Clinical Characteristics and Risk Factors of Cardiac Involvement in COVID-19.
Identifieur interne : 000610 ( Main/Curation ); précédent : 000609; suivant : 000611Clinical Characteristics and Risk Factors of Cardiac Involvement in COVID-19.
Auteurs : Huayan Xu ; Keke Hou ; Rong Xu ; Zhenlin Li ; Hang Fu ; Lingyi Wen ; Linjun Xie ; Hui Liu ; Joseph B. Selvanayagam ; Na Zhang ; Zhigang Yang ; Ming Yang ; Yingkun GuoSource :
- Journal of the American Heart Association [ 2047-9980 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Appréciation des risques (MeSH), Betacoronavirus (pathogénicité), Cardiopathies (diagnostic), Cardiopathies (thérapie), Cardiopathies (virologie), Cardiopathies (épidémiologie), Chine (épidémiologie), Comorbidité (MeSH), Facteurs de risque (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (thérapie), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Interactions hôte-pathogène (MeSH), Jeune adulte (MeSH), Marqueurs biologiques (sang), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (thérapie), Pneumopathie virale (virologie), Pneumopathie virale (épidémiologie), Pronostic (MeSH), Protéine C-réactive (métabolisme), Régulation positive (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Valeur prédictive des tests (MeSH), Études rétrospectives (MeSH).
- MESH :
- diagnostic : Cardiopathies, Infections à coronavirus, Pneumopathie virale.
- métabolisme : Protéine C-réactive.
- pathogénicité : Betacoronavirus.
- sang : Marqueurs biologiques.
- thérapie : Cardiopathies, Infections à coronavirus, Pneumopathie virale.
- virologie : Cardiopathies, Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Cardiopathies, Chine, Infections à coronavirus, Pneumopathie virale.
- Adulte, Adulte d'âge moyen, Appréciation des risques, Comorbidité, Facteurs de risque, Facteurs âges, Femelle, Humains, Indice de gravité de la maladie, Interactions hôte-pathogène, Jeune adulte, Mâle, Pandémies, Pronostic, Régulation positive, Sujet âgé, Sujet âgé de 80 ans ou plus, Valeur prédictive des tests, Études rétrospectives.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adult (MeSH), Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (pathogenicity), Biomarkers (blood), C-Reactive Protein (metabolism), China (epidemiology), Comorbidity (MeSH), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (therapy), Coronavirus Infections (virology), Female (MeSH), Heart Diseases (diagnosis), Heart Diseases (epidemiology), Heart Diseases (therapy), Heart Diseases (virology), Host-Pathogen Interactions (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (therapy), Pneumonia, Viral (virology), Predictive Value of Tests (MeSH), Prognosis (MeSH), Retrospective Studies (MeSH), Risk Assessment (MeSH), Risk Factors (MeSH), Severity of Illness Index (MeSH), Up-Regulation (MeSH), Young Adult (MeSH).
- MESH :
- chemical , blood : Biomarkers.
- chemical , metabolism : C-Reactive Protein.
- geographic , epidemiology : China.
- diagnosis : Coronavirus Infections, Heart Diseases, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Heart Diseases, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- therapy : Coronavirus Infections, Heart Diseases, Pneumonia, Viral.
- virology : Coronavirus Infections, Heart Diseases, Pneumonia, Viral.
- Adult, Age Factors, Aged, Aged, 80 and over, Comorbidity, Female, Host-Pathogen Interactions, Humans, Male, Middle Aged, Pandemics, Predictive Value of Tests, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Up-Regulation, Young Adult.
Abstract
Background Increasing studies demonstrated that the cardiac involvements are related to coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical characteristics of patients with COVID-19 and further determined the risk factors for cardiac involvement in them. Methods and Results We analyzed data from 102 consecutive laboratory-confirmed and hospitalized patients with COVID-19 (52 women aged 19-87 years). Epidemiologic and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury biomarkers), echocardiography, electrocardiography, chest imaging findings, management methods, and clinical outcomes were collected. Patients were divided into acute cardiac injury, with and without cardiac marker abnormities groups according to different level of cardiac markers. In this research, cardiac involvement was found in 72 of the 102 (70.6%) patients: tachycardia (n=20), electrocardiography abnormalities (n=23), echocardiography abnormalities (n=59), elevated myocardial enzymes (n=55), and acute cardiac injury (n=9). Eight patients with acute cardiac injury were aged >60 years; seven of them had ≥2 underlying comorbidities (hypertension, diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, and chronic kidney disease). Novel coronavirus pneumonia was much more severe in the patients with acute cardiac injury than in patients with nondefinite acute cardiac injury (P<0.001). Multivariate analyses showed that CRP (C-reactive protein) levels, old age, novel coronavirus pneumonia severity, and underlying comorbidities were the risk factors for cardiac abnormalities in patients with COVID-19. Conclusions Cardiac involvements are common in patients with COVID-19. Elevated CRP levels, old age, underlying comorbidities, and novel coronavirus pneumonia severity are the main risk factors for cardiac involvement in patients with COVID-19. More attention should be given to cardiovascular protection during COVID-19 treatment for mortality reduction. Registration URL: https://www.chictr.org; Unique identifier: ChiCTR2000029955.
DOI: 10.1161/JAHA.120.016807
PubMed: 32806998
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Huayan Xu<affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology Public Health Clinical Center of Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Public Health Clinical Center of Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Cardiovascular Medicine Flinders Medical Centre Flinders University of South Australia Adelaide Australia.</nlm:affiliation><wicri:noCountry code="no comma">Department of Cardiovascular Medicine Flinders Medical Centre Flinders University of South Australia Adelaide Australia.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology Public Health Clinical Center of Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Public Health Clinical Center of Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Respiratory Medicine Public Health Clinical Center of Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Respiratory Medicine Public Health Clinical Center of Chengdu China.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation>Le document en format XML
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Selvanayagam</name><affiliation><nlm:affiliation>Department of Cardiovascular Medicine Flinders Medical Centre Flinders University of South Australia Adelaide Australia.</nlm:affiliation><wicri:noCountry code="no comma">Department of Cardiovascular Medicine Flinders Medical Centre Flinders University of South Australia Adelaide Australia.</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Na" sort="Zhang, Na" uniqKey="Zhang N" first="Na" last="Zhang">Na Zhang</name><affiliation><nlm:affiliation>Department of Radiology Public Health Clinical Center of Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Public Health Clinical Center of Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Zhigang" sort="Yang, Zhigang" uniqKey="Yang Z" first="Zhigang" last="Yang">Zhigang Yang</name><affiliation><nlm:affiliation>Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Ming" sort="Yang, Ming" uniqKey="Yang M" first="Ming" last="Yang">Ming Yang</name><affiliation><nlm:affiliation>Department of Respiratory Medicine Public Health Clinical Center of Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Respiratory Medicine Public Health Clinical Center of Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Guo, Yingkun" sort="Guo, Yingkun" uniqKey="Guo Y" first="Yingkun" last="Guo">Yingkun Guo</name><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32806998</idno><idno type="pmid">32806998</idno><idno type="doi">10.1161/JAHA.120.016807</idno><idno type="wicri:Area/Main/Corpus">000610</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000610</idno><idno type="wicri:Area/Main/Curation">000610</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000610</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical Characteristics and Risk Factors of Cardiac Involvement in COVID-19.</title><author><name sortKey="Xu, Huayan" sort="Xu, Huayan" uniqKey="Xu H" first="Huayan" last="Xu">Huayan Xu</name><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Hou, Keke" sort="Hou, Keke" uniqKey="Hou K" first="Keke" last="Hou">Keke Hou</name><affiliation><nlm:affiliation>Department of Radiology Public Health Clinical Center of Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Public Health Clinical Center of Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Rong" sort="Xu, Rong" uniqKey="Xu R" first="Rong" last="Xu">Rong Xu</name><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Li, Zhenlin" sort="Li, Zhenlin" uniqKey="Li Z" first="Zhenlin" last="Li">Zhenlin Li</name><affiliation><nlm:affiliation>Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Fu, Hang" sort="Fu, Hang" uniqKey="Fu H" first="Hang" last="Fu">Hang Fu</name><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Wen, Lingyi" sort="Wen, Lingyi" uniqKey="Wen L" first="Lingyi" last="Wen">Lingyi Wen</name><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Xie, Linjun" sort="Xie, Linjun" uniqKey="Xie L" first="Linjun" last="Xie">Linjun Xie</name><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Liu, Hui" sort="Liu, Hui" uniqKey="Liu H" first="Hui" last="Liu">Hui Liu</name><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Selvanayagam, Joseph B" sort="Selvanayagam, Joseph B" uniqKey="Selvanayagam J" first="Joseph B" last="Selvanayagam">Joseph B. Selvanayagam</name><affiliation><nlm:affiliation>Department of Cardiovascular Medicine Flinders Medical Centre Flinders University of South Australia Adelaide Australia.</nlm:affiliation><wicri:noCountry code="no comma">Department of Cardiovascular Medicine Flinders Medical Centre Flinders University of South Australia Adelaide Australia.</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Na" sort="Zhang, Na" uniqKey="Zhang N" first="Na" last="Zhang">Na Zhang</name><affiliation><nlm:affiliation>Department of Radiology Public Health Clinical Center of Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Public Health Clinical Center of Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Zhigang" sort="Yang, Zhigang" uniqKey="Yang Z" first="Zhigang" last="Yang">Zhigang Yang</name><affiliation><nlm:affiliation>Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Ming" sort="Yang, Ming" uniqKey="Yang M" first="Ming" last="Yang">Ming Yang</name><affiliation><nlm:affiliation>Department of Respiratory Medicine Public Health Clinical Center of Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Respiratory Medicine Public Health Clinical Center of Chengdu China.</wicri:noCountry></affiliation></author><author><name sortKey="Guo, Yingkun" sort="Guo, Yingkun" uniqKey="Guo Y" first="Yingkun" last="Guo">Yingkun Guo</name><affiliation><nlm:affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</nlm:affiliation><wicri:noCountry code="no comma">Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of the American Heart Association</title><idno type="eISSN">2047-9980</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (pathogenicity)</term><term>Biomarkers (blood)</term><term>C-Reactive Protein (metabolism)</term><term>China (epidemiology)</term><term>Comorbidity (MeSH)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (therapy)</term><term>Coronavirus Infections (virology)</term><term>Female (MeSH)</term><term>Heart Diseases (diagnosis)</term><term>Heart Diseases (epidemiology)</term><term>Heart Diseases (therapy)</term><term>Heart Diseases (virology)</term><term>Host-Pathogen Interactions (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (therapy)</term><term>Pneumonia, Viral (virology)</term><term>Predictive Value of Tests (MeSH)</term><term>Prognosis (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Risk Assessment (MeSH)</term><term>Risk Factors (MeSH)</term><term>Severity of Illness Index (MeSH)</term><term>Up-Regulation (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Appréciation des risques (MeSH)</term><term>Betacoronavirus (pathogénicité)</term><term>Cardiopathies (diagnostic)</term><term>Cardiopathies (thérapie)</term><term>Cardiopathies (virologie)</term><term>Cardiopathies (épidémiologie)</term><term>Chine (épidémiologie)</term><term>Comorbidité (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Indice de gravité de la maladie (MeSH)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (thérapie)</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Interactions hôte-pathogène (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Marqueurs biologiques (sang)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (thérapie)</term><term>Pneumopathie virale (virologie)</term><term>Pneumopathie virale (épidémiologie)</term><term>Pronostic (MeSH)</term><term>Protéine C-réactive (métabolisme)</term><term>Régulation positive (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Valeur prédictive des tests (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Heart Diseases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Cardiopathies</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Heart Diseases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine C-réactive</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Heart Diseases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Cardiopathies</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cardiopathies</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Heart Diseases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Cardiopathies</term><term>Chine</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Comorbidity</term><term>Female</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Predictive Value of Tests</term><term>Prognosis</term><term>Retrospective Studies</term><term>Risk Assessment</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Up-Regulation</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Appréciation des risques</term><term>Comorbidité</term><term>Facteurs de risque</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Indice de gravité de la maladie</term><term>Interactions hôte-pathogène</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Pronostic</term><term>Régulation positive</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Valeur prédictive des tests</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Increasing studies demonstrated that the cardiac involvements are related to coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical characteristics of patients with COVID-19 and further determined the risk factors for cardiac involvement in them. Methods and Results We analyzed data from 102 consecutive laboratory-confirmed and hospitalized patients with COVID-19 (52 women aged 19-87 years). Epidemiologic and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury biomarkers), echocardiography, electrocardiography, chest imaging findings, management methods, and clinical outcomes were collected. Patients were divided into acute cardiac injury, with and without cardiac marker abnormities groups according to different level of cardiac markers. In this research, cardiac involvement was found in 72 of the 102 (70.6%) patients: tachycardia (n=20), electrocardiography abnormalities (n=23), echocardiography abnormalities (n=59), elevated myocardial enzymes (n=55), and acute cardiac injury (n=9). Eight patients with acute cardiac injury were aged >60 years; seven of them had ≥2 underlying comorbidities (hypertension, diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, and chronic kidney disease). Novel coronavirus pneumonia was much more severe in the patients with acute cardiac injury than in patients with nondefinite acute cardiac injury (<i>P</i><0.001). Multivariate analyses showed that CRP (C-reactive protein) levels, old age, novel coronavirus pneumonia severity, and underlying comorbidities were the risk factors for cardiac abnormalities in patients with COVID-19. Conclusions Cardiac involvements are common in patients with COVID-19. Elevated CRP levels, old age, underlying comorbidities, and novel coronavirus pneumonia severity are the main risk factors for cardiac involvement in patients with COVID-19. More attention should be given to cardiovascular protection during COVID-19 treatment for mortality reduction. Registration URL: https://www.chictr.org; Unique identifier: ChiCTR2000029955.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32806998</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>23</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2047-9980</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>18</Issue><PubDate><Year>2020</Year><Month>09</Month><Day>15</Day></PubDate></JournalIssue><Title>Journal of the American Heart Association</Title><ISOAbbreviation>J Am Heart Assoc</ISOAbbreviation></Journal><ArticleTitle>Clinical Characteristics and Risk Factors of Cardiac Involvement in COVID-19.</ArticleTitle><Pagination><MedlinePgn>e016807</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1161/JAHA.120.016807</ELocationID><Abstract><AbstractText>Background Increasing studies demonstrated that the cardiac involvements are related to coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical characteristics of patients with COVID-19 and further determined the risk factors for cardiac involvement in them. Methods and Results We analyzed data from 102 consecutive laboratory-confirmed and hospitalized patients with COVID-19 (52 women aged 19-87 years). Epidemiologic and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury biomarkers), echocardiography, electrocardiography, chest imaging findings, management methods, and clinical outcomes were collected. Patients were divided into acute cardiac injury, with and without cardiac marker abnormities groups according to different level of cardiac markers. In this research, cardiac involvement was found in 72 of the 102 (70.6%) patients: tachycardia (n=20), electrocardiography abnormalities (n=23), echocardiography abnormalities (n=59), elevated myocardial enzymes (n=55), and acute cardiac injury (n=9). Eight patients with acute cardiac injury were aged >60 years; seven of them had ≥2 underlying comorbidities (hypertension, diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, and chronic kidney disease). Novel coronavirus pneumonia was much more severe in the patients with acute cardiac injury than in patients with nondefinite acute cardiac injury (<i>P</i><0.001). Multivariate analyses showed that CRP (C-reactive protein) levels, old age, novel coronavirus pneumonia severity, and underlying comorbidities were the risk factors for cardiac abnormalities in patients with COVID-19. Conclusions Cardiac involvements are common in patients with COVID-19. Elevated CRP levels, old age, underlying comorbidities, and novel coronavirus pneumonia severity are the main risk factors for cardiac involvement in patients with COVID-19. More attention should be given to cardiovascular protection during COVID-19 treatment for mortality reduction. Registration URL: https://www.chictr.org; Unique identifier: ChiCTR2000029955.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Huayan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Keke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Radiology Public Health Clinical Center of Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Rong</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Zhenlin</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>Hang</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wen</LastName><ForeName>Lingyi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Linjun</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Selvanayagam</LastName><ForeName>Joseph B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Medicine Flinders Medical Centre Flinders University of South Australia Adelaide Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Na</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Radiology Public Health Clinical Center of Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Zhigang</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Radiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Ming</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine Public Health Clinical Center of Chengdu China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Yingkun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education West China Second University Hospital Sichuan University Chengdu China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Am Heart Assoc</MedlineTA><NlmUniqueID>101580524</NlmUniqueID><ISSNLinking>2047-9980</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006331" MajorTopicYN="N">Heart Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID‐19</Keyword><Keyword MajorTopicYN="Y">acute cardiac injury</Keyword><Keyword MajorTopicYN="Y">cardiac involvement</Keyword><Keyword MajorTopicYN="Y">risk factor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32806998</ArticleId><ArticleId IdType="doi">10.1161/JAHA.120.016807</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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