CovidSeniorV1, Main, Exploration, bibRecord, 000770

Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study.

Identifieur interne : 000770 ( Main/Exploration ); précédent : 000769; suivant : 000771

Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study.

Source :

Intensive care medicine [ 1432-1238 ] ; 2020.

RBID : pubmed:32816098

Descripteurs français

English descriptors

KwdEn :
- Aged (MeSH), Betacoronavirus (MeSH), China (epidemiology), Coronavirus Infections (complications), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (virology), Critical Illness (MeSH), Disease Outbreaks (MeSH), Female (MeSH), Humans (MeSH), Intensive Care Units (MeSH), Kidney Diseases (epidemiology), Kidney Diseases (etiology), Male (MeSH), Middle Aged (MeSH), Nervous System Diseases (epidemiology), Nervous System Diseases (etiology), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Pneumonia, Viral (virology), Proportional Hazards Models (MeSH), Respiratory Insufficiency (epidemiology), Respiratory Insufficiency (etiology), Retrospective Studies (MeSH), Risk Factors (MeSH), Shock (epidemiology), Shock (etiology), Thrombocytopenia (epidemiology), Thrombocytopenia (etiology).
MESH :
- geographic , epidemiology : China.
- complications : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Kidney Diseases, Nervous System Diseases, Pneumonia, Viral, Respiratory Insufficiency, Shock, Thrombocytopenia.
- etiology : Kidney Diseases, Nervous System Diseases, Respiratory Insufficiency, Shock, Thrombocytopenia.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Aged, Betacoronavirus, Critical Illness, Disease Outbreaks, Female, Humans, Intensive Care Units, Male, Middle Aged, Pandemics, Proportional Hazards Models, Retrospective Studies, Risk Factors.

Abstract

PURPOSE

An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality.

METHODS

We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors.

RESULTS

Of the 733 patients included in the study, the median (IQR) age was 65 (56-73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high D-dimer level, low PaO

CONCLUSION

In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources.

DOI: 10.1007/s00134-020-06211-2
PubMed: 32816098
PubMed Central: PMC7439240

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000568
to stream Main, to step Curation: 000568

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study.</title>
<author><name sortKey="Xie, Jianfeng" sort="Xie, Jianfeng" uniqKey="Xie J" first="Jianfeng" last="Xie">Jianfeng Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Wenjuan" sort="Wu, Wenjuan" uniqKey="Wu W" first="Wenjuan" last="Wu">Wenjuan Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Wuhan Jin-Yintan Hospital, Wuhan, 430071, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Wuhan Jin-Yintan Hospital, Wuhan, 430071</wicri:regionArea>
<wicri:noRegion>430071</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Shusheng" sort="Li, Shusheng" uniqKey="Li S" first="Shusheng" last="Li">Shusheng Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430030, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430030</wicri:regionArea>
<wicri:noRegion>430030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hu, Yu" sort="Hu, Yu" uniqKey="Hu Y" first="Yu" last="Hu">Yu Hu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430022, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea>
<wicri:noRegion>430022</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hu, Ming" sort="Hu, Ming" uniqKey="Hu M" first="Ming" last="Hu">Ming Hu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Infection Disease, Wuhan Pulmonary Hospital, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infection Disease, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jinxiu" sort="Li, Jinxiu" uniqKey="Li J" first="Jinxiu" last="Li">Jinxiu Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Critical Care Medicine, Shenzhen Third Hospital, Shenzhen, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Shenzhen Third Hospital, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Yi" sort="Yang, Yi" uniqKey="Yang Y" first="Yi" last="Yang">Yi Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Tingrong" sort="Huang, Tingrong" uniqKey="Huang T" first="Tingrong" last="Huang">Tingrong Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Huangshi Hospital of Chinese Medicine, Huangshi, 435000, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Huangshi Hospital of Chinese Medicine, Huangshi, 435000</wicri:regionArea>
<wicri:noRegion>435000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Kun" sort="Zheng, Kun" uniqKey="Zheng K" first="Kun" last="Zheng">Kun Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Huangshi Central Hospital, Huangshi, 435000, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Huangshi Central Hospital, Huangshi, 435000</wicri:regionArea>
<wicri:noRegion>435000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Yishan" sort="Wang, Yishan" uniqKey="Wang Y" first="Yishan" last="Wang">Yishan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020</wicri:regionArea>
<wicri:noRegion>100020</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kang, Hanyujie" sort="Kang, Hanyujie" uniqKey="Kang H" first="Hanyujie" last="Kang">Hanyujie Kang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020</wicri:regionArea>
<wicri:noRegion>100020</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Yingzi" sort="Huang, Yingzi" uniqKey="Huang Y" first="Yingzi" last="Huang">Yingzi Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Li" sort="Jiang, Li" uniqKey="Jiang L" first="Li" last="Jiang">Li Jiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053</wicri:regionArea>
<wicri:noRegion>100053</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Emergency Department, The 900th Hospital of Joint Service Corps of Chinese PLA, Fuzhou, 350025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Emergency Department, The 900th Hospital of Joint Service Corps of Chinese PLA, Fuzhou, 350025</wicri:regionArea>
<wicri:noRegion>350025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhong, Ming" sort="Zhong, Ming" uniqKey="Zhong M" first="Ming" last="Zhong">Ming Zhong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032</wicri:regionArea>
<wicri:noRegion>200032</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sang, Ling" sort="Sang, Ling" uniqKey="Sang L" first="Ling" last="Sang">Ling Sang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120</wicri:regionArea>
<wicri:noRegion>510120</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Xia" sort="Zheng, Xia" uniqKey="Zheng X" first="Xia" last="Zheng">Xia Zheng</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003</wicri:regionArea>
<orgName type="university">Université de Zhejiang</orgName>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pan, Chun" sort="Pan, Chun" uniqKey="Pan C" first="Chun" last="Pan">Chun Pan</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Ruiqiang" sort="Zheng, Ruiqiang" uniqKey="Zheng R" first="Ruiqiang" last="Zheng">Ruiqiang Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical School, Yangzhou University, Yangzhou, 225001, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical School, Yangzhou University, Yangzhou, 225001</wicri:regionArea>
<wicri:noRegion>225001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Xuyan" sort="Li, Xuyan" uniqKey="Li X" first="Xuyan" last="Li">Xuyan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020</wicri:regionArea>
<wicri:noRegion>100020</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tong, Zhaohui" sort="Tong, Zhaohui" uniqKey="Tong Z" first="Zhaohui" last="Tong">Zhaohui Tong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. tongzhaohuicy@sina.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020</wicri:regionArea>
<wicri:noRegion>100020</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qiu, Haibo" sort="Qiu, Haibo" uniqKey="Qiu H" first="Haibo" last="Qiu">Haibo Qiu</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China. haiboq2000@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Du, Bin" sort="Du, Bin" uniqKey="Du B" first="Bin" last="Du">Bin Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and, Chinese Academy of Medical Sciences, Beijing, 100730, China. dubin98@gmail.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and, Chinese Academy of Medical Sciences, Beijing, 100730</wicri:regionArea>
<wicri:noRegion>100730</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32816098</idno>
<idno type="pmid">32816098</idno>
<idno type="doi">10.1007/s00134-020-06211-2</idno>
<idno type="pmc">PMC7439240</idno>
<idno type="wicri:Area/Main/Corpus">000568</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000568</idno>
<idno type="wicri:Area/Main/Curation">000568</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000568</idno>
<idno type="wicri:Area/Main/Exploration">000568</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study.</title>
<author><name sortKey="Xie, Jianfeng" sort="Xie, Jianfeng" uniqKey="Xie J" first="Jianfeng" last="Xie">Jianfeng Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Wenjuan" sort="Wu, Wenjuan" uniqKey="Wu W" first="Wenjuan" last="Wu">Wenjuan Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Wuhan Jin-Yintan Hospital, Wuhan, 430071, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Wuhan Jin-Yintan Hospital, Wuhan, 430071</wicri:regionArea>
<wicri:noRegion>430071</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Shusheng" sort="Li, Shusheng" uniqKey="Li S" first="Shusheng" last="Li">Shusheng Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430030, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430030</wicri:regionArea>
<wicri:noRegion>430030</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hu, Yu" sort="Hu, Yu" uniqKey="Hu Y" first="Yu" last="Hu">Yu Hu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430022, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430022</wicri:regionArea>
<wicri:noRegion>430022</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hu, Ming" sort="Hu, Ming" uniqKey="Hu M" first="Ming" last="Hu">Ming Hu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Infection Disease, Wuhan Pulmonary Hospital, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infection Disease, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jinxiu" sort="Li, Jinxiu" uniqKey="Li J" first="Jinxiu" last="Li">Jinxiu Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Critical Care Medicine, Shenzhen Third Hospital, Shenzhen, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Shenzhen Third Hospital, Shenzhen</wicri:regionArea>
<placeName><settlement type="city">Shenzhen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Yi" sort="Yang, Yi" uniqKey="Yang Y" first="Yi" last="Yang">Yi Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Tingrong" sort="Huang, Tingrong" uniqKey="Huang T" first="Tingrong" last="Huang">Tingrong Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Huangshi Hospital of Chinese Medicine, Huangshi, 435000, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Huangshi Hospital of Chinese Medicine, Huangshi, 435000</wicri:regionArea>
<wicri:noRegion>435000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Kun" sort="Zheng, Kun" uniqKey="Zheng K" first="Kun" last="Zheng">Kun Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Huangshi Central Hospital, Huangshi, 435000, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Huangshi Central Hospital, Huangshi, 435000</wicri:regionArea>
<wicri:noRegion>435000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Yishan" sort="Wang, Yishan" uniqKey="Wang Y" first="Yishan" last="Wang">Yishan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020</wicri:regionArea>
<wicri:noRegion>100020</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kang, Hanyujie" sort="Kang, Hanyujie" uniqKey="Kang H" first="Hanyujie" last="Kang">Hanyujie Kang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020</wicri:regionArea>
<wicri:noRegion>100020</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Yingzi" sort="Huang, Yingzi" uniqKey="Huang Y" first="Yingzi" last="Huang">Yingzi Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Li" sort="Jiang, Li" uniqKey="Jiang L" first="Li" last="Jiang">Li Jiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053</wicri:regionArea>
<wicri:noRegion>100053</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Emergency Department, The 900th Hospital of Joint Service Corps of Chinese PLA, Fuzhou, 350025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Emergency Department, The 900th Hospital of Joint Service Corps of Chinese PLA, Fuzhou, 350025</wicri:regionArea>
<wicri:noRegion>350025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhong, Ming" sort="Zhong, Ming" uniqKey="Zhong M" first="Ming" last="Zhong">Ming Zhong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032</wicri:regionArea>
<wicri:noRegion>200032</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sang, Ling" sort="Sang, Ling" uniqKey="Sang L" first="Ling" last="Sang">Ling Sang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120</wicri:regionArea>
<wicri:noRegion>510120</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Xia" sort="Zheng, Xia" uniqKey="Zheng X" first="Xia" last="Zheng">Xia Zheng</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003</wicri:regionArea>
<orgName type="university">Université de Zhejiang</orgName>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pan, Chun" sort="Pan, Chun" uniqKey="Pan C" first="Chun" last="Pan">Chun Pan</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Ruiqiang" sort="Zheng, Ruiqiang" uniqKey="Zheng R" first="Ruiqiang" last="Zheng">Ruiqiang Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical School, Yangzhou University, Yangzhou, 225001, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical School, Yangzhou University, Yangzhou, 225001</wicri:regionArea>
<wicri:noRegion>225001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Xuyan" sort="Li, Xuyan" uniqKey="Li X" first="Xuyan" last="Li">Xuyan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020</wicri:regionArea>
<wicri:noRegion>100020</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tong, Zhaohui" sort="Tong, Zhaohui" uniqKey="Tong Z" first="Zhaohui" last="Tong">Zhaohui Tong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. tongzhaohuicy@sina.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020</wicri:regionArea>
<wicri:noRegion>100020</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qiu, Haibo" sort="Qiu, Haibo" uniqKey="Qiu H" first="Haibo" last="Qiu">Haibo Qiu</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China. haiboq2000@163.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu</wicri:regionArea>
<wicri:noRegion>Jiangsu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Du, Bin" sort="Du, Bin" uniqKey="Du B" first="Bin" last="Du">Bin Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and, Chinese Academy of Medical Sciences, Beijing, 100730, China. dubin98@gmail.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and, Chinese Academy of Medical Sciences, Beijing, 100730</wicri:regionArea>
<wicri:noRegion>100730</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Intensive care medicine</title>
<idno type="eISSN">1432-1238</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>China (epidemiology)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (virology)</term>
<term>Critical Illness (MeSH)</term>
<term>Disease Outbreaks (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Intensive Care Units (MeSH)</term>
<term>Kidney Diseases (epidemiology)</term>
<term>Kidney Diseases (etiology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Nervous System Diseases (epidemiology)</term>
<term>Nervous System Diseases (etiology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Proportional Hazards Models (MeSH)</term>
<term>Respiratory Insufficiency (epidemiology)</term>
<term>Respiratory Insufficiency (etiology)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Shock (epidemiology)</term>
<term>Shock (etiology)</term>
<term>Thrombocytopenia (epidemiology)</term>
<term>Thrombocytopenia (etiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Chine (épidémiologie)</term>
<term>Choc (épidémiologie)</term>
<term>Choc (étiologie)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (complications)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Insuffisance respiratoire (épidémiologie)</term>
<term>Insuffisance respiratoire (étiologie)</term>
<term>Maladie grave (MeSH)</term>
<term>Maladies du rein (épidémiologie)</term>
<term>Maladies du rein (étiologie)</term>
<term>Maladies du système nerveux (épidémiologie)</term>
<term>Maladies du système nerveux (étiologie)</term>
<term>Modèles des risques proportionnels (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (complications)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Thrombopénie (épidémiologie)</term>
<term>Thrombopénie (étiologie)</term>
<term>Unités de soins intensifs (MeSH)</term>
<term>Épidémies de maladies (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Kidney Diseases</term>
<term>Nervous System Diseases</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Insufficiency</term>
<term>Shock</term>
<term>Thrombocytopenia</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Kidney Diseases</term>
<term>Nervous System Diseases</term>
<term>Respiratory Insufficiency</term>
<term>Shock</term>
<term>Thrombocytopenia</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term>
<term>Choc</term>
<term>Infections à coronavirus</term>
<term>Insuffisance respiratoire</term>
<term>Maladies du rein</term>
<term>Maladies du système nerveux</term>
<term>Pneumopathie virale</term>
<term>Thrombopénie</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Choc</term>
<term>Insuffisance respiratoire</term>
<term>Maladies du rein</term>
<term>Maladies du système nerveux</term>
<term>Thrombopénie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Betacoronavirus</term>
<term>Critical Illness</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Proportional Hazards Models</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Betacoronavirus</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Maladie grave</term>
<term>Modèles des risques proportionnels</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Sujet âgé</term>
<term>Unités de soins intensifs</term>
<term>Épidémies de maladies</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b>
</p>
<p>An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Of the 733 patients included in the study, the median (IQR) age was 65 (56-73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high D-dimer level, low PaO</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32816098</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>46</Volume>
<Issue>10</Issue>
<PubDate><Year>2020</Year>
<Month>10</Month>
</PubDate>
</JournalIssue>
<Title>Intensive care medicine</Title>
<ISOAbbreviation>Intensive Care Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study.</ArticleTitle>
<Pagination><MedlinePgn>1863-1872</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-020-06211-2</ELocationID>
<Abstract><AbstractText Label="PURPOSE">An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality.</AbstractText>
<AbstractText Label="METHODS">We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors.</AbstractText>
<AbstractText Label="RESULTS">Of the 733 patients included in the study, the median (IQR) age was 65 (56-73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high D-dimer level, low PaO<sub>2</sub>
/FiO<sub>2</sub>
 level, high creatinine level, high hscTnI level and low albumin level were independent risk factors of 28-day mortality in critically ill patients with COVID-19.</AbstractText>
<AbstractText Label="CONCLUSION">In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Jianfeng</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Wenjuan</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Wuhan Jin-Yintan Hospital, Wuhan, 430071, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Shusheng</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Yu</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430022, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Ming</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Infection Disease, Wuhan Pulmonary Hospital, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jinxiu</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Shenzhen Third Hospital, Shenzhen, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Yi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Tingrong</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Huangshi Hospital of Chinese Medicine, Huangshi, 435000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Kun</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Huangshi Central Hospital, Huangshi, 435000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yishan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kang</LastName>
<ForeName>Hanyujie</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Yingzi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Emergency Department, The 900th Hospital of Joint Service Corps of Chinese PLA, Fuzhou, 350025, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhong</LastName>
<ForeName>Ming</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sang</LastName>
<ForeName>Ling</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Xia</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pan</LastName>
<ForeName>Chun</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Ruiqiang</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical School, Yangzhou University, Yangzhou, 225001, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Xuyan</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tong</LastName>
<ForeName>Zhaohui</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. tongzhaohuicy@sina.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qiu</LastName>
<ForeName>Haibo</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China. haiboq2000@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Du</LastName>
<ForeName>Bin</ForeName>
<Initials>B</Initials>
<Identifier Source="ORCID">0000-0001-6237-2895</Identifier>
<AffiliationInfo><Affiliation>Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and, Chinese Academy of Medical Sciences, Beijing, 100730, China. dubin98@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>BE2018743</GrantID>
<Agency>Key Research and Development Plan of Jiangsu Province</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>BE2019749</GrantID>
<Agency>Key Research and Development Plan of Jiangsu Province</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>2016-I2M-1-014</GrantID>
<Agency>Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College (CN)</Agency>
<Country>International</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Intensive Care Med</MedlineTA>
<NlmUniqueID>7704851</NlmUniqueID>
<ISSNLinking>0342-4642</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016638" MajorTopicYN="Y">Critical Illness</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007362" MajorTopicYN="Y">Intensive Care Units</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007674" MajorTopicYN="N">Kidney Diseases</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009422" MajorTopicYN="N">Nervous System Diseases</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012131" MajorTopicYN="N">Respiratory Insufficiency</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012769" MajorTopicYN="N">Shock</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013921" MajorTopicYN="N">Thrombocytopenia</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">Critically ill</Keyword>
<Keyword MajorTopicYN="Y">Mortality</Keyword>
<Keyword MajorTopicYN="Y">Organ failure</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>04</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>8</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>10</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32816098</ArticleId>
<ArticleId IdType="doi">10.1007/s00134-020-06211-2</ArticleId>
<ArticleId IdType="pii">10.1007/s00134-020-06211-2</ArticleId>
<ArticleId IdType="pmc">PMC7439240</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Guangdong</li>
<li>Hubei</li>
<li>Zhejiang</li>
</region>
<settlement><li>Hangzhou</li>
<li>Shenzhen</li>
<li>Wuhan</li>
</settlement>
<orgName><li>Université de Zhejiang</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Xie, Jianfeng" sort="Xie, Jianfeng" uniqKey="Xie J" first="Jianfeng" last="Xie">Jianfeng Xie</name>
</noRegion>
<name sortKey="Du, Bin" sort="Du, Bin" uniqKey="Du B" first="Bin" last="Du">Bin Du</name>
<name sortKey="Hu, Ming" sort="Hu, Ming" uniqKey="Hu M" first="Ming" last="Hu">Ming Hu</name>
<name sortKey="Hu, Yu" sort="Hu, Yu" uniqKey="Hu Y" first="Yu" last="Hu">Yu Hu</name>
<name sortKey="Huang, Tingrong" sort="Huang, Tingrong" uniqKey="Huang T" first="Tingrong" last="Huang">Tingrong Huang</name>
<name sortKey="Huang, Yingzi" sort="Huang, Yingzi" uniqKey="Huang Y" first="Yingzi" last="Huang">Yingzi Huang</name>
<name sortKey="Jiang, Li" sort="Jiang, Li" uniqKey="Jiang L" first="Li" last="Jiang">Li Jiang</name>
<name sortKey="Kang, Hanyujie" sort="Kang, Hanyujie" uniqKey="Kang H" first="Hanyujie" last="Kang">Hanyujie Kang</name>
<name sortKey="Li, Jinxiu" sort="Li, Jinxiu" uniqKey="Li J" first="Jinxiu" last="Li">Jinxiu Li</name>
<name sortKey="Li, Shusheng" sort="Li, Shusheng" uniqKey="Li S" first="Shusheng" last="Li">Shusheng Li</name>
<name sortKey="Li, Xuyan" sort="Li, Xuyan" uniqKey="Li X" first="Xuyan" last="Li">Xuyan Li</name>
<name sortKey="Pan, Chun" sort="Pan, Chun" uniqKey="Pan C" first="Chun" last="Pan">Chun Pan</name>
<name sortKey="Qiu, Haibo" sort="Qiu, Haibo" uniqKey="Qiu H" first="Haibo" last="Qiu">Haibo Qiu</name>
<name sortKey="Sang, Ling" sort="Sang, Ling" uniqKey="Sang L" first="Ling" last="Sang">Ling Sang</name>
<name sortKey="Tong, Zhaohui" sort="Tong, Zhaohui" uniqKey="Tong Z" first="Zhaohui" last="Tong">Zhaohui Tong</name>
<name sortKey="Wang, Yishan" sort="Wang, Yishan" uniqKey="Wang Y" first="Yishan" last="Wang">Yishan Wang</name>
<name sortKey="Wu, Wenjuan" sort="Wu, Wenjuan" uniqKey="Wu W" first="Wenjuan" last="Wu">Wenjuan Wu</name>
<name sortKey="Yang, Yi" sort="Yang, Yi" uniqKey="Yang Y" first="Yi" last="Yang">Yi Yang</name>
<name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name>
<name sortKey="Zheng, Kun" sort="Zheng, Kun" uniqKey="Zheng K" first="Kun" last="Zheng">Kun Zheng</name>
<name sortKey="Zheng, Ruiqiang" sort="Zheng, Ruiqiang" uniqKey="Zheng R" first="Ruiqiang" last="Zheng">Ruiqiang Zheng</name>
<name sortKey="Zheng, Xia" sort="Zheng, Xia" uniqKey="Zheng X" first="Xia" last="Zheng">Xia Zheng</name>
<name sortKey="Zhong, Ming" sort="Zhong, Ming" uniqKey="Zhong M" first="Ming" last="Zhong">Ming Zhong</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000770 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000770 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidSeniorV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32816098
   |texte=   Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32816098" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidSeniorV1

This area was generated with Dilib version V0.6.37.
Data generation: Thu Oct 15 09:49:45 2020. Site generation: Wed Jan 27 17:10:23 2021

	Serveur d'exploration sur la COVID chez les séniors
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la COVID chez les séniors

Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study.

Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki