Mechanism of demyelination in JHM virus encephalomyelitis
Identifieur interne : 000885 ( Istex/Checkpoint ); précédent : 000884; suivant : 000886Mechanism of demyelination in JHM virus encephalomyelitis
Auteurs : Peter W. Lampert [États-Unis] ; Joel K. Sims [États-Unis] ; Alexis J. Kniazeff [États-Unis]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1973-03-01.
English descriptors
- KwdEn :
- Teeft :
- Acta neuropath, Axon, Cell biol, Cellular infiltrates, Corona viruses, Cytoplasmic, Cytoplasmic processes, Demyelinated axons, Demyelination, Electron microscopy, Encephalomyelitis, Extensive destruction, Glial, Glial cells, Granular cytoplasm, Hind quarter paralysis, Immune reaction, Infiltrates, Inoculation, Intact axons, Lamella, Lampert, Lesion, Mononuclear cells, Mononuclear leucocytes, Mouse hepatitis virus, Multinucleated giant cells, Murine virus, Myelin, Myelin debris, Myelin lamellae, Myelin sheaths, National institutes, Oligodendrocyte, Paraphenylene diamine, Percent phosphate, Plasma membranes, Spinal, Spinal cord, Tellurium neuropathy, Virus encephalomyelitis, Virus inoculation, Virus particles, Virus passages, Weanling mice.
Abstract
Summary: Weanling mice were given intraperitoneal inoculations of the neurotropic, JHM strain of mouse hepatitis virus, the virulence of which had been altered by repeated mouse passages. Five to seven days later many animals developed hind leg paralysis. The pathology consisted of an acute encephalomyelitis with patchy demyelinating lesions in the brain stem and spinal cord. Virus particles, consistent with the appearance of corona viruses, were found in the cytoplasm of cells that were identified as oligondendrocytes by demonstrating connections of their plasma membranes with myelin lamellae. Following the degeneration of oligodendrocytes the myelin sheaths disintegrated or were stripped off intact axons by cytoplasmic tongues of polymorpho- and mononuclear leucocytes that intruded between myelin lamellae. The findings indicate that JHM virus has an affinity for oligodendrocytes in weanling mice and that demyelination occurs subsequently to the degeneration of the infected oligodendrocytes.
Url:
DOI: 10.1007/BF00691421
Affiliations:
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Kniazeff</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Departments of Pathology and Medicine, University of California, 92037, San Diego, La Jolla, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1973-03-01">1973-03-01</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="76">76</biblScope><biblScope unit="page" to="85">85</biblScope></imprint><idno type="ISSN">0001-6322</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Corona Virus</term><term>Mouse Hepatitis Virus</term><term>Myelin Breakdown</term><term>Oligodendrocytes</term><term>Phagocytes</term><term>Stripping of Myelin Lamellae</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acta neuropath</term><term>Axon</term><term>Cell biol</term><term>Cellular infiltrates</term><term>Corona viruses</term><term>Cytoplasmic</term><term>Cytoplasmic processes</term><term>Demyelinated axons</term><term>Demyelination</term><term>Electron microscopy</term><term>Encephalomyelitis</term><term>Extensive destruction</term><term>Glial</term><term>Glial cells</term><term>Granular cytoplasm</term><term>Hind quarter paralysis</term><term>Immune reaction</term><term>Infiltrates</term><term>Inoculation</term><term>Intact axons</term><term>Lamella</term><term>Lampert</term><term>Lesion</term><term>Mononuclear cells</term><term>Mononuclear leucocytes</term><term>Mouse hepatitis virus</term><term>Multinucleated giant cells</term><term>Murine virus</term><term>Myelin</term><term>Myelin debris</term><term>Myelin lamellae</term><term>Myelin sheaths</term><term>National institutes</term><term>Oligodendrocyte</term><term>Paraphenylene diamine</term><term>Percent phosphate</term><term>Plasma membranes</term><term>Spinal</term><term>Spinal cord</term><term>Tellurium neuropathy</term><term>Virus encephalomyelitis</term><term>Virus inoculation</term><term>Virus particles</term><term>Virus passages</term><term>Weanling mice</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Weanling mice were given intraperitoneal inoculations of the neurotropic, JHM strain of mouse hepatitis virus, the virulence of which had been altered by repeated mouse passages. Five to seven days later many animals developed hind leg paralysis. The pathology consisted of an acute encephalomyelitis with patchy demyelinating lesions in the brain stem and spinal cord. Virus particles, consistent with the appearance of corona viruses, were found in the cytoplasm of cells that were identified as oligondendrocytes by demonstrating connections of their plasma membranes with myelin lamellae. Following the degeneration of oligodendrocytes the myelin sheaths disintegrated or were stripped off intact axons by cytoplasmic tongues of polymorpho- and mononuclear leucocytes that intruded between myelin lamellae. The findings indicate that JHM virus has an affinity for oligodendrocytes in weanling mice and that demyelination occurs subsequently to the degeneration of the infected oligodendrocytes.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Lampert, Peter W" sort="Lampert, Peter W" uniqKey="Lampert P" first="Peter W." last="Lampert">Peter W. Lampert</name></region><name sortKey="Kniazeff, Alexis J" sort="Kniazeff, Alexis J" uniqKey="Kniazeff A" first="Alexis J." last="Kniazeff">Alexis J. Kniazeff</name><name sortKey="Sims, Joel K" sort="Sims, Joel K" uniqKey="Sims J" first="Joel K." last="Sims">Joel K. Sims</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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