Low prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniaeamong patients with symptoms of respiratory tract infections inDutch general practices
Identifieur interne : 000572 ( Istex/Corpus ); précédent : 000571; suivant : 000573Low prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniaeamong patients with symptoms of respiratory tract infections inDutch general practices
Auteurs : A. Meijer ; C. F. Dagnelie ; J. C. De Jong ; A. De Vries ; T. M. Bestebroer ; A. M. Van Loon ; A. I. M. Bartelds ; J. M. OssewaardeSource :
- European Journal of Epidemiology [ 0393-2990 ] ; 2000-12-01.
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Abstract
Abstract: Acute respiratory disease is one of the most common reasons to consult a general practitioner. A substantial part of these diseases cannot be explained by an infection with a virus or a common pathogenic bacterium. To study this diagnostic deficit, the prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae infections was determined in two groups of patients consulting a general practitioner. DNA of C. pneumoniae and M. pneumoniae was detected by a polymerase chain reaction (PCR) in nose/throat swabs from six (1.1%), and from seven (1.3%) patients, respectively, of 557 patients consulting a general practitioner for complaints suggestive for a virus infection during the 1994/1995 respiratory infections season. Two patients remained C. pneumoniae PCR-positive for at least 4 weeks. All others were negative within 3 weeks. Double infections of C. pneumoniae and influenza virus (3/6), and of M. pneumoniae and respiratory syncytial virus (1/7) or rhinovirus (1/7) were diagnosed. During the 1992/1993 season, attempts to isolate C. pneumoniae in cell culture or to detect C. pneumoniae DNA by PCR using throat swabs were all negative for 80 patients with a sore throat, although serological data suggested a C. pneumoniae infection in 13 (16%) patients. A specimen from another patient of this group was M. pneumoniae PCR-positive and the corresponding serum specimens showed a persistent high antibody titre. In summary, the prevalence of acute C. pneumoniae and M. pneumoniae infections was less than 2% in patients consulting a general practitioner.
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DOI: 10.1023/A:1010912012932
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A substantial part of these diseases cannot be explained by an infection with a virus or a common pathogenic bacterium. To study this diagnostic deficit, the prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae infections was determined in two groups of patients consulting a general practitioner. DNA of C. pneumoniae and M. pneumoniae was detected by a polymerase chain reaction (PCR) in nose/throat swabs from six (1.1%), and from seven (1.3%) patients, respectively, of 557 patients consulting a general practitioner for complaints suggestive for a virus infection during the 1994/1995 respiratory infections season. Two patients remained C. pneumoniae PCR-positive for at least 4 weeks. All others were negative within 3 weeks. Double infections of C. pneumoniae and influenza virus (3/6), and of M. pneumoniae and respiratory syncytial virus (1/7) or rhinovirus (1/7) were diagnosed. During the 1992/1993 season, attempts to isolate C. pneumoniae in cell culture or to detect C. pneumoniae DNA by PCR using throat swabs were all negative for 80 patients with a sore throat, although serological data suggested a C. pneumoniae infection in 13 (16%) patients. A specimen from another patient of this group was M. pneumoniae PCR-positive and the corresponding serum specimens showed a persistent high antibody titre. In summary, the prevalence of acute C. pneumoniae and M. pneumoniae infections was less than 2% in patients consulting a general practitioner.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>A. Meijer</name><affiliations><json:string>Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven</json:string></affiliations></json:item><json:item><name>C.F. 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A substantial part of these diseases cannot be explained by an infection with a virus or a common pathogenic bacterium. To study this diagnostic deficit, the prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae infections was determined in two groups of patients consulting a general practitioner. DNA of C. pneumoniae and M. pneumoniae was detected by a polymerase chain reaction (PCR) in nose/throat swabs from six (1.1%), and from seven (1.3%) patients, respectively, of 557 patients consulting a general practitioner for complaints suggestive for a virus infection during the 1994/1995 respiratory infections season. Two patients remained C. pneumoniae PCR-positive for at least 4 weeks. All others were negative within 3 weeks. Double infections of C. pneumoniae and influenza virus (3/6), and of M. pneumoniae and respiratory syncytial virus (1/7) or rhinovirus (1/7) were diagnosed. During the 1992/1993 season, attempts to isolate C. pneumoniae in cell culture or to detect C. pneumoniae DNA by PCR using throat swabs were all negative for 80 patients with a sore throat, although serological data suggested a C. pneumoniae infection in 13 (16%) patients. A specimen from another patient of this group was M. pneumoniae PCR-positive and the corresponding serum specimens showed a persistent high antibody titre. 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During the 1992/1993 season, attempts to isolate C. pneumoniae in cell culture or to detect C. pneumoniae DNA by PCR using throat swabs were all negative for 80 patients with a sore throat, although serological data suggested a C. pneumoniae infection in 13 (16%) patients. A specimen from another patient of this group was M. pneumoniae PCR-positive and the corresponding serum specimens showed a persistent high antibody titre. 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AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>J.M.</GivenName><FamilyName>Ossewaarde</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Research Laboratory for Infectious Diseases</OrgDivision><OrgName>National Institute of Public Health and the Environment</OrgName><OrgAddress><City>Bilthoven</City></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Family Medicine</OrgDivision><OrgName>University of Utrecht</OrgName><OrgAddress><City>Utrecht</City><Country>The Netherlands</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Department of Virology</OrgDivision><OrgName>University Hospital Utrecht</OrgName><OrgAddress><City>Utrecht</City><Country>The Netherlands</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgName>Netherlands Institute of Primary Health Care (NIVEL)</OrgName><OrgAddress><City>Utrecht</City><Country>The Netherlands</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Acute respiratory disease is one of the most common reasons to consult a general practitioner. A substantial part of these diseases cannot be explained by an infection with a virus or a common pathogenic bacterium. To study this diagnostic deficit, the prevalence of <Emphasis Type="Italic">Chlamydia pneumoniae</Emphasis> and <Emphasis Type="Italic">Mycoplasma pneumoniae</Emphasis> infections was determined in two groups of patients consulting a general practitioner. DNA of <Emphasis Type="Italic">C. pneumoniae</Emphasis> and <Emphasis Type="Italic">M. pneumoniae</Emphasis> was detected by a polymerase chain reaction (PCR) in nose/throat swabs from six (1.1%), and from seven (1.3%) patients, respectively, of 557 patients consulting a general practitioner for complaints suggestive for a virus infection during the 1994/1995 respiratory infections season. Two patients remained <Emphasis Type="Italic">C. pneumoniae</Emphasis> PCR-positive for at least 4 weeks. All others were negative within 3 weeks. Double infections of <Emphasis Type="Italic">C. pneumoniae</Emphasis> and influenza virus (3/6), and of <Emphasis Type="Italic">M. pneumoniae</Emphasis> and respiratory syncytial virus (1/7) or rhinovirus (1/7) were diagnosed. During the 1992/1993 season, attempts to isolate <Emphasis Type="Italic">C. pneumoniae</Emphasis> in cell culture or to detect <Emphasis Type="Italic">C. pneumoniae</Emphasis> DNA by PCR using throat swabs were all negative for 80 patients with a sore throat, although serological data suggested a <Emphasis Type="Italic">C. pneumoniae</Emphasis> infection in 13 (16%) patients. A specimen from another patient of this group was <Emphasis Type="Italic">M. pneumoniae</Emphasis> PCR-positive and the corresponding serum specimens showed a persistent high antibody titre. In summary, the prevalence of acute <Emphasis Type="Italic">C. pneumoniae</Emphasis> and <Emphasis Type="Italic">M. pneumoniae</Emphasis> infections was less than 2% in patients consulting a general practitioner.</Para></Abstract><KeywordGroup Language="En"><Keyword>Antibodies</Keyword><Keyword><Emphasis Type="Italic">Chlamydia pneumoniae</Emphasis></Keyword><Keyword>Family practice</Keyword><Keyword><Emphasis Type="Italic">Mycoplasma pneumoniae</Emphasis></Keyword><Keyword>Polymerase chain reaction</Keyword><Keyword>Respiratory tract diseases</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Low prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniaeamong patients with symptoms of respiratory tract infections inDutch general practices</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Low prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniaeamong patients with symptoms of respiratory tract infections inDutch general practices</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Meijer</namePart><affiliation>Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.F.</namePart><namePart type="family">Dagnelie</namePart><affiliation>Department of Family Medicine, University of Utrecht, Utrecht, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.C.</namePart><namePart type="family">De Jong</namePart><affiliation>Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">De Vries</namePart><affiliation>Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.M.</namePart><namePart type="family">Bestebroer</namePart><affiliation>Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.M.</namePart><namePart type="family">Van Loon</namePart><affiliation>Department of Virology, University Hospital Utrecht, Utrecht, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.I.M.</namePart><namePart type="family">Bartelds</namePart><affiliation>Netherlands Institute of Primary Health Care (NIVEL), Utrecht, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.M.</namePart><namePart type="family">Ossewaarde</namePart><affiliation>Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Kluwer Academic Publishers</publisher><place><placeTerm type="text">Dordrecht</placeTerm></place><dateIssued encoding="w3cdtf">2000-12-01</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Acute respiratory disease is one of the most common reasons to consult a general practitioner. A substantial part of these diseases cannot be explained by an infection with a virus or a common pathogenic bacterium. To study this diagnostic deficit, the prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae infections was determined in two groups of patients consulting a general practitioner. DNA of C. pneumoniae and M. pneumoniae was detected by a polymerase chain reaction (PCR) in nose/throat swabs from six (1.1%), and from seven (1.3%) patients, respectively, of 557 patients consulting a general practitioner for complaints suggestive for a virus infection during the 1994/1995 respiratory infections season. Two patients remained C. pneumoniae PCR-positive for at least 4 weeks. All others were negative within 3 weeks. Double infections of C. pneumoniae and influenza virus (3/6), and of M. pneumoniae and respiratory syncytial virus (1/7) or rhinovirus (1/7) were diagnosed. During the 1992/1993 season, attempts to isolate C. pneumoniae in cell culture or to detect C. pneumoniae DNA by PCR using throat swabs were all negative for 80 patients with a sore throat, although serological data suggested a C. pneumoniae infection in 13 (16%) patients. A specimen from another patient of this group was M. pneumoniae PCR-positive and the corresponding serum specimens showed a persistent high antibody titre. In summary, the prevalence of acute C. pneumoniae and M. pneumoniae infections was less than 2% in patients consulting a general practitioner.</abstract><subject lang="en"><topic>Antibodies</topic><topic>Chlamydia pneumoniae</topic><topic>Family practice</topic><topic>Mycoplasma pneumoniae</topic><topic>Polymerase chain reaction</topic><topic>Respiratory tract diseases</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Epidemiology</title></titleInfo><titleInfo type="abbreviated"><title>Eur J Epidemiol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2000-12-01</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Public Health/Gesundheitswesen</topic><topic>Cardiology</topic><topic>Infectious Diseases</topic><topic>Oncology</topic><topic>Epidemiology</topic></subject><identifier type="ISSN">0393-2990</identifier><identifier type="eISSN">1573-7284</identifier><identifier type="JournalID">10654</identifier><identifier type="IssueArticleCount">21</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2000</date><detail type="volume"><number>16</number><caption>vol.</caption></detail><detail type="issue"><number>12</number><caption>no.</caption></detail><extent unit="pages"><start>1099</start><end>1106</end></extent></part><recordInfo><recordOrigin>Kluwer Academic Publishers, 2000</recordOrigin></recordInfo></relatedItem><identifier type="istex">F612C9E1F8583C5377525C498A4523718B42A8B1</identifier><identifier type="ark">ark:/67375/VQC-H6XGPVB2-N</identifier><identifier type="DOI">10.1023/A:1010912012932</identifier><identifier type="ArticleID">336251</identifier><identifier type="ArticleID">Art2</identifier><accessCondition type="use and reproduction" contentType="copyright">Kluwer Academic Publishers, 2000</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Kluwer Academic Publishers, 2000</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-H6XGPVB2-N/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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