets containing a rice culture or fungal mat of the organism for 5 wk. The ground rice culture was mixed with a commercial purified diet at concentrations of 5, 7·5 and 10% and the fungal mat at concentrations of 1, 2 and 3%. In groups fed the rice-culture diets, weight gains were reduced and all the rats in the group fed the 10% diet died. Rats fed fungal-mat diets showed a marked reduction in weight gain, and the death rate was high (about 83%) in groups fed the 2 or 3% diet. Gross lesions found in groups fed either type of diet included focal necrosis in the liver, greenish discoloration of the kidneys, gastric ulceration, ulceration of the scrotal epidermis and corneal opacity. Histological changes in the liver included necrosis of the epithelium of biliary ducts, periductal oedema, pericholangitis, periductal fibrosis and disseminated focal hepatocellular necrosis. Necrosis of epithelium occurred also in the extraheptic ducts and was accompanied by an interstitial pancreatitis in certain rats. Foci of leucocytes and macrophages were found in the dermis of the scrotum and in the epididymal adipose connective tissue. Ulceration of the epidermis occurred late in the sequence of scrotal changes. Ocular lesions comprised corneal oedema, interstitital keratitis, iridocyclitis and hypopyon. 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Pharmac</sb:maintitle></sb:title><sb:volume-nr>19</sb:volume-nr></sb:series><sb:date>1971</sb:date></sb:issue><sb:pages><sb:first-page>712</sb:first-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib47"><ce:label>Zimmermann et al., 1976</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:given-name>J.L.</ce:given-name><ce:surname>Zimmermann</ce:surname></sb:author><sb:author><ce:given-name>W.W.</ce:given-name><ce:surname>Carlton</ce:surname></sb:author><sb:author><ce:given-name>J.</ce:given-name><ce:surname>Tuite</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>Mycotoxicosis produced in mice by cultural products of an isolate of Aspergillus ochraceus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Fd Cosmet. Toxicol</sb:maintitle></sb:title><sb:volume-nr>14</sb:volume-nr></sb:series><sb:date>1976</sb:date></sb:issue><sb:pages><sb:first-page>571</sb:first-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Mycotoxicosis produced in rats by cultural products of an isolate of aspergillus ochraceus</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Mycotoxicosis produced in rats by cultural products of an isolate of</title></titleInfo><name type="personal"><namePart type="given">J.L.</namePart><namePart type="family">Zimmermann</namePart><affiliation>Department of Veterinary Microbiology, Pathology and Public Health, School of Veterinary Medicine</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.W.</namePart><namePart type="family">Carlton</namePart><affiliation>Department of Veterinary Microbiology, Pathology and Public Health, School of Veterinary Medicine</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Tuite</namePart><affiliation>Department of Botany and Plant Pathology, School of Agriculture, Purdue University, West Lafayette, IN47907, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1978</dateIssued><dateModified encoding="w3cdtf">1978-05-09</dateModified><copyrightDate encoding="w3cdtf">1978</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The toxicity of an isolate of Aspergillus ochraceus was examined in weanling male Sprague-Dawley rats fed diets containing a rice culture or fungal mat of the organism for 5 wk. The ground rice culture was mixed with a commercial purified diet at concentrations of 5, 7·5 and 10% and the fungal mat at concentrations of 1, 2 and 3%. In groups fed the rice-culture diets, weight gains were reduced and all the rats in the group fed the 10% diet died. Rats fed fungal-mat diets showed a marked reduction in weight gain, and the death rate was high (about 83%) in groups fed the 2 or 3% diet. Gross lesions found in groups fed either type of diet included focal necrosis in the liver, greenish discoloration of the kidneys, gastric ulceration, ulceration of the scrotal epidermis and corneal opacity. Histological changes in the liver included necrosis of the epithelium of biliary ducts, periductal oedema, pericholangitis, periductal fibrosis and disseminated focal hepatocellular necrosis. Necrosis of epithelium occurred also in the extraheptic ducts and was accompanied by an interstitial pancreatitis in certain rats. Foci of leucocytes and macrophages were found in the dermis of the scrotum and in the epididymal adipose connective tissue. Ulceration of the epidermis occurred late in the sequence of scrotal changes. Ocular lesions comprised corneal oedema, interstitital keratitis, iridocyclitis and hypopyon. Renal lesions consisted of tubular necrosis and hyaline and biliary casts within convoluted tubules.</abstract><relatedItem type="host"><titleInfo><title>Food and Cosmetics Toxicology</title></titleInfo><titleInfo type="abbreviated"><title>FCTOX</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1978</dateIssued></originInfo><identifier type="ISSN">0015-6264</identifier><identifier type="PII">S0015-6264(78)X8256-3</identifier><part><date>1978</date><detail type="volume"><number>16</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>409</start><end>517</end></extent><extent unit="pages"><start>449</start><end>461</end></extent></part></relatedItem><identifier type="istex">369A9573CF12DB02DB7B6D9FB0128358F3D2E678</identifier><identifier type="ark">ark:/67375/6H6-LXP71G4C-3</identifier><identifier type="DOI">10.1016/S0015-6264(78)80303-4</identifier><identifier type="PII">S0015-6264(78)80303-4</identifier><identifier type="ArticleID">80303</identifier><accessCondition type="use and reproduction" contentType="copyright">©1978 Pergamon Press Ltd</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Pergamon Press Ltd, ©1978</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-LXP71G4C-3/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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