Reversible platypnea-orthodeoxia in COVID-19 acute respiratory distress syndrome survivors.
Identifieur interne : 000728 ( Main/Curation ); précédent : 000727; suivant : 000729Reversible platypnea-orthodeoxia in COVID-19 acute respiratory distress syndrome survivors.
Auteurs : Geak Poh Tan [Singapour] ; Sharlene Ho [Singapour] ; Bingwen Eugene Fan [Singapour] ; Sanjay H. Chotirmall [Singapour] ; Cher Heng Tan [Singapour] ; Sennen Jin Wen Lew [Singapour] ; Po Ying Chia [Singapour] ; Barnaby E. Young [Singapour] ; John Arputhan Abisheganaden [Singapour] ; Ser Hon Puah [Singapour]Source :
- Respiratory physiology & neurobiology [ 1878-1519 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Dyspnée (physiopathologie), Dyspnée (virologie), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (complications), Infections à coronavirus (physiopathologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (physiopathologie), Posture (MeSH), Sujet âgé (MeSH), Survivants (MeSH), Syndrome de détresse respiratoire de l'adulte (virologie), Études rétrospectives (MeSH).
- MESH :
- physiopathologie : Dyspnée, Infections à coronavirus, Pneumopathie virale.
- virologie : Dyspnée, Syndrome de détresse respiratoire de l'adulte.
- complications : Adulte d'âge moyen, Betacoronavirus, Femelle, Humains, Infections à coronavirus, Mâle, Pandémies, Pneumopathie virale, Posture, Sujet âgé, Survivants, Études rétrospectives.
English descriptors
- KwdEn :
- Aged (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (complications), Coronavirus Infections (physiopathology), Dyspnea (physiopathology), Dyspnea (virology), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (physiopathology), Posture (MeSH), Respiratory Distress Syndrome, Adult (virology), Retrospective Studies (MeSH), Survivors (MeSH).
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- physiopathology : Coronavirus Infections, Dyspnea, Pneumonia, Viral.
- virology : Dyspnea, Respiratory Distress Syndrome, Adult.
- Aged, Betacoronavirus, Female, Humans, Male, Middle Aged, Pandemics, Posture, Retrospective Studies, Survivors.
Abstract
Platypnea-orthodeoxia syndrome (POS) is a rare clinical syndrome characterized by orthostatic oxygen desaturation and positional dyspnea from supine to an upright position. We observed POS in 5 of 20 cases of severe 2019 novel coronavirus (COVID-19) pneumonia, which demonstrated persistently elevated shunt fraction even after liberation from mechanical ventilation. POS was first observed during physiotherapy sessions; median oxygen desaturation was 8 % (range: 8-12 %). Affected individuals were older (median 64 vs 53 years old, p = 0.05) and had lower body mass index (median 24.7 vs 27.6 kg/m2, p = 0.03) compared to those without POS. While POS caused alarm and reduced tolerance to therapy, this phenomenon resolved over a median of 17 days with improvement of parenchymal disease. The mechanisms of POS are likely due to gravitational redistribution of pulmonary blood flow resulting in increased basal physiological shunting and upper zone dead space ventilation due to the predominantly basal distribution of consolidative change and reported vasculoplegia and microthrombi in severe COVID-19 disease.
DOI: 10.1016/j.resp.2020.103515
PubMed: 32777268
PubMed Central: PMC7413098
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Electronic address: Po_Ying_CHIA@ttsh.com.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433</wicri:regionArea></affiliation></author><author><name sortKey="Young, Barnaby E" sort="Young, Barnaby E" uniqKey="Young B" first="Barnaby E" last="Young">Barnaby E. Young</name><affiliation wicri:level="1"><nlm:affiliation>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: barnaby_young@ncid.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433</wicri:regionArea></affiliation></author><author><name sortKey="Abisheganaden, John Arputhan" sort="Abisheganaden, John Arputhan" uniqKey="Abisheganaden J" first="John Arputhan" last="Abisheganaden">John Arputhan Abisheganaden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore; Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; Yong Loo Lin School of Medicine, National University Singapore, 10 Medical Drive, 117597, Singapore. 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Electronic address: geak_poh_tan@ttsh.com.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Sharlene" sort="Ho, Sharlene" uniqKey="Ho S" first="Sharlene" last="Ho">Sharlene Ho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: sharlene.ho@mohh.com.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433</wicri:regionArea></affiliation></author><author><name sortKey="Fan, Bingwen Eugene" sort="Fan, Bingwen Eugene" uniqKey="Fan B" first="Bingwen Eugene" last="Fan">Bingwen Eugene Fan</name><affiliation wicri:level="1"><nlm:affiliation>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; Yong Loo Lin School of Medicine, National University Singapore, 10 Medical Drive, 117597, Singapore; Department of Haematology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore; Department of Laboratory Medicine, Khoo Teck Puat Hospital, 90 Yishun Central, 768828, Singapore. Electronic address: Bingwen_Eugene_FAN@ttsh.com.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; Yong Loo Lin School of Medicine, National University Singapore, 10 Medical Drive, 117597, Singapore; Department of Haematology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore; Department of Laboratory Medicine, Khoo Teck Puat Hospital, 90 Yishun Central, 768828</wicri:regionArea></affiliation></author><author><name sortKey="Chotirmall, Sanjay H" sort="Chotirmall, Sanjay H" uniqKey="Chotirmall S" first="Sanjay H" last="Chotirmall">Sanjay H. Chotirmall</name><affiliation wicri:level="1"><nlm:affiliation>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore. Electronic address: schotirmall@ntu.edu.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Cher Heng" sort="Tan, Cher Heng" uniqKey="Tan C" first="Cher Heng" last="Tan">Cher Heng Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng Hospital, 308433, Singapore. Electronic address: Cher_Heng_TAN@ttsh.com.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng Hospital, 308433</wicri:regionArea></affiliation></author><author><name sortKey="Lew, Sennen Jin Wen" sort="Lew, Sennen Jin Wen" uniqKey="Lew S" first="Sennen Jin Wen" last="Lew">Sennen Jin Wen Lew</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: Sennen_Jw_LEW@ttsh.com.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433</wicri:regionArea></affiliation></author><author><name sortKey="Chia, Po Ying" sort="Chia, Po Ying" uniqKey="Chia P" first="Po Ying" last="Chia">Po Ying Chia</name><affiliation wicri:level="1"><nlm:affiliation>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: Po_Ying_CHIA@ttsh.com.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433</wicri:regionArea></affiliation></author><author><name sortKey="Young, Barnaby E" sort="Young, Barnaby E" uniqKey="Young B" first="Barnaby E" last="Young">Barnaby E. Young</name><affiliation wicri:level="1"><nlm:affiliation>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: barnaby_young@ncid.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433</wicri:regionArea></affiliation></author><author><name sortKey="Abisheganaden, John Arputhan" sort="Abisheganaden, John Arputhan" uniqKey="Abisheganaden J" first="John Arputhan" last="Abisheganaden">John Arputhan Abisheganaden</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore; Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; Yong Loo Lin School of Medicine, National University Singapore, 10 Medical Drive, 117597, Singapore. Electronic address: John_Abisheganaden@ttsh.com.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore; Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; Yong Loo Lin School of Medicine, National University Singapore, 10 Medical Drive, 117597</wicri:regionArea></affiliation></author><author><name sortKey="Puah, Ser Hon" sort="Puah, Ser Hon" uniqKey="Puah S" first="Ser Hon" last="Puah">Ser Hon Puah</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: Ser_Hon_PUAH@ttsh.com.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433</wicri:regionArea></affiliation></author></analytic><series><title level="j">Respiratory physiology & neurobiology</title><idno type="eISSN">1878-1519</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (physiopathology)</term><term>Dyspnea (physiopathology)</term><term>Dyspnea (virology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (physiopathology)</term><term>Posture (MeSH)</term><term>Respiratory Distress Syndrome, Adult (virology)</term><term>Retrospective Studies (MeSH)</term><term>Survivors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Dyspnée (physiopathologie)</term><term>Dyspnée (virologie)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (complications)</term><term>Infections à coronavirus (physiopathologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term><term>Pneumopathie virale (physiopathologie)</term><term>Posture (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Survivants (MeSH)</term><term>Syndrome de détresse respiratoire de l'adulte (virologie)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Dyspnée</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term><term>Dyspnea</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Dyspnée</term><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Dyspnea</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Betacoronavirus</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Posture</term><term>Retrospective Studies</term><term>Survivors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus</term><term>Mâle</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Posture</term><term>Sujet âgé</term><term>Survivants</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Platypnea-orthodeoxia syndrome (POS) is a rare clinical syndrome characterized by orthostatic oxygen desaturation and positional dyspnea from supine to an upright position. We observed POS in 5 of 20 cases of severe 2019 novel coronavirus (COVID-19) pneumonia, which demonstrated persistently elevated shunt fraction even after liberation from mechanical ventilation. POS was first observed during physiotherapy sessions; median oxygen desaturation was 8 % (range: 8-12 %). Affected individuals were older (median 64 vs 53 years old, p = 0.05) and had lower body mass index (median 24.7 vs 27.6 kg/m<sup>2</sup>, p = 0.03) compared to those without POS. While POS caused alarm and reduced tolerance to therapy, this phenomenon resolved over a median of 17 days with improvement of parenchymal disease. The mechanisms of POS are likely due to gravitational redistribution of pulmonary blood flow resulting in increased basal physiological shunting and upper zone dead space ventilation due to the predominantly basal distribution of consolidative change and reported vasculoplegia and microthrombi in severe COVID-19 disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32777268</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-1519</ISSN><JournalIssue CitedMedium="Internet"><Volume>282</Volume><PubDate><Year>2020</Year><Month>11</Month></PubDate></JournalIssue><Title>Respiratory physiology & neurobiology</Title><ISOAbbreviation>Respir Physiol Neurobiol</ISOAbbreviation></Journal><ArticleTitle>Reversible platypnea-orthodeoxia in COVID-19 acute respiratory distress syndrome survivors.</ArticleTitle><Pagination><MedlinePgn>103515</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1569-9048(20)30173-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.resp.2020.103515</ELocationID><Abstract><AbstractText>Platypnea-orthodeoxia syndrome (POS) is a rare clinical syndrome characterized by orthostatic oxygen desaturation and positional dyspnea from supine to an upright position. We observed POS in 5 of 20 cases of severe 2019 novel coronavirus (COVID-19) pneumonia, which demonstrated persistently elevated shunt fraction even after liberation from mechanical ventilation. POS was first observed during physiotherapy sessions; median oxygen desaturation was 8 % (range: 8-12 %). Affected individuals were older (median 64 vs 53 years old, p = 0.05) and had lower body mass index (median 24.7 vs 27.6 kg/m<sup>2</sup>, p = 0.03) compared to those without POS. While POS caused alarm and reduced tolerance to therapy, this phenomenon resolved over a median of 17 days with improvement of parenchymal disease. The mechanisms of POS are likely due to gravitational redistribution of pulmonary blood flow resulting in increased basal physiological shunting and upper zone dead space ventilation due to the predominantly basal distribution of consolidative change and reported vasculoplegia and microthrombi in severe COVID-19 disease.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Geak Poh</ForeName><Initials>GP</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: geak_poh_tan@ttsh.com.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Sharlene</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: sharlene.ho@mohh.com.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Bingwen Eugene</ForeName><Initials>BE</Initials><AffiliationInfo><Affiliation>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; Yong Loo Lin School of Medicine, National University Singapore, 10 Medical Drive, 117597, Singapore; Department of Haematology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore; Department of Laboratory Medicine, Khoo Teck Puat Hospital, 90 Yishun Central, 768828, Singapore. Electronic address: Bingwen_Eugene_FAN@ttsh.com.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chotirmall</LastName><ForeName>Sanjay H</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore. Electronic address: schotirmall@ntu.edu.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Cher Heng</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng Hospital, 308433, Singapore. Electronic address: Cher_Heng_TAN@ttsh.com.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lew</LastName><ForeName>Sennen Jin Wen</ForeName><Initials>SJW</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: Sennen_Jw_LEW@ttsh.com.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chia</LastName><ForeName>Po Ying</ForeName><Initials>PY</Initials><AffiliationInfo><Affiliation>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: Po_Ying_CHIA@ttsh.com.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Barnaby E</ForeName><Initials>BE</Initials><AffiliationInfo><Affiliation>Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, 308442, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: barnaby_young@ncid.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abisheganaden</LastName><ForeName>John Arputhan</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore; Lee Kong Chian School of Medicine, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; Yong Loo Lin School of Medicine, National University Singapore, 10 Medical Drive, 117597, Singapore. Electronic address: John_Abisheganaden@ttsh.com.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Puah</LastName><ForeName>Ser Hon</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address: Ser_Hon_PUAH@ttsh.com.sg.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Respir Physiol Neurobiol</MedlineTA><NlmUniqueID>101140022</NlmUniqueID><ISSNLinking>1569-9048</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004417" MajorTopicYN="N">Dyspnea</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011187" MajorTopicYN="N">Posture</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017741" MajorTopicYN="N">Survivors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Coronavirus</Keyword><Keyword MajorTopicYN="Y">Critical care</Keyword><Keyword MajorTopicYN="Y">Pneumonia</Keyword><Keyword MajorTopicYN="Y">Rehabilitation</Keyword><Keyword MajorTopicYN="Y">Respiratory physiology</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32777268</ArticleId><ArticleId IdType="pii">S1569-9048(20)30173-7</ArticleId><ArticleId IdType="doi">10.1016/j.resp.2020.103515</ArticleId><ArticleId IdType="pmc">PMC7413098</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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