Distemper‐like disease in Harbor Seals: Virus Isolation, further Pathologic and Serologic Findings
Identifieur interne : 000299 ( Istex/Corpus ); précédent : 000298; suivant : 000300Distemper‐like disease in Harbor Seals: Virus Isolation, further Pathologic and Serologic Findings
Auteurs : R. Hofmeister ; E. Breuer ; R. Ernst ; J. Hentschke ; G. Mölle ; H. LudwigSource :
- Journal of Veterinary Medicine, Series B [ 0931-1793 ] ; 1988-01-12.
English descriptors
- Teeft :
- Academic press, Acta neuropathol, Breuer, Canine, Canine distemper encephalitis, Canine distemper virus, Canine virus, Cerebellar folia, Dead seals, Distemper, Ecological factors, Freie universitat berlin, Further interdisciplinary investigations, Harbor seals, Hentschke, Hofmeister, Monoclonal, Monoclonal antibody, Organ sections, Osterhaus, Personal communication, Phoca vitulina, Polyclonal, Present deaths, Primary cause, Qualitative sense, Serologic, Serologic findings, Spinal cord, Supernatant fluid, Total number, Vero, Vero cell cultures, Vero cells, Virus isolation, White matter.
Abstract
Pathologic‐histologic and immunocytologic as well as serologic findings from a total number of 50 recently dead or euthanatized moribund harbor seals (Phoca vitulina) are described. In 14 of 31 histologically examined brains of affected seals alterations corresponding to canine distemper encephalitis (CDE) were found. Immunofluorescence‐serologic tests using polyclonal as well as monoclonal antibodies against canine distemper virus (CDV) resulted in positive findings in organ sections of 24 dead seals. An agent was isolated from organs of dead seals and subjected to several passages in vero cell cultures as well as in primary seal lung‐cell cultures. The agent was able to be identified as canine distemper‐like virus with both antibodies. CDV neutralising serum‐antibodies were detected in 13 out of 19 serum specimens. Further interdisciplinary investigations are required to determine whether the virus induced alterations — still to be interpretated only in a purely qualitative sense — should be considered as the manifestation of contributing ecological factors, or as the primary cause of the still present deaths of harbor seals.
Staupeähnliche Erkrankung beim Seehund: Virusisolierung, weitere pathologische und serologische Untersuchungsergebnisse Es werden pathologisch‐histologische, immunozytologische sowie serologische Untersuchungsergebnisse von insgesamt 50 frischtoten oder moribund euthanasierten Seehunden (Phoca vitulina) beschrieben. In 14 der 31 histologisch untersuchten Gehirne finden sich der caninen Staupeenzephalitis (CDE) entsprechende morphologische Veränderungen. Unter Verwendung eines polyklonalen (CDV Gamakon) sowie eines monoklonalen (D 110) Antikörpers gegen CDV wird bei immunozytologischen Untersuchungen an Organschnitten in 24 Fällen CDV‐Antigen nachgewiesen. Sowohl in Vero‐Zellen als auch in primären Seehundslungenzellkulturen gelingt die Isolierung eines Agens, das mit beiden Antikörpern als CDV‐ähnlich identifiziert werden kann. In 13 von 19 Fällen werden im Mikroneutralisationstest CDV neutralisierende Antikörper mit einem Titer ≥ 1:10 nachgewiesen. Weitere interdisziplinäre Untersuchungen sind erforderlich, um abschätzen zu können, ob die derzeit noch rein qualitativ zu verstehenden Ergebnisse Ausdruck begünstigender ökologischer Faktoren oder primäre Ursache des aktuellen Seehundsterbens sind.
Url:
DOI: 10.1111/j.1439-0450.1988.tb00557.x
Links to Exploration step
ISTEX:5BDA8FB39F9CD9E70085DBFB9DBC963F1B1CB3B0Le document en format XML
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In 14 of 31 histologically examined brains of affected seals alterations corresponding to canine distemper encephalitis (CDE) were found. Immunofluorescence‐serologic tests using polyclonal as well as monoclonal antibodies against canine distemper virus (CDV) resulted in positive findings in organ sections of 24 dead seals. An agent was isolated from organs of dead seals and subjected to several passages in vero cell cultures as well as in primary seal lung‐cell cultures. The agent was able to be identified as canine distemper‐like virus with both antibodies. CDV neutralising serum‐antibodies were detected in 13 out of 19 serum specimens. Further interdisciplinary investigations are required to determine whether the virus induced alterations — still to be interpretated only in a purely qualitative sense — should be considered as the manifestation of contributing ecological factors, or as the primary cause of the still present deaths of harbor seals.</div><div type="abstract" xml:lang="de">Staupeähnliche Erkrankung beim Seehund: Virusisolierung, weitere pathologische und serologische Untersuchungsergebnisse Es werden pathologisch‐histologische, immunozytologische sowie serologische Untersuchungsergebnisse von insgesamt 50 frischtoten oder moribund euthanasierten Seehunden (Phoca vitulina) beschrieben. In 14 der 31 histologisch untersuchten Gehirne finden sich der caninen Staupeenzephalitis (CDE) entsprechende morphologische Veränderungen. Unter Verwendung eines polyklonalen (CDV Gamakon) sowie eines monoklonalen (D 110) Antikörpers gegen CDV wird bei immunozytologischen Untersuchungen an Organschnitten in 24 Fällen CDV‐Antigen nachgewiesen. Sowohl in Vero‐Zellen als auch in primären Seehundslungenzellkulturen gelingt die Isolierung eines Agens, das mit beiden Antikörpern als CDV‐ähnlich identifiziert werden kann. In 13 von 19 Fällen werden im Mikroneutralisationstest CDV neutralisierende Antikörper mit einem Titer ≥ 1:10 nachgewiesen. Weitere interdisziplinäre Untersuchungen sind erforderlich, um abschätzen zu können, ob die derzeit noch rein qualitativ zu verstehenden Ergebnisse Ausdruck begünstigender ökologischer Faktoren oder primäre Ursache des aktuellen Seehundsterbens sind.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>harbor seals</json:string><json:string>distemper</json:string><json:string>canine</json:string><json:string>monoclonal</json:string><json:string>hentschke</json:string><json:string>osterhaus</json:string><json:string>monoclonal antibody</json:string><json:string>polyclonal</json:string><json:string>canine virus</json:string><json:string>serologic</json:string><json:string>hofmeister</json:string><json:string>canine distemper virus</json:string><json:string>vero cells</json:string><json:string>white matter</json:string><json:string>virus isolation</json:string><json:string>dead seals</json:string><json:string>personal communication</json:string><json:string>breuer</json:string><json:string>vero cell cultures</json:string><json:string>phoca vitulina</json:string><json:string>further interdisciplinary investigations</json:string><json:string>qualitative sense</json:string><json:string>ecological factors</json:string><json:string>primary cause</json:string><json:string>present deaths</json:string><json:string>freie universitat berlin</json:string><json:string>organ sections</json:string><json:string>serologic findings</json:string><json:string>spinal cord</json:string><json:string>supernatant fluid</json:string><json:string>canine distemper encephalitis</json:string><json:string>total number</json:string><json:string>cerebellar folia</json:string><json:string>acta neuropathol</json:string><json:string>academic press</json:string><json:string>vero</json:string></teeft></keywords><author><json:item><name>R. Hofmeister</name><affiliations><json:string>Institute of Veterinary Pathology, Universität Berlin</json:string><json:string>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</json:string></affiliations></json:item><json:item><name>E. Breuer</name><affiliations><json:string>Institute of Veterinary Pathology, Universität Berlin</json:string><json:string>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</json:string></affiliations></json:item><json:item><name>R. Ernst</name><affiliations><json:string>Institute of Veterinary Pathology, Universität Berlin</json:string><json:string>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</json:string></affiliations></json:item><json:item><name>J. Hentschke</name><affiliations><json:string>Landesuntersuchungsinstitut für Lebensmittel, Arzneimittel und Tierseuchen Berlin</json:string><json:string>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</json:string></affiliations></json:item><json:item><name>G. Mölle</name><affiliations><json:string>Landesuntersuchungsinstitut für Lebensmittel, Arzneimittel und Tierseuchen Berlin</json:string><json:string>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</json:string></affiliations></json:item><json:item><name>H. Ludwig</name><affiliations><json:string>Institute of Virology of the Freie Universität Berlin</json:string><json:string>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Harbor seal</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>canine distemper encephalitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>canine distemper‐like virus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>CDV neutralizing antibodies</value></json:item></subject><articleId><json:string>ZPH557</json:string></articleId><arkIstex>ark:/67375/WNG-G2WP2LP6-N</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>shortCommunication</json:string></originalGenre><abstract>Pathologic‐histologic and immunocytologic as well as serologic findings from a total number of 50 recently dead or euthanatized moribund harbor seals (Phoca vitulina) are described. In 14 of 31 histologically examined brains of affected seals alterations corresponding to canine distemper encephalitis (CDE) were found. Immunofluorescence‐serologic tests using polyclonal as well as monoclonal antibodies against canine distemper virus (CDV) resulted in positive findings in organ sections of 24 dead seals. An agent was isolated from organs of dead seals and subjected to several passages in vero cell cultures as well as in primary seal lung‐cell cultures. The agent was able to be identified as canine distemper‐like virus with both antibodies. CDV neutralising serum‐antibodies were detected in 13 out of 19 serum specimens. Further interdisciplinary investigations are required to determine whether the virus induced alterations — still to be interpretated only in a purely qualitative sense — should be considered as the manifestation of contributing ecological factors, or as the primary cause of the still present deaths of harbor seals.</abstract><qualityIndicators><score>5.557</score><pdfWordCount>1541</pdfWordCount><pdfCharCount>10521</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>450 x 684 pts</pdfPageSize><pdfWordsPerPage>308</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>168</abstractWordCount><abstractCharCount>1145</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Distemper‐like disease in Harbor Seals: Virus Isolation, further Pathologic and Serologic Findings</title><genre><json:string>brief-communication</json:string></genre><host><title>Journal of Veterinary Medicine, Series 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Summary</head><p>Pathologic‐histologic and immunocytologic as well as serologic findings from a total number of 50 recently dead or euthanatized moribund harbor seals (<hi rend="italic">Phoca vitulina</hi>) are described. In 14 of 31 histologically examined brains of affected seals alterations corresponding to canine distemper encephalitis (CDE) were found. Immunofluorescence‐serologic tests using polyclonal as well as monoclonal antibodies against canine distemper virus (CDV) resulted in positive findings in organ sections of 24 dead seals. An agent was isolated from organs of dead seals and subjected to several passages in vero cell cultures as well as in primary seal lung‐cell cultures. The agent was able to be identified as canine distemper‐like virus with both antibodies.</p><p>CDV neutralising serum‐antibodies were detected in 13 out of 19 serum specimens.</p><p>Further interdisciplinary investigations are required to determine whether the virus induced alterations — still to be interpretated only in a purely qualitative sense — should be considered as the manifestation of contributing ecological factors, or as the primary cause of the still present deaths of harbor seals.</p><head>Zusammenfassung</head><p>Staupeähnliche Erkrankung beim Seehund: Virusisolierung, weitere pathologische und serologische Untersuchungsergebnisse</p><p>Es werden pathologisch‐histologische, immunozytologische sowie serologische Untersuchungsergebnisse von insgesamt 50 frischtoten oder moribund euthanasierten Seehunden (<hi rend="italic">Phoca vitulina</hi>) beschrieben.</p><p>In 14 der 31 histologisch untersuchten Gehirne finden sich der caninen Staupeenzephalitis (CDE) entsprechende morphologische Veränderungen. Unter Verwendung eines polyklonalen (CDV Gamakon) sowie eines monoklonalen (D 110) Antikörpers gegen CDV wird bei immunozytologischen Untersuchungen an Organschnitten in 24 Fällen CDV‐Antigen nachgewiesen. Sowohl in Vero‐Zellen als auch in primären Seehundslungenzellkulturen gelingt die Isolierung eines Agens, das mit beiden Antikörpern als CDV‐ähnlich identifiziert werden kann. In 13 von 19 Fällen werden im Mikroneutralisationstest CDV neutralisierende Antikörper mit einem Titer ≥ 1:10 nachgewiesen. Weitere interdisziplinäre Untersuchungen sind erforderlich, um abschätzen zu können, ob die derzeit noch rein qualitativ zu verstehenden Ergebnisse Ausdruck begünstigender ökologischer Faktoren oder primäre Ursache des aktuellen Seehundsterbens sind.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Harbor seal</term><term xml:id="k2">canine distemper encephalitis</term><term xml:id="k3">canine distemper‐like virus</term><term xml:id="k4">CDV neutralizing antibodies</term></keywords><keywords rend="tocHeading1"><term>Short Communication</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-G2WP2LP6-N/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1439-0450</doi><issn type="print">0931-1793</issn><issn type="electronic">1439-0450</issn><idGroup><id type="product" value="ZPH"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF VETERINARY MEDICINE SERIES B">Journal of Veterinary Medicine, Series B</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/zph.1988.35.issue-1-10</doi><numberingGroup><numbering type="journalVolume" number="35">35</numbering><numbering type="journalIssue">1‐10</numbering></numberingGroup><coverDate startDate="1988-01-12">January‐December 1988</coverDate></publicationMeta><publicationMeta level="unit" type="shortCommunication" position="99" status="forIssue"><doi origin="wiley">10.1111/j.1439-0450.1988.tb00557.x</doi><idGroup><id type="unit" value="ZPH557"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Short Communication</title></titleGroup><copyright>© 1988 Blackwell Verlag GmbH</copyright><eventGroup><event type="firstOnline" date="2010-05-13"></event><event type="publishedOnlineFinalForm" date="2010-05-13"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G 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disease in Harbor Seals: Virus Isolation, further Pathologic and Serologic Findings<link href="#fn1">*</link></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>R.</givenNames><familyName>Hofmeister</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1" corresponding="yes"><personName><givenNames>E.</givenNames><familyName>Breuer</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1" corresponding="yes"><personName><givenNames>R.</givenNames><familyName>Ernst</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3" corresponding="yes"><personName><givenNames>J.</givenNames><familyName>Hentschke</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a3" corresponding="yes"><personName><givenNames>G.</givenNames><familyName>Mölle</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2" corresponding="yes"><personName><givenNames>H.</givenNames><familyName>Ludwig</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Institute of Veterinary Pathology, Universität Berlin</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Institute of Virology of the Freie Universität Berlin</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Landesuntersuchungsinstitut für Lebensmittel, Arzneimittel und Tierseuchen Berlin</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Harbor seal</keyword><keyword xml:id="k2">canine distemper encephalitis</keyword><keyword xml:id="k3">canine distemper‐like virus</keyword><keyword xml:id="k4">CDV neutralizing antibodies</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><section xml:id="abs1-1"><title type="main">Summary</title><p>Pathologic‐histologic and immunocytologic as well as serologic findings from a total number of 50 recently dead or euthanatized moribund harbor seals (<i>Phoca vitulina</i>) are described. In 14 of 31 histologically examined brains of affected seals alterations corresponding to canine distemper encephalitis (CDE) were found. Immunofluorescence‐serologic tests using polyclonal as well as monoclonal antibodies against canine distemper virus (CDV) resulted in positive findings in organ sections of 24 dead seals. An agent was isolated from organs of dead seals and subjected to several passages in vero cell cultures as well as in primary seal lung‐cell cultures. The agent was able to be identified as canine distemper‐like virus with both antibodies.</p><p>CDV neutralising serum‐antibodies were detected in 13 out of 19 serum specimens.</p><p>Further interdisciplinary investigations are required to determine whether the virus induced alterations — still to be interpretated only in a purely qualitative sense — should be considered as the manifestation of contributing ecological factors, or as the primary cause of the still present deaths of harbor seals.</p></section><section xml:id="abs1-2"><title type="main">Zusammenfassung</title><p>Staupeähnliche Erkrankung beim Seehund: Virusisolierung, weitere pathologische und serologische Untersuchungsergebnisse</p><p>Es werden pathologisch‐histologische, immunozytologische sowie serologische Untersuchungsergebnisse von insgesamt 50 frischtoten oder moribund euthanasierten Seehunden (<i>Phoca vitulina</i>) beschrieben.</p><p>In 14 der 31 histologisch untersuchten Gehirne finden sich der caninen Staupeenzephalitis (CDE) entsprechende morphologische Veränderungen. Unter Verwendung eines polyklonalen (CDV Gamakon) sowie eines monoklonalen (D 110) Antikörpers gegen CDV wird bei immunozytologischen Untersuchungen an Organschnitten in 24 Fällen CDV‐Antigen nachgewiesen. Sowohl in Vero‐Zellen als auch in primären Seehundslungenzellkulturen gelingt die Isolierung eines Agens, das mit beiden Antikörpern als CDV‐ähnlich identifiziert werden kann. In 13 von 19 Fällen werden im Mikroneutralisationstest CDV neutralisierende Antikörper mit einem Titer ≥ 1:10 nachgewiesen. Weitere interdisziplinäre Untersuchungen sind erforderlich, um abschätzen zu können, ob die derzeit noch rein qualitativ zu verstehenden Ergebnisse Ausdruck begünstigender ökologischer Faktoren oder primäre Ursache des aktuellen Seehundsterbens sind.</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>*</label><p>These studies have been conducted with support from the German Federal Minister for Environment, Nature Conservation and Nuclear Safety. Forschungsvorh. Nr.: 10805015</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Distemper‐like disease in Harbor Seals: Virus Isolation, further Pathologic and Serologic Findings</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Distemper‐like disease in Harbor Seals: Virus Isolation, further Pathologic and Serologic Findings*</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Hofmeister</namePart><affiliation>Institute of Veterinary Pathology, Universität Berlin</affiliation><affiliation>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Breuer</namePart><affiliation>Institute of Veterinary Pathology, Universität Berlin</affiliation><affiliation>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Ernst</namePart><affiliation>Institute of Veterinary Pathology, Universität Berlin</affiliation><affiliation>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Hentschke</namePart><affiliation>Landesuntersuchungsinstitut für Lebensmittel, Arzneimittel und Tierseuchen Berlin</affiliation><affiliation>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Mölle</namePart><affiliation>Landesuntersuchungsinstitut für Lebensmittel, Arzneimittel und Tierseuchen Berlin</affiliation><affiliation>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Ludwig</namePart><affiliation>Institute of Virology of the Freie Universität Berlin</affiliation><affiliation>Correspondence address: Institute of Veterinary Pathology, Freie Universität Berlin, Str. 518, Nr. 15, D‐1000 Berlin 37, FRG</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="shortCommunication" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1988-01-12</dateIssued><edition>Received for publication October 26, 1988</edition><copyrightDate encoding="w3cdtf">1988</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">14</extent><extent unit="linksCrossRef">13</extent></physicalDescription><abstract lang="en">Pathologic‐histologic and immunocytologic as well as serologic findings from a total number of 50 recently dead or euthanatized moribund harbor seals (Phoca vitulina) are described. In 14 of 31 histologically examined brains of affected seals alterations corresponding to canine distemper encephalitis (CDE) were found. Immunofluorescence‐serologic tests using polyclonal as well as monoclonal antibodies against canine distemper virus (CDV) resulted in positive findings in organ sections of 24 dead seals. An agent was isolated from organs of dead seals and subjected to several passages in vero cell cultures as well as in primary seal lung‐cell cultures. The agent was able to be identified as canine distemper‐like virus with both antibodies. CDV neutralising serum‐antibodies were detected in 13 out of 19 serum specimens. Further interdisciplinary investigations are required to determine whether the virus induced alterations — still to be interpretated only in a purely qualitative sense — should be considered as the manifestation of contributing ecological factors, or as the primary cause of the still present deaths of harbor seals.</abstract><abstract lang="de">Staupeähnliche Erkrankung beim Seehund: Virusisolierung, weitere pathologische und serologische Untersuchungsergebnisse Es werden pathologisch‐histologische, immunozytologische sowie serologische Untersuchungsergebnisse von insgesamt 50 frischtoten oder moribund euthanasierten Seehunden (Phoca vitulina) beschrieben. In 14 der 31 histologisch untersuchten Gehirne finden sich der caninen Staupeenzephalitis (CDE) entsprechende morphologische Veränderungen. Unter Verwendung eines polyklonalen (CDV Gamakon) sowie eines monoklonalen (D 110) Antikörpers gegen CDV wird bei immunozytologischen Untersuchungen an Organschnitten in 24 Fällen CDV‐Antigen nachgewiesen. Sowohl in Vero‐Zellen als auch in primären Seehundslungenzellkulturen gelingt die Isolierung eines Agens, das mit beiden Antikörpern als CDV‐ähnlich identifiziert werden kann. In 13 von 19 Fällen werden im Mikroneutralisationstest CDV neutralisierende Antikörper mit einem Titer ≥ 1:10 nachgewiesen. Weitere interdisziplinäre Untersuchungen sind erforderlich, um abschätzen zu können, ob die derzeit noch rein qualitativ zu verstehenden Ergebnisse Ausdruck begünstigender ökologischer Faktoren oder primäre Ursache des aktuellen Seehundsterbens sind.</abstract><note type="content">*These studies have been conducted with support from the German Federal Minister for Environment, Nature Conservation and Nuclear Safety. Forschungsvorh. Nr.: 10805015</note><subject lang="en"><genre>keywords</genre><topic>Harbor seal</topic><topic>canine distemper encephalitis</topic><topic>canine distemper‐like virus</topic><topic>CDV neutralizing antibodies</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Veterinary Medicine, Series B</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0931-1793</identifier><identifier type="eISSN">1439-0450</identifier><identifier type="DOI">10.1111/(ISSN)1439-0450</identifier><identifier type="PublisherID">ZPH</identifier><part><date>1988</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><detail type="issue"><caption>no.</caption><number>1‐10</number></detail><extent unit="pages"><start>765</start><end>769</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Pathogenesis of canine distemper</title></titleInfo><name type="personal"><namePart type="given">M.J.G.</namePart><namePart type="family">Appel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Appel, M.J.G., 1969: Pathogenesis of canine distemper. 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