Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation
Identifieur interne : 000120 ( Istex/Corpus ); précédent : 000119; suivant : 000121Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation
Auteurs : P. D. Griffiths ; S. I. Berney ; S. Argent ; R. B. HeathSource :
- Journal of Hygiene [ 0022-1724 ] ; 1982-10.
Abstract
Paired maternal and cord sera from 100 pregnancies were tested for antibodies against herpes simplex virus, measles virus and respiratory syncytial virus by complement fixation and for antibodies against rubella virus, influenza A virus and influenza B virus by haemagglutination-inhibition. For four viruses (herpes simplex, measles, respiratory syncytial and rubella) higher levels of antibody were found in cord than in maternal sera. There was no difference between maternal and cord serum titres against influenza B virus but significantly higher levels of antibody against influenza A virus were found in maternal sera than in cord sera. This discrepancy was investigated by measuring antibodies against the surface antigens of influenza A by a complement fixation technique, and by single radial haemolysis. Both methods showed a preponderance of virus-specific antibody in cord sera. We conclude that IgG antibodies against most, if not all, viruses are concentrated on the fetal side of the circulation, but that conventional haemagglutination-inhibition techniques may fail to detect this difference.
Url:
DOI: 10.1017/S0022172400070832
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Argent</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation></affiliation></author><author><name sortKey="Heath, R B" sort="Heath, R B" uniqKey="Heath R" first="R. B." last="Heath">R. B. Heath</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E50189B7E8121C0C8BC2A867EDAA92650C490902</idno><date when="1982" year="1982">1982</date><idno type="doi">10.1017/S0022172400070832</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-P09CT8JH-M/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000120</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000120</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation</title><author><name sortKey="Griffiths, P D" sort="Griffiths, P D" uniqKey="Griffiths P" first="P. D." last="Griffiths">P. D. Griffiths</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation></affiliation></author><author><name sortKey="Berney, S I" sort="Berney, S I" uniqKey="Berney S" first="S. I." last="Berney">S. I. Berney</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation></affiliation></author><author><name sortKey="Argent, S" sort="Argent, S" uniqKey="Argent S" first="S." last="Argent">S. Argent</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation></affiliation></author><author><name sortKey="Heath, R B" sort="Heath, R B" uniqKey="Heath R" first="R. B." last="Heath">R. B. Heath</name><affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="ISSN">0022-1724</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1982-10">1982-10</date><biblScope unit="volume">89</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="303">303</biblScope><biblScope unit="page" to="310">310</biblScope></imprint><idno type="ISSN">0022-1724</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1724</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Paired maternal and cord sera from 100 pregnancies were tested for antibodies against herpes simplex virus, measles virus and respiratory syncytial virus by complement fixation and for antibodies against rubella virus, influenza A virus and influenza B virus by haemagglutination-inhibition. For four viruses (herpes simplex, measles, respiratory syncytial and rubella) higher levels of antibody were found in cord than in maternal sera. There was no difference between maternal and cord serum titres against influenza B virus but significantly higher levels of antibody against influenza A virus were found in maternal sera than in cord sera. This discrepancy was investigated by measuring antibodies against the surface antigens of influenza A by a complement fixation technique, and by single radial haemolysis. Both methods showed a preponderance of virus-specific antibody in cord sera. We conclude that IgG antibodies against most, if not all, viruses are concentrated on the fetal side of the circulation, but that conventional haemagglutination-inhibition techniques may fail to detect this difference.</div></front></TEI><istex><corpusName>cambridge</corpusName><author><json:item><name>P. D. Griffiths</name><affiliations><json:string>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</json:string></affiliations></json:item><json:item><name>S. I. Berney</name><affiliations><json:string>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</json:string></affiliations></json:item><json:item><name>S. Argent</name><affiliations><json:string>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</json:string></affiliations></json:item><json:item><name>R. B. Heath</name><affiliations><json:string>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</json:string></affiliations></json:item></author><articleId><json:string>07083</json:string></articleId><arkIstex>ark:/67375/6GQ-P09CT8JH-M</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Paired maternal and cord sera from 100 pregnancies were tested for antibodies against herpes simplex virus, measles virus and respiratory syncytial virus by complement fixation and for antibodies against rubella virus, influenza A virus and influenza B virus by haemagglutination-inhibition. For four viruses (herpes simplex, measles, respiratory syncytial and rubella) higher levels of antibody were found in cord than in maternal sera. There was no difference between maternal and cord serum titres against influenza B virus but significantly higher levels of antibody against influenza A virus were found in maternal sera than in cord sera. This discrepancy was investigated by measuring antibodies against the surface antigens of influenza A by a complement fixation technique, and by single radial haemolysis. Both methods showed a preponderance of virus-specific antibody in cord sera. We conclude that IgG antibodies against most, if not all, viruses are concentrated on the fetal side of the circulation, but that conventional haemagglutination-inhibition techniques may fail to detect this difference.</abstract><qualityIndicators><score>6.551</score><pdfWordCount>2619</pdfWordCount><pdfCharCount>15902</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>612 x 892.8 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>161</abstractWordCount><abstractCharCount>1110</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation</title><pii><json:string>S0022172400070832</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Journal of Hygiene</title><language><json:string>unknown</json:string></language><issn><json:string>0022-1724</json:string></issn><publisherId><json:string>HYG</json:string></publisherId><volume>89</volume><issue>2</issue><pages><first>303</first><last>310</last><total>8</total></pages><genre><json:string>journal</json:string></genre></host><ark><json:string>ark:/67375/6GQ-P09CT8JH-M</json:string></ark><categories><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1982</publicationDate><copyrightDate>1982</copyrightDate><doi><json:string>10.1017/S0022172400070832</json:string></doi><id>E50189B7E8121C0C8BC2A867EDAA92650C490902</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-P09CT8JH-M/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-P09CT8JH-M/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6GQ-P09CT8JH-M/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><availability><licence><p>Copyright © Cambridge University Press 1982</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</p></availability><date>1982</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation</title><author xml:id="author-0000"><persName><forename type="first">P. D.</forename><surname>Griffiths</surname></persName><affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</affiliation></author><author xml:id="author-0001"><persName><forename type="first">S. I.</forename><surname>Berney</surname></persName><affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</affiliation></author><author xml:id="author-0002"><persName><forename type="first">S.</forename><surname>Argent</surname></persName><affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</affiliation></author><author xml:id="author-0003"><persName><forename type="first">R. B.</forename><surname>Heath</surname></persName><affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</affiliation></author><idno type="istex">E50189B7E8121C0C8BC2A867EDAA92650C490902</idno><idno type="ark">ark:/67375/6GQ-P09CT8JH-M</idno><idno type="DOI">10.1017/S0022172400070832</idno><idno type="PII">S0022172400070832</idno><idno type="article-id">07083</idno></analytic><monogr><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="pISSN">0022-1724</idno><idno type="publisher-id">HYG</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1982-10"></date><biblScope unit="volume">89</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="303">303</biblScope><biblScope unit="page" to="310">310</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1982</date></creation><langUsage><language ident="en">en</language></langUsage><abstract style="normal"><p>Paired maternal and cord sera from 100 pregnancies were tested for antibodies against herpes simplex virus, measles virus and respiratory syncytial virus by complement fixation and for antibodies against rubella virus, influenza A virus and influenza B virus by haemagglutination-inhibition. For four viruses (herpes simplex, measles, respiratory syncytial and rubella) higher levels of antibody were found in cord than in maternal sera. There was no difference between maternal and cord serum titres against influenza B virus but significantly higher levels of antibody against influenza A virus were found in maternal sera than in cord sera. This discrepancy was investigated by measuring antibodies against the surface antigens of influenza A by a complement fixation technique, and by single radial haemolysis. Both methods showed a preponderance of virus-specific antibody in cord sera. We conclude that IgG antibodies against most, if not all, viruses are concentrated on the fetal side of the circulation, but that conventional haemagglutination-inhibition techniques may fail to detect this difference.</p></abstract></profileDesc><revisionDesc><change when="1982-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-P09CT8JH-M/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus cambridge not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.2 20060430//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article dtd-version="2.2" article-type="research-article"><front><journal-meta><journal-id journal-id-type="publisher-id">HYG</journal-id><journal-title>Journal of Hygiene</journal-title><abbrev-journal-title>J. Hyg.</abbrev-journal-title><issn pub-type="ppub">0022-1724</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1017/S0022172400070832</article-id><article-id pub-id-type="pii">S0022172400070832</article-id><article-id pub-id-type="publisher-id">07083</article-id><title-group><article-title>Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation</article-title><alt-title alt-title-type="left-running">P. D. Griffiths and others</alt-title><alt-title alt-title-type="right-running">Passive immunization of the fetus</alt-title></title-group><contrib-group><contrib><name><surname>Griffiths</surname><given-names>P. D.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Berney</surname><given-names>S. I.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Argent</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Heath</surname><given-names>R. B.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1"><addr-line>Virology Department</addr-line>, <institution>St Bartholomew's Hospital</institution>, <addr-line>West Smithfield</addr-line>, <addr-line>London EC1A 7BE</addr-line></aff><pub-date pub-type="ppub"><month>10</month><year>1982</year></pub-date><volume>89</volume><issue>2</issue><fpage seq="16">303</fpage><lpage>310</lpage><history><date date-type="received"><day>26</day><month>03</month><year>1982</year></date><date date-type="accepted"><day>02</day><month>05</month><year>1982</year></date></history><permissions><copyright-statement>Copyright © Cambridge University Press 1982</copyright-statement><copyright-year>1982</copyright-year><copyright-holder>Cambridge University Press</copyright-holder></permissions><abstract abstract-type="normal"><title>SUMMARY</title><p>Paired maternal and cord sera from 100 pregnancies were tested for antibodies against herpes simplex virus, measles virus and respiratory syncytial virus by complement fixation and for antibodies against rubella virus, influenza A virus and influenza B virus by haemagglutination-inhibition. For four viruses (herpes simplex, measles, respiratory syncytial and rubella) higher levels of antibody were found in cord than in maternal sera. There was no difference between maternal and cord serum titres against influenza B virus but significantly higher levels of antibody against influenza A virus were found in maternal sera than in cord sera. This discrepancy was investigated by measuring antibodies against the surface antigens of influenza A by a complement fixation technique, and by single radial haemolysis. Both methods showed a preponderance of virus-specific antibody in cord sera. We conclude that IgG antibodies against most, if not all, viruses are concentrated on the fetal side of the circulation, but that conventional haemagglutination-inhibition techniques may fail to detect this difference.</p></abstract><counts><page-count count="8"></page-count></counts><custom-meta-wrap><custom-meta><meta-name>pdf</meta-name><meta-value>S0022172400070832a.pdf</meta-value></custom-meta></custom-meta-wrap></article-meta></front><back><ref-list><title>REFERENCES</title><ref><citation id="ref001" citation-type="book"><name><surname>Armitage</surname><given-names>P.</given-names></name> (<year>1971</year>). <source>Statistical Methods in Medical Research</source>. <publisher-loc>Oxford</publisher-loc>: <publisher-name>Black well</publisher-name>.</citation></ref><ref><citation id="ref002" citation-type="journal"><name><surname>Brouwer</surname><given-names>R.</given-names></name>, <name><surname>DeGroot</surname><given-names>I. G. 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K.</given-names></name>, <name><surname>Ehrenkranz</surname><given-names>N. J.</given-names></name> & <name><surname>Rosenthal</surname><given-names>D.</given-names></name> (<year>1975</year>). <article-title>Placental passage of antibodies to dengue virus in persons living in a region of hyperendemic dengue virus infection</article-title>. <source>Journal of Infectious Diseases</source> <volume>131</volume>, S62.</citation></ref></ref-list></back></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation</title></titleInfo><name type="personal"><namePart type="given">P. D.</namePart><namePart type="family">Griffiths</namePart><affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. I.</namePart><namePart type="family">Berney</namePart><affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Argent</namePart><affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. B.</namePart><namePart type="family">Heath</namePart><affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Cambridge University Press</publisher><place><placeTerm type="text">Cambridge, UK</placeTerm></place><dateIssued encoding="w3cdtf">1982-10</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract type="normal">Paired maternal and cord sera from 100 pregnancies were tested for antibodies against herpes simplex virus, measles virus and respiratory syncytial virus by complement fixation and for antibodies against rubella virus, influenza A virus and influenza B virus by haemagglutination-inhibition. For four viruses (herpes simplex, measles, respiratory syncytial and rubella) higher levels of antibody were found in cord than in maternal sera. There was no difference between maternal and cord serum titres against influenza B virus but significantly higher levels of antibody against influenza A virus were found in maternal sera than in cord sera. This discrepancy was investigated by measuring antibodies against the surface antigens of influenza A by a complement fixation technique, and by single radial haemolysis. Both methods showed a preponderance of virus-specific antibody in cord sera. We conclude that IgG antibodies against most, if not all, viruses are concentrated on the fetal side of the circulation, but that conventional haemagglutination-inhibition techniques may fail to detect this difference.</abstract><relatedItem type="host"><titleInfo><title>Journal of Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>J. Hyg.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-1724</identifier><identifier type="PublisherID">HYG</identifier><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>89</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>303</start><end>310</end><total>8</total></extent></part></relatedItem><identifier type="istex">E50189B7E8121C0C8BC2A867EDAA92650C490902</identifier><identifier type="ark">ark:/67375/6GQ-P09CT8JH-M</identifier><identifier type="DOI">10.1017/S0022172400070832</identifier><identifier type="PII">S0022172400070832</identifier><identifier type="ArticleID">07083</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © Cambridge University Press 1982</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</recordContentSource><recordOrigin>Copyright © Cambridge University Press 1982</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-P09CT8JH-M/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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