Characteristics, treatment, outcomes and cause of death of invasively ventilated patients with COVID-19 ARDS in Milan, Italy.
Identifieur interne : 000800 ( Main/Exploration ); précédent : 000799; suivant : 000801Characteristics, treatment, outcomes and cause of death of invasively ventilated patients with COVID-19 ARDS in Milan, Italy.
Auteurs : Alberto Zangrillo [Italie] ; Luigi Beretta [Italie] ; Anna Mara Scandroglio [Italie] ; Giacomo Monti [Italie] ; Evgeny Fominskiy [Italie] ; Sergio Colombo [Italie] ; Federica Morselli [Italie] ; Alessandro Belletti [Italie] ; Paolo Silvani [Italie] ; Martina Crivellari [Italie] ; Fabrizio Monaco [Italie] ; Maria Luisa Azzolini [Italie] ; Raffaella Reineke [Italie] ; Pasquale Nardelli [Italie] ; Marianna Sartorelli [Italie] ; Carmine D. Votta [Italie] ; Annalisa Ruggeri [Italie] ; Fabio Ciceri [Italie] ; Francesco De Cobelli [Italie] ; Moreno Tresoldi [Italie] ; Lorenzo Dagna [Italie] ; Patrizia Rovere-Querini [Italie] ; Ary Serpa Neto [Australie] ; Rinaldo Bellomo [Australie] ; Giovanni Landoni [Italie]Source :
- Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine [ 1441-2772 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Cause de décès (MeSH), Facteurs de risque (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Humains (MeSH), Hypertension artérielle (complications), Infections à coronavirus (mortalité), Infections à coronavirus (thérapie), Italie (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (thérapie), Sujet âgé (MeSH), Syndrome de détresse respiratoire de l'adulte (mortalité), Syndrome de détresse respiratoire de l'adulte (thérapie), Syndrome de détresse respiratoire de l'adulte (virologie), Ventilation artificielle (MeSH).
- MESH :
- mortalité : Infections à coronavirus, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- thérapie : Infections à coronavirus, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- virologie : Syndrome de détresse respiratoire de l'adulte.
- Adulte d'âge moyen, Betacoronavirus, Cause de décès, Facteurs de risque, Facteurs âges, Femelle, Humains, Hypertension artérielle, Italie, Mâle, Pandémies, Sujet âgé, Ventilation artificielle.
- Wicri :
- geographic : Italie.
English descriptors
- KwdEn :
- Age Factors (MeSH), Aged (MeSH), Betacoronavirus (MeSH), Cause of Death (MeSH), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Female (MeSH), Humans (MeSH), Hypertension (complications), Italy (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Respiration, Artificial (MeSH), Respiratory Distress Syndrome, Adult (mortality), Respiratory Distress Syndrome, Adult (therapy), Respiratory Distress Syndrome, Adult (virology), Risk Factors (MeSH).
- MESH :
- geographic : Italy.
- complications : Hypertension.
- mortality : Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- therapy : Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- virology : Respiratory Distress Syndrome, Adult.
- Age Factors, Aged, Betacoronavirus, Cause of Death, Female, Humans, Male, Middle Aged, Pandemics, Respiration, Artificial, Risk Factors.
Abstract
OBJECTIVE
Describe characteristics, daily care and outcomes of patients with coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS).
DESIGN
Case series of 73 patients.
SETTING
Large tertiary hospital in Milan.
PARTICIPANTS
Mechanically ventilated patients with confirmed COVID-19 admitted to the intensive care unit (ICU) between 20 February and 2 April 2020.
MAIN OUTCOME MEASURES
Demographic and daily clinical data were collected to identify predictors of early mortality.
RESULTS
Of the 73 patients included in the study, most were male (83.6%), the median age was 61 years (interquartile range [IQR], 54-69 years), and hypertension affected 52.9% of patients. Lymphocytopenia (median, 0.77 x 10
CONCLUSIONS
Despite multiple advanced critical care interventions, COVID-19 ARDS was associated with prolonged ventilation and high short term mortality. Older age and pre-admission hypertension were key mortality risk factors.
TRIAL REGISTRATION
ClinicalTrials.gov identifier: NCT04318366.
PubMed: 32900326
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Monaco, Fabrizio" sort="Monaco, Fabrizio" uniqKey="Monaco F" first="Fabrizio" last="Monaco">Fabrizio Monaco</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Azzolini, Maria Luisa" sort="Azzolini, Maria Luisa" uniqKey="Azzolini M" first="Maria Luisa" last="Azzolini">Maria Luisa Azzolini</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Reineke, Raffaella" sort="Reineke, Raffaella" uniqKey="Reineke R" first="Raffaella" last="Reineke">Raffaella Reineke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Nardelli, Pasquale" sort="Nardelli, Pasquale" uniqKey="Nardelli P" first="Pasquale" last="Nardelli">Pasquale Nardelli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sartorelli, Marianna" sort="Sartorelli, Marianna" uniqKey="Sartorelli M" first="Marianna" last="Sartorelli">Marianna Sartorelli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Votta, Carmine D" sort="Votta, Carmine D" uniqKey="Votta C" first="Carmine D" last="Votta">Carmine D. Votta</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ciceri, Fabio" sort="Ciceri, Fabio" uniqKey="Ciceri F" first="Fabio" last="Ciceri">Fabio Ciceri</name><affiliation wicri:level="3"><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="De Cobelli, Francesco" sort="De Cobelli, Francesco" uniqKey="De Cobelli F" first="Francesco" last="De Cobelli">Francesco De Cobelli</name><affiliation wicri:level="3"><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Tresoldi, Moreno" sort="Tresoldi, Moreno" uniqKey="Tresoldi M" first="Moreno" last="Tresoldi">Moreno Tresoldi</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dagna, Lorenzo" sort="Dagna, Lorenzo" uniqKey="Dagna L" first="Lorenzo" last="Dagna">Lorenzo Dagna</name><affiliation wicri:level="3"><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Rovere Querini, Patrizia" sort="Rovere Querini, Patrizia" uniqKey="Rovere Querini P" first="Patrizia" last="Rovere-Querini">Patrizia Rovere-Querini</name><affiliation wicri:level="3"><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Serpa Neto, Ary" sort="Serpa Neto, Ary" uniqKey="Serpa Neto A" first="Ary" last="Serpa Neto">Ary Serpa Neto</name><affiliation wicri:level="1"><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><affiliation wicri:level="1"><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Landoni, Giovanni" sort="Landoni, Giovanni" uniqKey="Landoni G" first="Giovanni" last="Landoni">Giovanni Landoni</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. landoni.giovanni@hsr.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32900326</idno><idno type="pmid">32900326</idno><idno type="wicri:Area/Main/Corpus">000306</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000306</idno><idno type="wicri:Area/Main/Curation">000306</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000306</idno><idno type="wicri:Area/Main/Exploration">000306</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characteristics, treatment, outcomes and cause of death of invasively ventilated patients with COVID-19 ARDS in Milan, Italy.</title><author><name sortKey="Zangrillo, Alberto" sort="Zangrillo, Alberto" uniqKey="Zangrillo A" first="Alberto" last="Zangrillo">Alberto Zangrillo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Beretta, Luigi" sort="Beretta, Luigi" uniqKey="Beretta L" first="Luigi" last="Beretta">Luigi Beretta</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Scandroglio, Anna Mara" sort="Scandroglio, Anna Mara" uniqKey="Scandroglio A" first="Anna Mara" last="Scandroglio">Anna Mara Scandroglio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Monti, Giacomo" sort="Monti, Giacomo" uniqKey="Monti G" first="Giacomo" last="Monti">Giacomo Monti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Fominskiy, Evgeny" sort="Fominskiy, Evgeny" uniqKey="Fominskiy E" first="Evgeny" last="Fominskiy">Evgeny Fominskiy</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Colombo, Sergio" sort="Colombo, Sergio" uniqKey="Colombo S" first="Sergio" last="Colombo">Sergio Colombo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Morselli, Federica" sort="Morselli, Federica" uniqKey="Morselli F" first="Federica" last="Morselli">Federica Morselli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Belletti, Alessandro" sort="Belletti, Alessandro" uniqKey="Belletti A" first="Alessandro" last="Belletti">Alessandro Belletti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Silvani, Paolo" sort="Silvani, Paolo" uniqKey="Silvani P" first="Paolo" last="Silvani">Paolo Silvani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Crivellari, Martina" sort="Crivellari, Martina" uniqKey="Crivellari M" first="Martina" last="Crivellari">Martina Crivellari</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Monaco, Fabrizio" sort="Monaco, Fabrizio" uniqKey="Monaco F" first="Fabrizio" last="Monaco">Fabrizio Monaco</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Azzolini, Maria Luisa" sort="Azzolini, Maria Luisa" uniqKey="Azzolini M" first="Maria Luisa" last="Azzolini">Maria Luisa Azzolini</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Reineke, Raffaella" sort="Reineke, Raffaella" uniqKey="Reineke R" first="Raffaella" last="Reineke">Raffaella Reineke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Nardelli, Pasquale" sort="Nardelli, Pasquale" uniqKey="Nardelli P" first="Pasquale" last="Nardelli">Pasquale Nardelli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sartorelli, Marianna" sort="Sartorelli, Marianna" uniqKey="Sartorelli M" first="Marianna" last="Sartorelli">Marianna Sartorelli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Votta, Carmine D" sort="Votta, Carmine D" uniqKey="Votta C" first="Carmine D" last="Votta">Carmine D. Votta</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Ciceri, Fabio" sort="Ciceri, Fabio" uniqKey="Ciceri F" first="Fabio" last="Ciceri">Fabio Ciceri</name><affiliation wicri:level="3"><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="De Cobelli, Francesco" sort="De Cobelli, Francesco" uniqKey="De Cobelli F" first="Francesco" last="De Cobelli">Francesco De Cobelli</name><affiliation wicri:level="3"><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Tresoldi, Moreno" sort="Tresoldi, Moreno" uniqKey="Tresoldi M" first="Moreno" last="Tresoldi">Moreno Tresoldi</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dagna, Lorenzo" sort="Dagna, Lorenzo" uniqKey="Dagna L" first="Lorenzo" last="Dagna">Lorenzo Dagna</name><affiliation wicri:level="3"><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Rovere Querini, Patrizia" sort="Rovere Querini, Patrizia" uniqKey="Rovere Querini P" first="Patrizia" last="Rovere-Querini">Patrizia Rovere-Querini</name><affiliation wicri:level="3"><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Serpa Neto, Ary" sort="Serpa Neto, Ary" uniqKey="Serpa Neto A" first="Ary" last="Serpa Neto">Ary Serpa Neto</name><affiliation wicri:level="1"><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><affiliation wicri:level="1"><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Landoni, Giovanni" sort="Landoni, Giovanni" uniqKey="Landoni G" first="Giovanni" last="Landoni">Giovanni Landoni</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. landoni.giovanni@hsr.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><series><title level="j">Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine</title><idno type="ISSN">1441-2772</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Cause of Death (MeSH)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (therapy)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Hypertension (complications)</term><term>Italy (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (therapy)</term><term>Respiration, Artificial (MeSH)</term><term>Respiratory Distress Syndrome, Adult (mortality)</term><term>Respiratory Distress Syndrome, Adult (therapy)</term><term>Respiratory Distress Syndrome, Adult (virology)</term><term>Risk Factors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Cause de décès (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hypertension artérielle (complications)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (thérapie)</term><term>Italie (MeSH)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (thérapie)</term><term>Sujet âgé (MeSH)</term><term>Syndrome de détresse respiratoire de l'adulte (mortalité)</term><term>Syndrome de détresse respiratoire de l'adulte (thérapie)</term><term>Syndrome de détresse respiratoire de l'adulte (virologie)</term><term>Ventilation artificielle (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypertension</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Betacoronavirus</term><term>Cause of Death</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Respiration, Artificial</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Cause de décès</term><term>Facteurs de risque</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Hypertension artérielle</term><term>Italie</term><term>Mâle</term><term>Pandémies</term><term>Sujet âgé</term><term>Ventilation artificielle</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Italie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>Describe characteristics, daily care and outcomes of patients with coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS).</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>Case series of 73 patients.</p></div><div type="abstract" xml:lang="en"><p><b>SETTING</b></p><p>Large tertiary hospital in Milan.</p></div><div type="abstract" xml:lang="en"><p><b>PARTICIPANTS</b></p><p>Mechanically ventilated patients with confirmed COVID-19 admitted to the intensive care unit (ICU) between 20 February and 2 April 2020.</p></div><div type="abstract" xml:lang="en"><p><b>MAIN OUTCOME MEASURES</b></p><p>Demographic and daily clinical data were collected to identify predictors of early mortality.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Of the 73 patients included in the study, most were male (83.6%), the median age was 61 years (interquartile range [IQR], 54-69 years), and hypertension affected 52.9% of patients. Lymphocytopenia (median, 0.77 x 10</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Despite multiple advanced critical care interventions, COVID-19 ARDS was associated with prolonged ventilation and high short term mortality. Older age and pre-admission hypertension were key mortality risk factors.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b></p><p>ClinicalTrials.gov identifier: NCT04318366.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32900326</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1441-2772</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>3</Issue><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine</Title><ISOAbbreviation>Crit Care Resusc</ISOAbbreviation></Journal><ArticleTitle>Characteristics, treatment, outcomes and cause of death of invasively ventilated patients with COVID-19 ARDS in Milan, Italy.</ArticleTitle><Pagination><MedlinePgn>200-211</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Describe characteristics, daily care and outcomes of patients with coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS).</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Case series of 73 patients.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Large tertiary hospital in Milan.</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Mechanically ventilated patients with confirmed COVID-19 admitted to the intensive care unit (ICU) between 20 February and 2 April 2020.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURES" NlmCategory="METHODS">Demographic and daily clinical data were collected to identify predictors of early mortality.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 73 patients included in the study, most were male (83.6%), the median age was 61 years (interquartile range [IQR], 54-69 years), and hypertension affected 52.9% of patients. Lymphocytopenia (median, 0.77 x 10<sup>3</sup> per mm<sup>3</sup>; IQR, 0.58-1.00 x 10<sup>3</sup> per mm<sup>3</sup>), hyperinflammation with C-reactive protein (median, 184.5 mg/dL; IQR, 108.2-269.1 mg/dL) and pro-coagulant status with D-dimer (median, 10.1 μg/m; IQR, 5.0-23.8 μg/m) were present. Median tidal volume was 6.7 mL/kg (IQR, 6.0-7.5 mL/kg), and median positive end-expiratory pressure was 12 cmH<sub>2</sub>O (IQR, 10-14 cmH<sub>2</sub>O). In the first 3 days, prone positioning (12-16 h) was used in 63.8% of patients and extracorporeal membrane oxygenation in five patients (6.8%). After a median follow-up of 19.0 days (IQR, 15.0-27.0 days), 17 patients (23.3%) had died, 23 (31.5%) had been discharged from the ICU, and 33 (45.2%) were receiving invasive mechanical ventilation in the ICU. Older age (odds ratio [OR], 1.12; 95% CI, 1.04-1.22; <i>P</i> = 0.004) and hypertension (OR, 6.15; 95% CI, 1.75-29.11; <i>P</i> = 0.009) were associated with mortality, while early improvement in arterial partial pressure of oxygen (PaO<sub>2</sub>) to fraction of inspired oxygen (FiO<sub>2</sub>) ratio was associated with being discharged alive from the ICU (<i>P</i> = 0.002 for interaction).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Despite multiple advanced critical care interventions, COVID-19 ARDS was associated with prolonged ventilation and high short term mortality. Older age and pre-admission hypertension were key mortality risk factors.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov identifier: NCT04318366.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zangrillo</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beretta</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scandroglio</LastName><ForeName>Anna Mara</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monti</LastName><ForeName>Giacomo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fominskiy</LastName><ForeName>Evgeny</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colombo</LastName><ForeName>Sergio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morselli</LastName><ForeName>Federica</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belletti</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silvani</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crivellari</LastName><ForeName>Martina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monaco</LastName><ForeName>Fabrizio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Azzolini</LastName><ForeName>Maria Luisa</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reineke</LastName><ForeName>Raffaella</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nardelli</LastName><ForeName>Pasquale</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sartorelli</LastName><ForeName>Marianna</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Votta</LastName><ForeName>Carmine D</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruggeri</LastName><ForeName>Annalisa</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ciceri</LastName><ForeName>Fabio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Vita-Salute San Raffaele University, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Cobelli</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Vita-Salute San Raffaele University, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tresoldi</LastName><ForeName>Moreno</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dagna</LastName><ForeName>Lorenzo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Vita-Salute San Raffaele University, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rovere-Querini</LastName><ForeName>Patrizia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Vita-Salute San Raffaele University, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serpa Neto</LastName><ForeName>Ary</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellomo</LastName><ForeName>Rinaldo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landoni</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. landoni.giovanni@hsr.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>COVID-BioB Study Group
</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT04318366</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Australia</Country><MedlineTA>Crit Care Resusc</MedlineTA><NlmUniqueID>100888170</NlmUniqueID><ISSNLinking>1441-2772</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" 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sort="Zangrillo, Alberto" uniqKey="Zangrillo A" first="Alberto" last="Zangrillo">Alberto Zangrillo</name></region><name sortKey="Azzolini, Maria Luisa" sort="Azzolini, Maria Luisa" uniqKey="Azzolini M" first="Maria Luisa" last="Azzolini">Maria Luisa Azzolini</name><name sortKey="Belletti, Alessandro" sort="Belletti, Alessandro" uniqKey="Belletti A" first="Alessandro" last="Belletti">Alessandro Belletti</name><name sortKey="Beretta, Luigi" sort="Beretta, Luigi" uniqKey="Beretta L" first="Luigi" last="Beretta">Luigi Beretta</name><name sortKey="Ciceri, Fabio" sort="Ciceri, Fabio" uniqKey="Ciceri F" first="Fabio" last="Ciceri">Fabio Ciceri</name><name sortKey="Colombo, Sergio" sort="Colombo, Sergio" uniqKey="Colombo S" first="Sergio" last="Colombo">Sergio Colombo</name><name sortKey="Crivellari, Martina" sort="Crivellari, Martina" uniqKey="Crivellari M" first="Martina" last="Crivellari">Martina Crivellari</name><name sortKey="Dagna, Lorenzo" sort="Dagna, Lorenzo" uniqKey="Dagna L" first="Lorenzo" last="Dagna">Lorenzo Dagna</name><name sortKey="De Cobelli, Francesco" sort="De Cobelli, Francesco" uniqKey="De Cobelli F" first="Francesco" last="De Cobelli">Francesco De Cobelli</name><name sortKey="Fominskiy, Evgeny" sort="Fominskiy, Evgeny" uniqKey="Fominskiy E" first="Evgeny" last="Fominskiy">Evgeny Fominskiy</name><name sortKey="Landoni, Giovanni" sort="Landoni, Giovanni" uniqKey="Landoni G" first="Giovanni" last="Landoni">Giovanni Landoni</name><name sortKey="Monaco, Fabrizio" sort="Monaco, Fabrizio" uniqKey="Monaco F" first="Fabrizio" last="Monaco">Fabrizio Monaco</name><name sortKey="Monti, Giacomo" sort="Monti, Giacomo" uniqKey="Monti G" first="Giacomo" last="Monti">Giacomo Monti</name><name sortKey="Morselli, Federica" sort="Morselli, Federica" uniqKey="Morselli F" first="Federica" last="Morselli">Federica Morselli</name><name sortKey="Nardelli, Pasquale" sort="Nardelli, Pasquale" uniqKey="Nardelli P" first="Pasquale" last="Nardelli">Pasquale Nardelli</name><name sortKey="Reineke, Raffaella" sort="Reineke, Raffaella" uniqKey="Reineke R" first="Raffaella" last="Reineke">Raffaella Reineke</name><name sortKey="Rovere Querini, Patrizia" sort="Rovere Querini, Patrizia" uniqKey="Rovere Querini P" first="Patrizia" last="Rovere-Querini">Patrizia Rovere-Querini</name><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name><name sortKey="Sartorelli, Marianna" sort="Sartorelli, Marianna" uniqKey="Sartorelli M" first="Marianna" last="Sartorelli">Marianna Sartorelli</name><name sortKey="Scandroglio, Anna Mara" sort="Scandroglio, Anna Mara" uniqKey="Scandroglio A" first="Anna Mara" last="Scandroglio">Anna Mara Scandroglio</name><name sortKey="Silvani, Paolo" sort="Silvani, Paolo" uniqKey="Silvani P" first="Paolo" last="Silvani">Paolo Silvani</name><name sortKey="Tresoldi, Moreno" sort="Tresoldi, Moreno" uniqKey="Tresoldi M" first="Moreno" last="Tresoldi">Moreno Tresoldi</name><name sortKey="Votta, Carmine D" sort="Votta, Carmine D" uniqKey="Votta C" first="Carmine D" last="Votta">Carmine D. Votta</name></country><country name="Australie"><noRegion><name sortKey="Serpa Neto, Ary" sort="Serpa Neto, Ary" uniqKey="Serpa Neto A" first="Ary" last="Serpa Neto">Ary Serpa Neto</name></noRegion><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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