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Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study.

Identifieur interne : 000542 ( Main/Curation ); précédent : 000541; suivant : 000543

Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study.

Auteurs : David W. Eyre [Royaume-Uni] ; Sheila F. Lumley [Royaume-Uni] ; Denise O'Donnell [Royaume-Uni] ; Mark Campbell [Royaume-Uni] ; Elizabeth Sims [Royaume-Uni] ; Elaine Lawson [Royaume-Uni] ; Fiona Warren [Royaume-Uni] ; Tim James [Royaume-Uni] ; Stuart Cox [Royaume-Uni] ; Alison Howarth [Royaume-Uni] ; George Doherty [Royaume-Uni] ; Stephanie B. Hatch [Royaume-Uni] ; James Kavanagh [Royaume-Uni] ; Kevin K. Chau [Royaume-Uni] ; Philip W. Fowler [Royaume-Uni] ; Jeremy Swann [Royaume-Uni] ; Denis Volk [Royaume-Uni] ; Fan Yang-Turner [Royaume-Uni] ; Nicole Stoesser [Royaume-Uni] ; Philippa C. Matthews [Royaume-Uni] ; Maria Dudareva [Royaume-Uni] ; Timothy Davies [Royaume-Uni] ; Robert H. Shaw [Royaume-Uni] ; Leon Peto [Royaume-Uni] ; Louise O. Downs [Royaume-Uni] ; Alexander Vogt [Royaume-Uni] ; Ali Amini [Royaume-Uni] ; Bernadette C. Young [Royaume-Uni] ; Philip George Drennan [Royaume-Uni] ; Alexander J. Mentzer [Royaume-Uni] ; Donal T. Skelly [Royaume-Uni] ; Fredrik Karpe [Royaume-Uni] ; Matt J. Neville [Royaume-Uni] ; Monique Andersson [Royaume-Uni] ; Andrew J. Brent [Royaume-Uni] ; Nicola Jones [Royaume-Uni] ; Lucas Martins Ferreira [Royaume-Uni] ; Thomas Christott [Royaume-Uni] ; Brian D. Marsden [Royaume-Uni] ; Sarah Hoosdally [Royaume-Uni] ; Richard Cornall [Royaume-Uni] ; Derrick W. Crook [Royaume-Uni] ; David I. Stuart [Royaume-Uni] ; Gavin Screaton [Royaume-Uni] ; Adam Jr Watson [Royaume-Uni] ; Adan Taylor [Royaume-Uni] ; Alan Chetwynd [Royaume-Uni] ; Alexander Grassam-Rowe [Royaume-Uni] ; Alexandra S. Mighiu [Royaume-Uni] ; Angus Livingstone [Royaume-Uni] ; Annabel Killen [Royaume-Uni] ; Caitlin Rigler [Royaume-Uni] ; Callum Harries [Royaume-Uni] ; Cameron East [Royaume-Uni] ; Charlotte Lee [Royaume-Uni] ; Chris Jb Mason [Royaume-Uni] ; Christian Holland [Royaume-Uni] ; Connor Thompson [Royaume-Uni] ; Conor Hennesey [Royaume-Uni] ; Constantinos Savva [Royaume-Uni] ; David S. Kim [Royaume-Uni] ; Edward Wa Harris [Royaume-Uni] ; Euan J. Mcgivern [Royaume-Uni] ; Evelyn Qian [Royaume-Uni] ; Evie Rothwell [Royaume-Uni] ; Francesca Back [Royaume-Uni] ; Gabriella Kelly [Royaume-Uni] ; Gareth Watson [Royaume-Uni] ; Gregory Howgego [Royaume-Uni] ; Hannah Chase [Royaume-Uni] ; Hannah Danbury [Royaume-Uni] ; Hannah Laurenson-Schafer [Royaume-Uni] ; Harry L. Ward [Royaume-Uni] ; Holly Hendron [Royaume-Uni] ; Imogen C. Vorley [Royaume-Uni] ; Isabel Tol [Royaume-Uni] ; James Gunnell [Royaume-Uni] ; Jocelyn Lf Ward [Royaume-Uni] ; Jonathan Drake [Royaume-Uni] ; Joseph D. Wilson [Royaume-Uni] ; Joshua Morton [Royaume-Uni] ; Julie Dequaire [Royaume-Uni] ; Katherine O'Byrne [Royaume-Uni] ; Kenzo Motohashi [Royaume-Uni] ; Kirsty Harper [Royaume-Uni] ; Krupa Ravi [Royaume-Uni] ; Lancelot J. Millar [Royaume-Uni] ; Liam J. Peck [Royaume-Uni] ; Madeleine Oliver [Royaume-Uni] ; Marcus Rex English [Royaume-Uni] ; Mary Kumarendran [Royaume-Uni] ; Matthew Wedlich [Royaume-Uni] ; Olivia Ambler [Royaume-Uni] ; Oscar T. Deal [Royaume-Uni] ; Owen Sweeney [Royaume-Uni] ; Philip Cowie [Royaume-Uni] ; Rebecca Te Water Naudé [Royaume-Uni] ; Rebecca Young [Royaume-Uni] ; Rosie Freer [Royaume-Uni] ; Samuel Scott [Royaume-Uni] ; Samuel Sussmes [Royaume-Uni] ; Sarah Peters [Royaume-Uni] ; Saxon Pattenden [Royaume-Uni] ; Seren Waite [Royaume-Uni] ; Síle Ann Johnson [Royaume-Uni] ; Stefan Kourdov [Royaume-Uni] ; Stephanie Santos-Paulo [Royaume-Uni] ; Stoyan Dimitrov [Royaume-Uni] ; Sven Kerneis [Royaume-Uni] ; Tariq Ahmed-Firani [Royaume-Uni] ; Thomas B. King [Royaume-Uni] ; Thomas G. Ritter [Royaume-Uni] ; Thomas H. Foord [Royaume-Uni] ; Zoe De Toledo [Royaume-Uni] ; Thomas Christie [Royaume-Uni] ; Bernadett Gergely [Royaume-Uni] ; David Axten [Royaume-Uni] ; Emma-Jane Simons [Royaume-Uni] ; Heather Nevard [Royaume-Uni] ; Jane Philips [Royaume-Uni] ; Justyna Szczurkowska [Royaume-Uni] ; Kaisha Patel [Royaume-Uni] ; Kyla Smit [Royaume-Uni] ; Laura Warren [Royaume-Uni] ; Lisa Morgan [Royaume-Uni] ; Lucianne Smith [Royaume-Uni] ; Maria Robles [Royaume-Uni] ; Mary Mcknight [Royaume-Uni] ; Michael Luciw [Royaume-Uni] ; Michelle Gates [Royaume-Uni] ; Nellia Sande [Royaume-Uni] ; Rachel Turford [Royaume-Uni] ; Roshni Ray [Royaume-Uni] ; Sonam Rughani [Royaume-Uni] ; Tracey Mitchell [Royaume-Uni] ; Trisha Bellinger [Royaume-Uni] ; Vicki Wharton [Royaume-Uni] ; Anita Justice [Royaume-Uni] ; Gerald Jesuthasan [Royaume-Uni] ; Susan Wareing [Royaume-Uni] ; Nurul Huda Mohamad Fadzillah [Royaume-Uni] ; Kathryn Cann [Royaume-Uni] ; Richard Kirton [Royaume-Uni] ; Claire Sutton [Royaume-Uni] ; Claudia Salvagno [Royaume-Uni] ; Gabriella Damato [Royaume-Uni] ; Gemma Pill [Royaume-Uni] ; Lisa Butcher [Royaume-Uni] ; Lydia Rylance-Knight [Royaume-Uni] ; Merline Tabirao [Royaume-Uni] ; Ruth Moroney [Royaume-Uni] ; Sarah Wright [Royaume-Uni] ; Timothy Ea Peto [Royaume-Uni] ; Bruno Holthof [Royaume-Uni] ; Anne-Marie O'Donnell [Royaume-Uni] ; Daniel Ebner [Royaume-Uni] ; Christopher P. Conlon [Royaume-Uni] ; Katie Jeffery [Royaume-Uni] ; Timothy M. Walker [Royaume-Uni, Viêt Nam]

Source :

RBID : pubmed:32820721

Descripteurs français

English descriptors

Abstract

We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).

DOI: 10.7554/eLife.60675
PubMed: 32820721
PubMed Central: PMC7486122

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pubmed:32820721

Le document en format XML

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<name sortKey="Shaw, Robert H" sort="Shaw, Robert H" uniqKey="Shaw R" first="Robert H" last="Shaw">Robert H. Shaw</name>
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<name sortKey="Peto, Leon" sort="Peto, Leon" uniqKey="Peto L" first="Leon" last="Peto">Leon Peto</name>
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<name sortKey="Downs, Louise O" sort="Downs, Louise O" uniqKey="Downs L" first="Louise O" last="Downs">Louise O. Downs</name>
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<name sortKey="Vogt, Alexander" sort="Vogt, Alexander" uniqKey="Vogt A" first="Alexander" last="Vogt">Alexander Vogt</name>
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<name sortKey="Amini, Ali" sort="Amini, Ali" uniqKey="Amini A" first="Ali" last="Amini">Ali Amini</name>
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<name sortKey="Ray, Roshni" sort="Ray, Roshni" uniqKey="Ray R" first="Roshni" last="Ray">Roshni Ray</name>
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<name sortKey="Harries, Callum" sort="Harries, Callum" uniqKey="Harries C" first="Callum" last="Harries">Callum Harries</name>
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<name sortKey="East, Cameron" sort="East, Cameron" uniqKey="East C" first="Cameron" last="East">Cameron East</name>
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<name sortKey="Lee, Charlotte" sort="Lee, Charlotte" uniqKey="Lee C" first="Charlotte" last="Lee">Charlotte Lee</name>
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<name sortKey="Mason, Chris Jb" sort="Mason, Chris Jb" uniqKey="Mason C" first="Chris Jb" last="Mason">Chris Jb Mason</name>
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<name sortKey="Holland, Christian" sort="Holland, Christian" uniqKey="Holland C" first="Christian" last="Holland">Christian Holland</name>
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<name sortKey="Thompson, Connor" sort="Thompson, Connor" uniqKey="Thompson C" first="Connor" last="Thompson">Connor Thompson</name>
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<name sortKey="Hennesey, Conor" sort="Hennesey, Conor" uniqKey="Hennesey C" first="Conor" last="Hennesey">Conor Hennesey</name>
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<name sortKey="Savva, Constantinos" sort="Savva, Constantinos" uniqKey="Savva C" first="Constantinos" last="Savva">Constantinos Savva</name>
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<name sortKey="Kim, David S" sort="Kim, David S" uniqKey="Kim D" first="David S" last="Kim">David S. Kim</name>
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<name sortKey="Harris, Edward Wa" sort="Harris, Edward Wa" uniqKey="Harris E" first="Edward Wa" last="Harris">Edward Wa Harris</name>
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<name sortKey="Mcgivern, Euan J" sort="Mcgivern, Euan J" uniqKey="Mcgivern E" first="Euan J" last="Mcgivern">Euan J. Mcgivern</name>
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<name sortKey="Qian, Evelyn" sort="Qian, Evelyn" uniqKey="Qian E" first="Evelyn" last="Qian">Evelyn Qian</name>
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<name sortKey="Back, Francesca" sort="Back, Francesca" uniqKey="Back F" first="Francesca" last="Back">Francesca Back</name>
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<name sortKey="Foord, Thomas H" sort="Foord, Thomas H" uniqKey="Foord T" first="Thomas H" last="Foord">Thomas H. Foord</name>
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<name sortKey="De Toledo, Zoe" sort="De Toledo, Zoe" uniqKey="De Toledo Z" first="Zoe" last="De Toledo">Zoe De Toledo</name>
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<name sortKey="Christie, Thomas" sort="Christie, Thomas" uniqKey="Christie T" first="Thomas" last="Christie">Thomas Christie</name>
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<name sortKey="Gergely, Bernadett" sort="Gergely, Bernadett" uniqKey="Gergely B" first="Bernadett" last="Gergely">Bernadett Gergely</name>
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<name sortKey="Axten, David" sort="Axten, David" uniqKey="Axten D" first="David" last="Axten">David Axten</name>
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<name sortKey="Simons, Emma Jane" sort="Simons, Emma Jane" uniqKey="Simons E" first="Emma-Jane" last="Simons">Emma-Jane Simons</name>
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<name sortKey="Philips, Jane" sort="Philips, Jane" uniqKey="Philips J" first="Jane" last="Philips">Jane Philips</name>
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<name sortKey="Szczurkowska, Justyna" sort="Szczurkowska, Justyna" uniqKey="Szczurkowska J" first="Justyna" last="Szczurkowska">Justyna Szczurkowska</name>
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<name sortKey="Patel, Kaisha" sort="Patel, Kaisha" uniqKey="Patel K" first="Kaisha" last="Patel">Kaisha Patel</name>
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<name sortKey="Smit, Kyla" sort="Smit, Kyla" uniqKey="Smit K" first="Kyla" last="Smit">Kyla Smit</name>
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<name sortKey="Warren, Laura" sort="Warren, Laura" uniqKey="Warren L" first="Laura" last="Warren">Laura Warren</name>
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<name sortKey="Morgan, Lisa" sort="Morgan, Lisa" uniqKey="Morgan L" first="Lisa" last="Morgan">Lisa Morgan</name>
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<name sortKey="Smith, Lucianne" sort="Smith, Lucianne" uniqKey="Smith L" first="Lucianne" last="Smith">Lucianne Smith</name>
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<name sortKey="Robles, Maria" sort="Robles, Maria" uniqKey="Robles M" first="Maria" last="Robles">Maria Robles</name>
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<name sortKey="Ray, Roshni" sort="Ray, Roshni" uniqKey="Ray R" first="Roshni" last="Ray">Roshni Ray</name>
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<div type="abstract" xml:lang="en">We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).</div>
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<DateCompleted>
<Year>2020</Year>
<Month>09</Month>
<Day>24</Day>
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<Year>2020</Year>
<Month>09</Month>
<Day>24</Day>
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<ISSN IssnType="Electronic">2050-084X</ISSN>
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<Volume>9</Volume>
<PubDate>
<Year>2020</Year>
<Month>08</Month>
<Day>21</Day>
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<Title>eLife</Title>
<ISOAbbreviation>Elife</ISOAbbreviation>
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<ArticleTitle>Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study.</ArticleTitle>
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<Abstract>
<AbstractText>We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).</AbstractText>
<CopyrightInformation>© 2020, Eyre et al.</CopyrightInformation>
</Abstract>
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