Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis
Identifieur interne : 000037 ( Istex/Corpus ); précédent : 000036; suivant : 000038Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis
Auteurs : K. Nagashima ; H. Wege ; R. Meyermann ; V. Ter MeulenSource :
- Acta Neuropathologica [ 0001-6322 ] ; 1978-01-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Animal model, Astrocyte, Axon, Brain suspension, Corona, Corona virus, Degenerating, Degenerating cells, Degeneration, Demyelinating, Demyelinating lesions, Demyelinating plaques, Demyelination, Different kinds, Early lesions, Electron microscopy, Encephalomyelitis, Endoplasmic reticulum, Glial, Glial cells, Gray matter, Higher magnification, Histological findings, Intracerebral inoculation, Lampert, Lesion, Macrophage, Microtubule, Mononuclear, Mononuclear cell infiltration, Mononuclear cells, Myelin, Myelin sheaths, Naked axons, Necrotic cells, Neuron, Neuropathol, Oligodendrocyte, Optic, Optic chiasma, Optic nerve, Other demyelinating diseases, Perivascular, Perivascular cuffing, Plaque, Plasma cells, Specific tracts, Spinal, Spinal cord, Subacute, Subacute demyelinating encephalomyelitis, Viral, Viral antigen, Virus infection, Virus particles, Weanling, Weanling rats, White matter.
Abstract
Summary: Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.
Url:
DOI: 10.1007/BF00691641
Links to Exploration step
ISTEX:369E68C698D702B8B55A1E25964175B363432E3ELe document en format XML
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Nagashima</name><affiliation><mods:affiliation>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name><affiliation><mods:affiliation>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Meyermann, R" sort="Meyermann, R" uniqKey="Meyermann R" first="R." last="Meyermann">R. Meyermann</name><affiliation><mods:affiliation>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. 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Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</div></front></TEI><istex><corpusName>springer-journals</corpusName><keywords><teeft><json:string>demyelinating</json:string><json:string>myelin</json:string><json:string>oligodendrocyte</json:string><json:string>demyelination</json:string><json:string>spinal</json:string><json:string>encephalomyelitis</json:string><json:string>degenerating</json:string><json:string>viral</json:string><json:string>axon</json:string><json:string>astrocyte</json:string><json:string>optic</json:string><json:string>white matter</json:string><json:string>subacute</json:string><json:string>glial</json:string><json:string>neuropathol</json:string><json:string>acta</json:string><json:string>lampert</json:string><json:string>macrophage</json:string><json:string>perivascular</json:string><json:string>weanling</json:string><json:string>myelin sheaths</json:string><json:string>microtubule</json:string><json:string>acta neuropathol</json:string><json:string>lesion</json:string><json:string>degenerating cells</json:string><json:string>spinal cord</json:string><json:string>optic chiasma</json:string><json:string>demyelinating lesions</json:string><json:string>virus particles</json:string><json:string>subacute demyelinating encephalomyelitis</json:string><json:string>viral antigen</json:string><json:string>virus infection</json:string><json:string>corona virus</json:string><json:string>perivascular cuffing</json:string><json:string>degeneration</json:string><json:string>corona</json:string><json:string>mononuclear</json:string><json:string>glial cells</json:string><json:string>plasma cells</json:string><json:string>higher magnification</json:string><json:string>optic nerve</json:string><json:string>early lesions</json:string><json:string>neuron</json:string><json:string>necrotic cells</json:string><json:string>other demyelinating diseases</json:string><json:string>brain suspension</json:string><json:string>electron microscopy</json:string><json:string>different kinds</json:string><json:string>mononuclear cells</json:string><json:string>gray matter</json:string><json:string>demyelinating plaques</json:string><json:string>mononuclear cell infiltration</json:string><json:string>endoplasmic reticulum</json:string><json:string>animal model</json:string><json:string>intracerebral inoculation</json:string><json:string>specific tracts</json:string><json:string>weanling rats</json:string><json:string>naked axons</json:string><json:string>histological findings</json:string><json:string>plaque</json:string></teeft></keywords><author><json:item><name>K. Nagashima</name><affiliations><json:string>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</json:string></affiliations></json:item><json:item><name>H. Wege</name><affiliations><json:string>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</json:string></affiliations></json:item><json:item><name>R. Meyermann</name><affiliations><json:string>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</json:string></affiliations></json:item><json:item><name>V. ter Meulen</name><affiliations><json:string>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Corona virus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Weanling rats</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Demyelination</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Immunofluorescence</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Electron microscopy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Oligodendrocyte and Astrocyte</value></json:item></subject><articleId><json:string>BF00691641</json:string><json:string>Art10</json:string></articleId><arkIstex>ark:/67375/1BB-PN45ZG4G-X</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Summary: Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. 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Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Corona virus</term></item><item><term>Weanling rats</term></item><item><term>Demyelination</term></item><item><term>Immunofluorescence</term></item><item><term>Electron microscopy</term></item><item><term>Oligodendrocyte and Astrocyte</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pathology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1978-02-20">Created</change><change 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ContainsESM="No"><ArticleID>BF00691641</ArticleID><ArticleDOI>10.1007/BF00691641</ArticleDOI><ArticleSequenceNumber>10</ArticleSequenceNumber><ArticleTitle Language="En">Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis</ArticleTitle><ArticleCategory>Original Investigations</ArticleCategory><ArticleFirstPage>63</ArticleFirstPage><ArticleLastPage>70</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>11</Month><Day>9</Day></RegistrationDate><Received><Year>1978</Year><Month>2</Month><Day>20</Day></Received><Accepted><Year>1978</Year><Month>5</Month><Day>9</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1978</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>401</JournalID><VolumeIDStart>44</VolumeIDStart><VolumeIDEnd>44</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><FamilyName>Nagashima</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Wege</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" PresentAffiliationID="Aff2"><AuthorName DisplayOrder="Western"><GivenName>R.</GivenName><FamilyName>Meyermann</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>V.</GivenName><Particle>ter</Particle><FamilyName>Meulen</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Institute of Virology and Immunbiology</OrgDivision><OrgName>University of Würzburg</OrgName><OrgAddress><Street>Versbacher Landstr. 7</Street><Postcode>D-8700</Postcode><City>Würzburg</City><Country>Germany</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Neuropathology</OrgDivision><OrgName>University of Göttingen</OrgName><OrgAddress><Postcode>D-3400</Postcode><City>Göttingen</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found.</Para><Para>Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Corona virus</Keyword><Keyword>Weanling rats</Keyword><Keyword>Demyelination</Keyword><Keyword>Immunofluorescence</Keyword><Keyword>Electron microscopy</Keyword><Keyword>Oligodendrocyte and Astrocyte</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>Supported by Deutsche Forschungsgemeinschaft, Schwerpunkt: Multiple Sklerose und verwandte Erkrankungen</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Nagashima</namePart><affiliation>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Wege</namePart><affiliation>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Meyermann</namePart><affiliation>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">V.</namePart><namePart type="family">ter Meulen</namePart><affiliation>Institute of Virology and Immunbiology, University of Würzburg, Versbacher Landstr. 7, D-8700, Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1978-02-20</dateCreated><dateIssued encoding="w3cdtf">1978-01-01</dateIssued><copyrightDate encoding="w3cdtf">1978</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</abstract><note>Original Investigations</note><subject lang="en"><genre>Key words</genre><topic>Corona virus</topic><topic>Weanling rats</topic><topic>Demyelination</topic><topic>Immunofluorescence</topic><topic>Electron microscopy</topic><topic>Oligodendrocyte and Astrocyte</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neuropathologica</title></titleInfo><titleInfo type="abbreviated"><title>Acta Neuropathol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1978-01-01</dateIssued><copyrightDate encoding="w3cdtf">1978</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pathology</topic></subject><identifier type="ISSN">0001-6322</identifier><identifier type="eISSN">1432-0533</identifier><identifier type="JournalID">401</identifier><identifier type="IssueArticleCount">13</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>1978</date><detail type="volume"><number>44</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>63</start><end>70</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1978</recordOrigin></recordInfo></relatedItem><identifier type="istex">369E68C698D702B8B55A1E25964175B363432E3E</identifier><identifier type="ark">ark:/67375/1BB-PN45ZG4G-X</identifier><identifier type="DOI">10.1007/BF00691641</identifier><identifier type="ArticleID">BF00691641</identifier><identifier type="ArticleID">Art10</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1978</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1978</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-PN45ZG4G-X/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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