Serveur d'exploration Covid

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies

Identifieur interne : 000337 ( Istex/Corpus ); précédent : 000336; suivant : 000338

Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies

Auteurs : Shinji Tsujii ; Kenneth L. Rinehart ; Sarath P. Gunasekera ; Yoel Kashman ; Susan S. Cross ; May S. Lui ; Shirley A. Pomponi ; M. Cristina Diaz

Source :

RBID : ISTEX:8E6B2C49E31EF840C6E11F747D6B2D9FFCC4B490
Url:
DOI: 10.1021/jo00258a009

Links to Exploration step

ISTEX:8E6B2C49E31EF840C6E11F747D6B2D9FFCC4B490

Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title>Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies</title>
<author>
<name sortKey="Tsujii, Shinji" sort="Tsujii, Shinji" uniqKey="Tsujii S" first="Shinji" last="Tsujii">Shinji Tsujii</name>
</author>
<author>
<name sortKey="Rinehart, Kenneth L" sort="Rinehart, Kenneth L" uniqKey="Rinehart K" first="Kenneth L." last="Rinehart">Kenneth L. Rinehart</name>
</author>
<author>
<name sortKey="Gunasekera, Sarath P" sort="Gunasekera, Sarath P" uniqKey="Gunasekera S" first="Sarath P." last="Gunasekera">Sarath P. Gunasekera</name>
</author>
<author>
<name sortKey="Kashman, Yoel" sort="Kashman, Yoel" uniqKey="Kashman Y" first="Yoel" last="Kashman">Yoel Kashman</name>
</author>
<author>
<name sortKey="Cross, Susan S" sort="Cross, Susan S" uniqKey="Cross S" first="Susan S." last="Cross">Susan S. Cross</name>
</author>
<author>
<name sortKey="Lui, May S" sort="Lui, May S" uniqKey="Lui M" first="May S." last="Lui">May S. Lui</name>
</author>
<author>
<name sortKey="Pomponi, Shirley A" sort="Pomponi, Shirley A" uniqKey="Pomponi S" first="Shirley A." last="Pomponi">Shirley A. Pomponi</name>
</author>
<author>
<name sortKey="Diaz, M Cristina" sort="Diaz, M Cristina" uniqKey="Diaz M" first="M. Cristina" last="Diaz">M. Cristina Diaz</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:8E6B2C49E31EF840C6E11F747D6B2D9FFCC4B490</idno>
<date when="1988-11-01" year="1988">1988-11-01</date>
<idno type="doi">10.1021/jo00258a009</idno>
<idno type="url">https://api.istex.fr/ark:/67375/TPS-VGNL2D6B-T/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000337</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000337</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies</title>
<author>
<name sortKey="Tsujii, Shinji" sort="Tsujii, Shinji" uniqKey="Tsujii S" first="Shinji" last="Tsujii">Shinji Tsujii</name>
</author>
<author>
<name sortKey="Rinehart, Kenneth L" sort="Rinehart, Kenneth L" uniqKey="Rinehart K" first="Kenneth L." last="Rinehart">Kenneth L. Rinehart</name>
</author>
<author>
<name sortKey="Gunasekera, Sarath P" sort="Gunasekera, Sarath P" uniqKey="Gunasekera S" first="Sarath P." last="Gunasekera">Sarath P. Gunasekera</name>
</author>
<author>
<name sortKey="Kashman, Yoel" sort="Kashman, Yoel" uniqKey="Kashman Y" first="Yoel" last="Kashman">Yoel Kashman</name>
</author>
<author>
<name sortKey="Cross, Susan S" sort="Cross, Susan S" uniqKey="Cross S" first="Susan S." last="Cross">Susan S. Cross</name>
</author>
<author>
<name sortKey="Lui, May S" sort="Lui, May S" uniqKey="Lui M" first="May S." last="Lui">May S. Lui</name>
</author>
<author>
<name sortKey="Pomponi, Shirley A" sort="Pomponi, Shirley A" uniqKey="Pomponi S" first="Shirley A." last="Pomponi">Shirley A. Pomponi</name>
</author>
<author>
<name sortKey="Diaz, M Cristina" sort="Diaz, M Cristina" uniqKey="Diaz M" first="M. Cristina" last="Diaz">M. Cristina Diaz</name>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j" type="main">The Journal of Organic Chemistry</title>
<title level="j" type="abbrev">J. Org. Chem.</title>
<imprint>
<publisher>American Chemical Society</publisher>
<date type="e-published" when="2002-05-01">2002</date>
<date when="1988-11-01">1988</date>
<biblScope unit="vol">53</biblScope>
<biblScope unit="issue">23</biblScope>
<biblScope unit="page" from="5446">5446</biblScope>
<biblScope unit="page" to="5453">5453</biblScope>
</imprint>
<idno type="ISSN">0022-3263</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0022-3263</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
</TEI>
<istex>
<corpusName>acs</corpusName>
<keywords>
<teeft>
<json:string>mmol</json:string>
<json:string>topsentin</json:string>
<json:string>chem</json:string>
<json:string>lreims</json:string>
<json:string>hreims</json:string>
<json:string>bromotopsentin</json:string>
<json:string>indole</json:string>
<json:string>relative intensity</json:string>
<json:string>methanol</json:string>
<json:string>anal</json:string>
<json:string>antiviral</json:string>
<json:string>ammonia</json:string>
<json:string>spongosorites</json:string>
<json:string>room temperature</json:string>
<json:string>obzl</json:string>
<json:string>tetrahedron</json:string>
<json:string>column chromatography</json:string>
<json:string>ethanol</json:string>
<json:string>chemical shift</json:string>
<json:string>caled</json:string>
<json:string>asakawa</json:string>
<json:string>torus</json:string>
<json:string>sponge sample</json:string>
<json:string>reaction mixture</json:string>
<json:string>biological activity</json:string>
<json:string>amorphous solid</json:string>
<json:string>spectral datum</json:string>
<json:string>datum</json:string>
<json:string>tetrahedron lett</json:string>
<json:string>acetate monohydrate</json:string>
<json:string>aqueous ethanol</json:string>
<json:string>palladium</json:string>
<json:string>carbonyl</json:string>
<json:string>crude product</json:string>
<json:string>same manner</json:string>
<json:string>experimental section</json:string>
<json:string>natural topsentin</json:string>
<json:string>chloroacetyl chloride</json:string>
<json:string>mass spectrum</json:string>
<json:string>aqueous acetic acid</json:string>
<json:string>absolute ethanol</json:string>
<json:string>benzene ring</json:string>
<json:string>nonnatural aromatic compound</json:string>
<json:string>aqueous methanol</json:string>
<json:string>antiviral activity</json:string>
<json:string>oxidation product</json:string>
</teeft>
</keywords>
<author>
<json:item>
<name>TSUJII Shinji</name>
</json:item>
<json:item>
<name>RINEHART Kenneth L.</name>
</json:item>
<json:item>
<name>GUNASEKERA Sarath P.</name>
</json:item>
<json:item>
<name>KASHMAN Yoel</name>
</json:item>
<json:item>
<name>CROSS Susan S.</name>
</json:item>
<json:item>
<name>LUI May S.</name>
</json:item>
<json:item>
<name>POMPONI Shirley A.</name>
</json:item>
<json:item>
<name>DIAZ M. Cristina</name>
</json:item>
</author>
<arkIstex>ark:/67375/TPS-VGNL2D6B-T</arkIstex>
<language>
<json:string>unknown</json:string>
</language>
<originalGenre>
<json:string>Article</json:string>
</originalGenre>
<qualityIndicators>
<score>7.012</score>
<pdfWordCount>6468</pdfWordCount>
<pdfCharCount>39028</pdfCharCount>
<pdfVersion>1.6</pdfVersion>
<pdfPageCount>8</pdfPageCount>
<pdfPageSize>615.84 x 801.6 pts</pdfPageSize>
<pdfWordsPerPage>809</pdfWordsPerPage>
<pdfText>true</pdfText>
<refBibsNative>false</refBibsNative>
<abstractWordCount>1</abstractWordCount>
<abstractCharCount>0</abstractCharCount>
<keywordCount>0</keywordCount>
</qualityIndicators>
<title>Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies</title>
<genre>
<json:string>research-article</json:string>
</genre>
<host>
<title>The Journal of Organic Chemistry</title>
<language>
<json:string>unknown</json:string>
</language>
<issn>
<json:string>0022-3263</json:string>
</issn>
<publisherId>
<json:string>jo</json:string>
</publisherId>
<volume>53</volume>
<issue>23</issue>
<pages>
<first>5446</first>
<last>5453</last>
</pages>
<genre>
<json:string>journal</json:string>
</genre>
</host>
<ark>
<json:string>ark:/67375/TPS-VGNL2D6B-T</json:string>
</ark>
<categories>
<wos>
<json:string>1 - science</json:string>
<json:string>2 - chemistry, organic</json:string>
</wos>
<scienceMetrix>
<json:string>1 - natural sciences</json:string>
<json:string>2 - chemistry</json:string>
<json:string>3 - organic chemistry</json:string>
</scienceMetrix>
<scopus>
<json:string>1 - Physical Sciences</json:string>
<json:string>2 - Chemistry</json:string>
<json:string>3 - Organic Chemistry</json:string>
</scopus>
</categories>
<publicationDate>1988</publicationDate>
<doi>
<json:string>10.1021/jo00258a009</json:string>
</doi>
<id>8E6B2C49E31EF840C6E11F747D6B2D9FFCC4B490</id>
<score>1</score>
<fulltext>
<json:item>
<extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/ark:/67375/TPS-VGNL2D6B-T/fulltext.pdf</uri>
</json:item>
<json:item>
<extension>zip</extension>
<original>false</original>
<mimetype>application/zip</mimetype>
<uri>https://api.istex.fr/ark:/67375/TPS-VGNL2D6B-T/bundle.zip</uri>
</json:item>
<json:item>
<extension>txt</extension>
<original>false</original>
<mimetype>text/plain</mimetype>
<uri>https://api.istex.fr/ark:/67375/TPS-VGNL2D6B-T/fulltext.txt</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/TPS-VGNL2D6B-T/fulltext.tei">
<teiHeader>
<fileDesc>
<titleStmt>
<title level="a" type="main">Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies</title>
<respStmt>
<resp>Références bibliographiques récupérées via GROBID</resp>
<name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name>
</respStmt>
</titleStmt>
<publicationStmt>
<authority>ISTEX</authority>
<publisher>American Chemical Society</publisher>
<date type="e-published" when="2002-05-01">2002</date>
<date when="1988-11-01">1988</date>
</publicationStmt>
<notesStmt>
<note type="content-type" source="other" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-7474895G-0">other</note>
<note type="publication-type" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note>
</notesStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies</title>
<author xml:id="author-0000">
<persName>
<surname>Tsujii</surname>
<forename type="first">Shinji</forename>
</persName>
</author>
<author xml:id="author-0001">
<persName>
<surname>Rinehart</surname>
<forename type="first">Kenneth L.</forename>
</persName>
</author>
<author xml:id="author-0002">
<persName>
<surname>Gunasekera</surname>
<forename type="first">Sarath P.</forename>
</persName>
</author>
<author xml:id="author-0003">
<persName>
<surname>Kashman</surname>
<forename type="first">Yoel</forename>
</persName>
</author>
<author xml:id="author-0004">
<persName>
<surname>Cross</surname>
<forename type="first">Susan S.</forename>
</persName>
</author>
<author xml:id="author-0005">
<persName>
<surname>Lui</surname>
<forename type="first">May S.</forename>
</persName>
</author>
<author xml:id="author-0006">
<persName>
<surname>Pomponi</surname>
<forename type="first">Shirley A.</forename>
</persName>
</author>
<author xml:id="author-0007">
<persName>
<surname>Diaz</surname>
<forename type="first">M. Cristina</forename>
</persName>
</author>
<idno type="istex">8E6B2C49E31EF840C6E11F747D6B2D9FFCC4B490</idno>
<idno type="ark">ark:/67375/TPS-VGNL2D6B-T</idno>
<idno type="DOI">10.1021/jo00258a009</idno>
</analytic>
<monogr>
<title level="j" type="main">The Journal of Organic Chemistry</title>
<title level="j" type="abbrev">J. Org. Chem.</title>
<idno type="publisher-id">jo</idno>
<idno type="coden">joceah</idno>
<idno type="ISSN">0022-3263</idno>
<imprint>
<publisher>American Chemical Society</publisher>
<date type="e-published" when="2002-05-01">2002</date>
<date when="1988-11-01">1988</date>
<biblScope unit="vol">53</biblScope>
<biblScope unit="issue">23</biblScope>
<biblScope unit="page" from="5446">5446</biblScope>
<biblScope unit="page" to="5453">5453</biblScope>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass ana="subject">
<keywords scheme="document-type-name">
<term>Article</term>
</keywords>
</textClass>
<langUsage>
<language ident="en"></language>
</langUsage>
</profileDesc>
<revisionDesc>
<change xml:id="refBibs-istex" who="#ISTEX-API" when="2019-08-1">References added</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
</fulltext>
<metadata>
<istex:metadataXml wicri:clean="corpus acs not found" wicri:toSee="no header">
<istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration>
<istex:document>
<article specific-use="acs2jats-2.1.12" xml:lang="en" dtd-version="1.1">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">jo</journal-id>
<journal-id journal-id-type="coden">joceah</journal-id>
<journal-title-group>
<journal-title>The Journal of Organic Chemistry</journal-title>
<abbrev-journal-title>J. Org. Chem.</abbrev-journal-title>
</journal-title-group>
<issn publication-format="print">0022-3263</issn>
<publisher>
<publisher-name>American Chemical Society</publisher-name>
</publisher>
<self-uri xlink:type="simple">pubs.acs.org/joc</self-uri>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.1021/jo00258a009</article-id>
<article-categories>
<subj-group subj-group-type="document-type-name">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" xlink:type="simple">
<name name-style="western">
<surname>Tsujii</surname>
<given-names>Shinji</given-names>
</name>
</contrib>
<contrib contrib-type="author" xlink:type="simple">
<name name-style="western">
<surname>Rinehart</surname>
<given-names>Kenneth L.</given-names>
</name>
</contrib>
<contrib contrib-type="author" xlink:type="simple">
<name name-style="western">
<surname>Gunasekera</surname>
<given-names>Sarath P.</given-names>
</name>
</contrib>
<contrib contrib-type="author" xlink:type="simple">
<name name-style="western">
<surname>Kashman</surname>
<given-names>Yoel</given-names>
</name>
</contrib>
<contrib contrib-type="author" xlink:type="simple">
<name name-style="western">
<surname>Cross</surname>
<given-names>Susan S.</given-names>
</name>
</contrib>
<contrib contrib-type="author" xlink:type="simple">
<name name-style="western">
<surname>Lui</surname>
<given-names>May S.</given-names>
</name>
</contrib>
<contrib contrib-type="author" xlink:type="simple">
<name name-style="western">
<surname>Pomponi</surname>
<given-names>Shirley A.</given-names>
</name>
</contrib>
<contrib contrib-type="author" xlink:type="simple">
<name name-style="western">
<surname>Diaz</surname>
<given-names>M. Cristina</given-names>
</name>
</contrib>
</contrib-group>
<pub-date date-type="pub" publication-format="electronic">
<day>1</day>
<month>05</month>
<year>2002</year>
</pub-date>
<pub-date date-type="issue-pub">
<day>1</day>
<month>11</month>
<year>1988</year>
</pub-date>
<volume>53</volume>
<issue>23</issue>
<fpage>5446</fpage>
<lpage>5453</lpage>
<history></history>
<custom-meta-group>
<custom-meta xlink:type="simple">
<meta-name>document-id-backfile</meta-name>
<meta-value>jo00258a009</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</article>
</istex:document>
</istex:metadataXml>
<mods version="3.6">
<titleInfo>
<title>Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies</title>
</titleInfo>
<name type="personal">
<namePart type="family">TSUJII</namePart>
<namePart type="given">Shinji</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="family">RINEHART</namePart>
<namePart type="given">Kenneth L.</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="family">GUNASEKERA</namePart>
<namePart type="given">Sarath P.</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="family">KASHMAN</namePart>
<namePart type="given">Yoel</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="family">CROSS</namePart>
<namePart type="given">Susan S.</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="family">LUI</namePart>
<namePart type="given">May S.</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="family">POMPONI</namePart>
<namePart type="given">Shirley A.</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="family">DIAZ</namePart>
<namePart type="given">M. Cristina</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="Article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre>
<originInfo>
<publisher>American Chemical Society</publisher>
<dateIssued encoding="w3cdtf">1988-11-01</dateIssued>
</originInfo>
<relatedItem type="host">
<titleInfo>
<title>The Journal of Organic Chemistry</title>
</titleInfo>
<titleInfo type="abbreviated">
<title>J. Org. Chem.</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<identifier type="ISSN">0022-3263</identifier>
<identifier type="PublisherID">jo</identifier>
<identifier type="coden">JOCEAH</identifier>
<identifier type="uri">pubs.acs.org/joc</identifier>
<part>
<date>1988</date>
<detail type="volume">
<caption>vol.</caption>
<number>53</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>23</number>
</detail>
<extent unit="pages">
<start>5446</start>
<end>5453</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">8E6B2C49E31EF840C6E11F747D6B2D9FFCC4B490</identifier>
<identifier type="ark">ark:/67375/TPS-VGNL2D6B-T</identifier>
<identifier type="DOI">10.1021/jo00258a009</identifier>
<accessCondition type="use and reproduction" contentType="restricted">American Chemical Society. All rights reserved.</accessCondition>
<recordInfo>
<recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-X5HBJWF8-J">ACS</recordContentSource>
</recordInfo>
</mods>
<json:item>
<extension>json</extension>
<original>false</original>
<mimetype>application/json</mimetype>
<uri>https://api.istex.fr/ark:/67375/TPS-VGNL2D6B-T/record.json</uri>
</json:item>
</metadata>
<serie></serie>
</istex>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000337 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000337 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    CovidV1
   |flux=    Istex
   |étape=   Corpus
   |type=    RBID
   |clé=     ISTEX:8E6B2C49E31EF840C6E11F747D6B2D9FFCC4B490
   |texte=   Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies
}}

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Fri Mar 27 18:14:15 2020. Site generation: Sun Jan 31 15:15:08 2021