Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry
Identifieur interne : 000176 ( Istex/Checkpoint ); précédent : 000175; suivant : 000177Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry
Auteurs : Isabel Pérez-Castro [Espagne] ; Olga Caama O [Espagne] ; Franco Fernández [Espagne] ; Marcos D. García [Espagne] ; Carmen L Pez [Espagne] ; Erik De Clercq [Belgique]Source :
- Organic & Biomolecular Chemistry [ 1477-0520 ] ; 2007.
English descriptors
- Teeft :
- Alkyne, Antiviral, Aryl alkyne, Benzene, Biological evaluation, Biomol, Calcd, Cdcl3, Chem, Click chemistry, Column chromatography, Cycloaddition, Dabco, Dehydroiodination, Eluent, Eluting, Equiv, Etoac, Exch, Fractions eluting, Herpes simplex virus type, Hoch, Hrms, Hrms calcd, Identical spectroscopic features, Inhibitory activities, Mmax, Mmol, Reaction mixture, Room temperature, Royal society, Target compounds, Triazole, Virtual.
Abstract
The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′-iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′,3′-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary.
Url:
DOI: 10.1039/b710348d
Affiliations:
- Belgique, Espagne
- Galice, Province du Brabant flamand, Région flamande
- Louvain, Santiago de Compostela
- Katholieke Universiteit Leuven, Université de Saint-Jacques-de-Compostelle
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<term>Biomol</term>
<term>Calcd</term>
<term>Cdcl3</term>
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<term>Click chemistry</term>
<term>Column chromatography</term>
<term>Cycloaddition</term>
<term>Dabco</term>
<term>Dehydroiodination</term>
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<term>Eluting</term>
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<term>Exch</term>
<term>Fractions eluting</term>
<term>Herpes simplex virus type</term>
<term>Hoch</term>
<term>Hrms</term>
<term>Hrms calcd</term>
<term>Identical spectroscopic features</term>
<term>Inhibitory activities</term>
<term>Mmax</term>
<term>Mmol</term>
<term>Reaction mixture</term>
<term>Room temperature</term>
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<front><div type="abstract">The synthesis and biological evaluation as antiviral agents of a series of racemic 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′-iodocarbanucleosides and 4-aryl-1,2,3-triazolo-2′,3′-dideoxy-2′,3′-didehydrocarbanucleosides is presented. These compounds were produced using a click chemistry approach, with the iodoazide 13a as the key intermediary.</div>
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