COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium.
Identifieur interne : 000522 ( Main/Corpus ); précédent : 000521; suivant : 000523COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium.
Auteurs : Paolo Cravedi ; Suraj S. Mothi ; Yorg Azzi ; Meredith Haverly ; Samira S. Farouk ; María J. Pérez-Sáez ; Maria D. Redondo-Pach N ; Barbara Murphy ; Sander Florman ; Laura G. Cyrino ; Monica Grafals ; Sandheep Venkataraman ; Xingxing S. Cheng ; Aileen X. Wang ; Gianluigi Zaza ; Andrea Ranghino ; Lucrezia Furian ; Joaquin Manrique ; Umberto Maggiore ; Ilaria Gandolfini ; Nikhil Agrawal ; Het Patel ; Enver Akalin ; Leonardo V. RiellaSource :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2020.
English descriptors
- KwdEn :
- Aged (MeSH), COVID-19 (epidemiology), Comorbidity (MeSH), Europe (epidemiology), Female (MeSH), Follow-Up Studies (MeSH), Graft Rejection (epidemiology), Graft Rejection (prevention & control), Humans (MeSH), Immunocompromised Host (MeSH), Immunosuppression (methods), Immunosuppressive Agents (therapeutic use), Kidney Transplantation (statistics & numerical data), Male (MeSH), Middle Aged (MeSH), North America (epidemiology), Pandemics (MeSH), Retrospective Studies (MeSH), SARS-CoV-2 (MeSH), Transplant Recipients (MeSH).
- MESH :
- chemical , therapeutic use : Immunosuppressive Agents.
- geographic , epidemiology : Europe, North America.
- epidemiology : COVID-19, Graft Rejection.
- methods : Immunosuppression.
- prevention & control : Graft Rejection.
- statistics & numerical data : Kidney Transplantation.
- Aged, Comorbidity, Female, Follow-Up Studies, Humans, Immunocompromised Host, Male, Middle Aged, Pandemics, Retrospective Studies, SARS-CoV-2, Transplant Recipients.
Abstract
Kidney transplant recipients may be at a high risk of developing critical coronavirus disease 2019 (COVID-19) illness due to chronic immunosuppression and comorbidities. We identified hospitalized adult kidney transplant recipients at 12 transplant centers in the United States, Italy, and Spain who tested positive for COVID-19. Clinical presentation, laboratory values, immunosuppression, and treatment strategies were reviewed, and predictors of poor clinical outcomes were determined through multivariable analyses. Among 9845 kidney transplant recipients across centers, 144 were hospitalized due to COVID-19 during the 9-week study period. Of the 144 patients, 66% were male with a mean age of 60 (±12) years, and 40% were Hispanic and 25% were African American. Prevalent comorbidities included hypertension (95%), diabetes (52%), obesity (49%), and heart (28%) and lung (19%) disease. Therapeutic management included antimetabolite withdrawal (68%), calcineurin inhibitor withdrawal (23%), hydroxychloroquine (71%), antibiotics (74%), tocilizumab (13%), and antivirals (14%). During a median follow-up period of 52 days (IQR: 16-66 days), acute kidney injury occurred in 52% cases, with respiratory failure requiring intubation in 29%, and the mortality rate was 32%. The 46 patients who died were older, had lower lymphocyte counts and estimated glomerular filtration rate levels, and had higher serum lactate dehydrogenase, procalcitonin, and interleukin-6 levels. In sum, hospitalized kidney transplant recipients with COVID-19 have higher rates of acute kidney injury and mortality.
DOI: 10.1111/ajt.16185
PubMed: 32649791
PubMed Central: PMC7405285
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pubmed:32649791Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium.</title><author><name sortKey="Cravedi, Paolo" sort="Cravedi, Paolo" uniqKey="Cravedi P" first="Paolo" last="Cravedi">Paolo Cravedi</name><affiliation><nlm:affiliation>Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mothi, Suraj S" sort="Mothi, Suraj S" uniqKey="Mothi S" first="Suraj S" last="Mothi">Suraj S. Mothi</name><affiliation><nlm:affiliation>Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Azzi, Yorg" sort="Azzi, Yorg" uniqKey="Azzi Y" first="Yorg" last="Azzi">Yorg Azzi</name><affiliation><nlm:affiliation>Division of Nephrology, Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Haverly, Meredith" sort="Haverly, Meredith" uniqKey="Haverly M" first="Meredith" last="Haverly">Meredith Haverly</name><affiliation><nlm:affiliation>Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Farouk, Samira S" sort="Farouk, Samira S" uniqKey="Farouk S" first="Samira S" last="Farouk">Samira S. Farouk</name><affiliation><nlm:affiliation>Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Perez Saez, Maria J" sort="Perez Saez, Maria J" uniqKey="Perez Saez M" first="María J" last="Pérez-Sáez">María J. Pérez-Sáez</name><affiliation><nlm:affiliation>Servicio de Nefrología, Hospital del Mar, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Redondo Pach N, Maria D" sort="Redondo Pach N, Maria D" uniqKey="Redondo Pach N M" first="Maria D" last="Redondo-Pach N">Maria D. Redondo-Pach N</name><affiliation><nlm:affiliation>Servicio de Nefrología, Hospital del Mar, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Murphy, Barbara" sort="Murphy, Barbara" uniqKey="Murphy B" first="Barbara" last="Murphy">Barbara Murphy</name><affiliation><nlm:affiliation>Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Florman, Sander" sort="Florman, Sander" uniqKey="Florman S" first="Sander" last="Florman">Sander Florman</name><affiliation><nlm:affiliation>Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cyrino, Laura G" sort="Cyrino, Laura G" uniqKey="Cyrino L" first="Laura G" last="Cyrino">Laura G. Cyrino</name><affiliation><nlm:affiliation>Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Grafals, Monica" sort="Grafals, Monica" uniqKey="Grafals M" first="Monica" last="Grafals">Monica Grafals</name><affiliation><nlm:affiliation>Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Venkataraman, Sandheep" sort="Venkataraman, Sandheep" uniqKey="Venkataraman S" first="Sandheep" last="Venkataraman">Sandheep Venkataraman</name><affiliation><nlm:affiliation>Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Xingxing S" sort="Cheng, Xingxing S" uniqKey="Cheng X" first="Xingxing S" last="Cheng">Xingxing S. Cheng</name><affiliation><nlm:affiliation>Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Aileen X" sort="Wang, Aileen X" uniqKey="Wang A" first="Aileen X" last="Wang">Aileen X. Wang</name><affiliation><nlm:affiliation>Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zaza, Gianluigi" sort="Zaza, Gianluigi" uniqKey="Zaza G" first="Gianluigi" last="Zaza">Gianluigi Zaza</name><affiliation><nlm:affiliation>Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ranghino, Andrea" sort="Ranghino, Andrea" uniqKey="Ranghino A" first="Andrea" last="Ranghino">Andrea Ranghino</name><affiliation><nlm:affiliation>SOD Nefrologia, Dialisi e Trapianto Rene, AOU Ospedali Riuniti, Ancona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Furian, Lucrezia" sort="Furian, Lucrezia" uniqKey="Furian L" first="Lucrezia" last="Furian">Lucrezia Furian</name><affiliation><nlm:affiliation>Kidney and Pancreas Transplantation Unit, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Manrique, Joaquin" sort="Manrique, Joaquin" uniqKey="Manrique J" first="Joaquin" last="Manrique">Joaquin Manrique</name><affiliation><nlm:affiliation>Nephrology Service, Complejo Hospitalario de Navarra, Pamplona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Maggiore, Umberto" sort="Maggiore, Umberto" uniqKey="Maggiore U" first="Umberto" last="Maggiore">Umberto Maggiore</name><affiliation><nlm:affiliation>Dipartimento di Medicina e Chirurgia, Università di Parma, UO Nefrologia, Azienda Ospedaliera-Universitaria Parma, Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gandolfini, Ilaria" sort="Gandolfini, Ilaria" uniqKey="Gandolfini I" first="Ilaria" last="Gandolfini">Ilaria Gandolfini</name><affiliation><nlm:affiliation>Dipartimento di Medicina e Chirurgia, Università di Parma, UO Nefrologia, Azienda Ospedaliera-Universitaria Parma, Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Agrawal, Nikhil" sort="Agrawal, Nikhil" uniqKey="Agrawal N" first="Nikhil" last="Agrawal">Nikhil Agrawal</name><affiliation><nlm:affiliation>Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Het" sort="Patel, Het" uniqKey="Patel H" first="Het" last="Patel">Het Patel</name><affiliation><nlm:affiliation>Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Akalin, Enver" sort="Akalin, Enver" uniqKey="Akalin E" first="Enver" last="Akalin">Enver Akalin</name><affiliation><nlm:affiliation>Division of Nephrology, Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Riella, Leonardo V" sort="Riella, Leonardo V" uniqKey="Riella L" first="Leonardo V" last="Riella">Leonardo V. Riella</name><affiliation><nlm:affiliation>Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32649791</idno><idno type="pmid">32649791</idno><idno type="doi">10.1111/ajt.16185</idno><idno type="pmc">PMC7405285</idno><idno type="wicri:Area/Main/Corpus">000522</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000522</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium.</title><author><name sortKey="Cravedi, Paolo" sort="Cravedi, Paolo" uniqKey="Cravedi P" first="Paolo" last="Cravedi">Paolo Cravedi</name><affiliation><nlm:affiliation>Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mothi, Suraj S" sort="Mothi, Suraj S" uniqKey="Mothi S" first="Suraj S" last="Mothi">Suraj S. Mothi</name><affiliation><nlm:affiliation>Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Azzi, Yorg" sort="Azzi, Yorg" uniqKey="Azzi Y" first="Yorg" last="Azzi">Yorg Azzi</name><affiliation><nlm:affiliation>Division of Nephrology, Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Haverly, Meredith" sort="Haverly, Meredith" uniqKey="Haverly M" first="Meredith" last="Haverly">Meredith Haverly</name><affiliation><nlm:affiliation>Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Farouk, Samira S" sort="Farouk, Samira S" uniqKey="Farouk S" first="Samira S" last="Farouk">Samira S. Farouk</name><affiliation><nlm:affiliation>Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Perez Saez, Maria J" sort="Perez Saez, Maria J" uniqKey="Perez Saez M" first="María J" last="Pérez-Sáez">María J. Pérez-Sáez</name><affiliation><nlm:affiliation>Servicio de Nefrología, Hospital del Mar, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Redondo Pach N, Maria D" sort="Redondo Pach N, Maria D" uniqKey="Redondo Pach N M" first="Maria D" last="Redondo-Pach N">Maria D. Redondo-Pach N</name><affiliation><nlm:affiliation>Servicio de Nefrología, Hospital del Mar, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Murphy, Barbara" sort="Murphy, Barbara" uniqKey="Murphy B" first="Barbara" last="Murphy">Barbara Murphy</name><affiliation><nlm:affiliation>Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Florman, Sander" sort="Florman, Sander" uniqKey="Florman S" first="Sander" last="Florman">Sander Florman</name><affiliation><nlm:affiliation>Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cyrino, Laura G" sort="Cyrino, Laura G" uniqKey="Cyrino L" first="Laura G" last="Cyrino">Laura G. Cyrino</name><affiliation><nlm:affiliation>Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Grafals, Monica" sort="Grafals, Monica" uniqKey="Grafals M" first="Monica" last="Grafals">Monica Grafals</name><affiliation><nlm:affiliation>Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Venkataraman, Sandheep" sort="Venkataraman, Sandheep" uniqKey="Venkataraman S" first="Sandheep" last="Venkataraman">Sandheep Venkataraman</name><affiliation><nlm:affiliation>Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Xingxing S" sort="Cheng, Xingxing S" uniqKey="Cheng X" first="Xingxing S" last="Cheng">Xingxing S. Cheng</name><affiliation><nlm:affiliation>Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Aileen X" sort="Wang, Aileen X" uniqKey="Wang A" first="Aileen X" last="Wang">Aileen X. Wang</name><affiliation><nlm:affiliation>Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zaza, Gianluigi" sort="Zaza, Gianluigi" uniqKey="Zaza G" first="Gianluigi" last="Zaza">Gianluigi Zaza</name><affiliation><nlm:affiliation>Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ranghino, Andrea" sort="Ranghino, Andrea" uniqKey="Ranghino A" first="Andrea" last="Ranghino">Andrea Ranghino</name><affiliation><nlm:affiliation>SOD Nefrologia, Dialisi e Trapianto Rene, AOU Ospedali Riuniti, Ancona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Furian, Lucrezia" sort="Furian, Lucrezia" uniqKey="Furian L" first="Lucrezia" last="Furian">Lucrezia Furian</name><affiliation><nlm:affiliation>Kidney and Pancreas Transplantation Unit, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Manrique, Joaquin" sort="Manrique, Joaquin" uniqKey="Manrique J" first="Joaquin" last="Manrique">Joaquin Manrique</name><affiliation><nlm:affiliation>Nephrology Service, Complejo Hospitalario de Navarra, Pamplona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Maggiore, Umberto" sort="Maggiore, Umberto" uniqKey="Maggiore U" first="Umberto" last="Maggiore">Umberto Maggiore</name><affiliation><nlm:affiliation>Dipartimento di Medicina e Chirurgia, Università di Parma, UO Nefrologia, Azienda Ospedaliera-Universitaria Parma, Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gandolfini, Ilaria" sort="Gandolfini, Ilaria" uniqKey="Gandolfini I" first="Ilaria" last="Gandolfini">Ilaria Gandolfini</name><affiliation><nlm:affiliation>Dipartimento di Medicina e Chirurgia, Università di Parma, UO Nefrologia, Azienda Ospedaliera-Universitaria Parma, Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Agrawal, Nikhil" sort="Agrawal, Nikhil" uniqKey="Agrawal N" first="Nikhil" last="Agrawal">Nikhil Agrawal</name><affiliation><nlm:affiliation>Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Het" sort="Patel, Het" uniqKey="Patel H" first="Het" last="Patel">Het Patel</name><affiliation><nlm:affiliation>Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Akalin, Enver" sort="Akalin, Enver" uniqKey="Akalin E" first="Enver" last="Akalin">Enver Akalin</name><affiliation><nlm:affiliation>Division of Nephrology, Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Riella, Leonardo V" sort="Riella, Leonardo V" uniqKey="Riella L" first="Leonardo V" last="Riella">Leonardo V. Riella</name><affiliation><nlm:affiliation>Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>COVID-19 (epidemiology)</term><term>Comorbidity (MeSH)</term><term>Europe (epidemiology)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Graft Rejection (epidemiology)</term><term>Graft Rejection (prevention & control)</term><term>Humans (MeSH)</term><term>Immunocompromised Host (MeSH)</term><term>Immunosuppression (methods)</term><term>Immunosuppressive Agents (therapeutic use)</term><term>Kidney Transplantation (statistics & numerical data)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>North America (epidemiology)</term><term>Pandemics (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Transplant Recipients (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term><term>North America</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>COVID-19</term><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunosuppression</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Kidney Transplantation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Comorbidity</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunocompromised Host</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>SARS-CoV-2</term><term>Transplant Recipients</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Kidney transplant recipients may be at a high risk of developing critical coronavirus disease 2019 (COVID-19) illness due to chronic immunosuppression and comorbidities. We identified hospitalized adult kidney transplant recipients at 12 transplant centers in the United States, Italy, and Spain who tested positive for COVID-19. Clinical presentation, laboratory values, immunosuppression, and treatment strategies were reviewed, and predictors of poor clinical outcomes were determined through multivariable analyses. Among 9845 kidney transplant recipients across centers, 144 were hospitalized due to COVID-19 during the 9-week study period. Of the 144 patients, 66% were male with a mean age of 60 (±12) years, and 40% were Hispanic and 25% were African American. Prevalent comorbidities included hypertension (95%), diabetes (52%), obesity (49%), and heart (28%) and lung (19%) disease. Therapeutic management included antimetabolite withdrawal (68%), calcineurin inhibitor withdrawal (23%), hydroxychloroquine (71%), antibiotics (74%), tocilizumab (13%), and antivirals (14%). During a median follow-up period of 52 days (IQR: 16-66 days), acute kidney injury occurred in 52% cases, with respiratory failure requiring intubation in 29%, and the mortality rate was 32%. The 46 patients who died were older, had lower lymphocyte counts and estimated glomerular filtration rate levels, and had higher serum lactate dehydrogenase, procalcitonin, and interleukin-6 levels. In sum, hospitalized kidney transplant recipients with COVID-19 have higher rates of acute kidney injury and mortality.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32649791</PMID><DateCompleted><Year>2020</Year><Month>12</Month><Day>23</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>11</Issue><PubDate><Year>2020</Year><Month>11</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium.</ArticleTitle><Pagination><MedlinePgn>3140-3148</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.16185</ELocationID><Abstract><AbstractText>Kidney transplant recipients may be at a high risk of developing critical coronavirus disease 2019 (COVID-19) illness due to chronic immunosuppression and comorbidities. We identified hospitalized adult kidney transplant recipients at 12 transplant centers in the United States, Italy, and Spain who tested positive for COVID-19. Clinical presentation, laboratory values, immunosuppression, and treatment strategies were reviewed, and predictors of poor clinical outcomes were determined through multivariable analyses. Among 9845 kidney transplant recipients across centers, 144 were hospitalized due to COVID-19 during the 9-week study period. Of the 144 patients, 66% were male with a mean age of 60 (±12) years, and 40% were Hispanic and 25% were African American. Prevalent comorbidities included hypertension (95%), diabetes (52%), obesity (49%), and heart (28%) and lung (19%) disease. Therapeutic management included antimetabolite withdrawal (68%), calcineurin inhibitor withdrawal (23%), hydroxychloroquine (71%), antibiotics (74%), tocilizumab (13%), and antivirals (14%). During a median follow-up period of 52 days (IQR: 16-66 days), acute kidney injury occurred in 52% cases, with respiratory failure requiring intubation in 29%, and the mortality rate was 32%. The 46 patients who died were older, had lower lymphocyte counts and estimated glomerular filtration rate levels, and had higher serum lactate dehydrogenase, procalcitonin, and interleukin-6 levels. In sum, hospitalized kidney transplant recipients with COVID-19 have higher rates of acute kidney injury and mortality.</AbstractText><CopyrightInformation>© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cravedi</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0001-7837-0923</Identifier><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mothi</LastName><ForeName>Suraj S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azzi</LastName><ForeName>Yorg</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haverly</LastName><ForeName>Meredith</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farouk</LastName><ForeName>Samira S</ForeName><Initials>SS</Initials><Identifier Source="ORCID">0000-0001-5598-5925</Identifier><AffiliationInfo><Affiliation>Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pérez-Sáez</LastName><ForeName>María J</ForeName><Initials>MJ</Initials><Identifier Source="ORCID">0000-0002-8601-2699</Identifier><AffiliationInfo><Affiliation>Servicio de Nefrología, Hospital del Mar, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Redondo-Pachón</LastName><ForeName>Maria D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Servicio de Nefrología, Hospital del Mar, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murphy</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Florman</LastName><ForeName>Sander</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cyrino</LastName><ForeName>Laura G</ForeName><Initials>LG</Initials><AffiliationInfo><Affiliation>Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grafals</LastName><ForeName>Monica</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venkataraman</LastName><ForeName>Sandheep</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Xingxing S</ForeName><Initials>XS</Initials><Identifier Source="ORCID">0000-0002-0542-8749</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Aileen X</ForeName><Initials>AX</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaza</LastName><ForeName>Gianluigi</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0002-6004-6196</Identifier><AffiliationInfo><Affiliation>Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranghino</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>SOD Nefrologia, Dialisi e Trapianto Rene, AOU Ospedali Riuniti, Ancona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Furian</LastName><ForeName>Lucrezia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Kidney and Pancreas Transplantation Unit, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manrique</LastName><ForeName>Joaquin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Nephrology Service, Complejo Hospitalario de Navarra, Pamplona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maggiore</LastName><ForeName>Umberto</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Dipartimento di Medicina e Chirurgia, Università di Parma, UO Nefrologia, Azienda Ospedaliera-Universitaria Parma, Parma, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gandolfini</LastName><ForeName>Ilaria</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Dipartimento di Medicina e Chirurgia, Università di Parma, UO Nefrologia, Azienda Ospedaliera-Universitaria Parma, Parma, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agrawal</LastName><ForeName>Nikhil</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Het</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akalin</LastName><ForeName>Enver</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000-0003-1341-5144</Identifier><AffiliationInfo><Affiliation>Division of Nephrology, Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riella</LastName><ForeName>Leonardo V</ForeName><Initials>LV</Initials><Identifier Source="ORCID">0000-0002-7636-3196</Identifier><AffiliationInfo><Affiliation>Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName><QualifierName UI="Q000453" 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Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016030" MajorTopicYN="N">Kidney Transplantation</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009656" MajorTopicYN="N" Type="Geographic">North America</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" 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