CovidSeniorV1, Main, Exploration, bibRecord, 000057

[Clinical features of severe or critical ill patients with COVID-19].

Identifieur interne : 000057 ( Main/Exploration ); précédent : 000056; suivant : 000058

[Clinical features of severe or critical ill patients with COVID-19].

Auteurs : Weidang Xie [République populaire de Chine] ; Shijie Zhu [République populaire de Chine] ; Yanan Liu [République populaire de Chine] ; Yujia Bai [République populaire de Chine] ; Weijun Fu [République populaire de Chine] ; Hui Chen [République populaire de Chine] ; Zhongqing Chen [République populaire de Chine] ; Jianwu Zhang [République populaire de Chine]

Source :

Nan fang yi ke da xue xue bao = Journal of Southern Medical University [ 1673-4254 ] ; 2020.

RBID : pubmed:32895171

Descripteurs français

English descriptors

KwdEn :
- Aged (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (MeSH), Critical Illness (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (MeSH), Retrospective Studies (MeSH).
MESH :
- Aged, Betacoronavirus, Coronavirus Infections, Critical Illness, Female, Humans, Male, Middle Aged, Pandemics, Pneumonia, Viral, Retrospective Studies.

Abstract

OBJECTIVE

To analyze the clinical features of severe or critical ill adult patients with coronavirus disease (COVID-19).

METHODS

The clinical data of 75 patients with severe or critical COVID-19 in Honghu People's Hospital from January to March in 2020 were collected.

RESULTS

Of the 75 patients with COVID-19 pneumonia, 41 were male (54.67%) and 34 were female (45.33%) with a mean age of 67.53 ±12.37 years; 43 patients had severe and 32 had critical COVID-19, and 49.3% of the patients had underlying diseases. The main clinical manifestations included fever (78.67%) and coughing (70.67%). Compared with the severe patients, the critically ill patients had higher proportions of patients over 60 years old with elevated white blood cell count, increased prothrombin time, and higher levels of hsCRP, PCT, D-dimer, ALT, LDH, cTnI and NT-proBNP. Univariate logistic regression analysis showed that an age over 60 years, leukocytosis, hs-CRP elevation, prolonged prothrombin time, and increased levels of D-dimer, NT-proBNP and cTnI were associated with severe COVID-19. Multivariate logistic regression showed that an age over 60 years (OR=8.165, 95%

CONCLUSIONS

An age over 60 years, a prolonged prothrombin time and elevated NT-proBNP level are important clinical features of critically ill patients with COVID-19, and can be deemed as early warning signals for critical conditions of the disease.

DOI: 10.12122/j.issn.1673-4254.2020.08.07
PubMed: 32895171
PubMed Central: PMC7429169

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000323
to stream Main, to step Curation: 000323

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Coronavirus Infections (MeSH)</term>
<term>Critical Illness (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (MeSH)</term>
<term>Maladie grave (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Betacoronavirus</term>
<term>Coronavirus Infections</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Pneumonia, Viral</term>
<term>Retrospective Studies</term>
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<term>Betacoronavirus</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Pandémies</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To analyze the clinical features of severe or critical ill adult patients with coronavirus disease (COVID-19).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>The clinical data of 75 patients with severe or critical COVID-19 in Honghu People's Hospital from January to March in 2020 were collected.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Of the 75 patients with COVID-19 pneumonia, 41 were male (54.67%) and 34 were female (45.33%) with a mean age of 67.53 ±12.37 years; 43 patients had severe and 32 had critical COVID-19, and 49.3% of the patients had underlying diseases. The main clinical manifestations included fever (78.67%) and coughing (70.67%). Compared with the severe patients, the critically ill patients had higher proportions of patients over 60 years old with elevated white blood cell count, increased prothrombin time, and higher levels of hsCRP, PCT, D-dimer, ALT, LDH, cTnI and NT-proBNP. Univariate logistic regression analysis showed that an age over 60 years, leukocytosis, hs-CRP elevation, prolonged prothrombin time, and increased levels of D-dimer, NT-proBNP and cTnI were associated with severe COVID-19. Multivariate logistic regression showed that an age over 60 years (OR=8.165, 95% </p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>An age over 60 years, a prolonged prothrombin time and elevated NT-proBNP level are important clinical features of critically ill patients with COVID-19, and can be deemed as early warning signals for critical conditions of the disease.</p>
</div>
</front>
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<Month>09</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>01</Day>
</DateRevised>
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<Issue>8</Issue>
<PubDate><Year>2020</Year>
<Month>Aug</Month>
<Day>30</Day>
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<Title>Nan fang yi ke da xue xue bao = Journal of Southern Medical University</Title>
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<ArticleTitle>[Clinical features of severe or critical ill patients with COVID-19].</ArticleTitle>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To analyze the clinical features of severe or critical ill adult patients with coronavirus disease (COVID-19).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The clinical data of 75 patients with severe or critical COVID-19 in Honghu People's Hospital from January to March in 2020 were collected.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 75 patients with COVID-19 pneumonia, 41 were male (54.67%) and 34 were female (45.33%) with a mean age of 67.53 ±12.37 years; 43 patients had severe and 32 had critical COVID-19, and 49.3% of the patients had underlying diseases. The main clinical manifestations included fever (78.67%) and coughing (70.67%). Compared with the severe patients, the critically ill patients had higher proportions of patients over 60 years old with elevated white blood cell count, increased prothrombin time, and higher levels of hsCRP, PCT, D-dimer, ALT, LDH, cTnI and NT-proBNP. Univariate logistic regression analysis showed that an age over 60 years, leukocytosis, hs-CRP elevation, prolonged prothrombin time, and increased levels of D-dimer, NT-proBNP and cTnI were associated with severe COVID-19. Multivariate logistic regression showed that an age over 60 years (OR=8.165, 95% <i>CI</i>
: 1.483-45.576, <i>P</i>
=0.017), prolonged prothrombin time (OR=7.516, 95% <i>CI</i>
: 2.568-21.998, <i>P</i>
=0.006) and elevated NT-proBNP (OR=6.194, 95% <i>CI</i>
: 1.305-29.404, <i>P</i>
=0.022) were independent risk factors for critical type of COVID-19.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">An age over 60 years, a prolonged prothrombin time and elevated NT-proBNP level are important clinical features of critically ill patients with COVID-19, and can be deemed as early warning signals for critical conditions of the disease.</AbstractText>
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<Author ValidYN="Y"><LastName>Chen</LastName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
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<ReferenceList><Reference><Citation>JAMA. 2020 Apr 7;323(13):1239-1242</Citation>
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<affiliations><list><country><li>République populaire de Chine</li>
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<name sortKey="Chen, Zhongqing" sort="Chen, Zhongqing" uniqKey="Chen Z" first="Zhongqing" last="Chen">Zhongqing Chen</name>
<name sortKey="Fu, Weijun" sort="Fu, Weijun" uniqKey="Fu W" first="Weijun" last="Fu">Weijun Fu</name>
<name sortKey="Liu, Yanan" sort="Liu, Yanan" uniqKey="Liu Y" first="Yanan" last="Liu">Yanan Liu</name>
<name sortKey="Zhang, Jianwu" sort="Zhang, Jianwu" uniqKey="Zhang J" first="Jianwu" last="Zhang">Jianwu Zhang</name>
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	Serveur d'exploration sur la COVID chez les séniors
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la COVID chez les séniors

[Clinical features of severe or critical ill patients with COVID-19].

[Clinical features of severe or critical ill patients with COVID-19].

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