Coronavirus infection of polarized epithelial cells
Identifieur interne : 000441 ( Istex/Checkpoint ); précédent : 000440; suivant : 000442Coronavirus infection of polarized epithelial cells
Auteurs : John W. A Rossen [Pays-Bas] ; Marian C. Horzinek [Pays-Bas] ; Peter J. M Rottler [Pays-Bas]Source :
- Trends in Microbiology [ 0966-842X ] ; 1995.
English descriptors
- Teeft :
- Amino acid sequences, Apical, Apical membrane, Apical membrane domain, Apical plasma, Apical release, Basal membrane, Basolateral, Basolateral face, Basolateral release, Bovine coronavirus, Cell bioi, Cell lysis, Corona viruses, Coronavirus, Coronaviruses, Directional release, Enteritis, Ependymal celis, Epithelial, Epithelial cells, Epithelial layer, Human corona virus, Initial replication, Intercellular spaces, Intestine, Membrane, Model systems, Mouse hepatitis virus, Other coronaviruses, Polar release, Porcine, Receptor, Regulatory systems, Respiratory strains, Respiratory tract, Rough endoplasmic reticulum, Secretory proteins, Signal transduction, Spike protein, Tgev, Tight junctions, Transmissible gastroenteritis virus, Vesicle, Viral, Viral particles, Viral receptor, Virion, Virus, Virus release.
Abstract
Abstract: Epithelial cells are the first host cells to be infected by incoming coronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for the directional sorting of coronaviruses might be similar to those governing the polar release of secretory proteins.
Url:
DOI: 10.1016/S0966-842X(00)89018-6
Affiliations:
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<front><div type="abstract" xml:lang="en">Abstract: Epithelial cells are the first host cells to be infected by incoming coronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo. Mechanisms for the directional sorting of coronaviruses might be similar to those governing the polar release of secretory proteins.</div>
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