Organic acidemia in a young cat associated with cobalamin deficiency
Identifieur interne : 000497 ( Istex/Corpus ); précédent : 000496; suivant : 000498Organic acidemia in a young cat associated with cobalamin deficiency
Auteurs : Efrat Kelmer ; G. Diane Shelton ; David A. Williams ; Craig G. Ruaux ; Marie E. Kerl ; Dennis P. O'BrienSource :
- Journal of Veterinary Emergency and Critical Care [ 1479-3261 ] ; 2007-09.
Abstract
Objective: To describe a case of severe metabolic acidosis and encephalopathy secondary to cobalamin (Cbl) deficiency in a young cat. Case summary: A 4‐year‐old spayed female domestic short hair cat weighing 2.5 kg, presented with a 2‐day history of neurological signs referable to the cerebrum. The cat was evaluated for similar episodes twice before, however, no definitive diagnosis was made for either visit. On presentation the cat was minimally responsive and had a metabolic acidosis and ketonuria with no apparent reason, such as lactic acidosis or diabetic ketoacidosis. The patient was diagnosed postmortem with an organic acidemia secondary to low Cbl levels. New or unique information provided: The purpose of this report is to alert emergency clinicians to be suspicious of an organic acidemia in any case of metabolic acidosis and ketonuria that cannot be explained. Early identification of inherited organic acidemias in domestic animals may allow prompt and appropriate treatment of these conditions.
Url:
DOI: 10.1111/j.1476-4431.2007.00234.x
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ISTEX:24A045FDBC5AB9F0453B3518D41145ECF67BF88FLe document en format XML
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O'Brien</name><affiliation><mods:affiliation>Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO,</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Veterinary Emergency and Critical Care</title><title level="j" type="alt">JOURNAL OF VETERINARY EMERGENCY CRITICAL CARE</title><idno type="ISSN">1479-3261</idno><idno type="eISSN">1476-4431</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="299">299</biblScope><biblScope unit="page" to="304">304</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2007-09">2007-09</date></imprint><idno type="ISSN">1479-3261</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1479-3261</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To describe a case of severe metabolic acidosis and encephalopathy secondary to cobalamin (Cbl) deficiency in a young cat. Case summary: A 4‐year‐old spayed female domestic short hair cat weighing 2.5 kg, presented with a 2‐day history of neurological signs referable to the cerebrum. The cat was evaluated for similar episodes twice before, however, no definitive diagnosis was made for either visit. On presentation the cat was minimally responsive and had a metabolic acidosis and ketonuria with no apparent reason, such as lactic acidosis or diabetic ketoacidosis. The patient was diagnosed postmortem with an organic acidemia secondary to low Cbl levels. New or unique information provided: The purpose of this report is to alert emergency clinicians to be suspicious of an organic acidemia in any case of metabolic acidosis and ketonuria that cannot be explained. 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Diane</forename><surname>Shelton</surname><roleName type="degree">DVM, PhD</roleName></persName><affiliation><orgName type="department">Department of Pathology</orgName><orgName type="department">School of Medicine</orgName><orgName type="institution">University of California</orgName><address><addrLine>La Jolla</addrLine><addrLine>CA, and</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">David A.</forename><surname>Williams</surname><roleName type="degree">VetMB, PhD</roleName></persName><affiliation><orgName type="division">Department of Small Animal Medicine and Surgery</orgName><orgName type="laboratory">Gastrointestinal Laboratory</orgName><orgName type="institution">Texas A&M University</orgName><address><addrLine>College Station</addrLine><addrLine>TX</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Craig G.</forename><surname>Ruaux</surname><roleName type="degree">BVSc, PhD</roleName></persName><affiliation><orgName type="division">Department of Small Animal Medicine and Surgery</orgName><orgName type="laboratory">Gastrointestinal Laboratory</orgName><orgName type="institution">Texas A&M University</orgName><address><addrLine>College Station</addrLine><addrLine>TX</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Marie E.</forename><surname>Kerl</surname><roleName type="degree">DVM, DACVIM, DACVECC</roleName></persName><affiliation><orgName type="division">Department of Veterinary Medicine and Surgery</orgName><orgName type="institution">University of Missouri</orgName><address><addrLine>Columbia</addrLine><addrLine>MO,</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Dennis P.</forename><surname>O'Brien</surname><roleName type="degree">DVM, PhD, DACVIM</roleName></persName><affiliation><orgName type="division">Department of Veterinary Medicine and Surgery</orgName><orgName type="institution">University of Missouri</orgName><address><addrLine>Columbia</addrLine><addrLine>MO,</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><idno type="istex">24A045FDBC5AB9F0453B3518D41145ECF67BF88F</idno><idno type="ark">ark:/67375/WNG-J80NPBTL-V</idno><idno type="DOI">10.1111/j.1476-4431.2007.00234.x</idno><idno type="unit">VEC234</idno><idno type="supplier">234</idno><idno type="toTypesetVersion">file:VEC.VEC234.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Veterinary Emergency and Critical Care</title><title level="j" type="alt">JOURNAL OF VETERINARY EMERGENCY CRITICAL CARE</title><idno type="pISSN">1479-3261</idno><idno type="eISSN">1476-4431</idno><idno type="book-DOI">10.1111/(ISSN)1476-4431</idno><idno type="book-part-DOI">10.1111/vec.2007.17.issue-3</idno><idno type="product">VEC</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="299">299</biblScope><biblScope unit="page" to="304">304</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2007-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
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Efrat Kelmer, Department of Veterinary Medicine and Surgery, Veterinary Medical Teaching Hospital, University of Missouri‐Columbia, 379 East Campus Dr., Columbia, MO 65211.
E‐mail: <email normalForm="KelmerE@missouri.edu">KelmerE@missouri.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:VEC.VEC234.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="19"></count><count type="wordTotal" number="4058"></count><count type="linksCrossRef" number="40"></count></countGroup><titleGroup><title type="main">Organic acidemia in a young cat associated with cobalamin deficiency</title><title type="shortAuthors">E. Kelmer <i>et al.</i></title><title type="short">Organic acidemia in a cat</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Efrat</givenNames><familyName>Kelmer</familyName><degrees>DVM, MS</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>G. Diane</givenNames><familyName>Shelton</familyName><degrees>DVM, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>David A.</givenNames><familyName>Williams</familyName><degrees>VetMB, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>Craig G.</givenNames><familyName>Ruaux</familyName><degrees>BVSc, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Marie E.</givenNames><familyName>Kerl</familyName><degrees>DVM, DACVIM, DACVECC</degrees></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Dennis P.</givenNames><familyName>O'Brien</familyName><degrees>DVM, PhD, DACVIM</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO,</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>Department of Pathology, School of Medicine, University of California, La Jolla, CA, and</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="US"><unparsedAffiliation>Department of Small Animal Medicine and Surgery, Gastrointestinal Laboratory, Texas A&M University, College Station, TX</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">encephalopathy</keyword><keyword xml:id="k2">ketonuria</keyword><keyword xml:id="k3">metabolic acidosis</keyword><keyword xml:id="k4">organic aciduria</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b>Objective: </b> To describe a case of severe metabolic acidosis and encephalopathy secondary to cobalamin (Cbl) deficiency in a young cat.</p><p><b>Case summary: </b> A 4‐year‐old spayed female domestic short hair cat weighing 2.5 kg, presented with a 2‐day history of neurological signs referable to the cerebrum. The cat was evaluated for similar episodes twice before, however, no definitive diagnosis was made for either visit. On presentation the cat was minimally responsive and had a metabolic acidosis and ketonuria with no apparent reason, such as lactic acidosis or diabetic ketoacidosis. The patient was diagnosed postmortem with an organic acidemia secondary to low Cbl levels.</p><p><b>New or unique information provided: </b> The purpose of this report is to alert emergency clinicians to be suspicious of an organic acidemia in any case of metabolic acidosis and ketonuria that cannot be explained. Early identification of inherited organic acidemias in domestic animals may allow prompt and appropriate treatment of these conditions.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Organic acidemia in a young cat associated with cobalamin deficiency</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Organic acidemia in a cat</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Organic acidemia in a young cat associated with cobalamin deficiency</title></titleInfo><name type="personal"><namePart type="given">Efrat</namePart><namePart type="family">Kelmer</namePart><namePart type="termsOfAddress">DVM, MS</namePart><affiliation>Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. Diane</namePart><namePart type="family">Shelton</namePart><namePart type="termsOfAddress">DVM, PhD</namePart><affiliation>Department of Pathology, School of Medicine, University of California, La Jolla, CA, and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David A.</namePart><namePart type="family">Williams</namePart><namePart type="termsOfAddress">VetMB, PhD</namePart><affiliation>Department of Small Animal Medicine and Surgery, Gastrointestinal Laboratory, Texas A&M University, College Station, TX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Craig G.</namePart><namePart type="family">Ruaux</namePart><namePart type="termsOfAddress">BVSc, PhD</namePart><affiliation>Department of Small Animal Medicine and Surgery, Gastrointestinal Laboratory, Texas A&M University, College Station, TX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie E.</namePart><namePart type="family">Kerl</namePart><namePart type="termsOfAddress">DVM, DACVIM, DACVECC</namePart><affiliation>Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dennis P.</namePart><namePart type="family">O'Brien</namePart><namePart type="termsOfAddress">DVM, PhD, DACVIM</namePart><affiliation>Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="case-report" displayLabel="caseStudy" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2007-09</dateIssued><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="formulas">0</extent><extent unit="references">19</extent><extent unit="linksCrossRef">40</extent><extent unit="words">4058</extent></physicalDescription><abstract lang="en">Objective: To describe a case of severe metabolic acidosis and encephalopathy secondary to cobalamin (Cbl) deficiency in a young cat. Case summary: A 4‐year‐old spayed female domestic short hair cat weighing 2.5 kg, presented with a 2‐day history of neurological signs referable to the cerebrum. The cat was evaluated for similar episodes twice before, however, no definitive diagnosis was made for either visit. On presentation the cat was minimally responsive and had a metabolic acidosis and ketonuria with no apparent reason, such as lactic acidosis or diabetic ketoacidosis. The patient was diagnosed postmortem with an organic acidemia secondary to low Cbl levels. New or unique information provided: The purpose of this report is to alert emergency clinicians to be suspicious of an organic acidemia in any case of metabolic acidosis and ketonuria that cannot be explained. Early identification of inherited organic acidemias in domestic animals may allow prompt and appropriate treatment of these conditions.</abstract><subject lang="en"><genre>keywords</genre><topic>encephalopathy</topic><topic>ketonuria</topic><topic>metabolic acidosis</topic><topic>organic aciduria</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Veterinary Emergency and Critical Care</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1479-3261</identifier><identifier type="eISSN">1476-4431</identifier><identifier type="DOI">10.1111/(ISSN)1476-4431</identifier><identifier type="PublisherID">VEC</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>299</start><end>304</end><total>6</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Quantitative analysis for organic acids in biological samples</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Hoffmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Aramaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Blum‐Hoffmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hoffmann G, Aramaki S, Blum‐Hoffmann E, et al. 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