Murine coronavirus-induced encephalomyelitides in rats: Analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid
Identifieur interne : 000155 ( Istex/Corpus ); précédent : 000154; suivant : 000156Murine coronavirus-induced encephalomyelitides in rats: Analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid
Auteurs : R. Dörries ; R. Watanabe ; H. Wege ; V. Ter MeulenSource :
- Journal of Neuroimmunology [ 0165-5728 ] ; 1986.
English descriptors
- Teeft :
- Acta neuropathol, Animal sample blot, Antibody, Antibody indices, Antigen specificity, Antiviral activity, Antiviral antibodies, Black arrows, Causative agent, Cell clones, Cerebrospinal, Cerebrospinal fluid, Clinical disease, Clonal distribution, Coronavirus, Crystal violet, Demyelinating, Demyelinating disease, Demyelinating diseases, Demyelinating encephalomyelitis, Diseased animals, Encephalomyelitis, Filter area, Glial cells, Immune, Immune response, Immunoblot, Immunoblot analysis, Immunoblot technique, Immunoglobulin, Inflammatory demyelinating lesions, Inoculation, Intrathecal, Intrathecal synthesis, Keyhole limpet hemocyanine, Lewis rats, Meulen, Multiple sclerosis, Mumps meningitis, Murine coronavirus, Nervous system, Neurol, Nitrocellulose filter, Normal range, Oligoclonal, Oligoclonal pattern, Optical density, Rat, Same animal, Serum samples, Serum specimens, Specific antibody indices, Spinal cord, Subacute, Subacute demyelinating encephalomyelitis, Subacute sclerosing panencephalitis, Vandvik, Viral, Viral antibodies, Viral antigen, Viral antigens, Virus infection, Virus inoculation, Virus strain, Wege.
Abstract
Abstract: The humoral intrathecal immune response in coronavirus-induced demyelinating encephalomyelitis in rats associated with an autoimmune reaction to brain antigen, was analysed. The CSF of these animals revealed immune reactions which were directed against coronavirus and other, unknown, antigens. In general, no direct correlation between the disease, the state of the blood-brain barrier (BBB), intrathecal synthesis of Ig and the presence of virus-specific antibodies was detectable, suggesting that the humoral, in contrast to the cellular, immune response does not play a significant pathogenetic role in this CNS disease.
Url:
DOI: 10.1016/0165-5728(86)90026-3
Links to Exploration step
ISTEX:5432CB26672C2D1708D775E6ED0CE2A4F1D5B8A2Le document en format XML
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Dörries</name><affiliation><mods:affiliation>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</mods:affiliation></affiliation></author><author><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R." last="Watanabe">R. Watanabe</name><affiliation><mods:affiliation>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</mods:affiliation></affiliation></author><author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name><affiliation><mods:affiliation>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</mods:affiliation></affiliation></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name><affiliation><mods:affiliation>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimmunology</title><title level="j" type="abbrev">JNI</title><idno type="ISSN">0165-5728</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1986">1986</date><biblScope unit="volume">12</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="131">131</biblScope><biblScope unit="page" to="142">142</biblScope></imprint><idno type="ISSN">0165-5728</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-5728</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta neuropathol</term><term>Animal sample blot</term><term>Antibody</term><term>Antibody indices</term><term>Antigen specificity</term><term>Antiviral activity</term><term>Antiviral antibodies</term><term>Black arrows</term><term>Causative agent</term><term>Cell clones</term><term>Cerebrospinal</term><term>Cerebrospinal fluid</term><term>Clinical disease</term><term>Clonal distribution</term><term>Coronavirus</term><term>Crystal violet</term><term>Demyelinating</term><term>Demyelinating disease</term><term>Demyelinating diseases</term><term>Demyelinating encephalomyelitis</term><term>Diseased animals</term><term>Encephalomyelitis</term><term>Filter area</term><term>Glial cells</term><term>Immune</term><term>Immune response</term><term>Immunoblot</term><term>Immunoblot analysis</term><term>Immunoblot technique</term><term>Immunoglobulin</term><term>Inflammatory demyelinating lesions</term><term>Inoculation</term><term>Intrathecal</term><term>Intrathecal synthesis</term><term>Keyhole limpet hemocyanine</term><term>Lewis rats</term><term>Meulen</term><term>Multiple sclerosis</term><term>Mumps meningitis</term><term>Murine coronavirus</term><term>Nervous system</term><term>Neurol</term><term>Nitrocellulose filter</term><term>Normal range</term><term>Oligoclonal</term><term>Oligoclonal pattern</term><term>Optical density</term><term>Rat</term><term>Same animal</term><term>Serum samples</term><term>Serum specimens</term><term>Specific antibody indices</term><term>Spinal cord</term><term>Subacute</term><term>Subacute demyelinating encephalomyelitis</term><term>Subacute sclerosing panencephalitis</term><term>Vandvik</term><term>Viral</term><term>Viral antibodies</term><term>Viral antigen</term><term>Viral antigens</term><term>Virus infection</term><term>Virus inoculation</term><term>Virus strain</term><term>Wege</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The humoral intrathecal immune response in coronavirus-induced demyelinating encephalomyelitis in rats associated with an autoimmune reaction to brain antigen, was analysed. 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Dörries</name><affiliations><json:string>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</json:string></affiliations></json:item><json:item><name>R. Watanabe</name><affiliations><json:string>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</json:string></affiliations></json:item><json:item><name>H. Wege</name><affiliations><json:string>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</json:string></affiliations></json:item><json:item><name>V. ter Meulen</name><affiliations><json:string>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Coronavirus JHM</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Intrathecal antibody response</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Subacute demyelinating encephalitis</value></json:item></subject><arkIstex>ark:/67375/6H6-SGHDNK84-X</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The humoral intrathecal immune response in coronavirus-induced demyelinating encephalomyelitis in rats associated with an autoimmune reaction to brain antigen, was analysed. The CSF of these animals revealed immune reactions which were directed against coronavirus and other, unknown, antigens. In general, no direct correlation between the disease, the state of the blood-brain barrier (BBB), intrathecal synthesis of Ig and the presence of virus-specific antibodies was detectable, suggesting that the humoral, in contrast to the cellular, immune response does not play a significant pathogenetic role in this CNS disease.</abstract><qualityIndicators><score>8.056</score><pdfWordCount>5142</pdfWordCount><pdfCharCount>26042</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>12</pdfPageCount><pdfPageSize>533 x 742 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>88</abstractWordCount><abstractCharCount>634</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>Murine coronavirus-induced encephalomyelitides in rats: Analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid</title><pmid><json:string>3016024</json:string></pmid><pii><json:string>0165-5728(86)90026-3</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Journal of Neuroimmunology</title><language><json:string>unknown</json:string></language><publicationDate>1986</publicationDate><issn><json:string>0165-5728</json:string></issn><pii><json:string>S0165-5728(00)X0141-5</json:string></pii><volume>12</volume><issue>2</issue><pages><first>131</first><last>142</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1986</json:string></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Ig</json:string><json:string>Helga Kriesinger</json:string></persName><placeName></placeName><ref_url></ref_url><ref_bibl><json:string>Skorr et al. 1981</json:string><json:string>Woyciechowska et al. 1984</json:string><json:string>Arnadottir et al. 1982</json:string><json:string>Vartdal et al. 1982</json:string><json:string>Knobler et al. 1982a, b</json:string><json:string>Wege et al. 1984b</json:string><json:string>Reiber and Schunck 1983</json:string><json:string>Watanabe et al. 1983</json:string><json:string>Koga et al. 1984</json:string><json:string>Wege et al. 1983</json:string><json:string>Sorensen et al.</json:string><json:string>Wege et al. 1984a</json:string><json:string>Glynn et al. 1982</json:string><json:string>Accepted 6 January, 1986</json:string><json:string>Lowenthal et al. 1984</json:string><json:string>Sorensen et al. 1980</json:string><json:string>Nordal et al. 1978</json:string><json:string>Wege et al. 1982</json:string><json:string>Johnson 1982</json:string><json:string>Stohlman and Weiner 1981</json:string><json:string>Fleming et al. 1983</json:string><json:string>Sorensen et al. 1984</json:string><json:string>Arnadottir et al. (1982)</json:string><json:string>Link et al. 1981</json:string><json:string>Received 1 October, 1985</json:string><json:string>Vandvik et al. 1976, 1978a, b</json:string><json:string>Nagashima et al. 1978, 1979</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-SGHDNK84-X</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - neurosciences</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - neurology & neurosurgery</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Clinical Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Neuroscience</json:string><json:string>3 - Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - 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The CSF of these animals revealed immune reactions which were directed against coronavirus and other, unknown, antigens. In general, no direct correlation between the disease, the state of the blood-brain barrier (BBB), intrathecal synthesis of Ig and the presence of virus-specific antibodies was detectable, suggesting that the humoral, in contrast to the cellular, immune response does not play a significant pathogenetic role in this CNS disease.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Coronavirus JHM</term></item><item><term>Intrathecal antibody response</term></item><item><term>Subacute demyelinating encephalitis</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1986-01-06">Modified</change><change when="1986">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-SGHDNK84-X/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNI</jid><aid>86900263</aid><ce:pii>0165-5728(86)90026-3</ce:pii><ce:doi>10.1016/0165-5728(86)90026-3</ce:doi><ce:copyright type="unknown" year="1986"></ce:copyright></item-info><head><ce:title>Murine coronavirus-induced encephalomyelitides in rats: Analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid</ce:title><ce:author-group><ce:author><ce:given-name>R.</ce:given-name><ce:surname>Dörries</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>R.</ce:given-name><ce:surname>Watanabe</ce:surname></ce:author><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Wege</ce:surname></ce:author><ce:author><ce:given-name>V.</ce:given-name><ce:surname>ter Meulen</ce:surname></ce:author><ce:affiliation><ce:textfn>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>To whom reprint requests should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="1" month="10" year="1985"></ce:date-received><ce:date-revised day="6" month="1" year="1986"></ce:date-revised><ce:date-accepted day="6" month="1" year="1986"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The humoral intrathecal immune response in coronavirus-induced demyelinating encephalomyelitis in rats associated with an autoimmune reaction to brain antigen, was analysed. The CSF of these animals revealed immune reactions which were directed against coronavirus and other, unknown, antigens. In general, no direct correlation between the disease, the state of the blood-brain barrier (BBB), intrathecal synthesis of Ig and the presence of virus-specific antibodies was detectable, suggesting that the humoral, in contrast to the cellular, immune response does not play a significant pathogenetic role in this CNS disease.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Coronavirus JHM</ce:text></ce:keyword><ce:keyword><ce:text>Intrathecal antibody response</ce:text></ce:keyword><ce:keyword><ce:text>Subacute demyelinating encephalitis</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Murine coronavirus-induced encephalomyelitides in rats: Analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Murine coronavirus-induced encephalomyelitides in rats: Analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Dörries</namePart><affiliation>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</affiliation><description>To whom reprint requests should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Watanabe</namePart><affiliation>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Wege</namePart><affiliation>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">ter Meulen</namePart><affiliation>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg F.R.G.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1986</dateIssued><dateModified encoding="w3cdtf">1986-01-06</dateModified><copyrightDate encoding="w3cdtf">1986</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The humoral intrathecal immune response in coronavirus-induced demyelinating encephalomyelitis in rats associated with an autoimmune reaction to brain antigen, was analysed. The CSF of these animals revealed immune reactions which were directed against coronavirus and other, unknown, antigens. In general, no direct correlation between the disease, the state of the blood-brain barrier (BBB), intrathecal synthesis of Ig and the presence of virus-specific antibodies was detectable, suggesting that the humoral, in contrast to the cellular, immune response does not play a significant pathogenetic role in this CNS disease.</abstract><subject><genre>Keywords</genre><topic>Coronavirus JHM</topic><topic>Intrathecal antibody response</topic><topic>Subacute demyelinating encephalitis</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neuroimmunology</title></titleInfo><titleInfo type="abbreviated"><title>JNI</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1986</dateIssued></originInfo><identifier type="ISSN">0165-5728</identifier><identifier type="PII">S0165-5728(00)X0141-5</identifier><part><date>1986</date><detail type="volume"><number>12</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>89</start><end>172</end></extent><extent unit="pages"><start>131</start><end>142</end></extent></part></relatedItem><identifier type="istex">5432CB26672C2D1708D775E6ED0CE2A4F1D5B8A2</identifier><identifier type="ark">ark:/67375/6H6-SGHDNK84-X</identifier><identifier type="DOI">10.1016/0165-5728(86)90026-3</identifier><identifier type="PII">0165-5728(86)90026-3</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-SGHDNK84-X/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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