Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)
Identifieur interne : 000483 ( Istex/Corpus ); précédent : 000482; suivant : 000484Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)
Auteurs : M. Tardieu ; A. Goffinet ; G. Harmant-Van Rijckevorsel ; G. LyonSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1982-09-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Acute hepatic necrosis, Adjacent cortex, Adult mice, Aqueductal stenosis, Arch neurol, Chronic disease, Chronic infection, Chronic thrombotic vasculitis, Congenital rubella syndrome, Cyclophosphamide, Cyclophosphamide treatment, Days semithin section, Demyelination, Diffuse meningeal, Direct action, Dupuy, Electron microscope, Ependymal, Ependymal cell line, Ependymal cells, Ependymal lesions, Ependymitis, Fourth ventricle, Genetic factors, Genetic resistance, Granulomatous angiitis, Host cells, Hyaline necrosis, Hydrocephalus, Immunol, Infection, Inflammatory, Inflammatory cells, Inflammatory lesions, Inflammatory thrombus, Intracranial inoculation, Ischemic necrosis, Lesion, Leukoencephalitis, Meningeal, Microglial nodules, Mononuclear cells, Mouse, Mouse hepatitis virus, Mouse hepatitis virus type, Necrosis, Necrotic cells, Nervous system, Neurol, Neuropathol, Neuropathologic, Particular interest, Perivascular, Phosphate buffer, Plasmocytes, Prevost, Proc natl acad, Resistant mice, Saline buffer, Second injection, Semisusceptible, Semisusceptible animals, Semisusceptible mice, Semisusceptible strains, Small lymphocytes, Strain mice, Susceptible mice, Tardieu, Thrombotic, Thrombotic vasculitis, Vascular lesions, Vascular occlusions, Vasculitis, Ventricular dilatation, Vessel walls, Viral, Viral infections, Viral particles, Virus infection, Weiner, White matter, Widespread destruction.
Abstract
Summary: Mouse hepatitis virus 3 (MHV 3) is either avirulent (resistant mice), hepatotropic (susceptible mice). or neurotropic (semisusceptible mice), depending on the strain of mice infected. In semisusceptible mice, infection led first to a transient meningitis, ependymitis, and leukoencephalitis, followed by a permanent communicating hydrocephalus and, later on, to a chronic thrombotic vasculitis affecting meningeal and parenchymal vessels at the brain stem level. Small foci of ischemic necrosis related to vascular occlusions were seen in the dorsal brain stem. Cyclophosphamide treatment of semisusceptible mice significantly reduced the meningeal infiltrates but did not prevent the development of hydrocephalus and other neuropathologic changes. Identical lesions occurred in fully susceptible mice infected with a low dose of virus, but no neurologic disorder could be induced in genetically resistant mice even following immunosuppression or intracranial inoculation. The leukoencephalitis differed from the demyelinating lesions observed with MHV4. Vascular lesions were of particular interest. More attention should be given to the possibifity of virus induced chronic cerebral vasculitis in man.
Url:
DOI: 10.1007/BF00690797
Links to Exploration step
ISTEX:99169036D68B6D65B61177EC6EACE45A766C7BACLe document en format XML
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Harmant-Van Rijckevorsel</name><affiliation><mods:affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Chargé de Recherche of the FNRS, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Lyon, G" sort="Lyon, G" uniqKey="Lyon G" first="G." last="Lyon">G. Lyon</name><affiliation><mods:affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1982-09-01">1982-09-01</date><biblScope unit="volume">58</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="168">168</biblScope><biblScope unit="page" to="176">176</biblScope></imprint><idno type="ISSN">0001-6322</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Experimental hydrocephalus</term><term>Experimental leukoencephalitis</term><term>MHV 3</term><term>Viral vasculitis</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acta</term><term>Acta neuropathol</term><term>Acute hepatic necrosis</term><term>Adjacent cortex</term><term>Adult mice</term><term>Aqueductal stenosis</term><term>Arch neurol</term><term>Chronic disease</term><term>Chronic infection</term><term>Chronic thrombotic vasculitis</term><term>Congenital rubella syndrome</term><term>Cyclophosphamide</term><term>Cyclophosphamide treatment</term><term>Days semithin section</term><term>Demyelination</term><term>Diffuse meningeal</term><term>Direct action</term><term>Dupuy</term><term>Electron microscope</term><term>Ependymal</term><term>Ependymal cell line</term><term>Ependymal cells</term><term>Ependymal lesions</term><term>Ependymitis</term><term>Fourth ventricle</term><term>Genetic factors</term><term>Genetic resistance</term><term>Granulomatous angiitis</term><term>Host cells</term><term>Hyaline necrosis</term><term>Hydrocephalus</term><term>Immunol</term><term>Infection</term><term>Inflammatory</term><term>Inflammatory cells</term><term>Inflammatory lesions</term><term>Inflammatory thrombus</term><term>Intracranial inoculation</term><term>Ischemic necrosis</term><term>Lesion</term><term>Leukoencephalitis</term><term>Meningeal</term><term>Microglial nodules</term><term>Mononuclear cells</term><term>Mouse</term><term>Mouse hepatitis virus</term><term>Mouse hepatitis virus type</term><term>Necrosis</term><term>Necrotic cells</term><term>Nervous system</term><term>Neurol</term><term>Neuropathol</term><term>Neuropathologic</term><term>Particular interest</term><term>Perivascular</term><term>Phosphate buffer</term><term>Plasmocytes</term><term>Prevost</term><term>Proc natl acad</term><term>Resistant mice</term><term>Saline buffer</term><term>Second injection</term><term>Semisusceptible</term><term>Semisusceptible animals</term><term>Semisusceptible mice</term><term>Semisusceptible strains</term><term>Small lymphocytes</term><term>Strain mice</term><term>Susceptible mice</term><term>Tardieu</term><term>Thrombotic</term><term>Thrombotic vasculitis</term><term>Vascular lesions</term><term>Vascular occlusions</term><term>Vasculitis</term><term>Ventricular dilatation</term><term>Vessel walls</term><term>Viral</term><term>Viral infections</term><term>Viral particles</term><term>Virus infection</term><term>Weiner</term><term>White matter</term><term>Widespread destruction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Mouse hepatitis virus 3 (MHV 3) is either avirulent (resistant mice), hepatotropic (susceptible mice). or neurotropic (semisusceptible mice), depending on the strain of mice infected. 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Tardieu</name><affiliations><json:string>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</json:string><json:string>Unité de Recherche INSERM U 56, Hôpital de Bicêtre, F-94200, Bicêtre, France</json:string></affiliations></json:item><json:item><name>A. Goffinet</name><affiliations><json:string>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</json:string><json:string>Chargé de Recherche of the FNRS, Belgium</json:string></affiliations></json:item><json:item><name>G. Harmant-van Rijckevorsel</name><affiliations><json:string>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</json:string><json:string>Chargé de Recherche of the FNRS, Belgium</json:string></affiliations></json:item><json:item><name>G. Lyon</name><affiliations><json:string>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>MHV 3</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Viral vasculitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Experimental hydrocephalus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Experimental leukoencephalitis</value></json:item></subject><articleId><json:string>BF00690797</json:string><json:string>Art2</json:string></articleId><arkIstex>ark:/67375/1BB-XFFSZ19X-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Summary: Mouse hepatitis virus 3 (MHV 3) is either avirulent (resistant mice), hepatotropic (susceptible mice). or neurotropic (semisusceptible mice), depending on the strain of mice infected. In semisusceptible mice, infection led first to a transient meningitis, ependymitis, and leukoencephalitis, followed by a permanent communicating hydrocephalus and, later on, to a chronic thrombotic vasculitis affecting meningeal and parenchymal vessels at the brain stem level. Small foci of ischemic necrosis related to vascular occlusions were seen in the dorsal brain stem. Cyclophosphamide treatment of semisusceptible mice significantly reduced the meningeal infiltrates but did not prevent the development of hydrocephalus and other neuropathologic changes. Identical lesions occurred in fully susceptible mice infected with a low dose of virus, but no neurologic disorder could be induced in genetically resistant mice even following immunosuppression or intracranial inoculation. The leukoencephalitis differed from the demyelinating lesions observed with MHV4. Vascular lesions were of particular interest. 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pathologie infectieuse</json:string></inist></categories><publicationDate>1982</publicationDate><copyrightDate>1982</copyrightDate><doi><json:string>10.1007/BF00690797</json:string></doi><id>99169036D68B6D65B61177EC6EACE45A766C7BAC</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-XFFSZ19X-H/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-XFFSZ19X-H/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/1BB-XFFSZ19X-H/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><licence><p>Springer-Verlag, 1982</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>1982-07-12</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Original Works</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)</title><author xml:id="author-0000"><persName><forename type="first">M.</forename><surname>Tardieu</surname></persName><affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</affiliation><affiliation>Unité de Recherche INSERM U 56, Hôpital de Bicêtre, F-94200, Bicêtre, France</affiliation></author><author xml:id="author-0001"><persName><forename type="first">A.</forename><surname>Goffinet</surname></persName><affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</affiliation><affiliation>Chargé de Recherche of the FNRS, Belgium</affiliation></author><author xml:id="author-0002"><persName><forename type="first">G.</forename><surname>Harmant-van Rijckevorsel</surname></persName><affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</affiliation><affiliation>Chargé de Recherche of the FNRS, Belgium</affiliation></author><author xml:id="author-0003" corresp="yes"><persName><forename type="first">G.</forename><surname>Lyon</surname></persName><affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</affiliation></author><idno type="istex">99169036D68B6D65B61177EC6EACE45A766C7BAC</idno><idno type="ark">ark:/67375/1BB-XFFSZ19X-H</idno><idno type="DOI">10.1007/BF00690797</idno><idno type="article-id">BF00690797</idno><idno type="article-id">Art2</idno></analytic><monogr><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="pISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">12</idno><idno type="volume-issue-count">4</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1982-09-01"></date><biblScope unit="volume">58</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="168">168</biblScope><biblScope unit="page" to="176">176</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1982-07-12</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: Mouse hepatitis virus 3 (MHV 3) is either avirulent (resistant mice), hepatotropic (susceptible mice). or neurotropic (semisusceptible mice), depending on the strain of mice infected. In semisusceptible mice, infection led first to a transient meningitis, ependymitis, and leukoencephalitis, followed by a permanent communicating hydrocephalus and, later on, to a chronic thrombotic vasculitis affecting meningeal and parenchymal vessels at the brain stem level. Small foci of ischemic necrosis related to vascular occlusions were seen in the dorsal brain stem. Cyclophosphamide treatment of semisusceptible mice significantly reduced the meningeal infiltrates but did not prevent the development of hydrocephalus and other neuropathologic changes. Identical lesions occurred in fully susceptible mice infected with a low dose of virus, but no neurologic disorder could be induced in genetically resistant mice even following immunosuppression or intracranial inoculation. The leukoencephalitis differed from the demyelinating lesions observed with MHV4. Vascular lesions were of particular interest. More attention should be given to the possibifity of virus induced chronic cerebral vasculitis in man.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>MHV 3</term></item><item><term>Viral vasculitis</term></item><item><term>Experimental hydrocephalus</term></item><item><term>Experimental leukoencephalitis</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pathology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1982-07-12">Created</change><change when="1982-09-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-XFFSZ19X-H/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>401</JournalID><JournalPrintISSN>0001-6322</JournalPrintISSN><JournalElectronicISSN>1432-0533</JournalElectronicISSN><JournalTitle>Acta Neuropathologica</JournalTitle><JournalAbbreviatedTitle>Acta Neuropathol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Pathology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>58</VolumeIDStart><VolumeIDEnd>58</VolumeIDEnd><VolumeIssueCount>4</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>3</IssueIDStart><IssueIDEnd>3</IssueIDEnd><IssueArticleCount>12</IssueArticleCount><IssueHistory><CoverDate><DateString>1982</DateString><Year>1982</Year><Month>9</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1982</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art2"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00690797</ArticleID><ArticleDOI>10.1007/BF00690797</ArticleDOI><ArticleSequenceNumber>2</ArticleSequenceNumber><ArticleTitle Language="En">Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)</ArticleTitle><ArticleCategory>Original Works</ArticleCategory><ArticleFirstPage>168</ArticleFirstPage><ArticleLastPage>176</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>11</Month><Day>9</Day></RegistrationDate><Received><Year>1982</Year><Month>7</Month><Day>12</Day></Received><Accepted><Year>1982</Year><Month>9</Month><Day>14</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1982</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>401</JournalID><VolumeIDStart>58</VolumeIDStart><VolumeIDEnd>58</VolumeIDEnd><IssueIDStart>3</IssueIDStart><IssueIDEnd>3</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><FamilyName>Tardieu</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1 Aff3"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><FamilyName>Goffinet</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1 Aff3"><AuthorName DisplayOrder="Western"><GivenName>G.</GivenName><FamilyName>Harmant-van Rijckevorsel</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff4"><AuthorName DisplayOrder="Western"><GivenName>G.</GivenName><FamilyName>Lyon</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Unité de Neurologie du Développement</OrgDivision><OrgName>Université de Louvain, Ecole de Médecine</OrgName><OrgAddress><City>Bruxelles</City><Country>Belgium</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Unité de Recherche INSERM U 56</OrgDivision><OrgName>Hôpital de Bicêtre</OrgName><OrgAddress><Postcode>F-94200</Postcode><City>Bicêtre</City><Country>France</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgName>Chargé de Recherche of the FNRS</OrgName><OrgAddress><Country>Belgium</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>Service de Neurologie Pédiatrique</OrgDivision><OrgName>Cliniques Universitaires Saint-Luc, UCL</OrgName><OrgAddress><Street>Avenue Hippocrate 10</Street><Postcode>B-1200</Postcode><City>Bruxelles</City><Country>Belgique</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>Mouse hepatitis virus 3 (MHV 3) is either avirulent (resistant mice), hepatotropic (susceptible mice). or neurotropic (semisusceptible mice), depending on the strain of mice infected. In semisusceptible mice, infection led first to a transient meningitis, ependymitis, and leukoencephalitis, followed by a permanent communicating hydrocephalus and, later on, to a chronic thrombotic vasculitis affecting meningeal and parenchymal vessels at the brain stem level. Small foci of ischemic necrosis related to vascular occlusions were seen in the dorsal brain stem. Cyclophosphamide treatment of semisusceptible mice significantly reduced the meningeal infiltrates but did not prevent the development of hydrocephalus and other neuropathologic changes. Identical lesions occurred in fully susceptible mice infected with a low dose of virus, but no neurologic disorder could be induced in genetically resistant mice even following immunosuppression or intracranial inoculation. The leukoencephalitis differed from the demyelinating lesions observed with MHV4. Vascular lesions were of particular interest. More attention should be given to the possibifity of virus induced chronic cerebral vasculitis in man.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>MHV 3</Keyword><Keyword>Viral vasculitis</Keyword><Keyword>Experimental hydrocephalus</Keyword><Keyword>Experimental leukoencephalitis</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>Supported by the Fonds National de la Recherche Scientifique, Belgium, grant no. 3.4540.81, by the Fonds de Développement Scientifique, Faculté de Médecine, Université de Louvain, and by INSERM contract CRL 826036</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Tardieu</namePart><affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</affiliation><affiliation>Unité de Recherche INSERM U 56, Hôpital de Bicêtre, F-94200, Bicêtre, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Goffinet</namePart><affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</affiliation><affiliation>Chargé de Recherche of the FNRS, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Harmant-van Rijckevorsel</namePart><affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</affiliation><affiliation>Chargé de Recherche of the FNRS, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">G.</namePart><namePart type="family">Lyon</namePart><affiliation>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1982-07-12</dateCreated><dateIssued encoding="w3cdtf">1982-09-01</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: Mouse hepatitis virus 3 (MHV 3) is either avirulent (resistant mice), hepatotropic (susceptible mice). or neurotropic (semisusceptible mice), depending on the strain of mice infected. In semisusceptible mice, infection led first to a transient meningitis, ependymitis, and leukoencephalitis, followed by a permanent communicating hydrocephalus and, later on, to a chronic thrombotic vasculitis affecting meningeal and parenchymal vessels at the brain stem level. Small foci of ischemic necrosis related to vascular occlusions were seen in the dorsal brain stem. Cyclophosphamide treatment of semisusceptible mice significantly reduced the meningeal infiltrates but did not prevent the development of hydrocephalus and other neuropathologic changes. Identical lesions occurred in fully susceptible mice infected with a low dose of virus, but no neurologic disorder could be induced in genetically resistant mice even following immunosuppression or intracranial inoculation. The leukoencephalitis differed from the demyelinating lesions observed with MHV4. Vascular lesions were of particular interest. More attention should be given to the possibifity of virus induced chronic cerebral vasculitis in man.</abstract><note>Original Works</note><subject lang="en"><genre>Key words</genre><topic>MHV 3</topic><topic>Viral vasculitis</topic><topic>Experimental hydrocephalus</topic><topic>Experimental leukoencephalitis</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neuropathologica</title></titleInfo><titleInfo type="abbreviated"><title>Acta Neuropathol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1982-09-01</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pathology</topic></subject><identifier type="ISSN">0001-6322</identifier><identifier type="eISSN">1432-0533</identifier><identifier type="JournalID">401</identifier><identifier type="IssueArticleCount">12</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1982</date><detail type="volume"><number>58</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="pages"><start>168</start><end>176</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1982</recordOrigin></recordInfo></relatedItem><identifier type="istex">99169036D68B6D65B61177EC6EACE45A766C7BAC</identifier><identifier type="ark">ark:/67375/1BB-XFFSZ19X-H</identifier><identifier type="DOI">10.1007/BF00690797</identifier><identifier type="ArticleID">BF00690797</identifier><identifier type="ArticleID">Art2</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1982</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1982</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-XFFSZ19X-H/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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