Effect of different levels of mannan‐oligosaccharide supplementation on some immunological variables in weaned piglets
Identifieur interne : 000628 ( Istex/Corpus ); précédent : 000627; suivant : 000629Effect of different levels of mannan‐oligosaccharide supplementation on some immunological variables in weaned piglets
Auteurs : I. Nochta ; T. Tuboly ; V. Halas ; L. BabinszkySource :
- Journal of Animal Physiology and Animal Nutrition [ 0931-2439 ] ; 2009-08.
English descriptors
- Teeft :
- Animal nutrition, Animal physiology, Animal science, Antibiotic, Antibiotic supplementation, Antibiotic treatment, Antimannan antibodies, Basal diet, Blackwell verlag gmbh, Blackwell verlag gmbh effect, Blood samples, Cellular immunity, Chemical composition, Colorimetric assay, Complement system, Crude protein, Dietary treatments, Different doses, Different superscript letters, Disease virus, Experimental procedure, Feed additives, Feed industry, Fourth week, Further effect, Gmbh, Growth performance, Growth promoter, Higher doses, Highest value, Humoral, Immune, Immune function, Immune parameters, Immune response, Immune responses, Immune system, Immune variables, Interaction effect, Journal compilation, Kaposvar university, Lymphocyte, Mannan, Mannan oligosaccharide, Mannan oligosaccharides, Microbial population, Mitogen, Negative control, Nochta, Nottingham, Nottingham university press, Nutrient content, Oligosaccharide, Optical density, Pharmacological additions, Phosphorylated mannans, Physiology, Piglet, Piglet performance, Positive control, Positive control group, Poultry science, Replication effect, Rmse rmse, Same tendency, Sixth treatment, Small intestine, Square error, Statistical analysis, Supplementation, Systemic immunity, Transmissible gastroenteritis virus, Verlag, Veterinary science, Virus infection, Weanling pigs, Weekly intervals.
Abstract
The effect of different doses of mannan‐oligosaccharide (MOS) on specific and non‐specific immune responses was studied in piglets, weaned at 28 days. A total of 58 piglets were used in six groups. Five groups were fed 0, 1, 2, 4 g MOS product per kg diet or with growth promoting antibiotics and immunized by inactivated Aujeszky’s disease virus (AyV) vaccine at week 1 and 3 of the experiment (35 and 49 days). A sixth group, receiving the same non‐supplemented diets was not immunized. Blood samples for lymphocyte stimulation (LST) and AyV neutralization (VN) tests were taken from all pigs on the first day of the experiment and at weekly intervals for 5 weeks. At week 8, the immunized piglets were infected orally with transmissible gastroenteritis virus. All piglets were weighed and slaughtered at week 10, digesta from small intestine were collected and tested for the presence of secretory (s)IgA. Feeding MOS supplementation resulted in enhanced specific and non‐specific immune responses, however, a regressive dose‐response of MOS was observed. Both the specific cellular (LST) and humoral responses (VN) were enhanced after 2 weeks of feeding 1 g/kg MOS and significantly differed from the antibiotic positive control. The same tendency was detected in case of the non‐specific LSTs, although these started some weeks later showing significant differences by the fifth week. Higher doses of MOS had no further beneficial effect on systemic immunity. In addition, 1 g/kg MOS supplementation group also showed some advantage in local immune responsiveness. Therefore, based on the studied immune variables, 1 g/kg MOS product is suggested in the diet of weaned piglets.
Url:
DOI: 10.1111/j.1439-0396.2008.00835.x
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ISTEX:05498EFE87F7B79B28C78DAF0EF67300ABC5604ALe document en format XML
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Halas</name><affiliation><mods:affiliation> Department of Animal Nutrition, Faculty of Animal Science, Kaposvár University, Kaposvár, Hungary</mods:affiliation></affiliation></author><author><name sortKey="Babinszky, L" sort="Babinszky, L" uniqKey="Babinszky L" first="L." last="Babinszky">L. Babinszky</name><affiliation><mods:affiliation> Department of Animal Nutrition, Faculty of Animal Science, Kaposvár University, Kaposvár, Hungary</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:05498EFE87F7B79B28C78DAF0EF67300ABC5604A</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1439-0396.2008.00835.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-HR3SHBNF-H/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000628</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000628</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Effect of different levels of mannan‐oligosaccharide supplementation on some immunological variables in weaned piglets</title><author><name sortKey="Nochta, I" sort="Nochta, I" uniqKey="Nochta I" first="I." last="Nochta">I. Nochta</name><affiliation><mods:affiliation> Agrokomplex, CSZRT, Zichyújfalu, Hungary</mods:affiliation></affiliation></author><author><name sortKey="Tuboly, T" sort="Tuboly, T" uniqKey="Tuboly T" first="T." last="Tuboly">T. Tuboly</name><affiliation><mods:affiliation> Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent István University, Budapest, Hungary</mods:affiliation></affiliation></author><author><name sortKey="Halas, V" sort="Halas, V" uniqKey="Halas V" first="V." last="Halas">V. Halas</name><affiliation><mods:affiliation> Department of Animal Nutrition, Faculty of Animal Science, Kaposvár University, Kaposvár, Hungary</mods:affiliation></affiliation></author><author><name sortKey="Babinszky, L" sort="Babinszky, L" uniqKey="Babinszky L" first="L." last="Babinszky">L. 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A total of 58 piglets were used in six groups. Five groups were fed 0, 1, 2, 4 g MOS product per kg diet or with growth promoting antibiotics and immunized by inactivated Aujeszky’s disease virus (AyV) vaccine at week 1 and 3 of the experiment (35 and 49 days). A sixth group, receiving the same non‐supplemented diets was not immunized. Blood samples for lymphocyte stimulation (LST) and AyV neutralization (VN) tests were taken from all pigs on the first day of the experiment and at weekly intervals for 5 weeks. At week 8, the immunized piglets were infected orally with transmissible gastroenteritis virus. All piglets were weighed and slaughtered at week 10, digesta from small intestine were collected and tested for the presence of secretory (s)IgA. Feeding MOS supplementation resulted in enhanced specific and non‐specific immune responses, however, a regressive dose‐response of MOS was observed. Both the specific cellular (LST) and humoral responses (VN) were enhanced after 2 weeks of feeding 1 g/kg MOS and significantly differed from the antibiotic positive control. The same tendency was detected in case of the non‐specific LSTs, although these started some weeks later showing significant differences by the fifth week. Higher doses of MOS had no further beneficial effect on systemic immunity. In addition, 1 g/kg MOS supplementation group also showed some advantage in local immune responsiveness. Therefore, based on the studied immune variables, 1 g/kg MOS product is suggested in the diet of weaned piglets.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>piglet</json:string><json:string>supplementation</json:string><json:string>immune</json:string><json:string>lymphocyte</json:string><json:string>mannan</json:string><json:string>immune response</json:string><json:string>animal nutrition</json:string><json:string>animal science</json:string><json:string>gmbh</json:string><json:string>antibiotic</json:string><json:string>journal compilation</json:string><json:string>humoral</json:string><json:string>oligosaccharide</json:string><json:string>animal physiology</json:string><json:string>verlag</json:string><json:string>nottingham</json:string><json:string>nochta</json:string><json:string>antibiotic supplementation</json:string><json:string>mitogen</json:string><json:string>blackwell verlag gmbh</json:string><json:string>growth performance</json:string><json:string>immune parameters</json:string><json:string>dietary treatments</json:string><json:string>nottingham university press</json:string><json:string>kaposvar university</json:string><json:string>replication effect</json:string><json:string>blood samples</json:string><json:string>weanling pigs</json:string><json:string>mannan oligosaccharides</json:string><json:string>statistical analysis</json:string><json:string>small intestine</json:string><json:string>growth promoter</json:string><json:string>positive control</json:string><json:string>nutrient content</json:string><json:string>different superscript letters</json:string><json:string>interaction effect</json:string><json:string>disease virus</json:string><json:string>phosphorylated mannans</json:string><json:string>antimannan antibodies</json:string><json:string>immune responses</json:string><json:string>immune variables</json:string><json:string>colorimetric assay</json:string><json:string>square error</json:string><json:string>physiology</json:string><json:string>immune function</json:string><json:string>poultry science</json:string><json:string>blackwell verlag gmbh effect</json:string><json:string>same tendency</json:string><json:string>optical density</json:string><json:string>higher doses</json:string><json:string>further effect</json:string><json:string>piglet performance</json:string><json:string>systemic immunity</json:string><json:string>highest value</json:string><json:string>rmse rmse</json:string><json:string>different doses</json:string><json:string>feed additives</json:string><json:string>chemical composition</json:string><json:string>fourth week</json:string><json:string>positive control group</json:string><json:string>microbial population</json:string><json:string>negative control</json:string><json:string>weekly intervals</json:string><json:string>antibiotic treatment</json:string><json:string>virus infection</json:string><json:string>immune system</json:string><json:string>complement system</json:string><json:string>transmissible gastroenteritis virus</json:string><json:string>veterinary science</json:string><json:string>pharmacological additions</json:string><json:string>experimental procedure</json:string><json:string>sixth treatment</json:string><json:string>mannan oligosaccharide</json:string><json:string>feed industry</json:string><json:string>basal diet</json:string><json:string>cellular immunity</json:string><json:string>crude protein</json:string></teeft></keywords><author><json:item><name>I. 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A total of 58 piglets were used in six groups. Five groups were fed 0, 1, 2, 4 g MOS product per kg diet or with growth promoting antibiotics and immunized by inactivated Aujeszky’s disease virus (AyV) vaccine at week 1 and 3 of the experiment (35 and 49 days). A sixth group, receiving the same non‐supplemented diets was not immunized. Blood samples for lymphocyte stimulation (LST) and AyV neutralization (VN) tests were taken from all pigs on the first day of the experiment and at weekly intervals for 5 weeks. At week 8, the immunized piglets were infected orally with transmissible gastroenteritis virus. All piglets were weighed and slaughtered at week 10, digesta from small intestine were collected and tested for the presence of secretory (s)IgA. Feeding MOS supplementation resulted in enhanced specific and non‐specific immune responses, however, a regressive dose‐response of MOS was observed. Both the specific cellular (LST) and humoral responses (VN) were enhanced after 2 weeks of feeding 1 g/kg MOS and significantly differed from the antibiotic positive control. The same tendency was detected in case of the non‐specific LSTs, although these started some weeks later showing significant differences by the fifth week. Higher doses of MOS had no further beneficial effect on systemic immunity. In addition, 1 g/kg MOS supplementation group also showed some advantage in local immune responsiveness. Therefore, based on the studied immune variables, 1 g/kg MOS product is suggested in the diet of weaned piglets.</abstract><qualityIndicators><score>9.926</score><pdfWordCount>4926</pdfWordCount><pdfCharCount>31195</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><pdfWordsPerPage>547</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>257</abstractWordCount><abstractCharCount>1682</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Effect of different levels of mannan‐oligosaccharide supplementation on some immunological variables in weaned piglets</title><pmid><json:string>18700854</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Animal Physiology and Animal Nutrition</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1439-0396</json:string></doi><issn><json:string>0931-2439</json:string></issn><eissn><json:string>1439-0396</json:string></eissn><publisherId><json:string>JPN</json:string></publisherId><volume>93</volume><issue>4</issue><pages><first>496</first><last>504</last><total>9</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2009</json:string></date><geogName></geogName><orgName><json:string>Szent Istvan University</json:string><json:string>Department of Animal Nutrition, Faculty of Animal Science, Kaposvar University, Kaposvar, Hungary Keywords</json:string><json:string>SAS Institute</json:string><json:string>Kaposvar University, Hungary</json:string><json:string>AOAC</json:string><json:string>Department of Animal Nutrition</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Lys Met</json:string><json:string>T. Tuboly</json:string><json:string>V. Halas</json:string><json:string>L. Babinszky</json:string><json:string>Danish Landrace</json:string></persName><placeName><json:string>Germany</json:string><json:string>Eppendorf</json:string><json:string>European Union</json:string><json:string>Hungary</json:string><json:string>Budapest</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Kim et al., 2000</json:string><json:string>Ferket, 2002</json:string><json:string>Davis et al. (2002, 2004a,b)</json:string><json:string>Newman and Newman, 2001</json:string><json:string>Jakubik and Wittmann, 1978</json:string><json:string>Franklin et al. (2005)</json:string><json:string>Franklin et al., 2005</json:string><json:string>Shadhishara and Devegowda (2003)</json:string><json:string>Davis et al., 2002</json:string><json:string>Tuboly et al. 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(2002, 2004b)</json:string><json:string>Iwata and Inoue, 1993</json:string><json:string>Zukkermann, 2000</json:string><json:string>Verstegen and Williams, 2002</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-HR3SHBNF-H</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - veterinary sciences</json:string><json:string>2 - agriculture, dairy & animal science</json:string></wos><scienceMetrix><json:string>1 - applied sciences</json:string><json:string>2 - agriculture, fisheries & forestry</json:string><json:string>3 - dairy & animal science</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Agricultural and Biological Sciences</json:string><json:string>3 - Animal Science and Zoology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Veterinary</json:string><json:string>3 - Food Animals</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1111/j.1439-0396.2008.00835.x</json:string></doi><id>05498EFE87F7B79B28C78DAF0EF67300ABC5604A</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-HR3SHBNF-H/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-HR3SHBNF-H/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-HR3SHBNF-H/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Effect of different levels of mannan‐oligosaccharide supplementation on some immunological variables in weaned piglets</title><title level="a" type="short">Effect of dietary MOS levels on immunity of weaned piglets</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2008 The Authors. 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All piglets were weighed and slaughtered at week 10, digesta from small intestine were collected and tested for the presence of secretory (s)IgA. Feeding MOS supplementation resulted in enhanced specific and non‐specific immune responses, however, a regressive dose‐response of MOS was observed. Both the specific cellular (LST) and humoral responses (VN) were enhanced after 2 weeks of feeding 1 g/kg MOS and significantly differed from the antibiotic positive control. The same tendency was detected in case of the non‐specific LSTs, although these started some weeks later showing significant differences by the fifth week. Higher doses of MOS had no further beneficial effect on systemic immunity. In addition, 1 g/kg MOS supplementation group also showed some advantage in local immune responsiveness. Therefore, based on the studied immune variables, 1 g/kg MOS product is suggested in the diet of weaned piglets.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">mannan‐oligosaccharide</term><term xml:id="k2">weaned piglets</term><term xml:id="k3">non‐specific immunity</term><term xml:id="k4">specific immunity</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-HR3SHBNF-H/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1439-0396</doi><issn type="print">0931-2439</issn><issn type="electronic">1439-0396</issn><idGroup><id type="product" value="JPN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF ANIMAL PHYSIOLOGY ANIMAL NUTRITION">Journal of Animal Physiology and Animal Nutrition</title></titleGroup></publicationMeta><publicationMeta level="part" position="08004"><doi origin="wiley">10.1111/jpn.2009.93.issue-4</doi><numberingGroup><numbering type="journalVolume" number="93">93</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2009-08">August 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="13" status="forIssue"><doi origin="wiley">10.1111/j.1439-0396.2008.00835.x</doi><idGroup><id type="unit" value="JPN835"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2008 The Authors. Journal compilation © 2008 Blackwell Verlag GmbH</copyright><eventGroup><event type="firstOnline" date="2008-08-12"></event><event type="publishedOnlineFinalForm" date="2009-07-08"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-24"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="496">496</numbering><numbering type="pageLast" number="504">504</numbering></numberingGroup><correspondenceTo>V. Halas, Department of Animal Nutrition, Faculty of Animal Science, Kaposvár University, PO Box 16, 7401 Kaposvár, Hungary. Tel: +36 82 412 285; Fax: +36 82 313 562; E‐mail: <email>halas.veronika@ke.hu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JPN.JPN835.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received: 13 December 2007; accepted: 28 April 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Effect of different levels of mannan‐oligosaccharide supplementation on some immunological variables in weaned piglets</title><title type="shortAuthors">I. Nochta <i>et al</i>.</title><title type="short">Effect of dietary MOS levels on immunity of weaned piglets</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>I.</givenNames><familyName>Nochta</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>T.</givenNames><familyName>Tuboly</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>V.</givenNames><familyName>Halas</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>L.</givenNames><familyName>Babinszky</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="HU"><unparsedAffiliation> Agrokomplex, CSZRT, Zichyújfalu, Hungary</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="HU"><unparsedAffiliation> Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent István University, Budapest, Hungary</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="HU"><unparsedAffiliation> Department of Animal Nutrition, Faculty of Animal Science, Kaposvár University, Kaposvár, Hungary</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">mannan‐oligosaccharide</keyword><keyword xml:id="k2">weaned piglets</keyword><keyword xml:id="k3">non‐specific immunity</keyword><keyword xml:id="k4">specific immunity</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Summary</title><p>The effect of different doses of mannan‐oligosaccharide (MOS) on specific and non‐specific immune responses was studied in piglets, weaned at 28 days. A total of 58 piglets were used in six groups. Five groups were fed 0, 1, 2, 4 g MOS product per kg diet or with growth promoting antibiotics and immunized by inactivated Aujeszky’s disease virus (AyV) vaccine at week 1 and 3 of the experiment (35 and 49 days). A sixth group, receiving the same non‐supplemented diets was not immunized. Blood samples for lymphocyte stimulation (LST) and AyV neutralization (VN) tests were taken from all pigs on the first day of the experiment and at weekly intervals for 5 weeks. At week 8, the immunized piglets were infected orally with transmissible gastroenteritis virus. All piglets were weighed and slaughtered at week 10, digesta from small intestine were collected and tested for the presence of secretory (s)IgA. Feeding MOS supplementation resulted in enhanced specific and non‐specific immune responses, however, a regressive dose‐response of MOS was observed. Both the specific cellular (LST) and humoral responses (VN) were enhanced after 2 weeks of feeding 1 g/kg MOS and significantly differed from the antibiotic positive control. The same tendency was detected in case of the non‐specific LSTs, although these started some weeks later showing significant differences by the fifth week. Higher doses of MOS had no further beneficial effect on systemic immunity. In addition, 1 g/kg MOS supplementation group also showed some advantage in local immune responsiveness. Therefore, based on the studied immune variables, 1 g/kg MOS product is suggested in the diet of weaned piglets.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effect of different levels of mannan‐oligosaccharide supplementation on some immunological variables in weaned piglets</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Effect of dietary MOS levels on immunity of weaned piglets</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effect of different levels of mannan‐oligosaccharide supplementation on some immunological variables in weaned piglets</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Nochta</namePart><affiliation> Agrokomplex, CSZRT, Zichyújfalu, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Tuboly</namePart><affiliation> Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent István University, Budapest, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Halas</namePart><affiliation> Department of Animal Nutrition, Faculty of Animal Science, Kaposvár University, Kaposvár, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Babinszky</namePart><affiliation> Department of Animal Nutrition, Faculty of Animal Science, Kaposvár University, Kaposvár, Hungary</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2009-08</dateIssued><edition>Received: 13 December 2007; accepted: 28 April 2008</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">4</extent></physicalDescription><abstract lang="en">The effect of different doses of mannan‐oligosaccharide (MOS) on specific and non‐specific immune responses was studied in piglets, weaned at 28 days. A total of 58 piglets were used in six groups. Five groups were fed 0, 1, 2, 4 g MOS product per kg diet or with growth promoting antibiotics and immunized by inactivated Aujeszky’s disease virus (AyV) vaccine at week 1 and 3 of the experiment (35 and 49 days). A sixth group, receiving the same non‐supplemented diets was not immunized. Blood samples for lymphocyte stimulation (LST) and AyV neutralization (VN) tests were taken from all pigs on the first day of the experiment and at weekly intervals for 5 weeks. At week 8, the immunized piglets were infected orally with transmissible gastroenteritis virus. All piglets were weighed and slaughtered at week 10, digesta from small intestine were collected and tested for the presence of secretory (s)IgA. Feeding MOS supplementation resulted in enhanced specific and non‐specific immune responses, however, a regressive dose‐response of MOS was observed. Both the specific cellular (LST) and humoral responses (VN) were enhanced after 2 weeks of feeding 1 g/kg MOS and significantly differed from the antibiotic positive control. The same tendency was detected in case of the non‐specific LSTs, although these started some weeks later showing significant differences by the fifth week. Higher doses of MOS had no further beneficial effect on systemic immunity. In addition, 1 g/kg MOS supplementation group also showed some advantage in local immune responsiveness. Therefore, based on the studied immune variables, 1 g/kg MOS product is suggested in the diet of weaned piglets.</abstract><subject lang="en"><genre>keywords</genre><topic>mannan‐oligosaccharide</topic><topic>weaned piglets</topic><topic>non‐specific immunity</topic><topic>specific immunity</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Animal Physiology and Animal Nutrition</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0931-2439</identifier><identifier type="eISSN">1439-0396</identifier><identifier type="DOI">10.1111/(ISSN)1439-0396</identifier><identifier type="PublisherID">JPN</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>496</start><end>504</end><total>9</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>AOAC, 1989: Official Methods of Analysis, 13th edn. 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