Central oxytocin increases food intake and daily weight gain in rats
Identifieur interne : 000686 ( Istex/Corpus ); précédent : 000685; suivant : 000687Central oxytocin increases food intake and daily weight gain in rats
Auteurs : Eva Björkstrand ; Kerstin Uvn S-MobergSource :
- Physiology & Behavior [ 0031-9384 ] ; 1996.
English descriptors
- Teeft :
- Behav, Body weight, Daily weight gain, Deprivation, Dos, Female rats, Food deprivation, Food intake, High doses, Hyperphagia, Influence food intake, Injection, Intake, Lactational hyperphagia, Male rats, Microgram amounts, Oxytocin, Oxytocin treatment, Physiol, Present study, Prolactin, Rat, Statistical evaluation, Substrain, Suckling, Weight gain, Wilcoxon test.
Abstract
Abstract: The present study was performed to investigate the effects of centrally administered oxytocin on weight gain and food intake in rats. Two substrains of Sprague-Dawley rats (A and B) differing in average daily weight gain were used. Female rats of substrain A gained 2 g per day and males gained 7 g. Female rats of substrain B gained 5 g per day and males gained 8 g. Animals were implanted with a stainless steel guide cannula, allowing ICV injections into the lateral ventricle. ICV injections of 1, 5, or 10 μg of oxytocin or isotonic saline in a volume of 5 μl were given. In females, ICV treatment with either saline or 5 μg of oxytocin caused a transient loss of weight within 24 h of treatment. However, in the more slowly growing females of substrain A depression in body weight was observed after a single treatment with saline, whereas the body weight of oxytocin-treated females showed less marked depression and rapidly returned to the pretreatment weight. After a 3-day treatment period an even greater difference in daily weight gain was seen between oxytocin-treated and saline-treated female rats of substrain A. In contrast, no difference in daily weight gain or food intake was observed between oxytocin- and saline-treated male rats of substrain A, nor in females or males of the more rapidly growing substrain B. Intraperitoneal injections of 5 μg of oxytocin did not influence food intake or daily weight gain in female rats of substrain A. These data suggest that oxytocin may act centrally to influence food intake and daily weight gain in slowly growing female Sprague-Dawley rats.
Url:
DOI: 10.1016/0031-9384(95)02179-5
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Two substrains of Sprague-Dawley rats (A and B) differing in average daily weight gain were used. Female rats of substrain A gained 2 g per day and males gained 7 g. Female rats of substrain B gained 5 g per day and males gained 8 g. Animals were implanted with a stainless steel guide cannula, allowing ICV injections into the lateral ventricle. ICV injections of 1, 5, or 10 μg of oxytocin or isotonic saline in a volume of 5 μl were given. In females, ICV treatment with either saline or 5 μg of oxytocin caused a transient loss of weight within 24 h of treatment. However, in the more slowly growing females of substrain A depression in body weight was observed after a single treatment with saline, whereas the body weight of oxytocin-treated females showed less marked depression and rapidly returned to the pretreatment weight. After a 3-day treatment period an even greater difference in daily weight gain was seen between oxytocin-treated and saline-treated female rats of substrain A. In contrast, no difference in daily weight gain or food intake was observed between oxytocin- and saline-treated male rats of substrain A, nor in females or males of the more rapidly growing substrain B. Intraperitoneal injections of 5 μg of oxytocin did not influence food intake or daily weight gain in female rats of substrain A. These data suggest that oxytocin may act centrally to influence food intake and daily weight gain in slowly growing female Sprague-Dawley rats.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>oxytocin</json:string><json:string>food intake</json:string><json:string>substrain</json:string><json:string>daily weight gain</json:string><json:string>female rats</json:string><json:string>weight gain</json:string><json:string>prolactin</json:string><json:string>male rats</json:string><json:string>behav</json:string><json:string>physiol</json:string><json:string>hyperphagia</json:string><json:string>suckling</json:string><json:string>food deprivation</json:string><json:string>rat</json:string><json:string>intake</json:string><json:string>body weight</json:string><json:string>oxytocin treatment</json:string><json:string>influence food intake</json:string><json:string>statistical evaluation</json:string><json:string>dos</json:string><json:string>deprivation</json:string><json:string>present study</json:string><json:string>microgram amounts</json:string><json:string>wilcoxon test</json:string><json:string>lactational hyperphagia</json:string><json:string>high doses</json:string><json:string>injection</json:string></teeft></keywords><author><json:item><name>Eva Björkstrand</name><affiliations><json:string>Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden</json:string></affiliations></json:item><json:item><name>Kerstin Uvnäs-Moberg</name><affiliations><json:string>Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Oxytocin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Weight gain</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Food intake</value></json:item></subject><arkIstex>ark:/67375/6H6-8NBDR4W3-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The present study was performed to investigate the effects of centrally administered oxytocin on weight gain and food intake in rats. Two substrains of Sprague-Dawley rats (A and B) differing in average daily weight gain were used. Female rats of substrain A gained 2 g per day and males gained 7 g. Female rats of substrain B gained 5 g per day and males gained 8 g. Animals were implanted with a stainless steel guide cannula, allowing ICV injections into the lateral ventricle. ICV injections of 1, 5, or 10 μg of oxytocin or isotonic saline in a volume of 5 μl were given. In females, ICV treatment with either saline or 5 μg of oxytocin caused a transient loss of weight within 24 h of treatment. However, in the more slowly growing females of substrain A depression in body weight was observed after a single treatment with saline, whereas the body weight of oxytocin-treated females showed less marked depression and rapidly returned to the pretreatment weight. After a 3-day treatment period an even greater difference in daily weight gain was seen between oxytocin-treated and saline-treated female rats of substrain A. In contrast, no difference in daily weight gain or food intake was observed between oxytocin- and saline-treated male rats of substrain A, nor in females or males of the more rapidly growing substrain B. Intraperitoneal injections of 5 μg of oxytocin did not influence food intake or daily weight gain in female rats of substrain A. 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Two substrains of Sprague-Dawley rats (A and B) differing in average daily weight gain were used. Female rats of substrain A gained 2 g per day and males gained 7 g. Female rats of substrain B gained 5 g per day and males gained 8 g. Animals were implanted with a stainless steel guide cannula, allowing ICV injections into the lateral ventricle. ICV injections of 1, 5, or 10 μg of oxytocin or isotonic saline in a volume of 5 μl were given. In females, ICV treatment with either saline or 5 μg of oxytocin caused a transient loss of weight within 24 h of treatment. However, in the more slowly growing females of substrain A depression in body weight was observed after a single treatment with saline, whereas the body weight of oxytocin-treated females showed less marked depression and rapidly returned to the pretreatment weight. After a 3-day treatment period an even greater difference in daily weight gain was seen between oxytocin-treated and saline-treated female rats of substrain A. In contrast, no difference in daily weight gain or food intake was observed between oxytocin- and saline-treated male rats of substrain A, nor in females or males of the more rapidly growing substrain B. Intraperitoneal injections of 5 μg of oxytocin did not influence food intake or daily weight gain in female rats of substrain A. These data suggest that oxytocin may act centrally to influence food intake and daily weight gain in slowly growing female Sprague-Dawley rats.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Oxytocin</term></item><item><term>Weight gain</term></item><item><term>Food intake</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-8NBDR4W3-H/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PHB</jid><aid>95021795</aid><ce:pii>0031-9384(95)02179-5</ce:pii><ce:doi>10.1016/0031-9384(95)02179-5</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Article</ce:textfn></ce:dochead><ce:title>Central oxytocin increases food intake and daily weight gain in rats</ce:title><ce:author-group><ce:author><ce:given-name>Eva</ce:given-name><ce:surname>Björkstrand</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Kerstin</ce:given-name><ce:surname>Uvnäs-Moberg</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>To whom requests for reprints should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="15" month="3" year="1995"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The present study was performed to investigate the effects of centrally administered oxytocin on weight gain and food intake in rats. Two substrains of Sprague-Dawley rats (A and B) differing in average daily weight gain were used. Female rats of substrain A gained 2 g per day and males gained 7 g. Female rats of substrain B gained 5 g per day and males gained 8 g. Animals were implanted with a stainless steel guide cannula, allowing ICV injections into the lateral ventricle. ICV injections of 1, 5, or 10 μg of oxytocin or isotonic saline in a volume of 5 μl were given. In females, ICV treatment with either saline or 5 μg of oxytocin caused a transient loss of weight within 24 h of treatment. However, in the more slowly growing females of substrain A depression in body weight was observed after a single treatment with saline, whereas the body weight of oxytocin-treated females showed less marked depression and rapidly returned to the pretreatment weight. After a 3-day treatment period an even greater difference in daily weight gain was seen between oxytocin-treated and saline-treated female rats of substrain A. In contrast, no difference in daily weight gain or food intake was observed between oxytocin- and saline-treated male rats of substrain A, nor in females or males of the more rapidly growing substrain B. Intraperitoneal injections of 5 μg of oxytocin did not influence food intake or daily weight gain in female rats of substrain A. These data suggest that oxytocin may act centrally to influence food intake and daily weight gain in slowly growing female Sprague-Dawley rats.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Oxytocin</ce:text></ce:keyword><ce:keyword><ce:text>Weight gain</ce:text></ce:keyword><ce:keyword><ce:text>Food intake</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Central oxytocin increases food intake and daily weight gain in rats</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Central oxytocin increases food intake and daily weight gain in rats</title></titleInfo><name type="personal"><namePart type="given">Eva</namePart><namePart type="family">Björkstrand</namePart><affiliation>Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden</affiliation><description>To whom requests for reprints should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kerstin</namePart><namePart type="family">Uvnäs-Moberg</namePart><affiliation>Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The present study was performed to investigate the effects of centrally administered oxytocin on weight gain and food intake in rats. Two substrains of Sprague-Dawley rats (A and B) differing in average daily weight gain were used. Female rats of substrain A gained 2 g per day and males gained 7 g. Female rats of substrain B gained 5 g per day and males gained 8 g. Animals were implanted with a stainless steel guide cannula, allowing ICV injections into the lateral ventricle. ICV injections of 1, 5, or 10 μg of oxytocin or isotonic saline in a volume of 5 μl were given. In females, ICV treatment with either saline or 5 μg of oxytocin caused a transient loss of weight within 24 h of treatment. However, in the more slowly growing females of substrain A depression in body weight was observed after a single treatment with saline, whereas the body weight of oxytocin-treated females showed less marked depression and rapidly returned to the pretreatment weight. After a 3-day treatment period an even greater difference in daily weight gain was seen between oxytocin-treated and saline-treated female rats of substrain A. In contrast, no difference in daily weight gain or food intake was observed between oxytocin- and saline-treated male rats of substrain A, nor in females or males of the more rapidly growing substrain B. Intraperitoneal injections of 5 μg of oxytocin did not influence food intake or daily weight gain in female rats of substrain A. These data suggest that oxytocin may act centrally to influence food intake and daily weight gain in slowly growing female Sprague-Dawley rats.</abstract><note type="content">Section title: Article</note><subject><genre>Keywords</genre><topic>Oxytocin</topic><topic>Weight gain</topic><topic>Food intake</topic></subject><relatedItem type="host"><titleInfo><title>Physiology & Behavior</title></titleInfo><titleInfo type="abbreviated"><title>PHB</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued></originInfo><identifier type="ISSN">0031-9384</identifier><identifier type="PII">S0031-9384(00)X0002-9</identifier><part><date>1996</date><detail type="volume"><number>59</number><caption>vol.</caption></detail><detail type="issue"><number>4–5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>585</start><end>1015</end></extent><extent unit="pages"><start>947</start><end>952</end></extent></part></relatedItem><identifier type="istex">1F4D569D33DDA42C405CFCC61804DB747048E2A9</identifier><identifier type="ark">ark:/67375/6H6-8NBDR4W3-H</identifier><identifier type="DOI">10.1016/0031-9384(95)02179-5</identifier><identifier type="PII">0031-9384(95)02179-5</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-8NBDR4W3-H/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Central oxytocin increases food intake and daily weight gain in rats
}}
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