Influenza and Parainfluenza Associated Pediatric ICU Morbidity
Identifieur interne : 000370 ( Istex/Corpus ); précédent : 000369; suivant : 000371Influenza and Parainfluenza Associated Pediatric ICU Morbidity
Auteurs : Kam Lun Hon ; Ting Fan Leung ; Kam Lau Cheung ; Pak Cheung Ng ; Paul Kay Sheung ChanSource :
- The Indian Journal of Pediatrics [ 0019-5456 ] ; 2010-10-01.
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- KwdEn :
Abstract
Abstract: Objectives: To investigate if morbidity in young children admitted to a pediatric intensive care unit (PICU with a laboratory proven diagnosis of influenza and parainfluenza infection) had increased. Methods: Retrospective study from January 2003 through December 2009 was carried out. Every child in the PICU with a laboratory-confirmed influenza or parainfluenza infection was included. Results: 18 influenza (influenza A = 13 and influenza B = 5) and 17 parainfluenza admissions were identified over the 7-year period. Parainfluenza type 3 (n = 9) was the commonest subtype of parainfluenza infection. The median age of children admitted with influenza was higher than parainfluenza (4.5 vs 1.7 years, p = 0.044). Admissions associated with proven influenza and parainfluenza infections accounted for 2% of PICU annual admissions. There was only one death in 2003. 51% of these patients required ventilatory support, 45% received systemic corticosteroids, and 91% received initial broad spectrum antibiotic coverage. Bacterial co-infections were identified in 25% of these patients. The incidence of influenza admissions had not increased significantly in 2009 (H1N1 pandemic) when compared with 2003 (SARS epidemic) (p = 0.3). There were only two PICU cases of pandemic H1N1 in 2009 and both survived. The annual incidence of severe PICU cases of influenza and parainfluenza were 0.94 and 0.88 per 100,000 children per annum, respectively. Conclusions: Pandemic H1N1, influenza and parainfluenza viruses may be associated with significant childhood morbidity and PICU admissions.
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DOI: 10.1007/s12098-010-0197-8
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ISTEX:9C5931FC7C4E40BE3FB91C639B881DC52E0EA876Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza and Parainfluenza Associated Pediatric ICU Morbidity</title><author><name sortKey="Hon, Kam Lun" sort="Hon, Kam Lun" uniqKey="Hon K" first="Kam Lun" last="Hon">Kam Lun Hon</name><affiliation><mods:affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: ehon@hotmail.com</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: ehon@cuhk.edu.hk</mods:affiliation></affiliation></author><author><name sortKey="Leung, Ting Fan" sort="Leung, Ting Fan" uniqKey="Leung T" first="Ting Fan" last="Leung">Ting Fan Leung</name><affiliation><mods:affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Cheung, Kam Lau" sort="Cheung, Kam Lau" uniqKey="Cheung K" first="Kam Lau" last="Cheung">Kam Lau Cheung</name><affiliation><mods:affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Ng, Pak Cheung" sort="Ng, Pak Cheung" uniqKey="Ng P" first="Pak Cheung" last="Ng">Pak Cheung Ng</name><affiliation><mods:affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Chan, Paul Kay Sheung" sort="Chan, Paul Kay Sheung" uniqKey="Chan P" first="Paul Kay Sheung" last="Chan">Paul Kay Sheung Chan</name><affiliation><mods:affiliation>Department of Microbiology, Faculty of Medicine, The Chinese 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Clinical Science Building, Shatin, Hong Kong SAR, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: ehon@hotmail.com</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: ehon@cuhk.edu.hk</mods:affiliation></affiliation></author><author><name sortKey="Leung, Ting Fan" sort="Leung, Ting Fan" uniqKey="Leung T" first="Ting Fan" last="Leung">Ting Fan Leung</name><affiliation><mods:affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Cheung, Kam Lau" sort="Cheung, Kam Lau" uniqKey="Cheung K" first="Kam Lau" last="Cheung">Kam Lau Cheung</name><affiliation><mods:affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Ng, Pak Cheung" sort="Ng, Pak Cheung" uniqKey="Ng P" first="Pak Cheung" last="Ng">Pak Cheung Ng</name><affiliation><mods:affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Chan, Paul Kay Sheung" sort="Chan, Paul Kay Sheung" uniqKey="Chan P" first="Paul Kay Sheung" last="Chan">Paul Kay Sheung Chan</name><affiliation><mods:affiliation>Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The Indian Journal of Pediatrics</title><title level="j" type="abbrev">Indian J Pediatr</title><idno type="ISSN">0019-5456</idno><idno type="eISSN">0973-7693</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>India</pubPlace><date type="published" when="2010-10-01">2010-10-01</date><biblScope unit="volume">77</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1097">1097</biblScope><biblScope unit="page" to="1101">1101</biblScope></imprint><idno type="ISSN">0019-5456</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0019-5456</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>H1N1</term><term>Influenza</term><term>PICU</term><term>Parainfluenza</term><term>Pediatric intensive care</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Objectives: To investigate if morbidity in young children admitted to a pediatric intensive care unit (PICU with a laboratory proven diagnosis of influenza and parainfluenza infection) had increased. Methods: Retrospective study from January 2003 through December 2009 was carried out. Every child in the PICU with a laboratory-confirmed influenza or parainfluenza infection was included. Results: 18 influenza (influenza A = 13 and influenza B = 5) and 17 parainfluenza admissions were identified over the 7-year period. Parainfluenza type 3 (n = 9) was the commonest subtype of parainfluenza infection. The median age of children admitted with influenza was higher than parainfluenza (4.5 vs 1.7 years, p = 0.044). Admissions associated with proven influenza and parainfluenza infections accounted for 2% of PICU annual admissions. There was only one death in 2003. 51% of these patients required ventilatory support, 45% received systemic corticosteroids, and 91% received initial broad spectrum antibiotic coverage. Bacterial co-infections were identified in 25% of these patients. The incidence of influenza admissions had not increased significantly in 2009 (H1N1 pandemic) when compared with 2003 (SARS epidemic) (p = 0.3). There were only two PICU cases of pandemic H1N1 in 2009 and both survived. The annual incidence of severe PICU cases of influenza and parainfluenza were 0.94 and 0.88 per 100,000 children per annum, respectively. Conclusions: Pandemic H1N1, influenza and parainfluenza viruses may be associated with significant childhood morbidity and PICU admissions.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Kam Lun Hon</name><affiliations><json:string>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</json:string><json:string>E-mail: ehon@hotmail.com</json:string><json:string>E-mail: ehon@cuhk.edu.hk</json:string></affiliations></json:item><json:item><name>Ting Fan Leung</name><affiliations><json:string>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>Kam Lau Cheung</name><affiliations><json:string>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>Pak Cheung Ng</name><affiliations><json:string>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>Paul Kay Sheung Chan</name><affiliations><json:string>Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Influenza</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parainfluenza</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PICU</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>H1N1</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Pediatric intensive care</value></json:item></subject><articleId><json:string>197</json:string><json:string>s12098-010-0197-8</json:string></articleId><arkIstex>ark:/67375/VQC-B7T4HFFB-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Objectives: To investigate if morbidity in young children admitted to a pediatric intensive care unit (PICU with a laboratory proven diagnosis of influenza and parainfluenza infection) had increased. Methods: Retrospective study from January 2003 through December 2009 was carried out. Every child in the PICU with a laboratory-confirmed influenza or parainfluenza infection was included. Results: 18 influenza (influenza A = 13 and influenza B = 5) and 17 parainfluenza admissions were identified over the 7-year period. Parainfluenza type 3 (n = 9) was the commonest subtype of parainfluenza infection. The median age of children admitted with influenza was higher than parainfluenza (4.5 vs 1.7 years, p = 0.044). Admissions associated with proven influenza and parainfluenza infections accounted for 2% of PICU annual admissions. There was only one death in 2003. 51% of these patients required ventilatory support, 45% received systemic corticosteroids, and 91% received initial broad spectrum antibiotic coverage. Bacterial co-infections were identified in 25% of these patients. The incidence of influenza admissions had not increased significantly in 2009 (H1N1 pandemic) when compared with 2003 (SARS epidemic) (p = 0.3). There were only two PICU cases of pandemic H1N1 in 2009 and both survived. The annual incidence of severe PICU cases of influenza and parainfluenza were 0.94 and 0.88 per 100,000 children per annum, respectively. Conclusions: Pandemic H1N1, influenza and parainfluenza viruses may be associated with significant childhood morbidity and PICU admissions.</abstract><qualityIndicators><score>7.092</score><pdfWordCount>2428</pdfWordCount><pdfCharCount>16653</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>595.276 x 790.866 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>222</abstractWordCount><abstractCharCount>1593</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Influenza and Parainfluenza Associated Pediatric ICU Morbidity</title><genre><json:string>research-article</json:string></genre><host><title>The Indian Journal of 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Parainfluenza Associated Pediatric ICU Morbidity</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">Kam</forename><surname>Hon</surname></persName><email>ehon@hotmail.com</email><email>ehon@cuhk.edu.hk</email><affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Ting</forename><surname>Leung</surname></persName><affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Kam</forename><surname>Cheung</surname></persName><affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Pak</forename><surname>Ng</surname></persName><affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Paul</forename><surname>Chan</surname></persName><affiliation>Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China</affiliation></author><idno type="istex">9C5931FC7C4E40BE3FB91C639B881DC52E0EA876</idno><idno type="ark">ark:/67375/VQC-B7T4HFFB-H</idno><idno type="DOI">10.1007/s12098-010-0197-8</idno><idno type="article-id">197</idno><idno type="article-id">s12098-010-0197-8</idno></analytic><monogr><title level="j">The Indian Journal of Pediatrics</title><title level="j" type="abbrev">Indian J Pediatr</title><idno 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Methods: Retrospective study from January 2003 through December 2009 was carried out. Every child in the PICU with a laboratory-confirmed influenza or parainfluenza infection was included. Results: 18 influenza (influenza A = 13 and influenza B = 5) and 17 parainfluenza admissions were identified over the 7-year period. Parainfluenza type 3 (n = 9) was the commonest subtype of parainfluenza infection. The median age of children admitted with influenza was higher than parainfluenza (4.5 vs 1.7 years, p = 0.044). Admissions associated with proven influenza and parainfluenza infections accounted for 2% of PICU annual admissions. There was only one death in 2003. 51% of these patients required ventilatory support, 45% received systemic corticosteroids, and 91% received initial broad spectrum antibiotic coverage. Bacterial co-infections were identified in 25% of these patients. The incidence of influenza admissions had not increased significantly in 2009 (H1N1 pandemic) when compared with 2003 (SARS epidemic) (p = 0.3). There were only two PICU cases of pandemic H1N1 in 2009 and both survived. The annual incidence of severe PICU cases of influenza and parainfluenza were 0.94 and 0.88 per 100,000 children per annum, respectively. Conclusions: Pandemic H1N1, influenza and parainfluenza viruses may be associated with significant childhood morbidity and PICU admissions.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Influenza</term></item><item><term>Parainfluenza</term></item><item><term>PICU</term></item><item><term>H1N1</term></item><item><term>Pediatric intensive care</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Gynecology</term></item><item><term>Pediatrics</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-03-16">Created</change><change 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Article</ArticleCategory><ArticleFirstPage>1097</ArticleFirstPage><ArticleLastPage>1101</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2010</Year><Month>9</Month><Day>9</Day></RegistrationDate><Received><Year>2010</Year><Month>3</Month><Day>16</Day></Received><Accepted><Year>2010</Year><Month>6</Month><Day>17</Day></Accepted><OnlineDate><Year>2010</Year><Month>9</Month><Day>30</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Dr. K C Chaudhuri Foundation</CopyrightHolderName><CopyrightYear>2010</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Kam</GivenName><GivenName>Lun</GivenName><FamilyName>Hon</FamilyName></AuthorName><Contact><Phone>+852-2632-2859</Phone><Fax>+852-2636-0020</Fax><Email>ehon@hotmail.com</Email><Email>ehon@cuhk.edu.hk</Email></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Ting</GivenName><GivenName>Fan</GivenName><FamilyName>Leung</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Kam</GivenName><GivenName>Lau</GivenName><FamilyName>Cheung</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Pak</GivenName><GivenName>Cheung</GivenName><FamilyName>Ng</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Paul</GivenName><GivenName>Kay</GivenName><GivenName>Sheung</GivenName><FamilyName>Chan</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Pediatrics</OrgDivision><OrgName>The Chinese University of Hong Kong, Prince of Wales Hospital</OrgName><OrgAddress><Street>6/F, Clinical Science Building</Street><City>Shatin</City><State>Hong Kong SAR</State><Country Code="CN">China</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Microbiology, Faculty of Medicine</OrgDivision><OrgName>The Chinese University of Hong Kong, Prince of Wales Hospital</OrgName><OrgAddress><City>Shatin</City><State>NT, Hong Kong SAR</State><Country Code="CN">China</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><AbstractSection ID="ASec1"><Heading>Objectives</Heading><Para>To investigate if morbidity in young children admitted to a pediatric intensive care unit (PICU with a laboratory proven diagnosis of influenza and parainfluenza infection) had increased.</Para></AbstractSection><AbstractSection ID="ASec2"><Heading>Methods</Heading><Para>Retrospective study from January 2003 through December 2009 was carried out. Every child in the PICU with a laboratory-confirmed influenza or parainfluenza infection was included.</Para></AbstractSection><AbstractSection ID="ASec3"><Heading>Results</Heading><Para>18 influenza (influenza A = 13 and influenza B = 5) and 17 parainfluenza admissions were identified over the 7-year period. Parainfluenza type 3 (<Emphasis Type="Italic">n</Emphasis> = 9) was the commonest subtype of parainfluenza infection. The median age of children admitted with influenza was higher than parainfluenza (4.5 vs 1.7 years, <Emphasis Type="Italic">p</Emphasis> = 0.044). Admissions associated with proven influenza and parainfluenza infections accounted for 2% of PICU annual admissions. There was only one death in 2003. 51% of these patients required ventilatory support, 45% received systemic corticosteroids, and 91% received initial broad spectrum antibiotic coverage. Bacterial co-infections were identified in 25% of these patients. The incidence of influenza admissions had not increased significantly in 2009 (H1N1 pandemic) when compared with 2003 (SARS epidemic) (<Emphasis Type="Italic">p</Emphasis> = 0.3). There were only two PICU cases of pandemic H1N1 in 2009 and both survived. The annual incidence of severe PICU cases of influenza and parainfluenza were 0.94 and 0.88 per 100,000 children per annum, respectively.</Para></AbstractSection><AbstractSection ID="ASec4"><Heading>Conclusions</Heading><Para>Pandemic H1N1, influenza and parainfluenza viruses may be associated with significant childhood morbidity and PICU admissions.</Para></AbstractSection></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Influenza</Keyword><Keyword>Parainfluenza</Keyword><Keyword>PICU</Keyword><Keyword>H1N1</Keyword><Keyword>Pediatric intensive care</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Influenza and Parainfluenza Associated Pediatric ICU Morbidity</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Influenza and Parainfluenza Associated Pediatric ICU Morbidity</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Kam</namePart><namePart type="given">Lun</namePart><namePart type="family">Hon</namePart><affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</affiliation><affiliation>E-mail: ehon@hotmail.com</affiliation><affiliation>E-mail: ehon@cuhk.edu.hk</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ting</namePart><namePart type="given">Fan</namePart><namePart type="family">Leung</namePart><affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kam</namePart><namePart type="given">Lau</namePart><namePart type="family">Cheung</namePart><affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pak</namePart><namePart type="given">Cheung</namePart><namePart type="family">Ng</namePart><affiliation>Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Science Building, Shatin, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="given">Kay</namePart><namePart type="given">Sheung</namePart><namePart type="family">Chan</namePart><affiliation>Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">India</placeTerm></place><dateCreated encoding="w3cdtf">2010-03-16</dateCreated><dateIssued encoding="w3cdtf">2010-10-01</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Objectives: To investigate if morbidity in young children admitted to a pediatric intensive care unit (PICU with a laboratory proven diagnosis of influenza and parainfluenza infection) had increased. Methods: Retrospective study from January 2003 through December 2009 was carried out. Every child in the PICU with a laboratory-confirmed influenza or parainfluenza infection was included. Results: 18 influenza (influenza A = 13 and influenza B = 5) and 17 parainfluenza admissions were identified over the 7-year period. Parainfluenza type 3 (n = 9) was the commonest subtype of parainfluenza infection. The median age of children admitted with influenza was higher than parainfluenza (4.5 vs 1.7 years, p = 0.044). Admissions associated with proven influenza and parainfluenza infections accounted for 2% of PICU annual admissions. There was only one death in 2003. 51% of these patients required ventilatory support, 45% received systemic corticosteroids, and 91% received initial broad spectrum antibiotic coverage. Bacterial co-infections were identified in 25% of these patients. The incidence of influenza admissions had not increased significantly in 2009 (H1N1 pandemic) when compared with 2003 (SARS epidemic) (p = 0.3). There were only two PICU cases of pandemic H1N1 in 2009 and both survived. The annual incidence of severe PICU cases of influenza and parainfluenza were 0.94 and 0.88 per 100,000 children per annum, respectively. Conclusions: Pandemic H1N1, influenza and parainfluenza viruses may be associated with significant childhood morbidity and PICU admissions.</abstract><note>Original Article</note><subject lang="en"><genre>Keywords</genre><topic>Influenza</topic><topic>Parainfluenza</topic><topic>PICU</topic><topic>H1N1</topic><topic>Pediatric intensive care</topic></subject><relatedItem type="host"><titleInfo><title>The Indian Journal of Pediatrics</title></titleInfo><titleInfo type="abbreviated"><title>Indian J Pediatr</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2010-10-27</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Gynecology</topic><topic>Pediatrics</topic></subject><identifier type="ISSN">0019-5456</identifier><identifier type="eISSN">0973-7693</identifier><identifier type="JournalID">12098</identifier><identifier type="IssueArticleCount">24</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2010</date><detail type="volume"><number>77</number><caption>vol.</caption></detail><detail type="issue"><number>10</number><caption>no.</caption></detail><extent unit="pages"><start>1097</start><end>1101</end></extent></part><recordInfo><recordOrigin>Dr. K C Chaudhuri Foundation, 2010</recordOrigin></recordInfo></relatedItem><identifier type="istex">9C5931FC7C4E40BE3FB91C639B881DC52E0EA876</identifier><identifier type="ark">ark:/67375/VQC-B7T4HFFB-H</identifier><identifier type="DOI">10.1007/s12098-010-0197-8</identifier><identifier type="ArticleID">197</identifier><identifier type="ArticleID">s12098-010-0197-8</identifier><accessCondition type="use and reproduction" contentType="copyright">Dr. K C Chaudhuri Foundation, 2010</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Dr. K C Chaudhuri Foundation, 2010</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-B7T4HFFB-H/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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