Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China.
Identifieur interne : 000448 ( Main/Exploration ); précédent : 000447; suivant : 000449Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China.
Auteurs : Zhilin Zeng [République populaire de Chine] ; Haijing Yu [République populaire de Chine] ; Huilong Chen [République populaire de Chine] ; Weipeng Qi [République populaire de Chine] ; Liang Chen [République populaire de Chine] ; Guang Chen [République populaire de Chine] ; Weiming Yan [République populaire de Chine] ; Tao Chen [République populaire de Chine] ; Qin Ning [République populaire de Chine] ; Meifang Han [République populaire de Chine] ; Di Wu [République populaire de Chine]Source :
- Critical care (London, England) [ 1466-609X ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Chine (épidémiologie), Cytokines (sang), Facteurs de risque (MeSH), Femelle (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (sang), Infections à coronavirus (thérapie), Infections à coronavirus (épidémiologie), Inflammation (sang), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (sang), Pneumopathie virale (thérapie), Pneumopathie virale (épidémiologie), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Études longitudinales (MeSH), Études rétrospectives (MeSH).
- MESH :
- sang : Cytokines, Infections à coronavirus, Inflammation, Pneumopathie virale.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Chine, Infections à coronavirus, Pneumopathie virale.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Indice de gravité de la maladie, Mâle, Pandémies, Résultat thérapeutique, Sujet âgé, Études longitudinales, Études rétrospectives.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Aged (MeSH), China (epidemiology), Coronavirus Infections (blood), Coronavirus Infections (epidemiology), Coronavirus Infections (therapy), Cytokines (blood), Female (MeSH), Humans (MeSH), Inflammation (blood), Longitudinal Studies (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (epidemiology), Pneumonia, Viral (therapy), Retrospective Studies (MeSH), Risk Factors (MeSH), Severity of Illness Index (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , blood : Cytokines.
- geographic , epidemiology : China.
- blood : Coronavirus Infections, Inflammation, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Aged, Female, Humans, Longitudinal Studies, Male, Middle Aged, Pandemics, Retrospective Studies, Risk Factors, Severity of Illness Index, Treatment Outcome.
Abstract
BACKGROUND
Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-19 remains to be elucidated. We aimed to clarify correlation of systemic inflammation with disease severity and outcomes in COVID-19 patients.
METHODS
In this retrospective study, baseline characteristics, laboratory findings, and treatments were compared among 317 laboratory-confirmed COVID-19 patients with moderate, severe, or critically ill form of the disease. Moreover, the longitudinal changes of serum cytokines, lactate dehydrogenase (LDH), high-sensitivity C-reactive protein (hsCRP), and hsCRP to lymphocyte count ratio (hsCRP/L) as well as their associations with disease severity and outcomes were investigated in 68 COVID-19 patients.
RESULTS
Within 24 h of admission, the critically ill patients showed higher concentrations of inflammatory markers including serum soluble interleukin (IL)-2 receptor, IL-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-α), ferritin, procalcitonin, LDH, hsCRP, and hsCRP/L than patients with severe or moderate disease. The severe cases displayed the similar response patterns when compared with moderate cases. The longitudinal assays showed the levels of pro-inflammatory cytokines, LDH, hsCRP, and hsCRP/L gradually declined within 10 days post admission in moderate, severe cases or those who survived. However, there was no significant reduction in cytokines, LDH, hsCRP, and hsCRP/L levels in critically ill or deceased patients throughout the course of illness. Compared with female patients, male cases showed higher serum concentrations of soluble IL-2R, IL-6, ferritin, procalcitonin, LDH, and hsCRP. Multivariate logistic regression analysis revealed that IL-6 > 50 pg/mL and LDH > 400 U/L on admission were independently associated with disease severity in patients with COVID-19.
CONCLUSION
Exuberant inflammatory responses within 24 h of admission in patients with COVID-19 may correlate with disease severity. SARS-CoV-2 infection appears to elicit a sex-based differential immune response. IL-6 and LDH were independent predictive parameters for assessing the severity of COVID-19. An early decline of these inflammation markers may be associated with better outcomes.
DOI: 10.1186/s13054-020-03255-0
PubMed: 32854750
PubMed Central: PMC7450961
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Infections à coronavirus (thérapie)</term>
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<term>Risk Factors</term>
<term>Severity of Illness Index</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Études longitudinales</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-19 remains to be elucidated. We aimed to clarify correlation of systemic inflammation with disease severity and outcomes in COVID-19 patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>In this retrospective study, baseline characteristics, laboratory findings, and treatments were compared among 317 laboratory-confirmed COVID-19 patients with moderate, severe, or critically ill form of the disease. Moreover, the longitudinal changes of serum cytokines, lactate dehydrogenase (LDH), high-sensitivity C-reactive protein (hsCRP), and hsCRP to lymphocyte count ratio (hsCRP/L) as well as their associations with disease severity and outcomes were investigated in 68 COVID-19 patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Within 24 h of admission, the critically ill patients showed higher concentrations of inflammatory markers including serum soluble interleukin (IL)-2 receptor, IL-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-α), ferritin, procalcitonin, LDH, hsCRP, and hsCRP/L than patients with severe or moderate disease. The severe cases displayed the similar response patterns when compared with moderate cases. The longitudinal assays showed the levels of pro-inflammatory cytokines, LDH, hsCRP, and hsCRP/L gradually declined within 10 days post admission in moderate, severe cases or those who survived. However, there was no significant reduction in cytokines, LDH, hsCRP, and hsCRP/L levels in critically ill or deceased patients throughout the course of illness. Compared with female patients, male cases showed higher serum concentrations of soluble IL-2R, IL-6, ferritin, procalcitonin, LDH, and hsCRP. Multivariate logistic regression analysis revealed that IL-6 > 50 pg/mL and LDH > 400 U/L on admission were independently associated with disease severity in patients with COVID-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Exuberant inflammatory responses within 24 h of admission in patients with COVID-19 may correlate with disease severity. SARS-CoV-2 infection appears to elicit a sex-based differential immune response. IL-6 and LDH were independent predictive parameters for assessing the severity of COVID-19. An early decline of these inflammation markers may be associated with better outcomes.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32854750</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>31</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>08</Month>
<Day>31</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1466-609X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>24</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>08</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>Critical care (London, England)</Title>
<ISOAbbreviation>Crit Care</ISOAbbreviation>
</Journal>
<ArticleTitle>Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China.</ArticleTitle>
<Pagination><MedlinePgn>525</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13054-020-03255-0</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-19 remains to be elucidated. We aimed to clarify correlation of systemic inflammation with disease severity and outcomes in COVID-19 patients.</AbstractText>
<AbstractText Label="METHODS">In this retrospective study, baseline characteristics, laboratory findings, and treatments were compared among 317 laboratory-confirmed COVID-19 patients with moderate, severe, or critically ill form of the disease. Moreover, the longitudinal changes of serum cytokines, lactate dehydrogenase (LDH), high-sensitivity C-reactive protein (hsCRP), and hsCRP to lymphocyte count ratio (hsCRP/L) as well as their associations with disease severity and outcomes were investigated in 68 COVID-19 patients.</AbstractText>
<AbstractText Label="RESULTS">Within 24 h of admission, the critically ill patients showed higher concentrations of inflammatory markers including serum soluble interleukin (IL)-2 receptor, IL-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-α), ferritin, procalcitonin, LDH, hsCRP, and hsCRP/L than patients with severe or moderate disease. The severe cases displayed the similar response patterns when compared with moderate cases. The longitudinal assays showed the levels of pro-inflammatory cytokines, LDH, hsCRP, and hsCRP/L gradually declined within 10 days post admission in moderate, severe cases or those who survived. However, there was no significant reduction in cytokines, LDH, hsCRP, and hsCRP/L levels in critically ill or deceased patients throughout the course of illness. Compared with female patients, male cases showed higher serum concentrations of soluble IL-2R, IL-6, ferritin, procalcitonin, LDH, and hsCRP. Multivariate logistic regression analysis revealed that IL-6 > 50 pg/mL and LDH > 400 U/L on admission were independently associated with disease severity in patients with COVID-19.</AbstractText>
<AbstractText Label="CONCLUSION">Exuberant inflammatory responses within 24 h of admission in patients with COVID-19 may correlate with disease severity. SARS-CoV-2 infection appears to elicit a sex-based differential immune response. IL-6 and LDH were independent predictive parameters for assessing the severity of COVID-19. An early decline of these inflammation markers may be associated with better outcomes.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zeng</LastName>
<ForeName>Zhilin</ForeName>
<Initials>Z</Initials>
<Identifier Source="ORCID">0000-0003-3195-4010</Identifier>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Haijing</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Huilong</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qi</LastName>
<ForeName>Weipeng</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Liang</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Guang</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Weiming</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ning</LastName>
<ForeName>Qin</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Meifang</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China. mfhan@foxmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Di</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, China. woody_1984@163.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>81800041</GrantID>
<Agency>National Natural Science Foundation of China</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>2017ZX10202201</GrantID>
<Agency>Chinese National Thirteenth Five Years Project in Science and Technology</Agency>
<Country>International</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Crit Care</MedlineTA>
<NlmUniqueID>9801902</NlmUniqueID>
<ISSNLinking>1364-8535</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
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</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">Cytokine</Keyword>
<Keyword MajorTopicYN="Y">Disease severity</Keyword>
<Keyword MajorTopicYN="Y">Inflammatory mediators</Keyword>
<Keyword MajorTopicYN="Y">Outcome</Keyword>
<Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>04</Month>
<Day>20</Day>
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<Month>08</Month>
<Day>17</Day>
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<ArticleIdList><ArticleId IdType="pubmed">8880103</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zeng, Zhilin" sort="Zeng, Zhilin" uniqKey="Zeng Z" first="Zhilin" last="Zeng">Zhilin Zeng</name>
</noRegion>
<name sortKey="Chen, Guang" sort="Chen, Guang" uniqKey="Chen G" first="Guang" last="Chen">Guang Chen</name>
<name sortKey="Chen, Huilong" sort="Chen, Huilong" uniqKey="Chen H" first="Huilong" last="Chen">Huilong Chen</name>
<name sortKey="Chen, Liang" sort="Chen, Liang" uniqKey="Chen L" first="Liang" last="Chen">Liang Chen</name>
<name sortKey="Chen, Tao" sort="Chen, Tao" uniqKey="Chen T" first="Tao" last="Chen">Tao Chen</name>
<name sortKey="Han, Meifang" sort="Han, Meifang" uniqKey="Han M" first="Meifang" last="Han">Meifang Han</name>
<name sortKey="Ning, Qin" sort="Ning, Qin" uniqKey="Ning Q" first="Qin" last="Ning">Qin Ning</name>
<name sortKey="Qi, Weipeng" sort="Qi, Weipeng" uniqKey="Qi W" first="Weipeng" last="Qi">Weipeng Qi</name>
<name sortKey="Wu, Di" sort="Wu, Di" uniqKey="Wu D" first="Di" last="Wu">Di Wu</name>
<name sortKey="Yan, Weiming" sort="Yan, Weiming" uniqKey="Yan W" first="Weiming" last="Yan">Weiming Yan</name>
<name sortKey="Yu, Haijing" sort="Yu, Haijing" uniqKey="Yu H" first="Haijing" last="Yu">Haijing Yu</name>
</country>
</tree>
</affiliations>
</record>
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