Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice
Identifieur interne : 000254 ( Istex/Corpus ); précédent : 000253; suivant : 000255Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice
Auteurs : K. Pickel ; M. A. Müller ; V. Ter MeulenSource :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 1985-04-01.
English descriptors
- Teeft :
- Acta neuropathol, Adult mice, Antibody production, Antibody profile, Antibody titer, Antibody titers, Baby mice, Breast milk, Breast milk antibodies, Comparable antibody titers, Coronavirus, Crucial role, Days post partum, Days post transfer, Death days, Friend virus, High level, Immune, Immune mothers, Immune system, Immunization, Immunoglobulin, Infection, Intraperitoneal, Intraperitoneal infection, Jhmv, Jhmv infection, Lethal infection, Lethal outcome, Maternal immunity, Mouse, Mouse hepatitis virus, Murine coronavirus, Neutralizing, Neutralizing antibodies, Partum, Passive immunity, Plaque assay, Post infection, Post partum, Significant amount, Single immunization, Spleen cells, Suckling, Suckling mice, Tail vein, Titer, Total group, Total group occurrence, Various intervals, Various times.
Abstract
Abstract: Adult C3H mice are resistant to intraperitoneal infection with murine coronavirus JHM, whereas suckling offspring of non-immune females are susceptible. Resistance can be conferred on suckling C3H mice by postnatal transmission of maternal immunity, if transfer preceeds infection. Suckling mice succumb to infection even when they receive maternal antibodies within 1 day after infection. Prenatal transmission alone without subsequent postnatal transmission of maternal immunity is not sufficient to provide resistance. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Immune reactions restricted by histocompatibility antigens do not play a crucial role in bestowing resistance. As neutralizing anti-JHM serum antibody titers of adult mice only rise sharply 5 to 7 days after infection, these results indicate that infection of adults can be arrested by immunological means but that, in addition, the rate of virus dissemination must be limited by other non-immunological mechanisms.
Url:
DOI: 10.1007/BF02123666
Links to Exploration step
ISTEX:714BC042F31DA026A1E22128CD0788A3F79C206CLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice</title><author><name sortKey="Pickel, K" sort="Pickel, K" uniqKey="Pickel K" first="K." last="Pickel">K. Pickel</name><affiliation><mods:affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Muller, M A" sort="Muller, M A" uniqKey="Muller M" first="M. A." last="Müller">M. A. Müller</name><affiliation><mods:affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name><affiliation><mods:affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:714BC042F31DA026A1E22128CD0788A3F79C206C</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1007/BF02123666</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-KX269P8F-4/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000254</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000254</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice</title><author><name sortKey="Pickel, K" sort="Pickel, K" uniqKey="Pickel K" first="K." last="Pickel">K. Pickel</name><affiliation><mods:affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Muller, M A" sort="Muller, M A" uniqKey="Muller M" first="M. A." last="Müller">M. A. Müller</name><affiliation><mods:affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name><affiliation><mods:affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Microbiology and Immunology</title><title level="j" type="abbrev">Med Microbiol Immunol</title><idno type="ISSN">0300-8584</idno><idno type="eISSN">1432-1831</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1985-04-01">1985-04-01</date><biblScope unit="volume">174</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="15">15</biblScope><biblScope unit="page" to="24">24</biblScope></imprint><idno type="ISSN">0300-8584</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-8584</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta neuropathol</term><term>Adult mice</term><term>Antibody production</term><term>Antibody profile</term><term>Antibody titer</term><term>Antibody titers</term><term>Baby mice</term><term>Breast milk</term><term>Breast milk antibodies</term><term>Comparable antibody titers</term><term>Coronavirus</term><term>Crucial role</term><term>Days post partum</term><term>Days post transfer</term><term>Death days</term><term>Friend virus</term><term>High level</term><term>Immune</term><term>Immune mothers</term><term>Immune system</term><term>Immunization</term><term>Immunoglobulin</term><term>Infection</term><term>Intraperitoneal</term><term>Intraperitoneal infection</term><term>Jhmv</term><term>Jhmv infection</term><term>Lethal infection</term><term>Lethal outcome</term><term>Maternal immunity</term><term>Mouse</term><term>Mouse hepatitis virus</term><term>Murine coronavirus</term><term>Neutralizing</term><term>Neutralizing antibodies</term><term>Partum</term><term>Passive immunity</term><term>Plaque assay</term><term>Post infection</term><term>Post partum</term><term>Significant amount</term><term>Single immunization</term><term>Spleen cells</term><term>Suckling</term><term>Suckling mice</term><term>Tail vein</term><term>Titer</term><term>Total group</term><term>Total group occurrence</term><term>Various intervals</term><term>Various times</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Adult C3H mice are resistant to intraperitoneal infection with murine coronavirus JHM, whereas suckling offspring of non-immune females are susceptible. Resistance can be conferred on suckling C3H mice by postnatal transmission of maternal immunity, if transfer preceeds infection. Suckling mice succumb to infection even when they receive maternal antibodies within 1 day after infection. Prenatal transmission alone without subsequent postnatal transmission of maternal immunity is not sufficient to provide resistance. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Immune reactions restricted by histocompatibility antigens do not play a crucial role in bestowing resistance. As neutralizing anti-JHM serum antibody titers of adult mice only rise sharply 5 to 7 days after infection, these results indicate that infection of adults can be arrested by immunological means but that, in addition, the rate of virus dissemination must be limited by other non-immunological mechanisms.</div></front></TEI><istex><corpusName>springer-journals</corpusName><keywords><teeft><json:string>immune</json:string><json:string>suckling</json:string><json:string>suckling mice</json:string><json:string>maternal immunity</json:string><json:string>jhmv</json:string><json:string>immune mothers</json:string><json:string>neutralizing</json:string><json:string>neutralizing antibodies</json:string><json:string>coronavirus</json:string><json:string>partum</json:string><json:string>immunoglobulin</json:string><json:string>intraperitoneal</json:string><json:string>baby mice</json:string><json:string>immunization</json:string><json:string>infection</json:string><json:string>days post partum</json:string><json:string>breast milk</json:string><json:string>death days</json:string><json:string>antibody titer</json:string><json:string>murine coronavirus</json:string><json:string>lethal outcome</json:string><json:string>post partum</json:string><json:string>adult mice</json:string><json:string>jhmv infection</json:string><json:string>immune system</json:string><json:string>high level</json:string><json:string>post infection</json:string><json:string>mouse</json:string><json:string>titer</json:string><json:string>passive immunity</json:string><json:string>antibody production</json:string><json:string>comparable antibody titers</json:string><json:string>tail vein</json:string><json:string>various times</json:string><json:string>plaque assay</json:string><json:string>total group occurrence</json:string><json:string>mouse hepatitis virus</json:string><json:string>significant amount</json:string><json:string>days post transfer</json:string><json:string>various intervals</json:string><json:string>total group</json:string><json:string>antibody titers</json:string><json:string>crucial role</json:string><json:string>antibody profile</json:string><json:string>breast milk antibodies</json:string><json:string>lethal infection</json:string><json:string>intraperitoneal infection</json:string><json:string>friend virus</json:string><json:string>spleen cells</json:string><json:string>single immunization</json:string><json:string>acta neuropathol</json:string></teeft></keywords><author><json:item><name>K. Pickel</name><affiliations><json:string>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</json:string></affiliations></json:item><json:item><name>M. A. Müller</name><affiliations><json:string>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</json:string></affiliations></json:item><json:item><name>V. ter Meulen</name><affiliations><json:string>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</json:string></affiliations></json:item></author><articleId><json:string>BF02123666</json:string><json:string>Art1</json:string></articleId><arkIstex>ark:/67375/1BB-KX269P8F-4</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Adult C3H mice are resistant to intraperitoneal infection with murine coronavirus JHM, whereas suckling offspring of non-immune females are susceptible. Resistance can be conferred on suckling C3H mice by postnatal transmission of maternal immunity, if transfer preceeds infection. Suckling mice succumb to infection even when they receive maternal antibodies within 1 day after infection. Prenatal transmission alone without subsequent postnatal transmission of maternal immunity is not sufficient to provide resistance. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Immune reactions restricted by histocompatibility antigens do not play a crucial role in bestowing resistance. As neutralizing anti-JHM serum antibody titers of adult mice only rise sharply 5 to 7 days after infection, these results indicate that infection of adults can be arrested by immunological means but that, in addition, the rate of virus dissemination must be limited by other non-immunological mechanisms.</abstract><qualityIndicators><score>7.525</score><pdfWordCount>3665</pdfWordCount><pdfCharCount>20906</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>450 x 702 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>155</abstractWordCount><abstractCharCount>1103</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice</title><pmid><json:string>2987653</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Medical Microbiology and Immunology</title><language><json:string>unknown</json:string></language><publicationDate>1985</publicationDate><copyrightDate>1985</copyrightDate><issn><json:string>0300-8584</json:string></issn><eissn><json:string>1432-1831</json:string></eissn><journalId><json:string>430</json:string></journalId><volume>174</volume><issue>1</issue><pages><first>15</first><last>24</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Immunology</value></json:item><json:item><value>Medical Microbiology</value></json:item></subject></host><namedEntities><unitex><date></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/1BB-KX269P8F-4</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - microbiology</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Microbiology (medical)</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - General Medicine</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1985</publicationDate><copyrightDate>1985</copyrightDate><doi><json:string>10.1007/BF02123666</json:string></doi><id>714BC042F31DA026A1E22128CD0788A3F79C206C</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-KX269P8F-4/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-KX269P8F-4/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/1BB-KX269P8F-4/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><licence><p>Springer-Verlag, 1985</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>1984-10-29</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">K.</forename><surname>Pickel</surname></persName><affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</affiliation></author><author xml:id="author-0001"><persName><forename type="first">M.</forename><surname>Müller</surname></persName><affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</affiliation></author><author xml:id="author-0002"><persName><forename type="first">V.</forename><surname>ter Meulen</surname></persName><affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</affiliation></author><idno type="istex">714BC042F31DA026A1E22128CD0788A3F79C206C</idno><idno type="ark">ark:/67375/1BB-KX269P8F-4</idno><idno type="DOI">10.1007/BF02123666</idno><idno type="article-id">BF02123666</idno><idno type="article-id">Art1</idno></analytic><monogr><title level="j">Medical Microbiology and Immunology</title><title level="j" type="abbrev">Med Microbiol Immunol</title><idno type="pISSN">0300-8584</idno><idno type="eISSN">1432-1831</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">6</idno><idno type="volume-issue-count">6</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1985-04-01"></date><biblScope unit="volume">174</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="15">15</biblScope><biblScope unit="page" to="24">24</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1984-10-29</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Adult C3H mice are resistant to intraperitoneal infection with murine coronavirus JHM, whereas suckling offspring of non-immune females are susceptible. Resistance can be conferred on suckling C3H mice by postnatal transmission of maternal immunity, if transfer preceeds infection. Suckling mice succumb to infection even when they receive maternal antibodies within 1 day after infection. Prenatal transmission alone without subsequent postnatal transmission of maternal immunity is not sufficient to provide resistance. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Immune reactions restricted by histocompatibility antigens do not play a crucial role in bestowing resistance. As neutralizing anti-JHM serum antibody titers of adult mice only rise sharply 5 to 7 days after infection, these results indicate that infection of adults can be arrested by immunological means but that, in addition, the rate of virus dissemination must be limited by other non-immunological mechanisms.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Immunology</term></item><item><term>Medical Microbiology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1984-10-29">Created</change><change when="1985-04-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-KX269P8F-4/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>430</JournalID><JournalPrintISSN>0300-8584</JournalPrintISSN><JournalElectronicISSN>1432-1831</JournalElectronicISSN><JournalTitle>Medical Microbiology and Immunology</JournalTitle><JournalAbbreviatedTitle>Med Microbiol Immunol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Immunology</JournalSubject><JournalSubject Type="Secondary">Medical Microbiology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>174</VolumeIDStart><VolumeIDEnd>174</VolumeIDEnd><VolumeIssueCount>6</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>6</IssueArticleCount><IssueHistory><CoverDate><Year>1985</Year><Month>4</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1985</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art1"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF02123666</ArticleID><ArticleDOI>10.1007/BF02123666</ArticleDOI><ArticleSequenceNumber>1</ArticleSequenceNumber><ArticleTitle Language="En">Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice</ArticleTitle><ArticleFirstPage>15</ArticleFirstPage><ArticleLastPage>24</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>8</Month><Day>11</Day></RegistrationDate><Received><Year>1984</Year><Month>10</Month><Day>29</Day></Received></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1985</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>430</JournalID><VolumeIDStart>174</VolumeIDStart><VolumeIDEnd>174</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><FamilyName>Pickel</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><GivenName>A.</GivenName><FamilyName>Müller</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>V.</GivenName><Particle>ter</Particle><FamilyName>Meulen</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgName>Institute for Virology and Immunobiology</OrgName><OrgAddress><Street>Versbacher Str. 7</Street><Postcode>D-8700</Postcode><City>Würzburg</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Adult C3H mice are resistant to intraperitoneal infection with murine coronavirus JHM, whereas suckling offspring of non-immune females are susceptible. Resistance can be conferred on suckling C3H mice by postnatal transmission of maternal immunity, if transfer preceeds infection. Suckling mice succumb to infection even when they receive maternal antibodies within 1 day after infection. Prenatal transmission alone without subsequent postnatal transmission of maternal immunity is not sufficient to provide resistance. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Immune reactions restricted by histocompatibility antigens do not play a crucial role in bestowing resistance. As neutralizing anti-JHM serum antibody titers of adult mice only rise sharply 5 to 7 days after infection, these results indicate that infection of adults can be arrested by immunological means but that, in addition, the rate of virus dissemination must be limited by other non-immunological mechanisms.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">K.</namePart><namePart type="family">Pickel</namePart><affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="given">A.</namePart><namePart type="family">Müller</namePart><affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">ter Meulen</namePart><affiliation>Institute for Virology and Immunobiology, Versbacher Str. 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1984-10-29</dateCreated><dateIssued encoding="w3cdtf">1985-04-01</dateIssued><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Adult C3H mice are resistant to intraperitoneal infection with murine coronavirus JHM, whereas suckling offspring of non-immune females are susceptible. Resistance can be conferred on suckling C3H mice by postnatal transmission of maternal immunity, if transfer preceeds infection. Suckling mice succumb to infection even when they receive maternal antibodies within 1 day after infection. Prenatal transmission alone without subsequent postnatal transmission of maternal immunity is not sufficient to provide resistance. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Immune reactions restricted by histocompatibility antigens do not play a crucial role in bestowing resistance. As neutralizing anti-JHM serum antibody titers of adult mice only rise sharply 5 to 7 days after infection, these results indicate that infection of adults can be arrested by immunological means but that, in addition, the rate of virus dissemination must be limited by other non-immunological mechanisms.</abstract><relatedItem type="host"><titleInfo><title>Medical Microbiology and Immunology</title></titleInfo><titleInfo type="abbreviated"><title>Med Microbiol Immunol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1985-04-01</dateIssued><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Immunology</topic><topic>Medical Microbiology</topic></subject><identifier type="ISSN">0300-8584</identifier><identifier type="eISSN">1432-1831</identifier><identifier type="JournalID">430</identifier><identifier type="IssueArticleCount">6</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>1985</date><detail type="volume"><number>174</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>15</start><end>24</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1985</recordOrigin></recordInfo></relatedItem><identifier type="istex">714BC042F31DA026A1E22128CD0788A3F79C206C</identifier><identifier type="ark">ark:/67375/1BB-KX269P8F-4</identifier><identifier type="DOI">10.1007/BF02123666</identifier><identifier type="ArticleID">BF02123666</identifier><identifier type="ArticleID">Art1</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1985</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1985</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-KX269P8F-4/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000254 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000254 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:714BC042F31DA026A1E22128CD0788A3F79C206C
|texte= Influence of maternal immunity on the outcome of mutine coronavirus JHM infection in suckling mice
}}
| This area was generated with Dilib version V0.6.33. |  |