Coronavirus infects and causes demyelination in primate central nervous system
Identifieur interne : 000471 ( Istex/Corpus ); précédent : 000470; suivant : 000472Coronavirus infects and causes demyelination in primate central nervous system
Auteurs : Ronald S. Murray ; Guang-Yun Cai ; Kristen Hoel ; J.-Y. Zhang ; Kenneth F. Soike ; Gary F. CabiracSource :
- Virology [ 0042-6822 ] ; 1992.
English descriptors
- Teeft :
- Academic press, Agms, Antigen detection, Arachnoid meninges, Blood samples, Bovine coronavirus, Brain tissue, Cdna, Cdna probes, Cell line, Cells lane, Choroid plexus, Chronic phase, Clinical signs, Conjunctival inoculation, Coronavirus, Coronavirus infection, Coronaviruses, Days postinoculation, Demyelinating, Demyelination, Electron microscopy, Encephalomyelitis, Human coronavirus, Hybridization, Infection, Infectious virus, Inflammation, Inoculated, Inoculated intracerebrally, Inoculation, Mouse brain, Mouse hepatitis virus, Murine, Murine coronaviruses, Neurotropic coronavirus, Neutralizing, Nucleocapsid gene, Primate, Primate system, Primates, Primer, Random hexamers, Reaction conditions, Rodent system, Room temperature, Sclerosis, Severe encephalomyelitis, Species specificity, Staining magnification, Subhuman primate, Substrate solution, Tissue culture, Tissue sections, Viral, Viral antigen, Viral products, Virol, Virus, Virus entry, Virus replication, Virus strain, Weiner, Western blot analysis, White matter, White matter areas, White matter inflammation, White matter vacuolation.
Abstract
Abstract: Two species of primates, Owl and African green monkeys, were inoculated intracerebrally with either the neurotropic mouse hepatitis virus JHM or the putative multiple sclerosis brain coronavirus isolate SD. These viruses caused an acute to subacute panencephalitis and/or demyelination in the infected animals. The course of pathogenesis and sites of detected viral RNA and antigen was dependent both on animal species and virus strain but the results clearly showed that these viruses replicated and disseminated in the central nervous system (CNS) of these primates. This study suggests that human CNS may be susceptible to coronavirus infection.
Url:
DOI: 10.1016/0042-6822(92)90757-G
Links to Exploration step
ISTEX:3F80A4C0EDA0899530C915A20608D7A8DD3A5CE9Le document en format XML
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Murray</name><affiliation><mods:affiliation>Rocky Mountain Multiple Sclerosis Center, Colorado Neurological Institute, and Swedish Medical Center, Englewood, Colorado, 80150, USA</mods:affiliation></affiliation></author><author><name sortKey="Cai, Guang Yun" sort="Cai, Guang Yun" uniqKey="Cai G" first="Guang-Yun" last="Cai">Guang-Yun Cai</name><affiliation><mods:affiliation>Rocky Mountain Multiple Sclerosis Center, Colorado Neurological Institute, and Swedish Medical Center, Englewood, Colorado, 80150, USA</mods:affiliation></affiliation></author><author><name sortKey="Hoel, Kristen" sort="Hoel, Kristen" uniqKey="Hoel K" first="Kristen" last="Hoel">Kristen Hoel</name><affiliation><mods:affiliation>Rocky Mountain Multiple Sclerosis Center, Colorado Neurological Institute, and Swedish Medical Center, Englewood, Colorado, 80150, USA</mods:affiliation></affiliation></author><author><name sortKey="Zhang, J Y" sort="Zhang, J Y" uniqKey="Zhang J" first="J.-Y." last="Zhang">J.-Y. 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The course of pathogenesis and sites of detected viral RNA and antigen was dependent both on animal species and virus strain but the results clearly showed that these viruses replicated and disseminated in the central nervous system (CNS) of these primates. 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These viruses caused an acute to subacute panencephalitis and/or demyelination in the infected animals. The course of pathogenesis and sites of detected viral RNA and antigen was dependent both on animal species and virus strain but the results clearly showed that these viruses replicated and disseminated in the central nervous system (CNS) of these primates. This study suggests that human CNS may be susceptible to coronavirus infection.</p></abstract></profileDesc><revisionDesc><change when="1992">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-G3LSRW2V-V/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YVIRO</jid><aid>9290757G</aid><ce:pii>0042-6822(92)90757-G</ce:pii><ce:doi>10.1016/0042-6822(92)90757-G</ce:doi><ce:copyright type="unknown" year="1992"></ce:copyright></item-info><head><ce:title>Coronavirus infects and causes demyelination in primate central nervous system</ce:title><ce:author-group><ce:author><ce:given-name>Ronald S.</ce:given-name><ce:surname>Murray</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Guang-Yun</ce:given-name><ce:surname>Cai</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Kristen</ce:given-name><ce:surname>Hoel</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.-Y.</ce:given-name><ce:surname>Zhang</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Kenneth F.</ce:given-name><ce:surname>Soike</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Gary F.</ce:given-name><ce:surname>Cabirac</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF3"><ce:sup>‡</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>∗</ce:label><ce:textfn>Rocky Mountain Multiple Sclerosis Center, Colorado Neurological Institute, and Swedish Medical Center, Englewood, Colorado, 80150, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>†</ce:label><ce:textfn>Tulane Regional Primate Research Center, Covington, Louisiana, 70433, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>‡</ce:label><ce:textfn>Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>To whom reprint requests should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="17" month="10" year="1991"></ce:date-received><ce:date-accepted day="20" month="12" year="1991"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Two species of primates, Owl and African green monkeys, were inoculated intracerebrally with either the neurotropic mouse hepatitis virus JHM or the putative multiple sclerosis brain coronavirus isolate SD. These viruses caused an acute to subacute panencephalitis and/or demyelination in the infected animals. The course of pathogenesis and sites of detected viral RNA and antigen was dependent both on animal species and virus strain but the results clearly showed that these viruses replicated and disseminated in the central nervous system (CNS) of these primates. This study suggests that human CNS may be susceptible to coronavirus infection.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Coronavirus infects and causes demyelination in primate central nervous system</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Coronavirus infects and causes demyelination in primate central nervous system</title></titleInfo><name type="personal"><namePart type="given">Ronald S.</namePart><namePart type="family">Murray</namePart><affiliation>Rocky Mountain Multiple Sclerosis Center, Colorado Neurological Institute, and Swedish Medical Center, Englewood, Colorado, 80150, USA</affiliation><description>To whom reprint requests should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guang-Yun</namePart><namePart type="family">Cai</namePart><affiliation>Rocky Mountain Multiple Sclerosis Center, Colorado Neurological Institute, and Swedish Medical Center, Englewood, Colorado, 80150, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kristen</namePart><namePart type="family">Hoel</namePart><affiliation>Rocky Mountain Multiple Sclerosis Center, Colorado Neurological Institute, and Swedish Medical Center, Englewood, Colorado, 80150, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.-Y.</namePart><namePart type="family">Zhang</namePart><affiliation>Tulane Regional Primate Research Center, Covington, Louisiana, 70433, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kenneth F.</namePart><namePart type="family">Soike</namePart><affiliation>Tulane Regional Primate Research Center, Covington, Louisiana, 70433, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gary F.</namePart><namePart type="family">Cabirac</namePart><affiliation>Rocky Mountain Multiple Sclerosis Center, Colorado Neurological Institute, and Swedish Medical Center, Englewood, Colorado, 80150, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Two species of primates, Owl and African green monkeys, were inoculated intracerebrally with either the neurotropic mouse hepatitis virus JHM or the putative multiple sclerosis brain coronavirus isolate SD. These viruses caused an acute to subacute panencephalitis and/or demyelination in the infected animals. The course of pathogenesis and sites of detected viral RNA and antigen was dependent both on animal species and virus strain but the results clearly showed that these viruses replicated and disseminated in the central nervous system (CNS) of these primates. This study suggests that human CNS may be susceptible to coronavirus infection.</abstract><relatedItem type="host"><titleInfo><title>Virology</title></titleInfo><titleInfo type="abbreviated"><title>YVIRO</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued></originInfo><identifier type="ISSN">0042-6822</identifier><identifier type="PII">S0042-6822(00)X0381-9</identifier><part><date>1992</date><detail type="volume"><number>188</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>416</end></extent><extent unit="pages"><start>274</start><end>284</end></extent></part></relatedItem><identifier type="istex">3F80A4C0EDA0899530C915A20608D7A8DD3A5CE9</identifier><identifier type="ark">ark:/67375/6H6-G3LSRW2V-V</identifier><identifier type="DOI">10.1016/0042-6822(92)90757-G</identifier><identifier type="PII">0042-6822(92)90757-G</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-G3LSRW2V-V/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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