Studies on the intrathecal humoral immune response in canine distemper encephalitis
Identifieur interne : 000347 ( Istex/Corpus ); précédent : 000346; suivant : 000348Studies on the intrathecal humoral immune response in canine distemper encephalitis
Auteurs : M. Vandevelde ; A. Zurbriggen ; A. Steck ; P. BichselSource :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1986.
English descriptors
- Teeft :
- Acta neuropathol, Albumin content, Antibody concentrations, Antimyelin, Antimyelin antibodies, Appel, Bichsel, Canine, Canine distemper, Canine distemper virus, Cerebrospinal, Cerebrospinal fluid, Demyelinating, Demyelinating lesions, Demyelination, Distemper, Distemper virus, Encephalomyelitis, Higgins, Immune, Immune response, Inflammatory, Inflammatory demyelination, Inflammatory lesions, Intrathecal, Intrathecal production, Krakowka, Lesion, Myelin, Normal dogs, Spontaneous cases, Vandevelde, Viral.
Abstract
Abstract: Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.
Url:
DOI: 10.1016/0165-5728(86)90073-1
Links to Exploration step
ISTEX:E6A583E83F042E1DA7EDB24009CC662B18E60EB6Le document en format XML
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Vandevelde</name><affiliation><mods:affiliation>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Zurbriggen, A" sort="Zurbriggen, A" uniqKey="Zurbriggen A" first="A." last="Zurbriggen">A. Zurbriggen</name><affiliation><mods:affiliation>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Steck, A" sort="Steck, A" uniqKey="Steck A" first="A." last="Steck">A. Steck</name><affiliation><mods:affiliation>Department of Neurology, University of Lausanne, Lausanne Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Bichsel, P" sort="Bichsel, P" uniqKey="Bichsel P" first="P." last="Bichsel">P. Bichsel</name><affiliation><mods:affiliation>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1986">1986</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="41">41</biblScope><biblScope unit="page" to="51">51</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta neuropathol</term><term>Albumin content</term><term>Antibody concentrations</term><term>Antimyelin</term><term>Antimyelin antibodies</term><term>Appel</term><term>Bichsel</term><term>Canine</term><term>Canine distemper</term><term>Canine distemper virus</term><term>Cerebrospinal</term><term>Cerebrospinal fluid</term><term>Demyelinating</term><term>Demyelinating lesions</term><term>Demyelination</term><term>Distemper</term><term>Distemper virus</term><term>Encephalomyelitis</term><term>Higgins</term><term>Immune</term><term>Immune response</term><term>Inflammatory</term><term>Inflammatory demyelination</term><term>Inflammatory lesions</term><term>Intrathecal</term><term>Intrathecal production</term><term>Krakowka</term><term>Lesion</term><term>Myelin</term><term>Normal dogs</term><term>Spontaneous cases</term><term>Vandevelde</term><term>Viral</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>distemper</json:string><json:string>myelin</json:string><json:string>antimyelin</json:string><json:string>vandevelde</json:string><json:string>intrathecal</json:string><json:string>demyelinating</json:string><json:string>inflammatory lesions</json:string><json:string>krakowka</json:string><json:string>appel</json:string><json:string>demyelination</json:string><json:string>inflammatory</json:string><json:string>antimyelin antibodies</json:string><json:string>bichsel</json:string><json:string>viral</json:string><json:string>canine</json:string><json:string>immune</json:string><json:string>higgins</json:string><json:string>encephalomyelitis</json:string><json:string>cerebrospinal</json:string><json:string>lesion</json:string><json:string>distemper virus</json:string><json:string>canine distemper virus</json:string><json:string>acta neuropathol</json:string><json:string>spontaneous cases</json:string><json:string>cerebrospinal fluid</json:string><json:string>normal dogs</json:string><json:string>antibody concentrations</json:string><json:string>inflammatory demyelination</json:string><json:string>immune response</json:string><json:string>canine distemper</json:string><json:string>albumin content</json:string><json:string>intrathecal production</json:string><json:string>demyelinating lesions</json:string></teeft></keywords><author><json:item><name>M. Vandevelde</name><affiliations><json:string>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</json:string></affiliations></json:item><json:item><name>A. Zurbriggen</name><affiliations><json:string>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</json:string></affiliations></json:item><json:item><name>A. Steck</name><affiliations><json:string>Department of Neurology, University of Lausanne, Lausanne Switzerland</json:string></affiliations></json:item><json:item><name>P. Bichsel</name><affiliations><json:string>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Anti-CDV antibodies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Antimyelin antibodies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Canine distemper</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>IgG index</value></json:item></subject><arkIstex>ark:/67375/6H6-MW1TMNL2-Q</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.</abstract><qualityIndicators><score>7.035</score><pdfWordCount>3619</pdfWordCount><pdfCharCount>22623</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>526 x 742 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>118</abstractWordCount><abstractCharCount>851</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Studies on the intrathecal humoral immune response in canine distemper encephalitis</title><pmid><json:string>3944250</json:string></pmid><pii><json:string>0165-5728(86)90073-1</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Virology Monographs</title><language><json:string>unknown</json:string></language></serie><host><title>Journal of Neuroimmunology</title><language><json:string>unknown</json:string></language><publicationDate>1986</publicationDate><issn><json:string>0165-5728</json:string></issn><pii><json:string>S0165-5728(00)X0171-3</json:string></pii><volume>11</volume><issue>1</issue><pages><first>41</first><last>51</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1986</json:string></date><geogName></geogName><orgName><json:string>Department of Neurology, University of Lausanne, Lausanne</json:string><json:string>Swiss National Foundation Grants Nos</json:string></orgName><orgName_funder><json:string>Swiss National Foundation Grants Nos</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>P. Bichsel</json:string><json:string>P.O. Box</json:string><json:string>M. Vandevelde</json:string></persName><placeName><json:string>Switzerland</json:string><json:string>Bern</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Tsai et al. 1982</json:string><json:string>Appel and Robson (1973)</json:string><json:string>Higgins et al. 1982</json:string><json:string>Cerruti-Sola et al.</json:string><json:string>Vandevelde et al.</json:string><json:string>Wege et al. 1984</json:string><json:string>Watanabe et al. 1983</json:string><json:string>Link 1978</json:string><json:string>Vandevelde et al. 1985</json:string><json:string>Steck et al. 1981</json:string><json:string>Fankhauser 1962</json:string><json:string>Link and Tibbling (1977)</json:string><json:string>Cerruti-Sola et al. 1983</json:string><json:string>Tourtellotte et al. 1978</json:string><json:string>Higgins et al.</json:string><json:string>Krakowka et al. (1982)</json:string><json:string>Accepted 17 July, 1985</json:string><json:string>Krakowka et al. 1975</json:string><json:string>Appel et al. 1982</json:string><json:string>Wisniewski 1972</json:string><json:string>Ho and Babiuk 1979, 1980</json:string><json:string>Summers et al. 1979</json:string><json:string>TerMeulen et al. 1982</json:string><json:string>Bindrich and Schmidt 1952</json:string><json:string>Long et al. 1973</json:string><json:string>Tsai et al. (1982)</json:string><json:string>Metzler et al. 1980</json:string><json:string>Appel et al. 1981</json:string><json:string>Vandevelde et al. 1982</json:string><json:string>Appel and Gillespie 1972</json:string><json:string>Vandevelde et al. 19132</json:string><json:string>Received13 March, 1985</json:string><json:string>Krakowka et al. 1973</json:string><json:string>Cutler and Averill 1969</json:string><json:string>Bichsel et al. 1984</json:string><json:string>Krakowka et al. (1973)</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-MW1TMNL2-Q</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - neurosciences</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - neurology & neurosurgery</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Clinical Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Neuroscience</json:string><json:string>3 - Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1986</publicationDate><copyrightDate>1986</copyrightDate><doi><json:string>10.1016/0165-5728(86)90073-1</json:string></doi><id>E6A583E83F042E1DA7EDB24009CC662B18E60EB6</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-MW1TMNL2-Q/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-MW1TMNL2-Q/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-MW1TMNL2-Q/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Studies on the intrathecal humoral immune response in canine distemper encephalitis</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1986</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>This work was supported by the Swiss National Foundation Grants Nos. 3.949.84 and 3.52.082.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Studies on the intrathecal humoral immune response in canine distemper encephalitis</title><author xml:id="author-0000"><persName><forename type="first">M.</forename><surname>Vandevelde</surname></persName><affiliation>Address correspondence to: M. Vandevelde, Institut für vergleichende Neurologie, Universität Bern, P.O. Box 2735, CH-3001 Berne Switzerland.</affiliation><affiliation>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</affiliation></author><author xml:id="author-0001"><persName><forename type="first">A.</forename><surname>Zurbriggen</surname></persName><affiliation>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</affiliation></author><author xml:id="author-0002"><persName><forename type="first">A.</forename><surname>Steck</surname></persName><affiliation>Department of Neurology, University of Lausanne, Lausanne Switzerland</affiliation></author><author xml:id="author-0003"><persName><forename type="first">P.</forename><surname>Bichsel</surname></persName><affiliation>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</affiliation></author><idno type="istex">E6A583E83F042E1DA7EDB24009CC662B18E60EB6</idno><idno type="ark">ark:/67375/6H6-MW1TMNL2-Q</idno><idno type="DOI">10.1016/0165-5728(86)90073-1</idno><idno type="PII">0165-5728(86)90073-1</idno></analytic><monogr><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="pISSN">0165-5728</idno><idno type="PII">S0165-5728(00)X0171-3</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1986"></date><biblScope unit="volume">11</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="41">41</biblScope><biblScope unit="page" to="51">51</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1986</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Anti-CDV antibodies</term></item><item><term>Antimyelin antibodies</term></item><item><term>Canine distemper</term></item><item><term>IgG index</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1985-07-13">Modified</change><change when="1986">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-MW1TMNL2-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNI</jid><aid>86900731</aid><ce:pii>0165-5728(86)90073-1</ce:pii><ce:doi>10.1016/0165-5728(86)90073-1</ce:doi><ce:copyright type="unknown" year="1986"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This work was supported by the Swiss National Foundation Grants Nos. 3.949.84 and 3.52.082.</ce:note-para></ce:article-footnote><ce:title>Studies on the intrathecal humoral immune response in canine distemper encephalitis</ce:title><ce:author-group><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Vandevelde</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Zurbriggen</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Steck</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Bichsel</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>1</ce:label><ce:textfn>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>2</ce:label><ce:textfn>Department of Neurology, University of Lausanne, Lausanne Switzerland</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address correspondence to: M. Vandevelde, Institut für vergleichende Neurologie, Universität Bern, P.O. Box 2735, CH-3001 Berne Switzerland.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="13" month="3" year="1985"></ce:date-received><ce:date-revised day="13" month="7" year="1985"></ce:date-revised><ce:date-accepted day="17" month="7" year="1985"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Anti-CDV antibodies</ce:text></ce:keyword><ce:keyword><ce:text>Antimyelin antibodies</ce:text></ce:keyword><ce:keyword><ce:text>Canine distemper</ce:text></ce:keyword><ce:keyword><ce:text>IgG index</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Studies on the intrathecal humoral immune response in canine distemper encephalitis</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Studies on the intrathecal humoral immune response in canine distemper encephalitis</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Vandevelde</namePart><affiliation>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</affiliation><description>Address correspondence to: M. Vandevelde, Institut für vergleichende Neurologie, Universität Bern, P.O. Box 2735, CH-3001 Berne Switzerland.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Zurbriggen</namePart><affiliation>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Steck</namePart><affiliation>Department of Neurology, University of Lausanne, Lausanne Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Bichsel</namePart><affiliation>Institute of Comparative Neurology, University of Berne, Berne, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1986</dateIssued><dateModified encoding="w3cdtf">1985-07-13</dateModified><copyrightDate encoding="w3cdtf">1986</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinating lesions and elevated in dogs with inflammatory myelin lesions. Specific antibodies against CDV and myelin were quantitated in CSF and serum from 8 dogs with an elevated IgG index. Eight of these dogs had significant amounts of antimyelin antibody and 4 dogs had neutralizing anti-CDV antibody in the CSF. Whereas the pathogenetic significance of antimyelin antibodies remains uncertain, the intrathecal antiviral immune response provides a plausible explanation for immunopathologic destruction of myelin in distemper.</abstract><note>This work was supported by the Swiss National Foundation Grants Nos. 3.949.84 and 3.52.082.</note><subject><genre>Keywords</genre><topic>Anti-CDV antibodies</topic><topic>Antimyelin antibodies</topic><topic>Canine distemper</topic><topic>IgG index</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neuroimmunology</title></titleInfo><titleInfo type="abbreviated"><title>JNI</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1986</dateIssued></originInfo><identifier type="ISSN">0165-5728</identifier><identifier type="PII">S0165-5728(00)X0171-3</identifier><part><date>1986</date><detail type="volume"><number>11</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>92</end></extent><extent unit="pages"><start>41</start><end>51</end></extent></part></relatedItem><identifier type="istex">E6A583E83F042E1DA7EDB24009CC662B18E60EB6</identifier><identifier type="ark">ark:/67375/6H6-MW1TMNL2-Q</identifier><identifier type="DOI">10.1016/0165-5728(86)90073-1</identifier><identifier type="PII">0165-5728(86)90073-1</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-MW1TMNL2-Q/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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