Clinical and genetic features of human metapneumovirus infection in children
Identifieur interne : 000261 ( Istex/Corpus ); précédent : 000260; suivant : 000262Clinical and genetic features of human metapneumovirus infection in children
Auteurs : Ji Young Park ; Ki Wook Yun ; Jae Woo Lim ; Mi Kyung Lee ; In Seok Lim ; Eung Sang ChoiSource :
- Pediatrics International [ 1328-8067 ] ; 2016-01.
Abstract
Background: Human metapneumovirus (hMPV) is one of the main pathogens responsible for respiratory tract infection in children. Methods: From 2011 to 2013, nasopharyngeal aspirates were obtained from Korean children and tested for hMPV on reverse transcription–polymerase chain reaction (RT‐PCR). The genotype of hMPV in each sample was identified on PCR‐restriction length polymorphism analysis of the fusion gene. We divided patients into three groups according to degree of fever. Patients with fever peaking at >39.5°C or lasting >7 days were classified as the high fever (HF) group; those with fevers peaking at <38.5°C and lasting <72 h were classified as the low fever (LF) group; and the other subjects were classified as the moderate fever group. Results: Among 457 samples positive for hMPV, hMPV genotype was able to be identified in 399 (87.3%); of these, A2a was found in 97 (24.3%), B1 in 186 (46.6%), and B2 in 116 (29.1%). Clinical features of hMPV infection were compared between the HF and LF groups. We classified 80 subjects into the HF group and 84 subjects into the LF group. Mean absolute neutrophil count (5625 ± 4418 vs 4072 ± 3076/μL, P = 0.010) and C‐reactive protein (2.39 ± 3.39 vs 0.96 ± 1.77 mg/dL, P = 0.001) were higher in the HF group. Wheezing (5.0% vs 32.1%, P < 0.001) and dyspnea (2.5% vs 15.5%, P = 0.010) were more frequently seen in the LF group. Genotype distribution was similar in the two groups. Conclusion: Two distinct clinical presentations of hMPV infection were identified in this study.
Url:
DOI: 10.1111/ped.12782
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Behavioral Biology, Emory College of Arts and Sciences, Emory University, Georgia, Atlanta, USA</mods:affiliation></affiliation></author><author><name sortKey="Lee, Mi Kyung" sort="Lee, Mi Kyung" uniqKey="Lee M" first="Mi Kyung" last="Lee">Mi Kyung Lee</name><affiliation><mods:affiliation>Department of Laboratory Medicine, Chung‐Ang University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lim, In Seok" sort="Lim, In Seok" uniqKey="Lim I" first="In Seok" last="Lim">In Seok Lim</name><affiliation><mods:affiliation>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Choi, Eung Sang" sort="Choi, Eung Sang" uniqKey="Choi E" first="Eung Sang" last="Choi">Eung Sang Choi</name><affiliation><mods:affiliation>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, 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Wook" uniqKey="Yun K" first="Ki Wook" last="Yun">Ki Wook Yun</name><affiliation><mods:affiliation>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: pedwilly@gmail.com</mods:affiliation></affiliation></author><author><name sortKey="Lim, Jae Woo" sort="Lim, Jae Woo" uniqKey="Lim J" first="Jae Woo" last="Lim">Jae Woo Lim</name><affiliation><mods:affiliation>Neuroscience and Behavioral Biology, Emory College of Arts and Sciences, Emory University, Georgia, Atlanta, USA</mods:affiliation></affiliation></author><author><name sortKey="Lee, Mi Kyung" sort="Lee, Mi Kyung" uniqKey="Lee M" first="Mi Kyung" last="Lee">Mi Kyung Lee</name><affiliation><mods:affiliation>Department of Laboratory Medicine, Chung‐Ang University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lim, In Seok" sort="Lim, In Seok" uniqKey="Lim I" first="In Seok" last="Lim">In Seok Lim</name><affiliation><mods:affiliation>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Choi, Eung Sang" sort="Choi, Eung Sang" uniqKey="Choi E" first="Eung Sang" last="Choi">Eung Sang Choi</name><affiliation><mods:affiliation>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatrics International</title><title level="j" type="alt">PEDIATRICS INTERNATIONAL</title><idno type="ISSN">1328-8067</idno><idno type="eISSN">1442-200X</idno><imprint><biblScope unit="vol">58</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="22">22</biblScope><biblScope unit="page" to="26">26</biblScope><biblScope unit="page-count">5</biblScope><date type="published" when="2016-01">2016-01</date></imprint><idno 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Methods: From 2011 to 2013, nasopharyngeal aspirates were obtained from Korean children and tested for hMPV on reverse transcription–polymerase chain reaction (RT‐PCR). The genotype of hMPV in each sample was identified on PCR‐restriction length polymorphism analysis of the fusion gene. We divided patients into three groups according to degree of fever. Patients with fever peaking at >39.5°C or lasting >7 days were classified as the high fever (HF) group; those with fevers peaking at <38.5°C and lasting <72 h were classified as the low fever (LF) group; and the other subjects were classified as the moderate fever group. Results: Among 457 samples positive for hMPV, hMPV genotype was able to be identified in 399 (87.3%); of these, A2a was found in 97 (24.3%), B1 in 186 (46.6%), and B2 in 116 (29.1%). Clinical features of hMPV infection were compared between the HF and LF groups. We classified 80 subjects into the HF group and 84 subjects into the LF group. Mean absolute neutrophil count (5625 ± 4418 vs 4072 ± 3076/μL, P = 0.010) and C‐reactive protein (2.39 ± 3.39 vs 0.96 ± 1.77 mg/dL, P = 0.001) were higher in the HF group. Wheezing (5.0% vs 32.1%, P < 0.001) and dyspnea (2.5% vs 15.5%, P = 0.010) were more frequently seen in the LF group. Genotype distribution was similar in the two groups. Conclusion: Two distinct clinical presentations of hMPV infection were identified in this study.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Ji Young Park</name><affiliations><json:string>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Ki Wook Yun</name><affiliations><json:string>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</json:string><json:string>E-mail: pedwilly@gmail.com</json:string></affiliations></json:item><json:item><name>Jae Woo Lim</name><affiliations><json:string>Neuroscience and Behavioral Biology, Emory College of Arts and Sciences, Emory University, Georgia, Atlanta, USA</json:string></affiliations></json:item><json:item><name>Mi Kyung Lee</name><affiliations><json:string>Department of Laboratory Medicine, Chung‐Ang University College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>In Seok Lim</name><affiliations><json:string>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Eung Sang Choi</name><affiliations><json:string>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>children</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fever</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genotype</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>human metapneumovirus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Korea</value></json:item></subject><articleId><json:string>PED12782</json:string></articleId><arkIstex>ark:/67375/WNG-J2KNHDXW-Q</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Background: Human metapneumovirus (hMPV) is one of the main pathogens responsible for respiratory tract infection in children. Methods: From 2011 to 2013, nasopharyngeal aspirates were obtained from Korean children and tested for hMPV on reverse transcription–polymerase chain reaction (RT‐PCR). The genotype of hMPV in each sample was identified on PCR‐restriction length polymorphism analysis of the fusion gene. We divided patients into three groups according to degree of fever. Patients with fever peaking at >39.5°C or lasting >7 days were classified as the high fever (HF) group; those with fevers peaking at >38.5°C and lasting >72 h were classified as the low fever (LF) group; and the other subjects were classified as the moderate fever group. Results: Among 457 samples positive for hMPV, hMPV genotype was able to be identified in 399 (87.3%); of these, A2a was found in 97 (24.3%), B1 in 186 (46.6%), and B2 in 116 (29.1%). Clinical features of hMPV infection were compared between the HF and LF groups. We classified 80 subjects into the HF group and 84 subjects into the LF group. Mean absolute neutrophil count (5625 ± 4418 vs 4072 ± 3076/μL, P = 0.010) and C‐reactive protein (2.39 ± 3.39 vs 0.96 ± 1.77 mg/dL, P = 0.001) were higher in the HF group. Wheezing (5.0% vs 32.1%, P > 0.001) and dyspnea (2.5% vs 15.5%, P = 0.010) were more frequently seen in the LF group. Genotype distribution was similar in the two groups. 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features of human metapneumovirus infection in children</title><title level="a" type="short">hMPV infection in children</title><author xml:id="author-0000"><persName><forename type="first">Ji Young</forename><surname>Park</surname></persName><affiliation><orgName type="division">Departments of Pediatrics</orgName><orgName type="institution">Chung‐Ang University College of Medicine</orgName><address><settlement>Seoul</settlement><country>Korea</country></address></affiliation></author><author xml:id="author-0001" role="corresp"><persName><forename type="first">Ki Wook</forename><surname>Yun</surname></persName><affiliation><orgName type="division">Departments of Pediatrics</orgName><orgName type="institution">Chung‐Ang University College of Medicine</orgName><address><settlement>Seoul</settlement><country>Korea</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Jae Woo</forename><surname>Lim</surname></persName><affiliation><orgName type="division">Neuroscience and Behavioral Biology, Emory College of Arts and Sciences</orgName><orgName type="institution">Emory University</orgName><address><settlement>Atlanta</settlement><region>Georgia</region><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Mi Kyung</forename><surname>Lee</surname></persName><affiliation><orgName type="division">Department of Laboratory Medicine</orgName><orgName type="institution">Chung‐Ang University College of Medicine</orgName><address><settlement>Seoul</settlement><country>Korea</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">In Seok</forename><surname>Lim</surname></persName><affiliation><orgName type="division">Departments of Pediatrics</orgName><orgName type="institution">Chung‐Ang University College of Medicine</orgName><address><settlement>Seoul</settlement><country>Korea</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Eung Sang</forename><surname>Choi</surname></persName><affiliation><orgName type="division">Departments of Pediatrics</orgName><orgName type="institution">Chung‐Ang University College of Medicine</orgName><address><settlement>Seoul</settlement><country>Korea</country></address></affiliation></author><idno type="istex">C8E41C948933CB210E618F58C864D89A5964190C</idno><idno type="ark">ark:/67375/WNG-J2KNHDXW-Q</idno><idno type="DOI">10.1111/ped.12782</idno><idno type="unit">PED12782</idno><idno type="society">PED-00289-2014.R1</idno><idno type="toTypesetVersion">file:PED.PED12782.pdf</idno></analytic><monogr><title level="j" type="main">Pediatrics International</title><title level="j" type="alt">PEDIATRICS INTERNATIONAL</title><idno type="pISSN">1328-8067</idno><idno type="eISSN">1442-200X</idno><idno 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main"><head>Abstract</head><head>Background</head><p>Human metapneumovirus (hMPV) is one of the main pathogens responsible for respiratory tract infection in children.</p><head>Methods</head><p>From 2011 to 2013, nasopharyngeal aspirates were obtained from Korean children and tested for hMPV on reverse transcription–polymerase chain reaction (RT‐PCR). The genotype of hMPV in each sample was identified on PCR‐restriction length polymorphism analysis of the fusion gene. We divided patients into three groups according to degree of fever. Patients with fever peaking at >39.5°C or lasting >7 days were classified as the high fever (HF) group; those with fevers peaking at <38.5°C and lasting <72 h were classified as the low fever (LF) group; and the other subjects were classified as the moderate fever group.</p><head>Results</head><p>Among 457 samples positive for hMPV, hMPV genotype was able to be identified in 399 (87.3%); of these, A2a was found in 97 (24.3%), B1 in 186 (46.6%), and B2 in 116 (29.1%). Clinical features of hMPV infection were compared between the HF and LF groups. We classified 80 subjects into the HF group and 84 subjects into the LF group. Mean absolute neutrophil count (5625 ± 4418 vs 4072 ± 3076/μL, <hi rend="italic">P</hi> = 0.010) and C‐reactive protein (2.39 ± 3.39 vs 0.96 ± 1.77 mg/dL, <hi rend="italic">P</hi> = 0.001) were higher in the HF group. Wheezing (5.0% vs 32.1%, <hi rend="italic">P</hi> < 0.001) and dyspnea (2.5% vs 15.5%, <hi rend="italic">P</hi> = 0.010) were more frequently seen in the LF group. Genotype distribution was similar in the two groups.</p><head>Conclusion</head><p>Two distinct clinical presentations of hMPV infection were identified in this study.</p></abstract><textClass><keywords><term xml:id="ped12782-kwd-0001">children</term><term xml:id="ped12782-kwd-0002">fever</term><term xml:id="ped12782-kwd-0003">genotype</term><term xml:id="ped12782-kwd-0004">human metapneumovirus</term><term xml:id="ped12782-kwd-0005">Korea</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>ORIGINAL ARTICLES</term></keywords><keywords rend="tocHeading2"><term>Infectious Diseases</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-J2KNHDXW-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="ped12782"><header><publicationMeta level="product"><doi>10.1111/(ISSN)1442-200X</doi><issn type="print">1328-8067</issn><issn type="electronic">1442-200X</issn><idGroup><id type="product" value="PED"></id></idGroup><titleGroup><title type="main" sort="PEDIATRICS INTERNATIONAL">Pediatrics International</title><title type="short">Pediatrics International</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi>10.1111/ped.2016.58.issue-1</doi><copyright ownership="thirdParty">© 2016 Japan Pediatric Society</copyright><numberingGroup><numbering type="journalVolume" number="58">58</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2016-01">January 2016</coverDate></publicationMeta><publicationMeta level="unit" position="60" type="article" status="forIssue"><doi>10.1111/ped.12782</doi><idGroup><id type="unit" value="PED12782"></id><id type="society" value="PED-00289-2014.R1"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">ORIGINAL ARTICLES</title><title type="tocHeading2">Infectious Diseases</title></titleGroup><copyright ownership="publisher">© 2015 Japan Pediatric Society</copyright><eventGroup><event type="manuscriptReceived" date="2014-06-13"></event><event type="manuscriptRevised" date="2014-12-20"></event><event type="manuscriptAccepted" date="2015-06-17"></event><event type="xmlCreated" agent="SPi Global" date="2015-08-25"></event><event type="publishedOnlineAccepted" date="2015-08-11"></event><event type="publishedOnlineEarlyUnpaginated" date="2016-01-15"></event><event type="publishedOnlineFinalForm" date="2016-01-28"></event><event type="firstOnline" date="2016-01-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:5.0.6 mode:FullText" date="2017-02-09"></event></eventGroup><numberingGroup><numbering type="pageFirst">22</numbering><numbering type="pageLast">26</numbering></numberingGroup><correspondenceTo>Correspondence: Ki Wook Yun, MD PhD, Department of Pediatrics, Chung‐Ang University Medical Center, Heukseok‐dong, Dongjak‐gu, Seoul, Korea. Email: <email>pedwilly@gmail.com</email></correspondenceTo><selfCitationGroup><citation type="self" xml:id="ped12782-cit-0000"><author><familyName>Park</familyName>, <givenNames>J. Y.</givenNames></author>, <author><familyName>Yun</familyName>, <givenNames>K. W.</givenNames></author>, <author><familyName>Lim</familyName>, <givenNames>J. W.</givenNames></author>, <author><familyName>Lee</familyName>, <givenNames>M. K.</givenNames></author>, <author><familyName>Lim</familyName>, <givenNames>I. S.</givenNames></author>, and <author><familyName>Choi</familyName>, <givenNames>E. S.</givenNames></author> (<pubYear year="2016">2016</pubYear>) <articleTitle>Clinical and genetic features of human metapneumovirus infection in children</articleTitle>. <journalTitle>Pediatrics International</journalTitle>, <vol>58</vol>: <pageFirst>22</pageFirst>–<pageLast>26</pageLast>. doi: <accessionId ref="info:doi/10.1111/ped.12782">10.1111/ped.12782</accessionId>.</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:PED.PED12782.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Clinical and genetic features of human metapneumovirus infection in children</title><title type="short">hMPV infection in children</title><title type="shortAuthors">JY Park <i>et al</i>.</title></titleGroup><creators><creator creatorRole="author" xml:id="ped12782-cr-0001" affiliationRef="#ped12782-aff-0001"><personName><givenNames>Ji Young</givenNames><familyName>Park</familyName></personName></creator><creator creatorRole="author" xml:id="ped12782-cr-0002" affiliationRef="#ped12782-aff-0001" corresponding="yes"><personName><givenNames>Ki Wook</givenNames><familyName>Yun</familyName></personName></creator><creator creatorRole="author" xml:id="ped12782-cr-0003" affiliationRef="#ped12782-aff-0003"><personName><givenNames>Jae Woo</givenNames><familyName>Lim</familyName></personName></creator><creator creatorRole="author" xml:id="ped12782-cr-0004" affiliationRef="#ped12782-aff-0002"><personName><givenNames>Mi Kyung</givenNames><familyName>Lee</familyName></personName></creator><creator creatorRole="author" xml:id="ped12782-cr-0005" affiliationRef="#ped12782-aff-0001"><personName><givenNames>In Seok</givenNames><familyName>Lim</familyName></personName></creator><creator creatorRole="author" xml:id="ped12782-cr-0006" affiliationRef="#ped12782-aff-0001"><personName><givenNames>Eung Sang</givenNames><familyName>Choi</familyName></personName></creator></creators><affiliationGroup><affiliation type="organization" xml:id="ped12782-aff-0001"><orgDiv>Departments of Pediatrics</orgDiv><orgName>Chung‐Ang University College of Medicine</orgName><address><city>Seoul</city><country>Korea</country></address></affiliation><affiliation type="organization" xml:id="ped12782-aff-0002"><orgDiv>Department of Laboratory Medicine</orgDiv><orgName>Chung‐Ang University College of Medicine</orgName><address><city>Seoul</city><country>Korea</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="ped12782-aff-0003"><orgDiv>Neuroscience and Behavioral Biology, Emory College of Arts and Sciences</orgDiv><orgName>Emory University</orgName><address><city>Atlanta</city><countryPart>Georgia</countryPart><country>USA</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="ped12782-kwd-0001">children</keyword><keyword xml:id="ped12782-kwd-0002">fever</keyword><keyword xml:id="ped12782-kwd-0003">genotype</keyword><keyword xml:id="ped12782-kwd-0004">human metapneumovirus</keyword><keyword xml:id="ped12782-kwd-0005">Korea</keyword></keywordGroup><abstractGroup><abstract type="main"><title type="main">Abstract</title><section xml:id="ped12782-sec-0001" numbered="no"><title type="main">Background</title><p>Human metapneumovirus (hMPV) is one of the main pathogens responsible for respiratory tract infection in children.</p></section><section xml:id="ped12782-sec-0002" numbered="no"><title type="main">Methods</title><p>From 2011 to 2013, nasopharyngeal aspirates were obtained from Korean children and tested for hMPV on reverse transcription–polymerase chain reaction (RT‐PCR). The genotype of hMPV in each sample was identified on PCR‐restriction length polymorphism analysis of the fusion gene. We divided patients into three groups according to degree of fever. Patients with fever peaking at >39.5°C or lasting >7 days were classified as the high fever (HF) group; those with fevers peaking at <38.5°C and lasting <72 h were classified as the low fever (LF) group; and the other subjects were classified as the moderate fever group.</p></section><section xml:id="ped12782-sec-0003" numbered="no"><title type="main">Results</title><p>Among 457 samples positive for hMPV, hMPV genotype was able to be identified in 399 (87.3%); of these, A2a was found in 97 (24.3%), B1 in 186 (46.6%), and B2 in 116 (29.1%). Clinical features of hMPV infection were compared between the HF and LF groups. We classified 80 subjects into the HF group and 84 subjects into the LF group. Mean absolute neutrophil count (5625 ± 4418 vs 4072 ± 3076/μL, <i>P</i> = 0.010) and C‐reactive protein (2.39 ± 3.39 vs 0.96 ± 1.77 mg/dL, <i>P</i> = 0.001) were higher in the HF group. Wheezing (5.0% vs 32.1%, <i>P</i> < 0.001) and dyspnea (2.5% vs 15.5%, <i>P</i> = 0.010) were more frequently seen in the LF group. Genotype distribution was similar in the two groups.</p></section><section xml:id="ped12782-sec-0004" numbered="no"><title type="main">Conclusion</title><p>Two distinct clinical presentations of hMPV infection were identified in this study.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Clinical and genetic features of human metapneumovirus infection in children</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>hMPV infection in children</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Clinical and genetic features of human metapneumovirus infection in children</title></titleInfo><name type="personal"><namePart type="given">Ji Young</namePart><namePart type="family">Park</namePart><affiliation>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ki Wook</namePart><namePart type="family">Yun</namePart><affiliation>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</affiliation><affiliation>E-mail: pedwilly@gmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jae Woo</namePart><namePart type="family">Lim</namePart><affiliation>Neuroscience and Behavioral Biology, Emory College of Arts and Sciences, Emory University, Georgia, Atlanta, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mi Kyung</namePart><namePart type="family">Lee</namePart><affiliation>Department of Laboratory Medicine, Chung‐Ang University College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">In Seok</namePart><namePart type="family">Lim</namePart><affiliation>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eung Sang</namePart><namePart type="family">Choi</namePart><affiliation>Departments of Pediatrics, Chung‐Ang University College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2016-01</dateIssued><dateCreated encoding="w3cdtf">2015-08-25</dateCreated><dateCaptured encoding="w3cdtf">2014-06-13</dateCaptured><dateValid encoding="w3cdtf">2015-06-17</dateValid><edition>Park, J. Y., Yun, K. W., Lim, J. W., Lee, M. K., Lim, I. S., and Choi, E. S. (2016) Clinical and genetic features of human metapneumovirus infection in children. Pediatrics International, 58: 22–26. doi: 10.1111/ped.12782.</edition><copyrightDate encoding="w3cdtf">2016</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Background: Human metapneumovirus (hMPV) is one of the main pathogens responsible for respiratory tract infection in children. Methods: From 2011 to 2013, nasopharyngeal aspirates were obtained from Korean children and tested for hMPV on reverse transcription–polymerase chain reaction (RT‐PCR). The genotype of hMPV in each sample was identified on PCR‐restriction length polymorphism analysis of the fusion gene. We divided patients into three groups according to degree of fever. Patients with fever peaking at >39.5°C or lasting >7 days were classified as the high fever (HF) group; those with fevers peaking at <38.5°C and lasting <72 h were classified as the low fever (LF) group; and the other subjects were classified as the moderate fever group. Results: Among 457 samples positive for hMPV, hMPV genotype was able to be identified in 399 (87.3%); of these, A2a was found in 97 (24.3%), B1 in 186 (46.6%), and B2 in 116 (29.1%). Clinical features of hMPV infection were compared between the HF and LF groups. We classified 80 subjects into the HF group and 84 subjects into the LF group. Mean absolute neutrophil count (5625 ± 4418 vs 4072 ± 3076/μL, P = 0.010) and C‐reactive protein (2.39 ± 3.39 vs 0.96 ± 1.77 mg/dL, P = 0.001) were higher in the HF group. Wheezing (5.0% vs 32.1%, P < 0.001) and dyspnea (2.5% vs 15.5%, P = 0.010) were more frequently seen in the LF group. Genotype distribution was similar in the two groups. Conclusion: Two distinct clinical presentations of hMPV infection were identified in this study.</abstract><subject><genre>keywords</genre><topic>children</topic><topic>fever</topic><topic>genotype</topic><topic>human metapneumovirus</topic><topic>Korea</topic></subject><relatedItem type="host"><titleInfo><title>Pediatrics International</title></titleInfo><titleInfo type="abbreviated"><title>Pediatrics International</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic><topic>ORIGINAL ARTICLES</topic><topic>Infectious Diseases</topic></subject><identifier type="ISSN">1328-8067</identifier><identifier type="eISSN">1442-200X</identifier><identifier type="DOI">10.1111/(ISSN)1442-200X</identifier><identifier type="PublisherID">PED</identifier><part><date>2016</date><detail type="volume"><caption>vol.</caption><number>58</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>22</start><end>26</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="ped12782-cit-0001"><titleInfo><title>Seasonal patterns of respiratory syncytial virus, influenza a virus, human metapneumovirus, and parainfluenza virus type 3 infections on the basis of virus isolation data between 2004 and 2011 in Yamagata, Japan</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Mizuta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Abiko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Aoki</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mizuta K, Abiko C, Aoki Y et al. 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