Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors
Identifieur interne : 000735 ( Istex/Corpus ); précédent : 000734; suivant : 000736Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors
Auteurs : D. Sulzer ; E. HoltzmanSource :
- Journal of Neurocytology [ 0300-4864 ] ; 1989-08-01.
English descriptors
- Teeft :
- Acidification, Ammonium, Ammonium chloride, Annual review, Biological chemistry, Ceil biology, Cell biology, Cell bodies, Cell surface, Cisterna, Cone cell, Cycling, Endocytic, Endocytosis, Endosomes, Experiments retinas, Frog, Heuser, Heuser reese, Holtzman, Holtzman mercurio, Horseradish peroxidase, Large vacuoles, Liscum, Lysosome, Membrane, Membrane cycling, Mercurio, Mercurio holtzman, Miller heuser, Nerve terminals, Neuron, Okhuma poole, Osmotic effects, Other cell types, Peroxidase, Photoreceptor, Photoreceptor terminals, Photoreceptors, Plasma membrane, Presynaptic, Presynaptic terminal, Presynaptic terminals, Raviola, Recovery experiments, Recycling, Retina, Room temperature, Schacher, Schaeffer raviola, Secretory, Such vacuoles, Sulzer, Synaptic, Synaptic vesicle membrane, Synaptic vesicles, Terminal, Tracer, Transmitter release, Typical synaptic vesicles, Unlabelled vacuoles, Vacuolation, Vacuole, Vesicle, Weak bases.
Abstract
Summary: By using the ‘acidotropic’ vital dye, Acridine Orange, we have found that the presynaptic terminals of rod and cone photoreceptors in retinas ofRana pipiens maintain a low pH relative to the surrounding medium through an energy dependent mechanism. When this pH is raised, by exposing the retinas to weak bases like ammonium chloride, the terminals exhibit large, membrane-delimited compartments, many of which accumulate endocytic tracers. This effect is partly reversed when the weak bases are removed. We infer that among the acidified structures within the terminals are endocytic compartments with at least some of the characteristics of the endosomes that participate in receptor-mediated endocytosis in other cell types. One role of these structures in the terminals may be in the recycling of synaptic vesicles.
Url:
DOI: 10.1007/BF01474548
Links to Exploration step
ISTEX:FFADA1657A22084CED7E2A5F6868950CD49E8D99Le document en format XML
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When this pH is raised, by exposing the retinas to weak bases like ammonium chloride, the terminals exhibit large, membrane-delimited compartments, many of which accumulate endocytic tracers. This effect is partly reversed when the weak bases are removed. We infer that among the acidified structures within the terminals are endocytic compartments with at least some of the characteristics of the endosomes that participate in receptor-mediated endocytosis in other cell types. One role of these structures in the terminals may be in the recycling of synaptic vesicles.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Neurosciences</term></item><item><term>Neuroradiology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1989-04-18">Created</change><change when="1989-08-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-6RT64Z43-T/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Kluwer Academic Publishers</PublisherName><PublisherLocation>Dordrecht</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>11068</JournalID><JournalPrintISSN>0300-4864</JournalPrintISSN><JournalElectronicISSN>1573-7381</JournalElectronicISSN><JournalTitle>Journal of Neurocytology</JournalTitle><JournalAbbreviatedTitle>J Neurocytol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Neurosciences</JournalSubject><JournalSubject Type="Secondary">Neuroradiology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>18</VolumeIDStart><VolumeIDEnd>18</VolumeIDEnd><VolumeIssueCount>6</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>4</IssueIDStart><IssueIDEnd>4</IssueIDEnd><IssueArticleCount>12</IssueArticleCount><IssueHistory><CoverDate><Year>1989</Year><Month>8</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Chapman and Hall Ltd</CopyrightHolderName><CopyrightYear>1989</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art9"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF01474548</ArticleID><ArticleDOI>10.1007/BF01474548</ArticleDOI><ArticleSequenceNumber>9</ArticleSequenceNumber><ArticleTitle Language="En">Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors</ArticleTitle><ArticleFirstPage>529</ArticleFirstPage><ArticleLastPage>540</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>3</Month><Day>30</Day></RegistrationDate><Received><Year>1989</Year><Month>4</Month><Day>18</Day></Received><Accepted><Year>1989</Year><Month>5</Month><Day>18</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Chapman and Hall Ltd.</CopyrightHolderName><CopyrightYear>1989</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>11068</JournalID><VolumeIDStart>18</VolumeIDStart><VolumeIDEnd>18</VolumeIDEnd><IssueIDStart>4</IssueIDStart><IssueIDEnd>4</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" PresentAffiliationID="Aff2"><AuthorName DisplayOrder="Western"><GivenName>D.</GivenName><FamilyName>Sulzer</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><FamilyName>Holtzman</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Biological Sciences</OrgDivision><OrgName>Columbia University</OrgName><OrgAddress><Postcode>10027</Postcode><City>New York</City><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>New York State Psychiatric Institute</OrgDivision><OrgName>Columbia University</OrgName><OrgAddress><Postbox>Box 62</Postbox><Postcode>10032</Postcode><City>New York</City><Country>USA</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>By using the ‘acidotropic’ vital dye, Acridine Orange, we have found that the presynaptic terminals of rod and cone photoreceptors in retinas of<Emphasis Type="Italic">Rana pipiens</Emphasis> maintain a low pH relative to the surrounding medium through an energy dependent mechanism. When this pH is raised, by exposing the retinas to weak bases like ammonium chloride, the terminals exhibit large, membrane-delimited compartments, many of which accumulate endocytic tracers. This effect is partly reversed when the weak bases are removed. We infer that among the acidified structures within the terminals are endocytic compartments with at least some of the characteristics of the endosomes that participate in receptor-mediated endocytosis in other cell types. One role of these structures in the terminals may be in the recycling of synaptic vesicles.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors</title></titleInfo><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Sulzer</namePart><affiliation>Department of Biological Sciences, Columbia University, 10027, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">E.</namePart><namePart type="family">Holtzman</namePart><affiliation>Department of Biological Sciences, Columbia University, 10027, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Kluwer Academic Publishers</publisher><place><placeTerm type="text">Dordrecht</placeTerm></place><dateCreated encoding="w3cdtf">1989-04-18</dateCreated><dateIssued encoding="w3cdtf">1989-08-01</dateIssued><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: By using the ‘acidotropic’ vital dye, Acridine Orange, we have found that the presynaptic terminals of rod and cone photoreceptors in retinas ofRana pipiens maintain a low pH relative to the surrounding medium through an energy dependent mechanism. When this pH is raised, by exposing the retinas to weak bases like ammonium chloride, the terminals exhibit large, membrane-delimited compartments, many of which accumulate endocytic tracers. This effect is partly reversed when the weak bases are removed. We infer that among the acidified structures within the terminals are endocytic compartments with at least some of the characteristics of the endosomes that participate in receptor-mediated endocytosis in other cell types. One role of these structures in the terminals may be in the recycling of synaptic vesicles.</abstract><relatedItem type="host"><titleInfo><title>Journal of Neurocytology</title></titleInfo><titleInfo type="abbreviated"><title>J Neurocytol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1989-08-01</dateIssued><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Neurosciences</topic><topic>Neuroradiology</topic></subject><identifier type="ISSN">0300-4864</identifier><identifier type="eISSN">1573-7381</identifier><identifier type="JournalID">11068</identifier><identifier type="IssueArticleCount">12</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>1989</date><detail type="volume"><number>18</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="pages"><start>529</start><end>540</end></extent></part><recordInfo><recordOrigin>Chapman and Hall Ltd, 1989</recordOrigin></recordInfo></relatedItem><identifier type="istex">FFADA1657A22084CED7E2A5F6868950CD49E8D99</identifier><identifier type="ark">ark:/67375/1BB-6RT64Z43-T</identifier><identifier type="DOI">10.1007/BF01474548</identifier><identifier type="ArticleID">BF01474548</identifier><identifier type="ArticleID">Art9</identifier><accessCondition type="use and reproduction" contentType="copyright">Chapman and Hall Ltd., 1989</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Chapman and Hall Ltd., 1989</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-6RT64Z43-T/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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