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Association Between Time to Operation and Pathologic Stage in Ductal Carcinoma in Situ and Early-Stage Hormone Receptor-Positive Breast Cancer.

Identifieur interne : 000735 ( Main/Curation ); précédent : 000734; suivant : 000736

Association Between Time to Operation and Pathologic Stage in Ductal Carcinoma in Situ and Early-Stage Hormone Receptor-Positive Breast Cancer.

Auteurs : Christina A. Minami [États-Unis] ; Olga Kantor [États-Unis] ; Anna Weiss [États-Unis] ; Faina Nakhlis [États-Unis] ; Tari A. King [États-Unis] ; Elizabeth A. Mittendorf [États-Unis]

Source :

RBID : pubmed:32771654

Descripteurs français

English descriptors

Abstract

BACKGROUND

During the COVID-19 pandemic, surgical delays have been common for patients with ductal carcinoma in situ (DCIS) and early-stage estrogen receptor-positive (ER+) breast cancer, often in favor of neoadjuvant endocrine therapy (NET). To understand possible ramifications of these delays, we examined the association between time to operation and pathologic staging and overall survival (OS).

STUDY DESIGN

Patients with DCIS or ER+ cT1-2N0 breast cancer treated from 2010 through 2016 were identified in the National Cancer Database. Time to operation was recorded. Factors associated with pathologic upstaging were examined using logistic regression analyses. Cox proportional hazard models were used to analyze OS. Analyses were stratified by disease stage and initial treatment strategy.

RESULTS

There were 378,839 patients identified. Among those undergoing primary surgical procedure, time to operation was within 120 days in > 98% in all groups. Among cT1-2N0 patients selected for NET, operations were performed within 120 days in 59.6% of cT1N0 and 30.9% of cT2N0 patients. Increased time to operation was associated with increased odds of pathologic upstaging in DCIS patients (ER+: 60 to 120 days: odds ratio 1.15; 95% CI, 1.08 to 1.22; more than 120 days: odds ratio 1.44; 95% CI, 1.24 to 1.68; ER-: 60 to 120 days: NS; more than 120 days: odds ratio 1.36; 95% CI, 1.01 to 1.82; 60 days or less: reference), but not in patients with invasive cancer, irrespective of initial treatment strategy. No difference in OS was seen by time to operation in DCIS or NET patients.

CONCLUSIONS

Increased time to operation was associated with a small increase in pathologic upstaging in DCIS patients, but did not impact OS. In patients with cT1-2N0 disease, NET use did not impact stage or OS, supporting the safety of delay strategies in ER+ breast cancer patients during the pandemic.


DOI: 10.1016/j.jamcollsurg.2020.06.021
PubMed: 32771654
PubMed Central: PMC7409804

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pubmed:32771654

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<term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
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<term>Breast Neoplasms (diagnosis)</term>
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<term>Follow-Up Studies (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Mastectomy (methods)</term>
<term>Middle Aged (MeSH)</term>
<term>Neoplasm Staging (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Prognosis (MeSH)</term>
<term>Receptors, Estrogen (metabolism)</term>
<term>Retrospective Studies (MeSH)</term>
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<term>Survival Rate (trends)</term>
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<term>Young Adult (MeSH)</term>
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<term>Adolescent (MeSH)</term>
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<term>Betacoronavirus (MeSH)</term>
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<term>Carcinome canalaire du sein (diagnostic)</term>
<term>Carcinome canalaire du sein (épidémiologie)</term>
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<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
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<term>Jeune adulte (MeSH)</term>
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<term>Récepteurs des oestrogènes (métabolisme)</term>
<term>Stadification tumorale (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
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<term>Tumeurs du sein (diagnostic)</term>
<term>Tumeurs du sein (épidémiologie)</term>
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<term>Études rétrospectives (MeSH)</term>
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<term>Breast Neoplasms</term>
<term>Carcinoma, Ductal, Breast</term>
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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Betacoronavirus</term>
<term>Comorbidity</term>
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<term>Follow-Up Studies</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Betacoronavirus</term>
<term>Comorbidité</term>
<term>Délai jusqu'au traitement</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Pandémies</term>
<term>Pronostic</term>
<term>Stadification tumorale</term>
<term>Sujet âgé</term>
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<term>Études de suivi</term>
<term>Études rétrospectives</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>BACKGROUND</b>
</p>
<p>During the COVID-19 pandemic, surgical delays have been common for patients with ductal carcinoma in situ (DCIS) and early-stage estrogen receptor-positive (ER+) breast cancer, often in favor of neoadjuvant endocrine therapy (NET). To understand possible ramifications of these delays, we examined the association between time to operation and pathologic staging and overall survival (OS).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>STUDY DESIGN</b>
</p>
<p>Patients with DCIS or ER+ cT1-2N0 breast cancer treated from 2010 through 2016 were identified in the National Cancer Database. Time to operation was recorded. Factors associated with pathologic upstaging were examined using logistic regression analyses. Cox proportional hazard models were used to analyze OS. Analyses were stratified by disease stage and initial treatment strategy.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>There were 378,839 patients identified. Among those undergoing primary surgical procedure, time to operation was within 120 days in > 98% in all groups. Among cT1-2N0 patients selected for NET, operations were performed within 120 days in 59.6% of cT1N0 and 30.9% of cT2N0 patients. Increased time to operation was associated with increased odds of pathologic upstaging in DCIS patients (ER+: 60 to 120 days: odds ratio 1.15; 95% CI, 1.08 to 1.22; more than 120 days: odds ratio 1.44; 95% CI, 1.24 to 1.68; ER-: 60 to 120 days: NS; more than 120 days: odds ratio 1.36; 95% CI, 1.01 to 1.82; 60 days or less: reference), but not in patients with invasive cancer, irrespective of initial treatment strategy. No difference in OS was seen by time to operation in DCIS or NET patients.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>Increased time to operation was associated with a small increase in pathologic upstaging in DCIS patients, but did not impact OS. In patients with cT1-2N0 disease, NET use did not impact stage or OS, supporting the safety of delay strategies in ER+ breast cancer patients during the pandemic.</p>
</div>
</front>
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<Year>2020</Year>
<Month>09</Month>
<Day>29</Day>
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<Year>2020</Year>
<Month>09</Month>
<Day>29</Day>
</DateRevised>
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<Journal>
<ISSN IssnType="Electronic">1879-1190</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>231</Volume>
<Issue>4</Issue>
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<Year>2020</Year>
<Month>10</Month>
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<Title>Journal of the American College of Surgeons</Title>
<ISOAbbreviation>J Am Coll Surg</ISOAbbreviation>
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<ArticleTitle>Association Between Time to Operation and Pathologic Stage in Ductal Carcinoma in Situ and Early-Stage Hormone Receptor-Positive Breast Cancer.</ArticleTitle>
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<MedlinePgn>434-447.e2</MedlinePgn>
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<Abstract>
<AbstractText Label="BACKGROUND">During the COVID-19 pandemic, surgical delays have been common for patients with ductal carcinoma in situ (DCIS) and early-stage estrogen receptor-positive (ER+) breast cancer, often in favor of neoadjuvant endocrine therapy (NET). To understand possible ramifications of these delays, we examined the association between time to operation and pathologic staging and overall survival (OS).</AbstractText>
<AbstractText Label="STUDY DESIGN">Patients with DCIS or ER+ cT1-2N0 breast cancer treated from 2010 through 2016 were identified in the National Cancer Database. Time to operation was recorded. Factors associated with pathologic upstaging were examined using logistic regression analyses. Cox proportional hazard models were used to analyze OS. Analyses were stratified by disease stage and initial treatment strategy.</AbstractText>
<AbstractText Label="RESULTS">There were 378,839 patients identified. Among those undergoing primary surgical procedure, time to operation was within 120 days in > 98% in all groups. Among cT1-2N0 patients selected for NET, operations were performed within 120 days in 59.6% of cT1N0 and 30.9% of cT2N0 patients. Increased time to operation was associated with increased odds of pathologic upstaging in DCIS patients (ER+: 60 to 120 days: odds ratio 1.15; 95% CI, 1.08 to 1.22; more than 120 days: odds ratio 1.44; 95% CI, 1.24 to 1.68; ER-: 60 to 120 days: NS; more than 120 days: odds ratio 1.36; 95% CI, 1.01 to 1.82; 60 days or less: reference), but not in patients with invasive cancer, irrespective of initial treatment strategy. No difference in OS was seen by time to operation in DCIS or NET patients.</AbstractText>
<AbstractText Label="CONCLUSIONS">Increased time to operation was associated with a small increase in pathologic upstaging in DCIS patients, but did not impact OS. In patients with cT1-2N0 disease, NET use did not impact stage or OS, supporting the safety of delay strategies in ER+ breast cancer patients during the pandemic.</AbstractText>
<CopyrightInformation>Copyright © 2020 American College of Surgeons. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
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<LastName>Minami</LastName>
<ForeName>Christina A</ForeName>
<Initials>CA</Initials>
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<Affiliation>Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, and Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA.</Affiliation>
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