CovidSeniorV1, Main, Curation, bibRecord, 000813

Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report.

Identifieur interne : 000813 ( Main/Curation ); précédent : 000812; suivant : 000814

Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report.

Auteurs : Bing Liang ; Junhui Chen [République populaire de Chine] ; Tao Li ; Haiying Wu ; Wenjie Yang ; Yanjiao Li ; Jianchun Li ; Congtao Yu [République populaire de Chine] ; Fangang Nie ; Zhaoxia Ma ; Mingxi Yang ; Mingying Xiao ; Panrong Nie ; Yanfeng Gao [République populaire de Chine] ; Chuanyun Qian ; Min Hu [République populaire de Chine, Laos]

Source :

Medicine [ 1536-5964 ] ; 2020.

RBID : pubmed:32756149

Descripteurs français

KwdFr :
- Antibactériens (usage thérapeutique), Association thérapeutique (MeSH), Betacoronavirus (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (thérapie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Pandémies (MeSH), Pneumopathie virale (thérapie), Pneumopathie virale (virologie), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Thymalfasine (usage thérapeutique), Transplantation de cellules souches de sang du cordon (méthodes), Transplantation de cellules souches mésenchymateuses (méthodes).
MESH :
- méthodes : Transplantation de cellules souches de sang du cordon, Transplantation de cellules souches mésenchymateuses.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antibactériens, Thymalfasine.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Association thérapeutique, Betacoronavirus, Femelle, Humains, Pandémies, Résultat thérapeutique, Sujet âgé.

English descriptors

KwdEn :
- Aged (MeSH), Anti-Bacterial Agents (therapeutic use), Betacoronavirus (MeSH), Combined Modality Therapy (MeSH), Cord Blood Stem Cell Transplantation (methods), Coronavirus Infections (drug therapy), Coronavirus Infections (therapy), Coronavirus Infections (virology), Female (MeSH), Humans (MeSH), Mesenchymal Stem Cell Transplantation (methods), Pandemics (MeSH), Pneumonia, Viral (therapy), Pneumonia, Viral (virology), Thymalfasin (therapeutic use), Treatment Outcome (MeSH).
MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Thymalfasin.
- drug therapy : Coronavirus Infections.
- methods : Cord Blood Stem Cell Transplantation, Mesenchymal Stem Cell Transplantation.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Aged, Betacoronavirus, Combined Modality Therapy, Female, Humans, Pandemics, Treatment Outcome.

Abstract

RATIONALE

The COVID-19 cases increased very fast in January and February 2020. The mortality among critically ill patients, especially the elder ones, is relatively high. Considering many patients died of severe inflammation response, it is urgent to develop effective therapeutic strategies for these patients. The human umbilical cord mesenchymal stem cells (hUCMSCs) have shown good capabilities to modulate the immune response and repair the injured tissue. Therefore, investigating the potential of hUCMSCs to the treatment of COVID-19 critically ill patients is necessary.

PATIENT CONCERNS

A 65-year-old woman felt fatigued and had a fever with body temperature of 38.2C, coughed up white foaming sputum. After 1 day, she had chest tightness with SPO2 of 81%, and blood pressure of 160/91 mm Hg.

DIAGNOSE

According to the guideline for the diagnosis and treatment of 2019 novel coronavirus infected pneumonia (Trial 4th Edition), COVID-19 was diagnosed, based on the real-time RT-PCR test of SARS-CoV-2.

INTERVENTIONS

After regular treatment for 12 days, the inflammation symptom of the patient was still very severe and the potential side effects of corticosteroid were observed. Then, allogenic hUCMSCs were given 3 times (5 × 10 cells each time) with a 3-day interval, together with thymosin α1 and antibiotics daily injection.

OUTCOMES

After these treatments, most of the laboratory indexes and CT images showed remission of the inflammation symptom. The patient was subsequently transferred out of ICU, and the throat swabs test reported negative 4 days later.

LESSONS

These results indicated the clinical outcome and good tolerance of allogenic hUCMSCs transfer.

DOI: 10.1097/MD.0000000000021429
PubMed: 32756149
PubMed Central: PMC7402800

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Bing Liang

<affiliation><nlm:affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</nlm:affiliation>
<wicri:noCountry code="subField">Baoshan</wicri:noCountry>
</affiliation>

Tao Li

<affiliation><nlm:affiliation>Yunnan Yasheng Medical Technology Co., Ltd.</nlm:affiliation>
<wicri:noCountry code="subField">Ltd</wicri:noCountry>
</affiliation>

Haiying Wu

<affiliation><nlm:affiliation>Emergency Department of the First Affiliated Hospital of Kunming Medical University, EICU/MICU.</nlm:affiliation>
<wicri:noCountry code="subField">EICU/MICU</wicri:noCountry>
</affiliation>

Wenjie Yang

<affiliation><nlm:affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</nlm:affiliation>
<wicri:noCountry code="subField">Baoshan</wicri:noCountry>
</affiliation>

Yanjiao Li

<affiliation><nlm:affiliation>Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University.</nlm:affiliation>
<wicri:noCountry code="subField">Kunming University</wicri:noCountry>
</affiliation>

Jianchun Li

<affiliation><nlm:affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</nlm:affiliation>
<wicri:noCountry code="subField">Baoshan</wicri:noCountry>
</affiliation>

Fangang Nie

<affiliation><nlm:affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</nlm:affiliation>
<wicri:noCountry code="subField">Baoshan</wicri:noCountry>
</affiliation>

Zhaoxia Ma

<affiliation><nlm:affiliation>Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University.</nlm:affiliation>
<wicri:noCountry code="subField">Kunming University</wicri:noCountry>
</affiliation>

<affiliation><nlm:affiliation>Yunnan Jici Institute for Regenerative Medicine Co., Ltd., Kunming.</nlm:affiliation>
<wicri:noCountry code="subField">Kunming</wicri:noCountry>
</affiliation>

Zhaoxia Ma

<affiliation><nlm:affiliation>Yunnan Jici Institute for Regenerative Medicine Co., Ltd., Kunming.</nlm:affiliation>
<wicri:noCountry code="subField">Kunming</wicri:noCountry>
</affiliation>

Mingxi Yang

<affiliation><nlm:affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</nlm:affiliation>
<wicri:noCountry code="subField">Baoshan</wicri:noCountry>
</affiliation>

Mingying Xiao

<affiliation><nlm:affiliation>Department of Infectious Diseases.</nlm:affiliation>
<wicri:noCountry code="no comma">Department of Infectious Diseases.</wicri:noCountry>
</affiliation>

Panrong Nie

<affiliation><nlm:affiliation>Department of Neonatology, Baoshan People's Hospital, Baoshan.</nlm:affiliation>
<wicri:noCountry code="subField">Baoshan</wicri:noCountry>
</affiliation>

Chuanyun Qian

<affiliation><nlm:affiliation>Emergency Department of the First Affiliated Hospital of Kunming Medical University, EICU/MICU.</nlm:affiliation>
<wicri:noCountry code="subField">EICU/MICU</wicri:noCountry>
</affiliation>

Min Hu

<affiliation><nlm:affiliation>Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University.</nlm:affiliation>
<wicri:noCountry code="subField">Kunming University</wicri:noCountry>
</affiliation>

<affiliation wicri:level="1"><nlm:affiliation>Boten International Stem Cell Hospital, Boten, Laos.</nlm:affiliation>
<country xml:lang="fr">Laos</country>
<wicri:regionArea>Boten International Stem Cell Hospital, Boten</wicri:regionArea>
</affiliation>

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<author><name sortKey="Ma, Zhaoxia" sort="Ma, Zhaoxia" uniqKey="Ma Z" first="Zhaoxia" last="Ma">Zhaoxia Ma</name>
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<author><name sortKey="Yang, Mingxi" sort="Yang, Mingxi" uniqKey="Yang M" first="Mingxi" last="Yang">Mingxi Yang</name>
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<author><name sortKey="Gao, Yanfeng" sort="Gao, Yanfeng" uniqKey="Gao Y" first="Yanfeng" last="Gao">Yanfeng Gao</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Life Sciences, Zhengzhou University, Zhengzhou</wicri:regionArea>
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<author><name sortKey="Qian, Chuanyun" sort="Qian, Chuanyun" uniqKey="Qian C" first="Chuanyun" last="Qian">Chuanyun Qian</name>
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<author><name sortKey="Hu, Min" sort="Hu, Min" uniqKey="Hu M" first="Min" last="Hu">Min Hu</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Anti-Bacterial Agents (therapeutic use)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Combined Modality Therapy (MeSH)</term>
<term>Cord Blood Stem Cell Transplantation (methods)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Mesenchymal Stem Cell Transplantation (methods)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Thymalfasin (therapeutic use)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antibactériens (usage thérapeutique)</term>
<term>Association thérapeutique (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Thymalfasine (usage thérapeutique)</term>
<term>Transplantation de cellules souches de sang du cordon (méthodes)</term>
<term>Transplantation de cellules souches mésenchymateuses (méthodes)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Thymalfasin</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cord Blood Stem Cell Transplantation</term>
<term>Mesenchymal Stem Cell Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Transplantation de cellules souches de sang du cordon</term>
<term>Transplantation de cellules souches mésenchymateuses</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term>
<term>Thymalfasine</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Betacoronavirus</term>
<term>Combined Modality Therapy</term>
<term>Female</term>
<term>Humans</term>
<term>Pandemics</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Association thérapeutique</term>
<term>Betacoronavirus</term>
<term>Femelle</term>
<term>Humains</term>
<term>Pandémies</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>RATIONALE</b>
</p>
<p>The COVID-19 cases increased very fast in January and February 2020. The mortality among critically ill patients, especially the elder ones, is relatively high. Considering many patients died of severe inflammation response, it is urgent to develop effective therapeutic strategies for these patients. The human umbilical cord mesenchymal stem cells (hUCMSCs) have shown good capabilities to modulate the immune response and repair the injured tissue. Therefore, investigating the potential of hUCMSCs to the treatment of COVID-19 critically ill patients is necessary.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>PATIENT CONCERNS</b>
</p>
<p>A 65-year-old woman felt fatigued and had a fever with body temperature of 38.2C, coughed up white foaming sputum. After 1 day, she had chest tightness with SPO2 of 81%, and blood pressure of 160/91 mm Hg.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>DIAGNOSE</b>
</p>
<p>According to the guideline for the diagnosis and treatment of 2019 novel coronavirus infected pneumonia (Trial 4th Edition), COVID-19 was diagnosed, based on the real-time RT-PCR test of SARS-CoV-2.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>INTERVENTIONS</b>
</p>
<p>After regular treatment for 12 days, the inflammation symptom of the patient was still very severe and the potential side effects of corticosteroid were observed. Then, allogenic hUCMSCs were given 3 times (5 × 10 cells each time) with a 3-day interval, together with thymosin α1 and antibiotics daily injection.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OUTCOMES</b>
</p>
<p>After these treatments, most of the laboratory indexes and CT images showed remission of the inflammation symptom. The patient was subsequently transferred out of ICU, and the throat swabs test reported negative 4 days later.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>LESSONS</b>
</p>
<p>These results indicated the clinical outcome and good tolerance of allogenic hUCMSCs transfer.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32756149</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>08</Month>
<Day>24</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1536-5964</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>99</Volume>
<Issue>31</Issue>
<PubDate><Year>2020</Year>
<Month>Jul</Month>
<Day>31</Day>
</PubDate>
</JournalIssue>
<Title>Medicine</Title>
<ISOAbbreviation>Medicine (Baltimore)</ISOAbbreviation>
</Journal>
<ArticleTitle>Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report.</ArticleTitle>
<Pagination><MedlinePgn>e21429</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/MD.0000000000021429</ELocationID>
<Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">The COVID-19 cases increased very fast in January and February 2020. The mortality among critically ill patients, especially the elder ones, is relatively high. Considering many patients died of severe inflammation response, it is urgent to develop effective therapeutic strategies for these patients. The human umbilical cord mesenchymal stem cells (hUCMSCs) have shown good capabilities to modulate the immune response and repair the injured tissue. Therefore, investigating the potential of hUCMSCs to the treatment of COVID-19 critically ill patients is necessary.</AbstractText>
<AbstractText Label="PATIENT CONCERNS" NlmCategory="UNASSIGNED">A 65-year-old woman felt fatigued and had a fever with body temperature of 38.2C, coughed up white foaming sputum. After 1 day, she had chest tightness with SPO2 of 81%, and blood pressure of 160/91 mm Hg.</AbstractText>
<AbstractText Label="DIAGNOSE" NlmCategory="UNASSIGNED">According to the guideline for the diagnosis and treatment of 2019 novel coronavirus infected pneumonia (Trial 4th Edition), COVID-19 was diagnosed, based on the real-time RT-PCR test of SARS-CoV-2.</AbstractText>
<AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">After regular treatment for 12 days, the inflammation symptom of the patient was still very severe and the potential side effects of corticosteroid were observed. Then, allogenic hUCMSCs were given 3 times (5 × 10 cells each time) with a 3-day interval, together with thymosin α1 and antibiotics daily injection.</AbstractText>
<AbstractText Label="OUTCOMES" NlmCategory="RESULTS">After these treatments, most of the laboratory indexes and CT images showed remission of the inflammation symptom. The patient was subsequently transferred out of ICU, and the throat swabs test reported negative 4 days later.</AbstractText>
<AbstractText Label="LESSONS" NlmCategory="CONCLUSIONS">These results indicated the clinical outcome and good tolerance of allogenic hUCMSCs transfer.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liang</LastName>
<ForeName>Bing</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Junhui</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Yunnan Yasheng Medical Technology Co., Ltd.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Haiying</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Emergency Department of the First Affiliated Hospital of Kunming Medical University, EICU/MICU.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Wenjie</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yanjiao</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jianchun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Congtao</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nie</LastName>
<ForeName>Fangang</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Zhaoxia</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Yunnan Jici Institute for Regenerative Medicine Co., Ltd., Kunming.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Mingxi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiao</LastName>
<ForeName>Mingying</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nie</LastName>
<ForeName>Panrong</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Neonatology, Baoshan People's Hospital, Baoshan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Yanfeng</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Life Sciences, Zhengzhou University, Zhengzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qian</LastName>
<ForeName>Chuanyun</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Emergency Department of the First Affiliated Hospital of Kunming Medical University, EICU/MICU.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Min</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Boten International Stem Cell Hospital, Boten, Laos.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report.

Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report.

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