Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment.
Identifieur interne : 000741 ( Main/Exploration ); précédent : 000740; suivant : 000742Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment.
Auteurs : Siyi Xin [République populaire de Chine] ; Xueqi Cheng [République populaire de Chine] ; Bo Zhu [République populaire de Chine] ; Xiaolong Liao [République populaire de Chine] ; Feng Yang [République populaire de Chine] ; Lina Song [République populaire de Chine] ; Yan Shi [République populaire de Chine] ; Xuefeng Guan [République populaire de Chine] ; Renyi Su [République populaire de Chine] ; Jian Wang [République populaire de Chine] ; Limin Xing [République populaire de Chine] ; Xiping Xu [République populaire de Chine] ; Lin Jin [République populaire de Chine] ; Yanping Liu [République populaire de Chine] ; Wei Zhou [République populaire de Chine] ; Dongwei Zhang [République populaire de Chine] ; Liang Liang [République populaire de Chine] ; You Yu [République populaire de Chine] ; Rui Yu [République populaire de Chine]Source :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [ 1950-6007 ] ; 2020.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Antiviraux (administration et posologie), Association de médicaments (MeSH), Durée du séjour (MeSH), Défaillance multiviscérale (virologie), Femelle (MeSH), Hospitalisation (statistiques et données numériques), Humains (MeSH), Indice de gravité de la maladie (MeSH), Indoles (administration et posologie), Infections à coronavirus (mortalité), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Interférons (administration et posologie), Jeune adulte (MeSH), Lopinavir (administration et posologie), Mâle (MeSH), Médicaments issus de plantes chinoises (administration et posologie), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Études rétrospectives (MeSH).
- MESH :
- administration et posologie : Antiviraux, Indoles, Interférons, Lopinavir, Médicaments issus de plantes chinoises.
- mortalité : Infections à coronavirus, Pneumopathie virale.
- statistiques et données numériques : Hospitalisation.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- virologie : Défaillance multiviscérale, Infections à coronavirus, Pneumopathie virale.
- Adolescent, Adulte, Adulte d'âge moyen, Association de médicaments, Durée du séjour, Femelle, Humains, Indice de gravité de la maladie, Jeune adulte, Mâle, Pandémies, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antiviral Agents (administration & dosage), Coronavirus Infections (drug therapy), Coronavirus Infections (mortality), Coronavirus Infections (virology), Drug Therapy, Combination (MeSH), Drugs, Chinese Herbal (administration & dosage), Female (MeSH), Hospitalization (statistics & numerical data), Humans (MeSH), Indoles (administration & dosage), Interferons (administration & dosage), Length of Stay (MeSH), Lopinavir (administration & dosage), Male (MeSH), Middle Aged (MeSH), Multiple Organ Failure (virology), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (mortality), Pneumonia, Viral (virology), Retrospective Studies (MeSH), Severity of Illness Index (MeSH), Treatment Outcome (MeSH), Young Adult (MeSH).
- MESH :
- chemical , administration & dosage : Antiviral Agents, Drugs, Chinese Herbal, Indoles, Interferons, Lopinavir.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- statistics & numerical data : Hospitalization.
- virology : Coronavirus Infections, Multiple Organ Failure, Pneumonia, Viral.
- Adolescent, Adult, Aged, Aged, 80 and over, Drug Therapy, Combination, Female, Humans, Length of Stay, Male, Middle Aged, Pandemics, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Young Adult.
Abstract
BACKGROUND
Coronavirus disease 2019 (COVID-19)
METHODS
In this study, 63 patients with confirmed COVID-19 were analyzed. During the first 14 days of hospitalization, patients with deteriorating symptoms were administered QPD along with Western medicine therapy (the antiviral medicine selected from interferon, lopinavir, or arbidol). The clinical characteristics and blood laboratory indices (blood routine, inflammatory factors, and multi-organ biochemical indices) were examined, and the total lung severity scores were evaluated in each patient by reviewing chest computed tomography before treatment and at the end of treatment.
RESULTS
Before QPD treatment, the combined treatment group showed higher blood C-reactive protein levels and more severe pulmonary inflammation and clinical symptoms than the Western medicine treatment group. Both groups met the discharge criteria after a similar length of hospitalization. At the end of treatment, circulating white blood cells, total lymphocyte count, and glutamic-oxaloacetic transaminase levels improved dramatically in both groups (P < 0.05). In contrast, C-reactive protein, creatine kinase, creatine kinase-myocardial band, lactate dehydrogenase, and blood urea nitrogen levels were improved only in the combined treatment group (P < 0.05), and C-reactive protein and creatine kinase were the most pronounced (P < 0.01). Compared with baseline, at the end of treatment, the proportion of patients with normal values of C-reactive protein, total lymphocyte count, and lactate dehydrogenase were increased in the combined treatment group (P < 0.05), whereas no significant difference was observed in the Western medicine treatment group (P > 0.05).
CONCLUSION
The combination of QPD with Western medicine demonstrated significant anti-inflammatory effects compared with those of only Western medicine in patients with mild and moderate COVID-19; however, neither mortality nor length of hospitalization was affected. Moreover, the combined treatment tended to mitigate the extent of multi-organ impairment. Long-term randomized controlled trials with follow-up evaluations are required to confirm the results presented here.
DOI: 10.1016/j.biopha.2020.110500
PubMed: 32768975
PubMed Central: PMC7342031
Affiliations:
Links toward previous steps (curation, corpus...)
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Electronic address: lnzygxf@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847</wicri:regionArea><wicri:noRegion>110847</wicri:noRegion></affiliation></author><author><name sortKey="Su, Renyi" sort="Su, Renyi" uniqKey="Su R" first="Renyi" last="Su">Renyi Su</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 1574980469@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: Wj3421218@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Xing, Limin" sort="Xing, Limin" uniqKey="Xing L" first="Limin" last="Xing">Limin Xing</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: xinglimin97@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Xiping" sort="Xu, Xiping" uniqKey="Xu X" first="Xiping" last="Xu">Xiping Xu</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 4251061945@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Lin" sort="Jin, Lin" uniqKey="Jin L" first="Lin" last="Jin">Lin Jin</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 466843190@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yanping" sort="Liu, Yanping" uniqKey="Liu Y" first="Yanping" last="Liu">Yanping Liu</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: smilelyp2014@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: yiyang291314@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Dongwei" sort="Zhang, Dongwei" uniqKey="Zhang D" first="Dongwei" last="Zhang">Dongwei Zhang</name><affiliation wicri:level="1"><nlm:affiliation>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031, China. Electronic address: lovezdw1980@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031</wicri:regionArea><wicri:noRegion>110031</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Liang" sort="Liang, Liang" uniqKey="Liang L" first="Liang" last="Liang">Liang Liang</name><affiliation wicri:level="1"><nlm:affiliation>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031, China. Electronic address: soso314@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031</wicri:regionArea><wicri:noRegion>110031</wicri:noRegion></affiliation></author><author><name sortKey="Yu, You" sort="Yu, You" uniqKey="Yu Y" first="You" last="Yu">You Yu</name><affiliation wicri:level="1"><nlm:affiliation>The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110034, China. Electronic address: 526385550@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110034</wicri:regionArea><wicri:noRegion>110034</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Rui" sort="Yu, Rui" uniqKey="Yu R" first="Rui" last="Yu">Rui Yu</name><affiliation wicri:level="1"><nlm:affiliation>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, China. Electronic address: yurui196909@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847</wicri:regionArea><wicri:noRegion>110847</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32768975</idno><idno type="pmid">32768975</idno><idno type="doi">10.1016/j.biopha.2020.110500</idno><idno type="pmc">PMC7342031</idno><idno type="wicri:Area/Main/Corpus">000750</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000750</idno><idno type="wicri:Area/Main/Curation">000750</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000750</idno><idno type="wicri:Area/Main/Exploration">000750</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment.</title><author><name sortKey="Xin, Siyi" sort="Xin, Siyi" uniqKey="Xin S" first="Siyi" last="Xin">Siyi Xin</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: xinsiyi_122744763@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Xueqi" sort="Cheng, Xueqi" uniqKey="Cheng X" first="Xueqi" last="Cheng">Xueqi Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: cheng_xueqi@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Bo" sort="Zhu, Bo" uniqKey="Zhu B" first="Bo" last="Zhu">Bo Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 274770142@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Liao, Xiaolong" sort="Liao, Xiaolong" uniqKey="Liao X" first="Xiaolong" last="Liao">Xiaolong Liao</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 122744763@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Feng" sort="Yang, Feng" uniqKey="Yang F" first="Feng" last="Yang">Feng Yang</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: haitang76@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Song, Lina" sort="Song, Lina" uniqKey="Song L" first="Lina" last="Song">Lina Song</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: nana_loving2012@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Yan" sort="Shi, Yan" uniqKey="Shi Y" first="Yan" last="Shi">Yan Shi</name><affiliation wicri:level="1"><nlm:affiliation>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, China. Electronic address: 446139675@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847</wicri:regionArea><wicri:noRegion>110847</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Xuefeng" sort="Guan, Xuefeng" uniqKey="Guan X" first="Xuefeng" last="Guan">Xuefeng Guan</name><affiliation wicri:level="1"><nlm:affiliation>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, China. Electronic address: lnzygxf@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847</wicri:regionArea><wicri:noRegion>110847</wicri:noRegion></affiliation></author><author><name sortKey="Su, Renyi" sort="Su, Renyi" uniqKey="Su R" first="Renyi" last="Su">Renyi Su</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 1574980469@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: Wj3421218@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Xing, Limin" sort="Xing, Limin" uniqKey="Xing L" first="Limin" last="Xing">Limin Xing</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: xinglimin97@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Xiping" sort="Xu, Xiping" uniqKey="Xu X" first="Xiping" last="Xu">Xiping Xu</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 4251061945@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Lin" sort="Jin, Lin" uniqKey="Jin L" first="Lin" last="Jin">Lin Jin</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 466843190@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yanping" sort="Liu, Yanping" uniqKey="Liu Y" first="Yanping" last="Liu">Yanping Liu</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: smilelyp2014@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: yiyang291314@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000</wicri:regionArea><wicri:noRegion>441000</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Dongwei" sort="Zhang, Dongwei" uniqKey="Zhang D" first="Dongwei" last="Zhang">Dongwei Zhang</name><affiliation wicri:level="1"><nlm:affiliation>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031, China. Electronic address: lovezdw1980@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031</wicri:regionArea><wicri:noRegion>110031</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Liang" sort="Liang, Liang" uniqKey="Liang L" first="Liang" last="Liang">Liang Liang</name><affiliation wicri:level="1"><nlm:affiliation>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031, China. Electronic address: soso314@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031</wicri:regionArea><wicri:noRegion>110031</wicri:noRegion></affiliation></author><author><name sortKey="Yu, You" sort="Yu, You" uniqKey="Yu Y" first="You" last="Yu">You Yu</name><affiliation wicri:level="1"><nlm:affiliation>The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110034, China. Electronic address: 526385550@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110034</wicri:regionArea><wicri:noRegion>110034</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Rui" sort="Yu, Rui" uniqKey="Yu R" first="Rui" last="Yu">Rui Yu</name><affiliation wicri:level="1"><nlm:affiliation>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, China. Electronic address: yurui196909@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847</wicri:regionArea><wicri:noRegion>110847</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</title><idno type="eISSN">1950-6007</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Antiviral Agents (administration & dosage)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (virology)</term><term>Drug Therapy, Combination (MeSH)</term><term>Drugs, Chinese Herbal (administration & dosage)</term><term>Female (MeSH)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Indoles (administration & dosage)</term><term>Interferons (administration & dosage)</term><term>Length of Stay (MeSH)</term><term>Lopinavir (administration & dosage)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Multiple Organ Failure (virology)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (virology)</term><term>Retrospective Studies (MeSH)</term><term>Severity of Illness Index (MeSH)</term><term>Treatment Outcome (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antiviraux (administration et posologie)</term><term>Association de médicaments (MeSH)</term><term>Durée du séjour (MeSH)</term><term>Défaillance multiviscérale (virologie)</term><term>Femelle (MeSH)</term><term>Hospitalisation (statistiques et données numériques)</term><term>Humains (MeSH)</term><term>Indice de gravité de la maladie (MeSH)</term><term>Indoles (administration et posologie)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Interférons (administration et posologie)</term><term>Jeune adulte (MeSH)</term><term>Lopinavir (administration et posologie)</term><term>Mâle (MeSH)</term><term>Médicaments issus de plantes chinoises (administration et posologie)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Pneumopathie virale (virologie)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Drugs, Chinese Herbal</term><term>Indoles</term><term>Interferons</term><term>Lopinavir</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term><term>Indoles</term><term>Interférons</term><term>Lopinavir</term><term>Médicaments issus de plantes chinoises</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Défaillance multiviscérale</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Multiple Organ Failure</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Length of Stay</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Durée du séjour</term><term>Femelle</term><term>Humains</term><term>Indice de gravité de la maladie</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Coronavirus disease 2019 (COVID-19)</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>In this study, 63 patients with confirmed COVID-19 were analyzed. During the first 14 days of hospitalization, patients with deteriorating symptoms were administered QPD along with Western medicine therapy (the antiviral medicine selected from interferon, lopinavir, or arbidol). The clinical characteristics and blood laboratory indices (blood routine, inflammatory factors, and multi-organ biochemical indices) were examined, and the total lung severity scores were evaluated in each patient by reviewing chest computed tomography before treatment and at the end of treatment.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Before QPD treatment, the combined treatment group showed higher blood C-reactive protein levels and more severe pulmonary inflammation and clinical symptoms than the Western medicine treatment group. Both groups met the discharge criteria after a similar length of hospitalization. At the end of treatment, circulating white blood cells, total lymphocyte count, and glutamic-oxaloacetic transaminase levels improved dramatically in both groups (P < 0.05). In contrast, C-reactive protein, creatine kinase, creatine kinase-myocardial band, lactate dehydrogenase, and blood urea nitrogen levels were improved only in the combined treatment group (P < 0.05), and C-reactive protein and creatine kinase were the most pronounced (P < 0.01). Compared with baseline, at the end of treatment, the proportion of patients with normal values of C-reactive protein, total lymphocyte count, and lactate dehydrogenase were increased in the combined treatment group (P < 0.05), whereas no significant difference was observed in the Western medicine treatment group (P > 0.05).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The combination of QPD with Western medicine demonstrated significant anti-inflammatory effects compared with those of only Western medicine in patients with mild and moderate COVID-19; however, neither mortality nor length of hospitalization was affected. Moreover, the combined treatment tended to mitigate the extent of multi-organ impairment. Long-term randomized controlled trials with follow-up evaluations are required to confirm the results presented here.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32768975</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1950-6007</ISSN><JournalIssue CitedMedium="Internet"><Volume>129</Volume><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</Title><ISOAbbreviation>Biomed Pharmacother</ISOAbbreviation></Journal><ArticleTitle>Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment.</ArticleTitle><Pagination><MedlinePgn>110500</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0753-3322(20)30693-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biopha.2020.110500</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Coronavirus disease 2019 (COVID-19)<sup>2</sup> has emerged as a global pandemic. However, as effective treatments for this disease are still unclear, safe and efficient therapies are urgently needed. Qingfei Paidu decoction (QPD)<sup>3</sup> is strongly recommended in the Chinese Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional 6th Edition). However, clinical research data on the effects of QPD on COVID-19 are scarce. Our study aimed to explore the effects of combined treatment with QPD and Western medicine on COVID-19.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this study, 63 patients with confirmed COVID-19 were analyzed. During the first 14 days of hospitalization, patients with deteriorating symptoms were administered QPD along with Western medicine therapy (the antiviral medicine selected from interferon, lopinavir, or arbidol). The clinical characteristics and blood laboratory indices (blood routine, inflammatory factors, and multi-organ biochemical indices) were examined, and the total lung severity scores were evaluated in each patient by reviewing chest computed tomography before treatment and at the end of treatment.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Before QPD treatment, the combined treatment group showed higher blood C-reactive protein levels and more severe pulmonary inflammation and clinical symptoms than the Western medicine treatment group. Both groups met the discharge criteria after a similar length of hospitalization. At the end of treatment, circulating white blood cells, total lymphocyte count, and glutamic-oxaloacetic transaminase levels improved dramatically in both groups (P < 0.05). In contrast, C-reactive protein, creatine kinase, creatine kinase-myocardial band, lactate dehydrogenase, and blood urea nitrogen levels were improved only in the combined treatment group (P < 0.05), and C-reactive protein and creatine kinase were the most pronounced (P < 0.01). Compared with baseline, at the end of treatment, the proportion of patients with normal values of C-reactive protein, total lymphocyte count, and lactate dehydrogenase were increased in the combined treatment group (P < 0.05), whereas no significant difference was observed in the Western medicine treatment group (P > 0.05).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The combination of QPD with Western medicine demonstrated significant anti-inflammatory effects compared with those of only Western medicine in patients with mild and moderate COVID-19; however, neither mortality nor length of hospitalization was affected. Moreover, the combined treatment tended to mitigate the extent of multi-organ impairment. Long-term randomized controlled trials with follow-up evaluations are required to confirm the results presented here.</AbstractText><CopyrightInformation>Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xin</LastName><ForeName>Siyi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: xinsiyi_122744763@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Xueqi</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: cheng_xueqi@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Bo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 274770142@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Xiaolong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 122744763@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Feng</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: haitang76@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Lina</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: nana_loving2012@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, China. Electronic address: 446139675@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guan</LastName><ForeName>Xuefeng</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, China. Electronic address: lnzygxf@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Renyi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 1574980469@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: Wj3421218@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xing</LastName><ForeName>Limin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: xinglimin97@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Xiping</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 4251061945@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: 466843190@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yanping</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: smilelyp2014@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Xiangyang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine, Xiangyang, Hubei, 441000, China. Electronic address: yiyang291314@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Dongwei</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031, China. Electronic address: lovezdw1980@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Liang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110031, China. Electronic address: soso314@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>You</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110034, China. Electronic address: 526385550@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Rui</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, China. Electronic address: yurui196909@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Biomed Pharmacother</MedlineTA><NlmUniqueID>8213295</NlmUniqueID><ISSNLinking>0753-3322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004365">Drugs, Chinese Herbal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007211">Indoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000707138">qingfei paidu decoction</NameOfSubstance></Chemical><Chemical><RegistryNumber>2494G1JF75</RegistryNumber><NameOfSubstance UI="D061466">Lopinavir</NameOfSubstance></Chemical><Chemical><RegistryNumber>9008-11-1</RegistryNumber><NameOfSubstance UI="D007372">Interferons</NameOfSubstance></Chemical><Chemical><RegistryNumber>93M09WW4RU</RegistryNumber><NameOfSubstance UI="C086979">arbidol</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004365" MajorTopicYN="N">Drugs, Chinese Herbal</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007211" MajorTopicYN="N">Indoles</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007372" MajorTopicYN="N">Interferons</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061466" MajorTopicYN="N">Lopinavir</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009102" MajorTopicYN="N">Multiple Organ Failure</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Clinical trials</Keyword><Keyword MajorTopicYN="N">Qingfei Paidu decoction</Keyword><Keyword MajorTopicYN="N">Traditional Chinese medicine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32768975</ArticleId><ArticleId IdType="pii">S0753-3322(20)30693-4</ArticleId><ArticleId IdType="doi">10.1016/j.biopha.2020.110500</ArticleId><ArticleId IdType="pmc">PMC7342031</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xin, Siyi" sort="Xin, Siyi" uniqKey="Xin S" first="Siyi" last="Xin">Siyi Xin</name></noRegion><name sortKey="Cheng, Xueqi" sort="Cheng, Xueqi" uniqKey="Cheng X" first="Xueqi" last="Cheng">Xueqi Cheng</name><name sortKey="Guan, Xuefeng" sort="Guan, Xuefeng" uniqKey="Guan X" first="Xuefeng" last="Guan">Xuefeng Guan</name><name sortKey="Jin, Lin" sort="Jin, Lin" uniqKey="Jin L" first="Lin" last="Jin">Lin Jin</name><name sortKey="Liang, Liang" sort="Liang, Liang" uniqKey="Liang L" first="Liang" last="Liang">Liang Liang</name><name sortKey="Liao, Xiaolong" sort="Liao, Xiaolong" uniqKey="Liao X" first="Xiaolong" last="Liao">Xiaolong Liao</name><name sortKey="Liu, Yanping" sort="Liu, Yanping" uniqKey="Liu Y" first="Yanping" last="Liu">Yanping Liu</name><name sortKey="Shi, Yan" sort="Shi, Yan" uniqKey="Shi Y" first="Yan" last="Shi">Yan Shi</name><name sortKey="Song, Lina" sort="Song, Lina" uniqKey="Song L" first="Lina" last="Song">Lina Song</name><name sortKey="Su, Renyi" sort="Su, Renyi" uniqKey="Su R" first="Renyi" last="Su">Renyi Su</name><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><name sortKey="Xing, Limin" sort="Xing, Limin" uniqKey="Xing L" first="Limin" last="Xing">Limin Xing</name><name sortKey="Xu, Xiping" sort="Xu, Xiping" uniqKey="Xu X" first="Xiping" last="Xu">Xiping Xu</name><name sortKey="Yang, Feng" sort="Yang, Feng" uniqKey="Yang F" first="Feng" last="Yang">Feng Yang</name><name sortKey="Yu, Rui" sort="Yu, Rui" uniqKey="Yu R" first="Rui" last="Yu">Rui Yu</name><name sortKey="Yu, You" sort="Yu, You" uniqKey="Yu Y" first="You" last="Yu">You Yu</name><name sortKey="Zhang, Dongwei" sort="Zhang, Dongwei" uniqKey="Zhang D" first="Dongwei" last="Zhang">Dongwei Zhang</name><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name><name sortKey="Zhu, Bo" sort="Zhu, Bo" uniqKey="Zhu B" first="Bo" last="Zhu">Bo Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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