The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus
Identifieur interne : 000664 ( Istex/Corpus ); précédent : 000663; suivant : 000665The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus
Auteurs : Peter M. H Heegaard ; Dale L. Godson ; Mathilda J. M Toussaint ; Kirsten Tj Rneh J ; Lars E. Larsen ; Birgitte Viuff ; Leif R NsholtSource :
- Veterinary Immunology and Immunopathology [ 0165-2427 ] ; 2000.
English descriptors
- KwdEn :
- Teeft :
- Acute phase protein, Acute phase protein response, Acute phase proteins, Acute phase response, Acute phase responses, Alsemgeest, Assay, Bacterial infections, Bovine, Bovine haptoglobin, Brsv, Brsv infection, Clinical signs, Conner, Control animals, Detection limit, Domestic animals, Eckersall, Elsevier science, Experimental infection, Fever days, Godson, Gruys, Haptoglobin, Haptoglobin concentrations, Haptoglobin response, Haptoglobin side, Heegaard, Horadagoda, Horizontal line, Immunology, Immunopathology, Infection, Monoclonal antibody, Pathological lesions, Pathology score, Phase protein, Phase proteins, Phase response, Phase responses, Present study, Room temperature, Secondary response, Serum amyloid, Serum concentration, Serum concentrations, Serum haptoglobin, Syncytial virus, Veterinary immunology, Viral, Viral infection, Viral infections.
Abstract
Abstract: The ability of a pure virus infection to induce an acute phase protein response is of interest as viral infections are normally considered to be less efficient in inducing an acute phase protein response than bacterial infections. This was studied in a bovine model for infection with bovine respiratory syncytial virus (BRSV), analysing the induction of the two most dominant bovine acute phase proteins haptoglobin and serum amyloid A (SAA). Strong and reproducible acute phase responses were detected for both proteins, peaking at around 7–8 days after inoculation of BRSV, while no response was seen in mock-inoculated control animals. The serum concentrations reached for SAA and haptoglobin during the BRSV-induced acute phase response were generally the same or higher than previously reported for bacterial infections in calves. The magnitude and the duration of the haptoglobin response was found to correlate well with the severity of clinical signs (fever) and with the extent of lung consolidation while SAA responded most rapidly to infection.
Url:
DOI: 10.1016/S0165-2427(00)00226-9
Links to Exploration step
ISTEX:BC6F1843939BBFED41AACE5181639EB57547FA38Le document en format XML
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Godson</name><affiliation><mods:affiliation>Veterinary Infectious Disease Organization, University of Saskatchewan, 120, Veterinary Road, Saskatoon, Sask., Canada SK S7N 5E3</mods:affiliation></affiliation></author><author><name sortKey="Toussaint, Mathilda J M" sort="Toussaint, Mathilda J M" uniqKey="Toussaint M" first="Mathilda J. M" last="Toussaint">Mathilda J. M Toussaint</name><affiliation><mods:affiliation>Utrecht University, Department of Veterinary Pathology, Yalelaan 1, 3584 CL Utrecht, Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Tj Rneh J, Kirsten" sort="Tj Rneh J, Kirsten" uniqKey="Tj Rneh J K" first="Kirsten" last="Tj Rneh J">Kirsten Tj Rneh J</name><affiliation><mods:affiliation>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Lars E" sort="Larsen, Lars E" uniqKey="Larsen L" first="Lars E" last="Larsen">Lars E. 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H" last="Heegaard">Peter M. H Heegaard</name><affiliation><mods:affiliation>E-mail: pmhh@svs.dk</mods:affiliation></affiliation><affiliation><mods:affiliation>Danish Veterinary Laboratory, Department of Biochemistry and Immunology, 27, Bülowsvej, DK-1790 Copenhagen V, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Godson, Dale L" sort="Godson, Dale L" uniqKey="Godson D" first="Dale L" last="Godson">Dale L. Godson</name><affiliation><mods:affiliation>Veterinary Infectious Disease Organization, University of Saskatchewan, 120, Veterinary Road, Saskatoon, Sask., Canada SK S7N 5E3</mods:affiliation></affiliation></author><author><name sortKey="Toussaint, Mathilda J M" sort="Toussaint, Mathilda J M" uniqKey="Toussaint M" first="Mathilda J. M" last="Toussaint">Mathilda J. M Toussaint</name><affiliation><mods:affiliation>Utrecht University, Department of Veterinary Pathology, Yalelaan 1, 3584 CL Utrecht, Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Tj Rneh J, Kirsten" sort="Tj Rneh J, Kirsten" uniqKey="Tj Rneh J K" first="Kirsten" last="Tj Rneh J">Kirsten Tj Rneh J</name><affiliation><mods:affiliation>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Lars E" sort="Larsen, Lars E" uniqKey="Larsen L" first="Lars E" last="Larsen">Lars E. Larsen</name><affiliation><mods:affiliation>Danish Veterinary Laboratory, Department of Biochemistry and Immunology, 27, Bülowsvej, DK-1790 Copenhagen V, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Viuff, Birgitte" sort="Viuff, Birgitte" uniqKey="Viuff B" first="Birgitte" last="Viuff">Birgitte Viuff</name><affiliation><mods:affiliation>Royal Veterinary and Agricultural University, Institute of Veterinary Microbiology, Laboratory for Virology and Immunology, 3, Ridebanevej, DK-1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author><author><name sortKey="R Nsholt, Leif" sort="R Nsholt, Leif" uniqKey="R Nsholt L" first="Leif" last="R Nsholt">Leif R Nsholt</name><affiliation><mods:affiliation>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Veterinary Immunology and Immunopathology</title><title level="j" type="abbrev">VETIMM</title><idno type="ISSN">0165-2427</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">77</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="151">151</biblScope><biblScope unit="page" to="159">159</biblScope></imprint><idno type="ISSN">0165-2427</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-2427</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bovine acute phase response</term><term>Bovine haptoglobin</term><term>Bovine respiratory syncytial virus infection</term><term>Bovine serum amyloid A</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acute phase protein</term><term>Acute phase protein response</term><term>Acute phase proteins</term><term>Acute phase response</term><term>Acute phase responses</term><term>Alsemgeest</term><term>Assay</term><term>Bacterial infections</term><term>Bovine</term><term>Bovine haptoglobin</term><term>Brsv</term><term>Brsv infection</term><term>Clinical signs</term><term>Conner</term><term>Control animals</term><term>Detection limit</term><term>Domestic animals</term><term>Eckersall</term><term>Elsevier science</term><term>Experimental infection</term><term>Fever days</term><term>Godson</term><term>Gruys</term><term>Haptoglobin</term><term>Haptoglobin concentrations</term><term>Haptoglobin response</term><term>Haptoglobin side</term><term>Heegaard</term><term>Horadagoda</term><term>Horizontal line</term><term>Immunology</term><term>Immunopathology</term><term>Infection</term><term>Monoclonal antibody</term><term>Pathological lesions</term><term>Pathology score</term><term>Phase protein</term><term>Phase proteins</term><term>Phase response</term><term>Phase responses</term><term>Present study</term><term>Room temperature</term><term>Secondary response</term><term>Serum amyloid</term><term>Serum concentration</term><term>Serum concentrations</term><term>Serum haptoglobin</term><term>Syncytial virus</term><term>Veterinary immunology</term><term>Viral</term><term>Viral infection</term><term>Viral infections</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The ability of a pure virus infection to induce an acute phase protein response is of interest as viral infections are normally considered to be less efficient in inducing an acute phase protein response than bacterial infections. This was studied in a bovine model for infection with bovine respiratory syncytial virus (BRSV), analysing the induction of the two most dominant bovine acute phase proteins haptoglobin and serum amyloid A (SAA). Strong and reproducible acute phase responses were detected for both proteins, peaking at around 7–8 days after inoculation of BRSV, while no response was seen in mock-inoculated control animals. The serum concentrations reached for SAA and haptoglobin during the BRSV-induced acute phase response were generally the same or higher than previously reported for bacterial infections in calves. The magnitude and the duration of the haptoglobin response was found to correlate well with the severity of clinical signs (fever) and with the extent of lung consolidation while SAA responded most rapidly to infection.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>haptoglobin</json:string><json:string>eckersall</json:string><json:string>brsv</json:string><json:string>gruys</json:string><json:string>acute phase response</json:string><json:string>immunology</json:string><json:string>conner</json:string><json:string>heegaard</json:string><json:string>horadagoda</json:string><json:string>immunopathology</json:string><json:string>veterinary immunology</json:string><json:string>detection limit</json:string><json:string>viral</json:string><json:string>haptoglobin concentrations</json:string><json:string>godson</json:string><json:string>alsemgeest</json:string><json:string>control animals</json:string><json:string>bovine</json:string><json:string>phase proteins</json:string><json:string>syncytial virus</json:string><json:string>haptoglobin response</json:string><json:string>clinical signs</json:string><json:string>assay</json:string><json:string>bacterial infections</json:string><json:string>serum amyloid</json:string><json:string>bovine haptoglobin</json:string><json:string>acute phase responses</json:string><json:string>haptoglobin side</json:string><json:string>fever days</json:string><json:string>phase response</json:string><json:string>experimental infection</json:string><json:string>viral infections</json:string><json:string>horizontal line</json:string><json:string>serum haptoglobin</json:string><json:string>viral infection</json:string><json:string>acute phase protein</json:string><json:string>pathology score</json:string><json:string>acute phase proteins</json:string><json:string>infection</json:string><json:string>phase protein</json:string><json:string>monoclonal antibody</json:string><json:string>room temperature</json:string><json:string>serum concentration</json:string><json:string>domestic animals</json:string><json:string>brsv infection</json:string><json:string>serum concentrations</json:string><json:string>pathological lesions</json:string><json:string>secondary response</json:string><json:string>phase responses</json:string><json:string>present study</json:string><json:string>acute phase protein response</json:string><json:string>elsevier science</json:string></teeft></keywords><author><json:item><name>Peter M.H Heegaard</name><affiliations><json:string>E-mail: pmhh@svs.dk</json:string><json:string>Danish Veterinary Laboratory, Department of Biochemistry and Immunology, 27, Bülowsvej, DK-1790 Copenhagen V, Denmark</json:string></affiliations></json:item><json:item><name>Dale L Godson</name><affiliations><json:string>Veterinary Infectious Disease Organization, University of Saskatchewan, 120, Veterinary Road, Saskatoon, Sask., Canada SK S7N 5E3</json:string></affiliations></json:item><json:item><name>Mathilda J.M Toussaint</name><affiliations><json:string>Utrecht University, Department of Veterinary Pathology, Yalelaan 1, 3584 CL Utrecht, Netherlands</json:string></affiliations></json:item><json:item><name>Kirsten Tjørnehøj</name><affiliations><json:string>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</json:string></affiliations></json:item><json:item><name>Lars E Larsen</name><affiliations><json:string>Danish Veterinary Laboratory, Department of Biochemistry and Immunology, 27, Bülowsvej, DK-1790 Copenhagen V, Denmark</json:string></affiliations></json:item><json:item><name>Birgitte Viuff</name><affiliations><json:string>Royal Veterinary and Agricultural University, Institute of Veterinary Microbiology, Laboratory for Virology and Immunology, 3, Ridebanevej, DK-1870 Frederiksberg C, Denmark</json:string></affiliations></json:item><json:item><name>Leif Rønsholt</name><affiliations><json:string>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Bovine respiratory syncytial virus infection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Bovine acute phase response</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Bovine haptoglobin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Bovine serum amyloid A</value></json:item></subject><arkIstex>ark:/67375/6H6-HMDPJ520-X</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Short communication</json:string></originalGenre><abstract>Abstract: The ability of a pure virus infection to induce an acute phase protein response is of interest as viral infections are normally considered to be less efficient in inducing an acute phase protein response than bacterial infections. This was studied in a bovine model for infection with bovine respiratory syncytial virus (BRSV), analysing the induction of the two most dominant bovine acute phase proteins haptoglobin and serum amyloid A (SAA). Strong and reproducible acute phase responses were detected for both proteins, peaking at around 7–8 days after inoculation of BRSV, while no response was seen in mock-inoculated control animals. The serum concentrations reached for SAA and haptoglobin during the BRSV-induced acute phase response were generally the same or higher than previously reported for bacterial infections in calves. The magnitude and the duration of the haptoglobin response was found to correlate well with the severity of clinical signs (fever) and with the extent of lung consolidation while SAA responded most rapidly to infection.</abstract><qualityIndicators><score>7.725</score><pdfWordCount>3769</pdfWordCount><pdfCharCount>23265</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>466 x 681 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>163</abstractWordCount><abstractCharCount>1066</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus</title><pmid><json:string>11068073</json:string></pmid><pii><json:string>S0165-2427(00)00226-9</json:string></pii><genre><json:string>brief-communication</json:string></genre><host><title>Veterinary Immunology and Immunopathology</title><language><json:string>unknown</json:string></language><publicationDate>2000</publicationDate><issn><json:string>0165-2427</json:string></issn><pii><json:string>S0165-2427(00)X0078-5</json:string></pii><volume>77</volume><issue>1–2</issue><pages><first>151</first><last>159</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2000</json:string></date><geogName></geogName><orgName><json:string>Agricultural University</json:string><json:string>Denmark Received</json:string><json:string>Dynatech Laboratories, Chantilly</json:string><json:string>Institute of Veterinary Microbiology, Laboratory for Virology and Immunology</json:string><json:string>Utrecht University</json:string><json:string>Department of Veterinary Pathology, Yalelaan</json:string><json:string>Canada SK S</json:string><json:string>Veterinary Infectious Disease Organization, University of Saskatchewan</json:string><json:string>Danish Veterinary Institute for Virus Research, Lindholm, DK</json:string><json:string>Danish Ministry of Food, Agriculture and Fisheries</json:string><json:string>Danish Agricultural and Veterinary Research Council</json:string></orgName><orgName_funder><json:string>Danish Ministry of Food, Agriculture and Fisheries</json:string><json:string>Danish Agricultural and Veterinary Research Council</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Dale L. Godsonb</json:string><json:string>Lars E. Larsena</json:string><json:string>J.M. Toussaintc</json:string><json:string>Kirsten Tjùrnehùjd</json:string><json:string>Although</json:string><json:string>P.M.H. Heegaard</json:string></persName><placeName><json:string>Utrecht</json:string><json:string>Netherlands</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Tjùrnehùj (2000)</json:string><json:string>Spooner and Miller (1971)</json:string><json:string>Conner et al., 1986</json:string><json:string>Eckersall and Conner (1988)</json:string><json:string>Tjùrnehùj, 2000</json:string><json:string>Godson et al.</json:string><json:string>Horadagoda et al. (1993, 1994)</json:string><json:string>Bisgaard et al., 1991</json:string><json:string>Gruys et al., 1994</json:string><json:string>Uttenthal et al. (1996)</json:string><json:string>Gruys et al. (1994)</json:string><json:string>Baumann and Gauldie, 1994</json:string><json:string>Horadagoda et al., 1994</json:string><json:string>Eckersall et al., 1999</json:string><json:string>Collins et al., 1996</json:string><json:string>Horadagoda et al., 1999</json:string><json:string>rinderpest virus (Spooner and Miller, 1971</json:string><json:string>Hofner et al., 1994</json:string><json:string>Gruys et al., 1993</json:string><json:string>Alsemgeest et al., 1994</json:string><json:string>Skinner et al., 1991</json:string><json:string>Spooner and Miller, 1971</json:string><json:string>Rùnsholt et al., 1996</json:string><json:string>Werling et al., 1996</json:string><json:string>van Leeuwen and van Rijswijk, 1994</json:string><json:string>Nakagawa et al., 1997</json:string><json:string>Godson et al., 1996</json:string><json:string>Saini et al., 1998</json:string><json:string>Godson et al. (1996)</json:string><json:string>Kushner, 1982</json:string><json:string>Kushner and Rzewnicki, 1994</json:string><json:string>Boosman et al., 1989</json:string><json:string>Conner et al., 1988, 1989</json:string><json:string>Eckersall and Conner, 1988</json:string><json:string>P.M.H. Heegaard et al.</json:string><json:string>Viuff et al., 1996</json:string><json:string>McNair et al., 1997</json:string><json:string>Mackiewicz et al., 1993</json:string><json:string>Makimura and Suzuki, 1982</json:string><json:string>Hofner et al. (1994)</json:string><json:string>Skinner et al. (1991)</json:string><json:string>Alsemgeest et al. (1994)</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-HMDPJ520-X</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - veterinary sciences</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - applied sciences</json:string><json:string>2 - agriculture, fisheries & forestry</json:string><json:string>3 - veterinary sciences</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Veterinary</json:string><json:string>3 - General Veterinary</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - pathologie infectieuse</json:string></inist></categories><publicationDate>2000</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1016/S0165-2427(00)00226-9</json:string></doi><id>BC6F1843939BBFED41AACE5181639EB57547FA38</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-HMDPJ520-X/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-HMDPJ520-X/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-HMDPJ520-X/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>©2000 Elsevier Science B.V.</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</p></availability><date>2000</date></publicationStmt><notesStmt><note type="brief-communication" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Short communication</note><note type="content">Fig. 1: (A) SAA (left-hand side) and haptoglobin (right-hand side). Infected animals: (★) 1; (•) 2; (▾) 3; () 4; (▴) 5; (■) 6. Control animals: (○) 11; (□) 8; (▽) 9; (▵) 10. Horizontal line depicts the detection limit of the assay (haptoglobin). None of the control animals had haptoglobin levels above the detection limit of the assay. (B) SAA (left-hand side) and haptoglobin (right-hand side). Infected animal: (•) 11; (■) 12; (▴) 13; (▾) 14. Horizontal line depicts the detection limit of the assay (haptoglobin). (C) SAA (left-hand side) and haptoglobin (right-hand side). Infected animals: (•) 15; (▴) 16. Horizontal line depicts the detection limit of the assay (haptoglobin).</note><note type="content">Table 1: Clinical signs, pathological lesions and agents isolated at necroscopy in individual BRSV-infected and control calves</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus</title><author xml:id="author-0000"><persName><forename type="first">Peter M.H</forename><surname>Heegaard</surname></persName><email>pmhh@svs.dk</email><note type="correspondence"><p>Corresponding author. Tel.: +45-3530-0241; fax: +45-3530-0360</p></note><affiliation>Danish Veterinary Laboratory, Department of Biochemistry and Immunology, 27, Bülowsvej, DK-1790 Copenhagen V, Denmark</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Dale L</forename><surname>Godson</surname></persName><affiliation>Veterinary Infectious Disease Organization, University of Saskatchewan, 120, Veterinary Road, Saskatoon, Sask., Canada SK S7N 5E3</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Mathilda J.M</forename><surname>Toussaint</surname></persName><affiliation>Utrecht University, Department of Veterinary Pathology, Yalelaan 1, 3584 CL Utrecht, Netherlands</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Kirsten</forename><surname>Tjørnehøj</surname></persName><affiliation>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Lars E</forename><surname>Larsen</surname></persName><affiliation>Danish Veterinary Laboratory, Department of Biochemistry and Immunology, 27, Bülowsvej, DK-1790 Copenhagen V, Denmark</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Birgitte</forename><surname>Viuff</surname></persName><affiliation>Royal Veterinary and Agricultural University, Institute of Veterinary Microbiology, Laboratory for Virology and Immunology, 3, Ridebanevej, DK-1870 Frederiksberg C, Denmark</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Leif</forename><surname>Rønsholt</surname></persName><affiliation>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</affiliation></author><idno type="istex">BC6F1843939BBFED41AACE5181639EB57547FA38</idno><idno type="ark">ark:/67375/6H6-HMDPJ520-X</idno><idno type="DOI">10.1016/S0165-2427(00)00226-9</idno><idno type="PII">S0165-2427(00)00226-9</idno></analytic><monogr><title level="j">Veterinary Immunology and Immunopathology</title><title level="j" type="abbrev">VETIMM</title><idno type="pISSN">0165-2427</idno><idno type="PII">S0165-2427(00)X0078-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000"></date><biblScope unit="volume">77</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="151">151</biblScope><biblScope unit="page" to="159">159</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The ability of a pure virus infection to induce an acute phase protein response is of interest as viral infections are normally considered to be less efficient in inducing an acute phase protein response than bacterial infections. This was studied in a bovine model for infection with bovine respiratory syncytial virus (BRSV), analysing the induction of the two most dominant bovine acute phase proteins haptoglobin and serum amyloid A (SAA). Strong and reproducible acute phase responses were detected for both proteins, peaking at around 7–8 days after inoculation of BRSV, while no response was seen in mock-inoculated control animals. The serum concentrations reached for SAA and haptoglobin during the BRSV-induced acute phase response were generally the same or higher than previously reported for bacterial infections in calves. The magnitude and the duration of the haptoglobin response was found to correlate well with the severity of clinical signs (fever) and with the extent of lung consolidation while SAA responded most rapidly to infection.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Bovine respiratory syncytial virus infection</term></item><item><term>Bovine acute phase response</term></item><item><term>Bovine haptoglobin</term></item><item><term>Bovine serum amyloid A</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2000-02-23">Modified</change><change when="2000">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-HMDPJ520-X/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="sco" xml:lang="en"><item-info><jid>VETIMM</jid><aid>6358</aid><ce:pii>S0165-2427(00)00226-9</ce:pii><ce:doi>10.1016/S0165-2427(00)00226-9</ce:doi><ce:copyright type="full-transfer" year="2000">Elsevier Science B.V.</ce:copyright></item-info><head><ce:dochead><ce:textfn>Short communication</ce:textfn></ce:dochead><ce:title>The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus</ce:title><ce:author-group><ce:author><ce:given-name>Peter M.H</ce:given-name><ce:surname>Heegaard</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:e-address>pmhh@svs.dk</ce:e-address></ce:author><ce:author><ce:given-name>Dale L</ce:given-name><ce:surname>Godson</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Mathilda J.M</ce:given-name><ce:surname>Toussaint</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Kirsten</ce:given-name><ce:surname>Tjørnehøj</ce:surname><ce:cross-ref refid="AFF4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Lars E</ce:given-name><ce:surname>Larsen</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Birgitte</ce:given-name><ce:surname>Viuff</ce:surname><ce:cross-ref refid="AFF5"><ce:sup>e</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Leif</ce:given-name><ce:surname>Rønsholt</ce:surname><ce:cross-ref refid="AFF4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Danish Veterinary Laboratory, Department of Biochemistry and Immunology, 27, Bülowsvej, DK-1790 Copenhagen V, Denmark</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Veterinary Infectious Disease Organization, University of Saskatchewan, 120, Veterinary Road, Saskatoon, Sask., Canada SK S7N 5E3</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Utrecht University, Department of Veterinary Pathology, Yalelaan 1, 3584 CL Utrecht, Netherlands</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>d</ce:label><ce:textfn>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</ce:textfn></ce:affiliation><ce:affiliation id="AFF5"><ce:label>e</ce:label><ce:textfn>Royal Veterinary and Agricultural University, Institute of Veterinary Microbiology, Laboratory for Virology and Immunology, 3, Ridebanevej, DK-1870 Frederiksberg C, Denmark</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: +45-3530-0241; fax: +45-3530-0360</ce:text></ce:correspondence></ce:author-group><ce:date-received day="17" month="6" year="1999"></ce:date-received><ce:date-revised day="23" month="2" year="2000"></ce:date-revised><ce:date-accepted day="21" month="7" year="2000"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The ability of a pure virus infection to induce an acute phase protein response is of interest as viral infections are normally considered to be less efficient in inducing an acute phase protein response than bacterial infections. This was studied in a bovine model for infection with bovine respiratory syncytial virus (BRSV), analysing the induction of the two most dominant bovine acute phase proteins haptoglobin and serum amyloid A (SAA). Strong and reproducible acute phase responses were detected for both proteins, peaking at around 7–8 days after inoculation of BRSV, while no response was seen in mock-inoculated control animals. The serum concentrations reached for SAA and haptoglobin during the BRSV-induced acute phase response were generally the same or higher than previously reported for bacterial infections in calves. The magnitude and the duration of the haptoglobin response was found to correlate well with the severity of clinical signs (fever) and with the extent of lung consolidation while SAA responded most rapidly to infection.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Bovine respiratory syncytial virus infection</ce:text></ce:keyword><ce:keyword><ce:text>Bovine acute phase response</ce:text></ce:keyword><ce:keyword><ce:text>Bovine haptoglobin</ce:text></ce:keyword><ce:keyword><ce:text>Bovine serum amyloid A</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus</title></titleInfo><name type="personal"><namePart type="given">Peter M.H</namePart><namePart type="family">Heegaard</namePart><affiliation>E-mail: pmhh@svs.dk</affiliation><affiliation>Danish Veterinary Laboratory, Department of Biochemistry and Immunology, 27, Bülowsvej, DK-1790 Copenhagen V, Denmark</affiliation><description>Corresponding author. Tel.: +45-3530-0241; fax: +45-3530-0360</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dale L</namePart><namePart type="family">Godson</namePart><affiliation>Veterinary Infectious Disease Organization, University of Saskatchewan, 120, Veterinary Road, Saskatoon, Sask., Canada SK S7N 5E3</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mathilda J.M</namePart><namePart type="family">Toussaint</namePart><affiliation>Utrecht University, Department of Veterinary Pathology, Yalelaan 1, 3584 CL Utrecht, Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kirsten</namePart><namePart type="family">Tjørnehøj</namePart><affiliation>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars E</namePart><namePart type="family">Larsen</namePart><affiliation>Danish Veterinary Laboratory, Department of Biochemistry and Immunology, 27, Bülowsvej, DK-1790 Copenhagen V, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Birgitte</namePart><namePart type="family">Viuff</namePart><affiliation>Royal Veterinary and Agricultural University, Institute of Veterinary Microbiology, Laboratory for Virology and Immunology, 3, Ridebanevej, DK-1870 Frederiksberg C, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Leif</namePart><namePart type="family">Rønsholt</namePart><affiliation>Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="Short communication" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued><dateModified encoding="w3cdtf">2000-02-23</dateModified><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The ability of a pure virus infection to induce an acute phase protein response is of interest as viral infections are normally considered to be less efficient in inducing an acute phase protein response than bacterial infections. This was studied in a bovine model for infection with bovine respiratory syncytial virus (BRSV), analysing the induction of the two most dominant bovine acute phase proteins haptoglobin and serum amyloid A (SAA). Strong and reproducible acute phase responses were detected for both proteins, peaking at around 7–8 days after inoculation of BRSV, while no response was seen in mock-inoculated control animals. The serum concentrations reached for SAA and haptoglobin during the BRSV-induced acute phase response were generally the same or higher than previously reported for bacterial infections in calves. The magnitude and the duration of the haptoglobin response was found to correlate well with the severity of clinical signs (fever) and with the extent of lung consolidation while SAA responded most rapidly to infection.</abstract><note type="content">Section title: Short communication</note><note type="content">Fig. 1: (A) SAA (left-hand side) and haptoglobin (right-hand side). Infected animals: (★) 1; (•) 2; (▾) 3; () 4; (▴) 5; (■) 6. Control animals: (○) 11; (□) 8; (▽) 9; (▵) 10. Horizontal line depicts the detection limit of the assay (haptoglobin). None of the control animals had haptoglobin levels above the detection limit of the assay. (B) SAA (left-hand side) and haptoglobin (right-hand side). Infected animal: (•) 11; (■) 12; (▴) 13; (▾) 14. Horizontal line depicts the detection limit of the assay (haptoglobin). (C) SAA (left-hand side) and haptoglobin (right-hand side). Infected animals: (•) 15; (▴) 16. Horizontal line depicts the detection limit of the assay (haptoglobin).</note><note type="content">Table 1: Clinical signs, pathological lesions and agents isolated at necroscopy in individual BRSV-infected and control calves</note><subject lang="en"><genre>Keywords</genre><topic>Bovine respiratory syncytial virus infection</topic><topic>Bovine acute phase response</topic><topic>Bovine haptoglobin</topic><topic>Bovine serum amyloid A</topic></subject><relatedItem type="host"><titleInfo><title>Veterinary Immunology and Immunopathology</title></titleInfo><titleInfo type="abbreviated"><title>VETIMM</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued></originInfo><identifier type="ISSN">0165-2427</identifier><identifier type="PII">S0165-2427(00)X0078-5</identifier><part><date>2000</date><detail type="volume"><number>77</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>159</end></extent><extent unit="pages"><start>151</start><end>159</end></extent></part></relatedItem><identifier type="istex">BC6F1843939BBFED41AACE5181639EB57547FA38</identifier><identifier type="ark">ark:/67375/6H6-HMDPJ520-X</identifier><identifier type="DOI">10.1016/S0165-2427(00)00226-9</identifier><identifier type="PII">S0165-2427(00)00226-9</identifier><accessCondition type="use and reproduction" contentType="copyright">©2000 Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Elsevier Science B.V., ©2000</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-HMDPJ520-X/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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