Characterization of Filoviruses Based on Differences in Structure and Antigenicity of the Virion Glycoprotein
Identifieur interne : 000556 ( Istex/Corpus ); précédent : 000555; suivant : 000557Characterization of Filoviruses Based on Differences in Structure and Antigenicity of the Virion Glycoprotein
Auteurs : Heinz Feldmann ; Stuart T. Nichol ; Hans-Dieter Klenk ; Clarence J. Peters ; Anthony SanchezSource :
- Virology [ 0042-6822 ] ; 1994.
Abstract
Abstract: Eight different filovirus isolates, representing major episodes of filovirus hemorrhagic disease, were propagated for structural and antigenetic analyses of their glycoprotein (GP). Carbohydrate analysis revealed that N- and O-glycosylation are features of filovirus GPs. Oligosaccharide side chains differed in their sialylation pattern and seemed to be cell line-dependent. Marburg virus (MBG) isolates are clearly distinguished from Ebola (EBO) and Reston viruses by a lack of terminal sialic acids when propagated in E6 and MA-104 cells. It was also determined that GP-specific antisera failed to show any cross-reactivity between MBG isolates and other filoviruses. These data, together with prior findings, indicate that the genus Filovirus can be divided into a MBG group and EBO group.
Url:
DOI: 10.1006/viro.1994.1147
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ISTEX:72428862B7F22AA253CE3EAAE64044AC79CD1372Le document en format XML
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Nichol</name><affiliation><mods:affiliation>Special Pathogens Branch, Division of Vital and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; and Institut für Virologie, Robert-Koch-Strasse 17, 35037 Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name><affiliation><mods:affiliation>Special Pathogens Branch, Division of Vital and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; and Institut für Virologie, Robert-Koch-Strasse 17, 35037 Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Peters, Clarence J" sort="Peters, Clarence J" uniqKey="Peters C" first="Clarence J." last="Peters">Clarence J. Peters</name><affiliation><mods:affiliation>Special Pathogens Branch, Division of Vital and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; and Institut für Virologie, Robert-Koch-Strasse 17, 35037 Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Sanchez, Anthony" sort="Sanchez, Anthony" uniqKey="Sanchez A" first="Anthony" last="Sanchez">Anthony Sanchez</name><affiliation><mods:affiliation>Special Pathogens Branch, Division of Vital and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; and Institut für Virologie, Robert-Koch-Strasse 17, 35037 Marburg, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">199</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="469">469</biblScope><biblScope unit="page" to="473">473</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Eight different filovirus isolates, representing major episodes of filovirus hemorrhagic disease, were propagated for structural and antigenetic analyses of their glycoprotein (GP). 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Carbohydrate analysis revealed that N- and O-glycosylation are features of filovirus GPs. Oligosaccharide side chains differed in their sialylation pattern and seemed to be cell line-dependent. Marburg virus (MBG) isolates are clearly distinguished from Ebola (EBO) and Reston viruses by a lack of terminal sialic acids when propagated in E6 and MA-104 cells. It was also determined that GP-specific antisera failed to show any cross-reactivity between MBG isolates and other filoviruses. 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Carbohydrate analysis revealed that N- and O-glycosylation are features of filovirus GPs. Oligosaccharide side chains differed in their sialylation pattern and seemed to be cell line-dependent. Marburg virus (MBG) isolates are clearly distinguished from Ebola (EBO) and Reston viruses by a lack of terminal sialic acids when propagated in E6 and MA-104 cells. It was also determined that GP-specific antisera failed to show any cross-reactivity between MBG isolates and other filoviruses. These data, together with prior findings, indicate that the genus <ce:italic>Filovirus</ce:italic> can be divided into a MBG group and EBO group.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Characterization of Filoviruses Based on Differences in Structure and Antigenicity of the Virion Glycoprotein</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Characterization of Filoviruses Based on Differences in Structure and Antigenicity of the Virion Glycoprotein</title></titleInfo><name type="personal"><namePart type="given">Heinz</namePart><namePart type="family">Feldmann</namePart><affiliation>Special Pathogens Branch, Division of Vital and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; and Institut für Virologie, Robert-Koch-Strasse 17, 35037 Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stuart T.</namePart><namePart type="family">Nichol</namePart><affiliation>Special Pathogens Branch, Division of Vital and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; and Institut für Virologie, Robert-Koch-Strasse 17, 35037 Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hans-Dieter</namePart><namePart type="family">Klenk</namePart><affiliation>Special Pathogens Branch, Division of Vital and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; and Institut für Virologie, Robert-Koch-Strasse 17, 35037 Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clarence J.</namePart><namePart type="family">Peters</namePart><affiliation>Special Pathogens Branch, Division of Vital and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; and Institut für Virologie, Robert-Koch-Strasse 17, 35037 Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony</namePart><namePart type="family">Sanchez</namePart><affiliation>Special Pathogens Branch, Division of Vital and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333; and Institut für Virologie, Robert-Koch-Strasse 17, 35037 Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="Short communication" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Eight different filovirus isolates, representing major episodes of filovirus hemorrhagic disease, were propagated for structural and antigenetic analyses of their glycoprotein (GP). Carbohydrate analysis revealed that N- and O-glycosylation are features of filovirus GPs. Oligosaccharide side chains differed in their sialylation pattern and seemed to be cell line-dependent. Marburg virus (MBG) isolates are clearly distinguished from Ebola (EBO) and Reston viruses by a lack of terminal sialic acids when propagated in E6 and MA-104 cells. It was also determined that GP-specific antisera failed to show any cross-reactivity between MBG isolates and other filoviruses. 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