Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis
Identifieur interne : 000315 ( Istex/Corpus ); précédent : 000314; suivant : 000316Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis
Auteurs : Y. Fischer ; S. Ritz ; K. Weber ; C. Sauter-Louis ; K. HartmannSource :
- Journal of Veterinary Internal Medicine [ 0891-6640 ] ; 2011-11.
English descriptors
- Teeft :
- Alanine aminotransferase, Alkaline phosphatase, Automatic analyzer, Blood cells, Blood parameter, Brinogen levels, Cat, Control days, Cytokine, Decrease vasculitis, Feline, Feline coronavirus, General condition, Glucocorticoid, Glucocorticoid treatment, Hartmann, Infectious peritonitis, Intravascular coagulation, Leukemia virus, Median, Median survival, Median survival time, Molecular weight heparin, Neutrophil, Pentoxifylline, Peritonitis, Placebo, Placebo group, Present study, Product characteristics, Propentofylline, Randomized trial, Retrospective study, Room temperature, Sample diluent, Serum sample, Serum samples, Small animal biochemistry, Small animal medicine, Survival time, Time point, Total protein, Treatment initiation, Treatment option, Tumor necrosis factor, Vasculitis, White blood cells.
Abstract
Background: Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (FIP). Hypothesis: Propentofylline (PPF) can decrease vasculitis, and therefore prolong survival time in cats with FIP, and increase their quality of life. Animals: Twenty‐three privately owned cats with FIP. Methods: Placebo‐controlled double‐blind trial. FIP was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either PPF or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods. Results: There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4–10.6) versus placebo (7.5 days, 95% CI 4.4–9.6). The median survival time of all cats was 8 days (4–36 days). There was neither a difference in quality of life (day 7, P = .892), in the amount of effusion (day 7, P = .710), the tumor necrosis factor‐alpha (TNF‐α) concentration (day 7, P = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile. Conclusions and Clinical Importance: This study did not detect an effect of PPF on the survival time, the quality of life, or any clinical or laboratory parameter in cats with FIP. Therefore, PPF does not appear to be an effective treatment option in cats with a late stage of the disease FIP.
Url:
DOI: 10.1111/j.1939-1676.2011.00806.x
Links to Exploration step
ISTEX:5E3315B43CFA4A2F4E4750B1E5EFE7826467F8EFLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis</title><author><name sortKey="Fischer, Y" sort="Fischer, Y" uniqKey="Fischer Y" first="Y." last="Fischer">Y. Fischer</name><affiliation><mods:affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ritz, S" sort="Ritz, S" uniqKey="Ritz S" first="S." last="Ritz">S. Ritz</name><affiliation><mods:affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Weber, K" sort="Weber, K" uniqKey="Weber K" first="K." last="Weber">K. Weber</name><affiliation><mods:affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Sauter Ouis, C" sort="Sauter Ouis, C" uniqKey="Sauter Ouis C" first="C." last="Sauter-Louis">C. Sauter-Louis</name><affiliation><mods:affiliation>Clinic for Ruminants LMU, University of Munich, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hartmann, K" sort="Hartmann, K" uniqKey="Hartmann K" first="K." last="Hartmann">K. Hartmann</name><affiliation><mods:affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hartmann@lmu.de</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5E3315B43CFA4A2F4E4750B1E5EFE7826467F8EF</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.1939-1676.2011.00806.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-K03BGFLP-2/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000315</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000315</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis</title><author><name sortKey="Fischer, Y" sort="Fischer, Y" uniqKey="Fischer Y" first="Y." last="Fischer">Y. Fischer</name><affiliation><mods:affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ritz, S" sort="Ritz, S" uniqKey="Ritz S" first="S." last="Ritz">S. Ritz</name><affiliation><mods:affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Weber, K" sort="Weber, K" uniqKey="Weber K" first="K." last="Weber">K. Weber</name><affiliation><mods:affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Sauter Ouis, C" sort="Sauter Ouis, C" uniqKey="Sauter Ouis C" first="C." last="Sauter-Louis">C. Sauter-Louis</name><affiliation><mods:affiliation>Clinic for Ruminants LMU, University of Munich, Munich, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hartmann, K" sort="Hartmann, K" uniqKey="Hartmann K" first="K." last="Hartmann">K. Hartmann</name><affiliation><mods:affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hartmann@lmu.de</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Veterinary Internal Medicine</title><title level="j" type="alt">JOURNAL OF VETERINARY INTERNAL MEDICINE</title><idno type="ISSN">0891-6640</idno><idno type="eISSN">1939-1676</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1270">1270</biblScope><biblScope unit="page" to="1276">1276</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2011-11">2011-11</date></imprint><idno type="ISSN">0891-6640</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0891-6640</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Alanine aminotransferase</term><term>Alkaline phosphatase</term><term>Automatic analyzer</term><term>Blood cells</term><term>Blood parameter</term><term>Brinogen levels</term><term>Cat</term><term>Control days</term><term>Cytokine</term><term>Decrease vasculitis</term><term>Feline</term><term>Feline coronavirus</term><term>General condition</term><term>Glucocorticoid</term><term>Glucocorticoid treatment</term><term>Hartmann</term><term>Infectious peritonitis</term><term>Intravascular coagulation</term><term>Leukemia virus</term><term>Median</term><term>Median survival</term><term>Median survival time</term><term>Molecular weight heparin</term><term>Neutrophil</term><term>Pentoxifylline</term><term>Peritonitis</term><term>Placebo</term><term>Placebo group</term><term>Present study</term><term>Product characteristics</term><term>Propentofylline</term><term>Randomized trial</term><term>Retrospective study</term><term>Room temperature</term><term>Sample diluent</term><term>Serum sample</term><term>Serum samples</term><term>Small animal biochemistry</term><term>Small animal medicine</term><term>Survival time</term><term>Time point</term><term>Total protein</term><term>Treatment initiation</term><term>Treatment option</term><term>Tumor necrosis factor</term><term>Vasculitis</term><term>White blood cells</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (FIP). Hypothesis: Propentofylline (PPF) can decrease vasculitis, and therefore prolong survival time in cats with FIP, and increase their quality of life. Animals: Twenty‐three privately owned cats with FIP. Methods: Placebo‐controlled double‐blind trial. FIP was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either PPF or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods. Results: There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4–10.6) versus placebo (7.5 days, 95% CI 4.4–9.6). The median survival time of all cats was 8 days (4–36 days). There was neither a difference in quality of life (day 7, P = .892), in the amount of effusion (day 7, P = .710), the tumor necrosis factor‐alpha (TNF‐α) concentration (day 7, P = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile. Conclusions and Clinical Importance: This study did not detect an effect of PPF on the survival time, the quality of life, or any clinical or laboratory parameter in cats with FIP. Therefore, PPF does not appear to be an effective treatment option in cats with a late stage of the disease FIP.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>placebo</json:string><json:string>peritonitis</json:string><json:string>glucocorticoid</json:string><json:string>pentoxifylline</json:string><json:string>survival time</json:string><json:string>propentofylline</json:string><json:string>vasculitis</json:string><json:string>placebo group</json:string><json:string>feline</json:string><json:string>median survival time</json:string><json:string>median</json:string><json:string>neutrophil</json:string><json:string>cytokine</json:string><json:string>hartmann</json:string><json:string>present study</json:string><json:string>serum samples</json:string><json:string>treatment initiation</json:string><json:string>tumor necrosis factor</json:string><json:string>blood cells</json:string><json:string>alanine aminotransferase</json:string><json:string>brinogen levels</json:string><json:string>small animal medicine</json:string><json:string>general condition</json:string><json:string>small animal biochemistry</json:string><json:string>time point</json:string><json:string>cat</json:string><json:string>feline coronavirus</json:string><json:string>intravascular coagulation</json:string><json:string>infectious peritonitis</json:string><json:string>control days</json:string><json:string>automatic analyzer</json:string><json:string>randomized trial</json:string><json:string>molecular weight heparin</json:string><json:string>leukemia virus</json:string><json:string>white blood cells</json:string><json:string>alkaline phosphatase</json:string><json:string>total protein</json:string><json:string>serum sample</json:string><json:string>sample diluent</json:string><json:string>room temperature</json:string><json:string>treatment option</json:string><json:string>blood parameter</json:string><json:string>decrease vasculitis</json:string><json:string>median survival</json:string><json:string>glucocorticoid treatment</json:string><json:string>product characteristics</json:string><json:string>retrospective study</json:string></teeft></keywords><author><json:item><name>Y. Fischer</name><affiliations><json:string>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</json:string></affiliations></json:item><json:item><name>S. Ritz</name><affiliations><json:string>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</json:string></affiliations></json:item><json:item><name>K. Weber</name><affiliations><json:string>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</json:string></affiliations></json:item><json:item><name>C. Sauter‐Louis</name><affiliations><json:string>Clinic for Ruminants LMU, University of Munich, Munich, Germany</json:string></affiliations></json:item><json:item><name>K. Hartmann</name><affiliations><json:string>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</json:string><json:string>E-mail: hartmann@lmu.de</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>FIP</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Feline corona virus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Methylxanthine derivative</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Vasculitis</value></json:item></subject><articleId><json:string>JVIM806</json:string></articleId><arkIstex>ark:/67375/WNG-K03BGFLP-2</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Background: Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (FIP). Hypothesis: Propentofylline (PPF) can decrease vasculitis, and therefore prolong survival time in cats with FIP, and increase their quality of life. Animals: Twenty‐three privately owned cats with FIP. Methods: Placebo‐controlled double‐blind trial. FIP was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either PPF or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods. Results: There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4–10.6) versus placebo (7.5 days, 95% CI 4.4–9.6). The median survival time of all cats was 8 days (4–36 days). There was neither a difference in quality of life (day 7, P = .892), in the amount of effusion (day 7, P = .710), the tumor necrosis factor‐alpha (TNF‐α) concentration (day 7, P = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile. Conclusions and Clinical Importance: This study did not detect an effect of PPF on the survival time, the quality of life, or any clinical or laboratory parameter in cats with FIP. Therefore, PPF does not appear to be an effective treatment option in cats with a late stage of the disease FIP.</abstract><qualityIndicators><score>9.576</score><pdfWordCount>4744</pdfWordCount><pdfCharCount>31017</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>585.071 x 782.929 pts</pdfPageSize><pdfWordsPerPage>678</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>236</abstractWordCount><abstractCharCount>1540</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis</title><pmid><json:string>22092616</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Veterinary Internal Medicine</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1939-1676</json:string></doi><issn><json:string>0891-6640</json:string></issn><eissn><json:string>1939-1676</json:string></eissn><publisherId><json:string>JVIM</json:string></publisherId><volume>25</volume><issue>6</issue><pages><first>1270</first><last>1276</last><total>7</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Standard Article</value></json:item><json:item><value>Standard Articles</value></json:item></subject></host><namedEntities><unitex><date><json:string>2011-08-29</json:string><json:string>between April 2009 and December 2010</json:string></date><geogName></geogName><orgName><json:string>Bio Tek Germany, Bad Friedrichshall, Germany</json:string><json:string>American College of Veterinary Internal Medicine</json:string><json:string>PAA Laboratories</json:string><json:string>University of Munich</json:string><json:string>US, Bridgewater, NJ Feline Leukemia Virus Antigen/Feline Immunode</json:string><json:string>Abott Laboratories</json:string><json:string>D Systems, Inc, Minneapolis</json:string><json:string>University of Munich, Germany</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Katrin Hartmann</json:string><json:string>K. Weber</json:string><json:string>C. Sauter-Louis</json:string><json:string>S. Ritz</json:string><json:string>Hartmann Background</json:string></persName><placeName><json:string>Berlin</json:string><json:string>Germany</json:string><json:string>Kiel</json:string><json:string>Munich</json:string><json:string>Burgdorf</json:string><json:string>Lichtenstein</json:string><json:string>Worrstadt</json:string></placeName><ref_url><json:string>http://www.spss.com</json:string><json:string>http://www.ncss</json:string><json:string>http://www.VIN.com</json:string></ref_url><ref_bibl><json:string>Fischer et al</json:string><json:string>Ritz et al</json:string><json:string>Ritz et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-K03BGFLP-2</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - veterinary sciences</json:string></wos><scienceMetrix><json:string>1 - applied sciences</json:string><json:string>2 - agriculture, fisheries & forestry</json:string><json:string>3 - veterinary sciences</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Veterinary</json:string><json:string>3 - General Veterinary</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1111/j.1939-1676.2011.00806.x</json:string></doi><id>5E3315B43CFA4A2F4E4750B1E5EFE7826467F8EF</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-K03BGFLP-2/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-K03BGFLP-2/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-K03BGFLP-2/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-QW5Q88H5-V">Wiley Publishing Ltd</publisher><availability><licence>Copyright © 2011 by the American College of Veterinary Internal Medicine</licence></availability><date type="published" when="2011-11"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis</title><author xml:id="author-0000"><persName><forename type="first">Y.</forename><surname>Fischer</surname></persName><affiliation><orgName type="institution">Clinic of Small Animal Medicine</orgName>
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<country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><idno type="istex">5E3315B43CFA4A2F4E4750B1E5EFE7826467F8EF</idno><idno type="ark">ark:/67375/WNG-K03BGFLP-2</idno><idno type="DOI">10.1111/j.1939-1676.2011.00806.x</idno><idno type="unit">JVIM806</idno><idno type="toTypesetVersion">file:JVIM.JVIM806.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Veterinary Internal Medicine</title><title level="j" type="alt">JOURNAL OF VETERINARY INTERNAL MEDICINE</title><idno type="pISSN">0891-6640</idno><idno type="eISSN">1939-1676</idno><idno type="book-DOI">10.1111/(ISSN)1939-1676</idno><idno type="book-part-DOI">10.1111/jvim.2011.25.issue-6</idno><idno type="product">JVIM</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1270">1270</biblScope><biblScope unit="page" to="1276">1276</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2011-11"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main" xml:id="jvim806-abs-0001"><head>Background</head><p>Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (<hi rend="fc">FIP</hi>).</p><head>Hypothesis</head><p>Propentofylline (<hi rend="fc">PPF</hi>) can decrease vasculitis, and therefore prolong survival time in cats with <hi rend="fc">FIP</hi>, and increase their quality of life.</p><head>Animals</head><p>Twenty‐three privately owned cats with <hi rend="fc">FIP</hi>.</p><head>Methods</head><p>Placebo‐controlled double‐blind trial. <hi rend="fc">FIP</hi> was confirmed by histology or immunostaining of feline coronavirus (<hi rend="fc">FC</hi>oV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either <hi rend="fc">PPF</hi> or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods.</p><head>Results</head><p>There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4–10.6) versus placebo (7.5 days, 95% CI 4.4–9.6). The median survival time of all cats was 8 days (4–36 days). There was neither a difference in quality of life (day 7, <hi rend="italic">P</hi> = .892), in the amount of effusion (day 7, <hi rend="italic">P</hi> = .710), the tumor necrosis factor‐alpha (<hi rend="fc">TNF</hi>‐α) concentration (day 7, <hi rend="italic">P</hi> = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile.</p><head>Conclusions and Clinical Importance</head><p>This study did not detect an effect of <hi rend="fc">PPF</hi> on the survival time, the quality of life, or any clinical or laboratory parameter in cats with <hi rend="fc">FIP</hi>. Therefore, <hi rend="fc">PPF</hi> does not appear to be an effective treatment option in cats with a late stage of the disease <hi rend="fc">FIP</hi>.</p></abstract><textClass><keywords><term xml:id="jvim806-kwd-0001"><hi rend="fc">FIP</hi></term><term xml:id="jvim806-kwd-0002">Feline corona virus</term><term xml:id="jvim806-kwd-0003">Methylxanthine derivative</term><term xml:id="jvim806-kwd-0004">Vasculitis</term></keywords><keywords rend="articleCategory"><term>Standard Article</term></keywords><keywords rend="tocHeading1"><term>Standard Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-K03BGFLP-2/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="jvim806" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1939-1676</doi><issn type="print">0891-6640</issn><issn type="electronic">1939-1676</issn><idGroup><id type="product" value="JVIM"></id></idGroup><titleGroup><title sort="JOURNAL OF VETERINARY INTERNAL MEDICINE" type="main">Journal of Veterinary Internal Medicine</title><title type="short">J Vet Intern Med</title></titleGroup></publicationMeta><publicationMeta level="part" position="11106"><doi origin="wiley">10.1111/jvim.2011.25.issue-6</doi><copyright ownership="thirdParty">© 2011 American College of Veterinary Internal Medicine</copyright><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2011-11">November-December 2011</coverDate></publicationMeta><publicationMeta level="unit" position="10" status="forIssue" type="article"><doi>10.1111/j.1939-1676.2011.00806.x</doi><idGroup><id type="unit" value="JVIM806"></id></idGroup><countGroup><count number="7" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Standard Article</title><title type="tocHeading1">Standard Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 by the American College of Veterinary Internal Medicine</copyright><eventGroup><event date="2011-04-20" type="manuscriptReceived"></event><event date="2011-06-14" type="manuscriptRevised"></event><event date="2011-08-15" type="manuscriptAccepted"></event><event agent="SPS" date="2011-08-29" type="xmlCreated"></event><event agent="SPS" date="2011-10-17" type="xmlCorrected"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-10-12"></event><event type="firstOnline" date="2011-10-12"></event><event type="publishedOnlineFinalForm" date="2011-11-16"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1270</numbering><numbering type="pageLast">1276</numbering></numberingGroup><correspondenceTo>Corresponding author: Katrin Hartmann, Clinic of Small Animal Medicine, LMU University of Munich, Veterinaerstrasse 13, 80539 Munich, Germany; e‐mail: <email>hartmann@lmu.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JVIM.JVIM806.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis</title><title type="shortAuthors">Fischer et al</title></titleGroup><creators><creator affiliationRef="#jvim806-aff-0001" creatorRole="author" xml:id="jvim806-cr-0001"><personName><givenNames>Y.</givenNames> <familyName>Fischer</familyName></personName></creator><creator affiliationRef="#jvim806-aff-0001" creatorRole="author" xml:id="jvim806-cr-0002"><personName><givenNames>S.</givenNames> <familyName>Ritz</familyName></personName></creator><creator affiliationRef="#jvim806-aff-0001" creatorRole="author" xml:id="jvim806-cr-0003"><personName><givenNames>K.</givenNames> <familyName>Weber</familyName></personName></creator><creator affiliationRef="#jvim806-aff-0002" creatorRole="author" xml:id="jvim806-cr-0004"><personName><givenNames>C.</givenNames> <familyName>Sauter‐Louis</familyName></personName></creator><creator affiliationRef="#jvim806-aff-0001" corresponding="yes" creatorRole="author" xml:id="jvim806-cr-0005"><personName><givenNames>K.</givenNames> <familyName>Hartmann</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="DE" type="organization" xml:id="jvim806-aff-0001"><orgName>Clinic of Small Animal Medicine</orgName> <orgName>University of Munich</orgName> <address><city>Munich</city> <country>Germany</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="jvim806-aff-0002"><orgName>Clinic for Ruminants LMU</orgName> <orgName>University of Munich</orgName> <address><city>Munich</city> <country>Germany</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jvim806-kwd-0001"><fc>FIP</fc></keyword><keyword xml:id="jvim806-kwd-0002">Feline corona virus</keyword><keyword xml:id="jvim806-kwd-0003">Methylxanthine derivative</keyword><keyword xml:id="jvim806-kwd-0004">Vasculitis</keyword></keywordGroup><fundingInfo><fundingAgency>Intervet Deutschland GmbH</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="jvim806-abs-0001"><section xml:id="jvim806-sec-0001"><title type="main">Background</title><p>Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (<fc>FIP</fc>).</p></section><section xml:id="jvim806-sec-0002"><title type="main">Hypothesis</title><p>Propentofylline (<fc>PPF</fc>) can decrease vasculitis, and therefore prolong survival time in cats with <fc>FIP</fc>, and increase their quality of life.</p></section><section xml:id="jvim806-sec-0003"><title type="main">Animals</title><p>Twenty‐three privately owned cats with <fc>FIP</fc>.</p></section><section xml:id="jvim806-sec-0004"><title type="main">Methods</title><p>Placebo‐controlled double‐blind trial. <fc>FIP</fc> was confirmed by histology or immunostaining of feline coronavirus (<fc>FC</fc>oV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either <fc>PPF</fc> or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods.</p></section><section xml:id="jvim806-sec-0005"><title type="main">Results</title><p>There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4–10.6) versus placebo (7.5 days, 95% CI 4.4–9.6). The median survival time of all cats was 8 days (4–36 days). There was neither a difference in quality of life (day 7, <i>P</i> = .892), in the amount of effusion (day 7, <i>P</i> = .710), the tumor necrosis factor‐alpha (<fc>TNF</fc>‐α) concentration (day 7, <i>P</i> = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile.</p></section><section xml:id="jvim806-sec-0006"><title type="main">Conclusions and Clinical Importance</title><p>This study did not detect an effect of <fc>PPF</fc> on the survival time, the quality of life, or any clinical or laboratory parameter in cats with <fc>FIP</fc>. Therefore, <fc>PPF</fc> does not appear to be an effective treatment option in cats with a late stage of the disease <fc>FIP</fc>.</p></section></abstract></abstractGroup></contentMeta><noteGroup xml:id="jvim806-ntgp-0001"><note numbered="no" xml:id="jvim806-note-0001">This study was performed at the Clinic of Small Animal Medicine, LMU University of Munich, Munich, Germany.</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Randomized, Placebo Controlled Study of the Effect of Propentofylline on Survival Time and Quality of Life of Cats with Feline Infectious Peritonitis</title></titleInfo><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Fischer</namePart><affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Ritz</namePart><affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Weber</namePart><affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Sauter‐Louis</namePart><affiliation>Clinic for Ruminants LMU, University of Munich, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Hartmann</namePart><affiliation>Clinic of Small Animal Medicine, University of Munich, Munich, Germany</affiliation><affiliation>E-mail: hartmann@lmu.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2011-11</dateIssued><dateCreated encoding="w3cdtf">2011-08-29</dateCreated><dateCaptured encoding="w3cdtf">2011-04-20</dateCaptured><dateValid encoding="w3cdtf">2011-08-15</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Background: Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (FIP). Hypothesis: Propentofylline (PPF) can decrease vasculitis, and therefore prolong survival time in cats with FIP, and increase their quality of life. Animals: Twenty‐three privately owned cats with FIP. Methods: Placebo‐controlled double‐blind trial. FIP was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either PPF or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods. Results: There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4–10.6) versus placebo (7.5 days, 95% CI 4.4–9.6). The median survival time of all cats was 8 days (4–36 days). There was neither a difference in quality of life (day 7, P = .892), in the amount of effusion (day 7, P = .710), the tumor necrosis factor‐alpha (TNF‐α) concentration (day 7, P = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile. Conclusions and Clinical Importance: This study did not detect an effect of PPF on the survival time, the quality of life, or any clinical or laboratory parameter in cats with FIP. 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