Therapeutic Effectiveness of Interferon-α2b Against COVID-19: The Cuban Experience.
Identifieur interne : 000132 ( Main/Exploration ); précédent : 000131; suivant : 000133Therapeutic Effectiveness of Interferon-α2b Against COVID-19: The Cuban Experience.
Auteurs : Ricardo Pereda [Cuba] ; Daniel González [Cuba] ; Hubert Blas Rivero [Cuba] ; Juan Carlos Rivero [Cuba] ; Albadio Pérez [Cuba] ; Lissette Del Rosario L Pez [Cuba] ; Natacha Mezquia [Cuba] ; Rafael Venegas [Cuba] ; Julio Roberto Betancourt [Cuba] ; Rodolfo Emilio Domínguez [Cuba]Source :
- Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [ 1557-7465 ] ; 2020.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Antiviraux (usage thérapeutique), Association de médicaments (MeSH), Betacoronavirus (effets des médicaments et des substances chimiques), Chloroquine (usage thérapeutique), Cuba (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (mortalité), Infections à coronavirus (traitement médicamenteux), Interféron alpha (usage thérapeutique), Jeune adulte (MeSH), Lopinavir (usage thérapeutique), Mâle (MeSH), Nourrisson (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (traitement médicamenteux), Ritonavir (usage thérapeutique), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Études prospectives (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Betacoronavirus.
- mortalité : Infections à coronavirus, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux, Chloroquine, Interféron alpha, Lopinavir, Ritonavir.
- Adolescent, Adulte, Adulte d'âge moyen, Association de médicaments, Cuba, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Pandémies, Sujet âgé, Sujet âgé de 80 ans ou plus, Études prospectives.
- Wicri :
- geographic : Cuba.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antiviral Agents (therapeutic use), Betacoronavirus (drug effects), Child (MeSH), Child, Preschool (MeSH), Chloroquine (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (mortality), Cuba (MeSH), Drug Therapy, Combination (MeSH), Female (MeSH), Humans (MeSH), Infant (MeSH), Interferon-alpha (therapeutic use), Lopinavir (therapeutic use), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (mortality), Prospective Studies (MeSH), Ritonavir (therapeutic use), Young Adult (MeSH).
- MESH :
- chemical , therapeutic use : Antiviral Agents, Chloroquine, Interferon-alpha, Lopinavir, Ritonavir.
- geographic : Cuba.
- drug effects : Betacoronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Drug Therapy, Combination, Female, Humans, Infant, Male, Middle Aged, Pandemics, Prospective Studies, Young Adult.
Abstract
A prospective observational study was conducted for assessing the therapeutic efficacy of interferon (IFN)-α2b in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first month after the coronavirus disease 2019 (COVID-19) outbreak began in Cuba. From March 11th to April 14th, 814 patients were confirmed SARS-CoV-2 positive in Cuba. Seven hundred sixty-one (93.4%) were treated with a combination of oral antivirals (lopinavir/ritonavir and chloroquine) with intramuscular administration of IFN-α2b (Heberon® Alpha R, Center for Genetic Engineering and Biotechnology, Havana, Cuba), 3 times per week, for 2 weeks. Fifty-three patients received the approved COVID protocol without IFN treatment. The proportion of patients discharged from hospital (without clinical and radiological symptoms and nondetectable virus by real-time polymerase chain reaction) was higher in the IFN-treated compared with the non-IFN treated group (95.4% vs. 26.1%, P < 0.01). The case fatality rate (CFR) for all patients was 2.95%, and for those patients who received IFN-α2b the CFR was reduced to 0.92. Intensive care was required for 82 patients (10.1%), 42 (5.5%) had been treated with IFN. This report provides preliminary evidence for the therapeutic effectiveness of IFN-α2b for COVID-19 and suggests that the use of Heberon Alpha R may contribute to complete recovery of patients.
DOI: 10.1089/jir.2020.0124
PubMed: 32960147
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Betacoronavirus (drug effects)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
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<term>Coronavirus Infections (mortality)</term>
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<term>Humans (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Interferon-alpha (therapeutic use)</term>
<term>Lopinavir (therapeutic use)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Prospective Studies (MeSH)</term>
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<term>Association de médicaments (MeSH)</term>
<term>Betacoronavirus (effets des médicaments et des substances chimiques)</term>
<term>Chloroquine (usage thérapeutique)</term>
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<term>Enfant d'âge préscolaire (MeSH)</term>
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<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Interféron alpha (usage thérapeutique)</term>
<term>Jeune adulte (MeSH)</term>
<term>Lopinavir (usage thérapeutique)</term>
<term>Mâle (MeSH)</term>
<term>Nourrisson (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
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<term>Child, Preschool</term>
<term>Drug Therapy, Combination</term>
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<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Prospective Studies</term>
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<front><div type="abstract" xml:lang="en">A prospective observational study was conducted for assessing the therapeutic efficacy of interferon (IFN)-α2b in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first month after the coronavirus disease 2019 (COVID-19) outbreak began in Cuba. From March 11th to April 14th, 814 patients were confirmed SARS-CoV-2 positive in Cuba. Seven hundred sixty-one (93.4%) were treated with a combination of oral antivirals (lopinavir/ritonavir and chloroquine) with intramuscular administration of IFN-α2b (Heberon<sup>®</sup>
Alpha R, Center for Genetic Engineering and Biotechnology, Havana, Cuba), 3 times per week, for 2 weeks. Fifty-three patients received the approved COVID protocol without IFN treatment. The proportion of patients discharged from hospital (without clinical and radiological symptoms and nondetectable virus by real-time polymerase chain reaction) was higher in the IFN-treated compared with the non-IFN treated group (95.4% vs. 26.1%, <i>P</i>
< 0.01). The case fatality rate (CFR) for all patients was 2.95%, and for those patients who received IFN-α2b the CFR was reduced to 0.92. Intensive care was required for 82 patients (10.1%), 42 (5.5%) had been treated with IFN. This report provides preliminary evidence for the therapeutic effectiveness of IFN-α2b for COVID-19 and suggests that the use of Heberon Alpha R may contribute to complete recovery of patients.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>05</Day>
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<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>05</Day>
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<JournalIssue CitedMedium="Internet"><Volume>40</Volume>
<Issue>9</Issue>
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<Month>09</Month>
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<Title>Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research</Title>
<ISOAbbreviation>J Interferon Cytokine Res</ISOAbbreviation>
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<ArticleTitle>Therapeutic Effectiveness of Interferon-α2b Against COVID-19: The Cuban Experience.</ArticleTitle>
<Pagination><MedlinePgn>438-442</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1089/jir.2020.0124</ELocationID>
<Abstract><AbstractText>A prospective observational study was conducted for assessing the therapeutic efficacy of interferon (IFN)-α2b in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first month after the coronavirus disease 2019 (COVID-19) outbreak began in Cuba. From March 11th to April 14th, 814 patients were confirmed SARS-CoV-2 positive in Cuba. Seven hundred sixty-one (93.4%) were treated with a combination of oral antivirals (lopinavir/ritonavir and chloroquine) with intramuscular administration of IFN-α2b (Heberon<sup>®</sup>
Alpha R, Center for Genetic Engineering and Biotechnology, Havana, Cuba), 3 times per week, for 2 weeks. Fifty-three patients received the approved COVID protocol without IFN treatment. The proportion of patients discharged from hospital (without clinical and radiological symptoms and nondetectable virus by real-time polymerase chain reaction) was higher in the IFN-treated compared with the non-IFN treated group (95.4% vs. 26.1%, <i>P</i>
< 0.01). The case fatality rate (CFR) for all patients was 2.95%, and for those patients who received IFN-α2b the CFR was reduced to 0.92. Intensive care was required for 82 patients (10.1%), 42 (5.5%) had been treated with IFN. This report provides preliminary evidence for the therapeutic effectiveness of IFN-α2b for COVID-19 and suggests that the use of Heberon Alpha R may contribute to complete recovery of patients.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pereda</LastName>
<ForeName>Ricardo</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Intensive Medicine Department, Medical College of Havana, Havana, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>González</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Internal Medicine Department, Pedro Kouri Institute, Havana, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rivero</LastName>
<ForeName>Hubert Blas</ForeName>
<Initials>HB</Initials>
<AffiliationInfo><Affiliation>Internal Medicine Department, Enrique Cabrera General Hospital, Havana, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rivero</LastName>
<ForeName>Juan Carlos</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Intensive Medicine Department, Miguel Enríquez Surgical Clinical Hospital, Havana, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pérez</LastName>
<ForeName>Albadio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Intensive Medicine Department, Enrique Cabrera General Hospital, Havana, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>López</LastName>
<ForeName>Lissette Del Rosario</ForeName>
<Initials>LDR</Initials>
<AffiliationInfo><Affiliation>Intensive Medicine Department, Juan Manuel Marquez Pediatric Hospital, Havana, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mezquia</LastName>
<ForeName>Natacha</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Intensive Medicine Department, Miguel Enríquez Surgical Clinical Hospital, Havana, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Venegas</LastName>
<ForeName>Rafael</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Intensive Medicine Department, Luis Díaz Soto Central Military Hospital, Havana, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Betancourt</LastName>
<ForeName>Julio Roberto</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Intensive Medicine Department, Manuel Piti Fajardo Surgical Clinical Military Hospital, Villa Clara, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Domínguez</LastName>
<ForeName>Rodolfo Emilio</ForeName>
<Initials>RE</Initials>
<AffiliationInfo><Affiliation>Intensive Medicine Department, Octavio de la Concepcion y la Pedraja Military Hospital. Camagüey, Cuba.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Interferon Cytokine Res</MedlineTA>
<NlmUniqueID>9507088</NlmUniqueID>
<ISSNLinking>1079-9907</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C000614170">Interferon-alpha2b</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>2494G1JF75</RegistryNumber>
<NameOfSubstance UI="D061466">Lopinavir</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>886U3H6UFF</RegistryNumber>
<NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>O3J8G9O825</RegistryNumber>
<NameOfSubstance UI="D019438">Ritonavir</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003462" MajorTopicYN="N" Type="Geographic">Cuba</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061466" MajorTopicYN="N">Lopinavir</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019438" MajorTopicYN="N">Ritonavir</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">SARS-Cov-2</Keyword>
<Keyword MajorTopicYN="Y">interferon</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>9</Month>
<Day>22</Day>
<Hour>12</Hour>
<Minute>11</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>9</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>10</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32960147</ArticleId>
<ArticleId IdType="doi">10.1089/jir.2020.0124</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Cuba</li>
</country>
</list>
<tree><country name="Cuba"><noRegion><name sortKey="Pereda, Ricardo" sort="Pereda, Ricardo" uniqKey="Pereda R" first="Ricardo" last="Pereda">Ricardo Pereda</name>
</noRegion>
<name sortKey="Betancourt, Julio Roberto" sort="Betancourt, Julio Roberto" uniqKey="Betancourt J" first="Julio Roberto" last="Betancourt">Julio Roberto Betancourt</name>
<name sortKey="Dominguez, Rodolfo Emilio" sort="Dominguez, Rodolfo Emilio" uniqKey="Dominguez R" first="Rodolfo Emilio" last="Domínguez">Rodolfo Emilio Domínguez</name>
<name sortKey="Gonzalez, Daniel" sort="Gonzalez, Daniel" uniqKey="Gonzalez D" first="Daniel" last="González">Daniel González</name>
<name sortKey="L Pez, Lissette Del Rosario" sort="L Pez, Lissette Del Rosario" uniqKey="L Pez L" first="Lissette Del Rosario" last="L Pez">Lissette Del Rosario L Pez</name>
<name sortKey="Mezquia, Natacha" sort="Mezquia, Natacha" uniqKey="Mezquia N" first="Natacha" last="Mezquia">Natacha Mezquia</name>
<name sortKey="Perez, Albadio" sort="Perez, Albadio" uniqKey="Perez A" first="Albadio" last="Pérez">Albadio Pérez</name>
<name sortKey="Rivero, Hubert Blas" sort="Rivero, Hubert Blas" uniqKey="Rivero H" first="Hubert Blas" last="Rivero">Hubert Blas Rivero</name>
<name sortKey="Rivero, Juan Carlos" sort="Rivero, Juan Carlos" uniqKey="Rivero J" first="Juan Carlos" last="Rivero">Juan Carlos Rivero</name>
<name sortKey="Venegas, Rafael" sort="Venegas, Rafael" uniqKey="Venegas R" first="Rafael" last="Venegas">Rafael Venegas</name>
</country>
</tree>
</affiliations>
</record>
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