Serial serum SARS-CoV-2 RNA results in two COVID-19 cases with severe respiratory failure.
Identifieur interne : 000664 ( Main/Curation ); précédent : 000663; suivant : 000665Serial serum SARS-CoV-2 RNA results in two COVID-19 cases with severe respiratory failure.
Auteurs : Tatsuya Kodama [Japon] ; Yuji Kouzaki [Japon] ; Shuichi Kawano [Japon] ; Hirofumi Obinata [Japon] ; Hiroaki Taniguchi [Japon] ; Hisashi Sasaki [Japon] ; Shinichiro Ota [Japon] ; Akihiko Kawana [Japon] ; Kaku Tamura [Japon]Source :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy [ 1437-7780 ] ; 2020.
Descripteurs français
- KwdFr :
- ARN viral (isolement et purification), ARN viral (sang), Adulte (MeSH), Betacoronavirus (génétique), Betacoronavirus (isolement et purification), Facteurs temps (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (complications), Infections à coronavirus (diagnostic), Infections à coronavirus (sang), Infections à coronavirus (virologie), Insuffisance respiratoire (diagnostic), Insuffisance respiratoire (sang), Insuffisance respiratoire (virologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (diagnostic), Pneumopathie virale (sang), Pneumopathie virale (virologie), RT-PCR (MeSH), Sujet âgé (MeSH), Techniques de laboratoire clinique (MeSH), Virémie (complications), Virémie (diagnostic), Virémie (virologie), Études rétrospectives (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Insuffisance respiratoire, Pneumopathie virale, Virémie.
- génétique : Betacoronavirus.
- isolement et purification : ARN viral, Betacoronavirus.
- sang : ARN viral, Infections à coronavirus, Insuffisance respiratoire, Pneumopathie virale, Virémie.
- virologie : Infections à coronavirus, Insuffisance respiratoire, Pneumopathie virale, Virémie.
- Adulte, Facteurs temps, Humains, Indice de gravité de la maladie, Mâle, Pandémies, RT-PCR, Sujet âgé, Techniques de laboratoire clinique, Études rétrospectives.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Clinical Laboratory Techniques (MeSH), Coronavirus Infections (blood), Coronavirus Infections (complications), Coronavirus Infections (diagnosis), Coronavirus Infections (virology), Humans (MeSH), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (complications), Pneumonia, Viral (diagnosis), Pneumonia, Viral (virology), RNA, Viral (blood), RNA, Viral (isolation & purification), Respiratory Insufficiency (blood), Respiratory Insufficiency (diagnosis), Respiratory Insufficiency (virology), Retrospective Studies (MeSH), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Severity of Illness Index (MeSH), Time Factors (MeSH), Viremia (complications), Viremia (diagnosis), Viremia (virology).
- MESH :
- chemical , blood : RNA, Viral.
- blood : Coronavirus Infections, Pneumonia, Viral, Respiratory Insufficiency.
- complications : Coronavirus Infections, Pneumonia, Viral, Viremia.
- diagnosis : Coronavirus Infections, Pneumonia, Viral, Respiratory Insufficiency, Viremia.
- genetics : Betacoronavirus.
- isolation & purification : Betacoronavirus, RNA, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral, Respiratory Insufficiency, Viremia.
- Adult, Aged, Clinical Laboratory Techniques, Humans, Male, Pandemics, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Severity of Illness Index, Time Factors.
Abstract
Coronavirus disease 2019 (COVID-19) is spreading worldwide and poses an imminent threat to public health. We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment. To examine the course of infection, we performed reverse-transcription (RT) polymerase chain reaction assay with serum specimens, and serum SARS-CoV-2 RNA was detected in both cases when body temperature increased and respiratory status deteriorated. We, then examined, retrospectively and prospectively, the clinical course during hospitalization by performing serial examinations of serum SARS-CoV-2 RNA status. The findings from our cases suggest that not only is detection of viremia useful as a predictive marker of severity, but also serial serum SARS-CoV-2 RNA results can be helpful for predicting the clinical course.
DOI: 10.1016/j.jiac.2020.07.003
PubMed: 32792249
PubMed Central: PMC7366999
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154-8532, Japan. 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uniqKey="Kawano S" first="Shuichi" last="Kawano">Shuichi Kawano</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pulmonary Medicine, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pulmonary Medicine, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532</wicri:regionArea></affiliation></author><author><name sortKey="Obinata, Hirofumi" sort="Obinata, Hirofumi" uniqKey="Obinata H" first="Hirofumi" last="Obinata">Hirofumi Obinata</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anesthesiology, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532</wicri:regionArea></affiliation></author><author><name sortKey="Taniguchi, Hiroaki" sort="Taniguchi, Hiroaki" uniqKey="Taniguchi H" first="Hiroaki" last="Taniguchi">Hiroaki Taniguchi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Emergency, Japan Self Defense Force Sapporo Hospital, 17 Makomanai, Minami, Sapporo 005-8543, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Emergency, Japan Self Defense Force Sapporo Hospital, 17 Makomanai, Minami, Sapporo 005-8543</wicri:regionArea></affiliation></author><author><name sortKey="Sasaki, Hisashi" sort="Sasaki, Hisashi" uniqKey="Sasaki H" first="Hisashi" last="Sasaki">Hisashi Sasaki</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pulmonary Medicine, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pulmonary Medicine, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532</wicri:regionArea></affiliation></author><author><name sortKey="Ota, Shinichiro" sort="Ota, Shinichiro" uniqKey="Ota S" first="Shinichiro" last="Ota">Shinichiro Ota</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Japan Self Defense Forces Hospital, 1776-1 Tauraminatomachi, Yokosuka, Kanagawa 237-0071, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Internal Medicine, Japan Self Defense Forces Hospital, 1776-1 Tauraminatomachi, Yokosuka, Kanagawa 237-0071</wicri:regionArea></affiliation></author><author><name sortKey="Kawana, Akihiko" sort="Kawana, Akihiko" uniqKey="Kawana A" first="Akihiko" last="Kawana">Akihiko Kawana</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513</wicri:regionArea></affiliation></author><author><name sortKey="Tamura, Kaku" sort="Tamura, Kaku" uniqKey="Tamura K" first="Kaku" last="Tamura">Kaku Tamura</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Disease, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Infectious Disease, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</title><idno type="eISSN">1437-7780</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (isolation & purification)</term><term>Clinical Laboratory Techniques (MeSH)</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (virology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (blood)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (virology)</term><term>RNA, Viral (blood)</term><term>RNA, Viral (isolation & purification)</term><term>Respiratory Insufficiency (blood)</term><term>Respiratory Insufficiency (diagnosis)</term><term>Respiratory Insufficiency (virology)</term><term>Retrospective Studies (MeSH)</term><term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term><term>Severity of Illness Index (MeSH)</term><term>Time Factors (MeSH)</term><term>Viremia (complications)</term><term>Viremia (diagnosis)</term><term>Viremia (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (isolement et purification)</term><term>ARN viral (sang)</term><term>Adulte (MeSH)</term><term>Betacoronavirus (génétique)</term><term>Betacoronavirus (isolement et purification)</term><term>Facteurs temps (MeSH)</term><term>Humains (MeSH)</term><term>Indice de gravité de la maladie (MeSH)</term><term>Infections à coronavirus (complications)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (virologie)</term><term>Insuffisance respiratoire (diagnostic)</term><term>Insuffisance respiratoire (sang)</term><term>Insuffisance respiratoire (virologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (sang)</term><term>Pneumopathie virale (virologie)</term><term>RT-PCR (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Techniques de laboratoire clinique (MeSH)</term><term>Virémie (complications)</term><term>Virémie (diagnostic)</term><term>Virémie (virologie)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiratory Insufficiency</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Viremia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiratory Insufficiency</term><term>Viremia</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Insuffisance respiratoire</term><term>Pneumopathie virale</term><term>Virémie</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>ARN viral</term><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term><term>Infections à coronavirus</term><term>Insuffisance respiratoire</term><term>Pneumopathie virale</term><term>Virémie</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Insuffisance respiratoire</term><term>Pneumopathie virale</term><term>Virémie</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiratory Insufficiency</term><term>Viremia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Clinical Laboratory Techniques</term><term>Humans</term><term>Male</term><term>Pandemics</term><term>Retrospective Studies</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Severity of Illness Index</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Facteurs temps</term><term>Humains</term><term>Indice de gravité de la maladie</term><term>Mâle</term><term>Pandémies</term><term>RT-PCR</term><term>Sujet âgé</term><term>Techniques de laboratoire clinique</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease 2019 (COVID-19) is spreading worldwide and poses an imminent threat to public health. We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment. To examine the course of infection, we performed reverse-transcription (RT) polymerase chain reaction assay with serum specimens, and serum SARS-CoV-2 RNA was detected in both cases when body temperature increased and respiratory status deteriorated. We, then examined, retrospectively and prospectively, the clinical course during hospitalization by performing serial examinations of serum SARS-CoV-2 RNA status. The findings from our cases suggest that not only is detection of viremia useful as a predictive marker of severity, but also serial serum SARS-CoV-2 RNA results can be helpful for predicting the clinical course.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32792249</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>14</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1437-7780</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>11</Issue><PubDate><Year>2020</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</Title><ISOAbbreviation>J Infect Chemother</ISOAbbreviation></Journal><ArticleTitle>Serial serum SARS-CoV-2 RNA results in two COVID-19 cases with severe respiratory failure.</ArticleTitle><Pagination><MedlinePgn>1220-1223</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1341-321X(20)30216-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jiac.2020.07.003</ELocationID><Abstract><AbstractText>Coronavirus disease 2019 (COVID-19) is spreading worldwide and poses an imminent threat to public health. We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment. To examine the course of infection, we performed reverse-transcription (RT) polymerase chain reaction assay with serum specimens, and serum SARS-CoV-2 RNA was detected in both cases when body temperature increased and respiratory status deteriorated. We, then examined, retrospectively and prospectively, the clinical course during hospitalization by performing serial examinations of serum SARS-CoV-2 RNA status. The findings from our cases suggest that not only is detection of viremia useful as a predictive marker of severity, but also serial serum SARS-CoV-2 RNA results can be helpful for predicting the clinical course.</AbstractText><CopyrightInformation>Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kodama</LastName><ForeName>Tatsuya</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Pulmonary Medicine, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan. Electronic address: kodaaman1986@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kouzaki</LastName><ForeName>Yuji</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kawano</LastName><ForeName>Shuichi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Pulmonary Medicine, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obinata</LastName><ForeName>Hirofumi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taniguchi</LastName><ForeName>Hiroaki</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Emergency, Japan Self Defense Force Sapporo Hospital, 17 Makomanai, Minami, Sapporo 005-8543, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sasaki</LastName><ForeName>Hisashi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Pulmonary Medicine, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ota</LastName><ForeName>Shinichiro</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Japan Self Defense Forces Hospital, 1776-1 Tauraminatomachi, Yokosuka, Kanagawa 237-0071, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kawana</LastName><ForeName>Akihiko</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamura</LastName><ForeName>Kaku</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Infectious Disease, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Infect Chemother</MedlineTA><NlmUniqueID>9608375</NlmUniqueID><ISSNLinking>1341-321X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000657964">COVID-19 diagnostic testing</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012131" MajorTopicYN="N">Respiratory Insufficiency</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014766" MajorTopicYN="N">Viremia</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Serum SARS-CoV-2 RNA</Keyword><Keyword MajorTopicYN="N">Severe respiratory failure</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest None.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32792249</ArticleId><ArticleId IdType="pii">S1341-321X(20)30216-6</ArticleId><ArticleId IdType="doi">10.1016/j.jiac.2020.07.003</ArticleId><ArticleId IdType="pmc">PMC7366999</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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